Bus Buffalo, NY to Charleston, SC - Compare all Companies

Compare all timetables for the bus from Buffalo, NY to Charleston, SC

Here is a selection of the cheapest bus trips from the schedule from Buffalo, NY to Charleston, SC from various bus operators like FlixBus for the next days.

today

tomorrow

$246

Friday

Saturday

Sunday

Monday

Tuesday

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	39h 5m	11:00 PM	Buffalo, NY	Central Bus Station	2:05 PM	Charleston, SC	Bus Station		Economy	$246	A Bus from FlixBus goes from Central Bus Station, Buffalo, NY (USA) at 10/22/2026 11:00:00 PM to Bus Station, Charleston, SC (USA) arriving at 10/24/2026 2:05:00 PM. 50 Economy ticket for $246 per person are available. Travel duration is 39h 5m
	FlixBus	27h 35m	10:30 AM	Buffalo, NY	Central Bus Station	2:05 PM	Charleston, SC	Bus Station		Economy	$304	A Bus from FlixBus goes from Central Bus Station, Buffalo, NY (USA) at 10/22/2026 10:30:00 AM to Bus Station, Charleston, SC (USA) arriving at 10/23/2026 2:05:00 PM. 50 Economy ticket for $304 per person are available. Travel duration is 27h 35m

Did you know that if you travel from Buffalo, NY to Charleston, SC via Washington, DC, you can save more than $84? You can find the corresponding connections below.
- FlixBus
  
  27h 10m
  
  0
  
  10:30 AM
  
  Buffalo, NY
  Central Bus Station
  
  11:40 PM
  
  Washington, DC
  Union Station
  
  0
  
  Economy
  
  $72
  
  A Bus from FlixBus goes from Central Bus Station, Buffalo, NY (USA) at 10/22/2026 10:30:00 AM to Union Station, Washington, DC (USA) arriving at 10/22/2026 11:40:00 PM. 50 Economy ticket for $72 per person are available. Travel duration is 13h 10m
- Greyhound US
  
  13h 45m
  
  0
  
  11:55 PM
  
  Washington, DC
  Union Station
  
  1:40 PM
  
  Charleston, SC
  Bus Station
  
  0
  
  Economy
  
  $90
  
  A Bus from Greyhound US goes from Union Station, Washington, DC (USA) at 10/22/2026 11:55:00 PM to Bus Station, Charleston, SC (USA) arriving at 10/23/2026 1:40:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 13h 45m
Travel Time is 0h 25m shorter, and you will save $84

Best Price Offer: The price for the cheapest bus from Buffalo, NY to Charleston, SC is $246 on 10/22/2026. Flexible travelers save on ticket prices.

Facts about the bus from Buffalo, NY to Charleston, SC

Compare all providers like FlixBus that travel 2 times every day by bus from Buffalo, NY to Charleston, SC in one click! Book your bus ticket from Buffalo, NY to Charleston, SC starting from $246!

Cheapest Bus	$246
Fastest Bus	27h 35m
Earliest Bus	10:30 AM
Latest Bus	11:00 PM
Daily Bus Routes	2 Ø
Distance	700.9 miles
Bus Companies	FlixBus

Cheapest bus connections from Buffalo, NY to Charleston, SC

Every day, 2 buses from 1 bus companies leave Buffalo, NY for Charleston, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/21/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 10/18

Monday 10/19

Tuesday 10/20

Wednesday 10/21

Thursday 10/22

$246

Friday 10/23

Saturday 10/24

Sunday 10/25

Monday 10/26

Tuesday 10/27

Wednesday 10/28

Thursday 10/29

Friday 10/30

Saturday 10/31

Sunday 11/01

Monday 11/02

Tuesday 11/03

Wednesday 11/04

Thursday 11/05

Friday 11/06

Saturday 11/07

Sunday 11/08

Monday 11/09

Tuesday 11/10

Wednesday 11/11

Thursday 11/12

Friday 11/13

Saturday 11/14

How to save money travelling from Buffalo, NY to Charleston, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Buffalo, NY to Charleston, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Buffalo, NY to Charleston, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Buffalo, NY to Charleston, SC are also emptier.

All bus stations and stops in Buffalo, NY and Charleston, SC

In the map below, you can see where to find all bus stations in Buffalo, NY and Charleston, SC.

Central Bus Station

Ellicott Street 181

MTC / Downtown Terminal

Ellicott Street 181

Maple Road Gulf

Maple Rd 4641

Cleveland Hall

Asia Food Market

Niagara Falls Blvd 2055

Bus Station

Dorchester Rd 3610

BI-LO Shopping Center Downtown

Meeting St 445

Service and Comfort on the bus from Buffalo, NY to Charleston, SC

Want to know which seat classes are available on the buses from Buffalo, NY to Charleston, SC? Or which bus companies serve the route Buffalo, NY to Charleston, SC? Below you will find answers to your questions.

FAQs about the Buffalo, NY to Charleston, SC bus

How much does a Buffalo, NY Charleston, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $246 and takes 39h 5m to reach Charleston, SC. Compare offers to save money!

How much could I save by comparing buses from Buffalo, NY to Charleston, SC?

This route is offered by 1 companies with a range of ticket prices between $246 and $304. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Charleston, SC.

On average, how many connections are available from Buffalo, NY to Charleston, SC each day?

Every day, the Buffalo, NY to Charleston, SC bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Buffalo, NY to Charleston, SC take?

The fastest bus from Buffalo, NY to Charleston, SC is offered by FlixBus and takes 27h 35m. Bus tickets for this connection cost $304. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Buffalo, NY to Charleston, SC?

The earliest bus arriving in Charleston, SC from Buffalo, NY starts at 10:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Buffalo, NY to Charleston, SC?

The latest bus trip departing from Buffalo, NY for Charleston, SC starts at 11:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Buffalo, NY Charleston, SC route?

When traveling by bus from Buffalo, NY to Charleston, SC, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Buffalo, NY and Charleston, SC?

You can check all the direct connections between Buffalo, NY and Charleston, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Buffalo, NY to Charleston, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Buffalo, NY Charleston, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Buffalo, NY Charleston, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Buffalo, NY to Charleston, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Buffalo, NY to Charleston, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 2 daily trips between Buffalo, NY and Charleston, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Buffalo, NY to Charleston, SC?

Prices and availability for 2 trips between Buffalo, NY and Charleston, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Buffalo, NY to Charleston, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Buffalo, NY and to Charleston, SC

Here’s an overview of the most popular bus routes to Buffalo, NY and to Charleston, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!