Bus Key West, FL to Jacksonville, FL: Compare prices and save money

Compare all timetables for the bus from Key West, FL to Jacksonville, FL

Here is a selection of the cheapest bus trips from the schedule from Key West, FL to Jacksonville, FL from various bus operators like Greyhound US for the next days.

today

$91

tomorrow

Sunday

Monday

$85

Tuesday

Wednesday

$81

Thursday

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	21h 0m	10:00 AM	Key West, FL	Bus Stop	7:00 AM	Jacksonville, FL	Amtrak Train Station		Economy	$91	A Bus from Greyhound US goes from Bus Stop, Key West, FL (USA) at 12/5/2025 10:00:00 AM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 12/6/2025 7:00:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 21h 0m
	Greyhound US	14h 45m	5:00 PM	Key West, FL	Bus Stop	7:45 AM	Jacksonville, FL	Amtrak Train Station		Economy	$95	A Bus from Greyhound US goes from Bus Stop, Key West, FL (USA) at 12/5/2025 5:00:00 PM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 12/6/2025 7:45:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 14h 45m

Did you know that if you travel from Key West, FL to Jacksonville, FL via Orlando, FL, you can save more than $14? You can find the corresponding connections below.
- Busbud
  
  14h 0m
  
  0
  
  5:00 PM
  
  Key West, FL
  Bus Stop
  
  3:40 AM
  
  Orlando, FL
  Florida Mall
  
  0
  
  Economy
  
  $53
  
  A Bus from Busbud goes from Bus Stop, Key West, FL (USA) at 12/7/2025 5:00:00 PM to Florida Mall, Orlando, FL (USA) arriving at 12/8/2025 3:40:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 10h 40m
- FlixBus
  
  3h 0m
  
  0
  
  4:00 AM
  
  Orlando, FL
  Bus Station
  
  7:00 AM
  
  Jacksonville, FL
  Amtrak Train Station
  
  0
  
  Economy
  
  $24
  
  A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 12/8/2025 4:00:00 AM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 12/8/2025 7:00:00 AM. 50 Economy ticket for $24 per person are available. Travel duration is 3h 0m
Travel Time is 0h 45m shorter, and you will save $14

Cheapest bus trips Monday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	21h 0m	10:00 AM	Key West, FL	Bus Stop	7:00 AM	Jacksonville, FL	Amtrak Train Station		Economy	$85	A Bus from Greyhound US goes from Bus Stop, Key West, FL (USA) at 12/8/2025 10:00:00 AM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 12/9/2025 7:00:00 AM. 50 Economy ticket for $85 per person are available. Travel duration is 21h 0m
	Greyhound US	15h 50m	5:00 PM	Key West, FL	Bus Stop	8:50 AM	Jacksonville, FL	Amtrak Train Station		Economy	$85	A Bus from Greyhound US goes from Bus Stop, Key West, FL (USA) at 12/8/2025 5:00:00 PM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 12/9/2025 8:50:00 AM. 50 Economy ticket for $85 per person are available. Travel duration is 15h 50m

Did you know that if you travel from Key West, FL to Jacksonville, FL via Orlando, FL, you can save more than $16? You can find the corresponding connections below.
- FlixBus
  
  15h 50m
  
  0
  
  5:00 PM
  
  Key West, FL
  Bus Stop
  
  4:15 AM
  
  Orlando, FL
  Bus Station
  
  0
  
  Economy
  
  $52
  
  A Bus from FlixBus goes from Bus Stop, Key West, FL (USA) at 12/8/2025 5:00:00 PM to Bus Station, Orlando, FL (USA) arriving at 12/9/2025 4:15:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 11h 15m
- Busbud
  
  2h 50m
  
  0
  
  6:00 AM
  
  Orlando, FL
  Bus Station
  
  8:50 AM
  
  Jacksonville, FL
  Downtown Bus Stop
  
  0
  
  Economy
  
  $17
  
  A Bus from Busbud goes from Bus Station, Orlando, FL (USA) at 12/9/2025 6:00:00 AM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 12/9/2025 8:50:00 AM. 50 Economy ticket for $17 per person are available. Travel duration is 2h 50m
Travel time is the same as the direct connection, but you will save $16

Cheapest bus trips Wednesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	14h 45m	5:00 PM	Key West, FL	Bus Stop	7:45 AM	Jacksonville, FL	Amtrak Train Station		Economy	$81	A Bus from Greyhound US goes from Bus Stop, Key West, FL (USA) at 12/10/2025 5:00:00 PM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 12/11/2025 7:45:00 AM. 50 Economy ticket for $81 per person are available. Travel duration is 14h 45m
	Greyhound US	21h 0m	10:00 AM	Key West, FL	Bus Stop	7:00 AM	Jacksonville, FL	Amtrak Train Station		Economy	$83	A Bus from Greyhound US goes from Bus Stop, Key West, FL (USA) at 12/10/2025 10:00:00 AM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 12/11/2025 7:00:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 21h 0m

Did you know that if you travel from Key West, FL to Jacksonville, FL via Orlando, FL, you can save more than $12? You can find the corresponding connections below.
- FlixBus
  
  15h 50m
  
  0
  
  5:00 PM
  
  Key West, FL
  Bus Stop
  
  4:15 AM
  
  Orlando, FL
  Bus Station
  
  0
  
  Economy
  
  $52
  
  A Bus from FlixBus goes from Bus Stop, Key West, FL (USA) at 12/8/2025 5:00:00 PM to Bus Station, Orlando, FL (USA) arriving at 12/9/2025 4:15:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 11h 15m
- Busbud
  
  2h 50m
  
  0
  
  6:00 AM
  
  Orlando, FL
  Bus Station
  
  8:50 AM
  
  Jacksonville, FL
  Downtown Bus Stop
  
  0
  
  Economy
  
  $17
  
  A Bus from Busbud goes from Bus Station, Orlando, FL (USA) at 12/9/2025 6:00:00 AM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 12/9/2025 8:50:00 AM. 50 Economy ticket for $17 per person are available. Travel duration is 2h 50m
Travel time is 1h 5m longer, but you will save $12

Best Price Offer: The price for the cheapest bus from Key West, FL to Jacksonville, FL is $81 on 12/10/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Key West, FL and Jacksonville, FL

See here how frequent the connections between Key West, FL and Jacksonville, FL are, during different times and days of the week.

Monday is the busiest day, with more than 2 daily buses from Key West, FL to Jacksonville, FL. Monday has instead the fewest connections, with only 2 daily coaches between Key West, FL and Jacksonville, FL.

The busiest time of the day is the Morning, with 3 buses from Key West, FL to Jacksonville, FL, while Morning sees the fewest connections between Key West, FL and Jacksonville, FL, with 3 offers.

Facts about the bus from Key West, FL to Jacksonville, FL

Compare all providers like Greyhound US that travel 2 times every day by bus from Key West, FL to Jacksonville, FL in one click! Book your bus ticket from Key West, FL to Jacksonville, FL starting from $81!

Cheapest Bus	$81
Fastest Bus	14h 45m
Earliest Bus	10:00 AM
Latest Bus	5:00 PM
Daily Bus Routes	2 Ø
Distance	399.1 miles
Bus Companies	Greyhound US

Cheapest bus connections from Key West, FL to Jacksonville, FL

Every day, 2 buses from 1 bus companies leave Key West, FL for Jacksonville, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

$91

Saturday 12/06

Sunday 12/07

Monday 12/08

$85

Tuesday 12/09

Wednesday 12/10

$81

Thursday 12/11

Friday 12/12

Saturday 12/13

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

The cheapest time to travel from Key West, FL to Jacksonville, FL

See here on which day and which time of the day you can find the cheapest bus ticket from Key West, FL to Jacksonville, FL, for the next 30 days.

With a price starting from $81, Wednesday is the cheapest day for a bus from Key West, FL to Jacksonville, FL. Friday instead is the most expensive day with prices starting from $91.

Afternoon is the cheapest day time for bus tickets from Key West, FL to Jacksonville, FL, with $81. Morning is the most expensive time of the day with prices starting from $83.

How to save money travelling from Key West, FL to Jacksonville, FL

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Key West, FL to Jacksonville, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Key West, FL to Jacksonville, FL, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Key West, FL to Jacksonville, FL are also emptier.

All bus stations and stops in Key West, FL and Jacksonville, FL

In the map below, you can see where to find all bus stations in Key West, FL and Jacksonville, FL.

Bus Stop

S Roosevelt Blvd 3535

Caroline St

Caroline St 900-998

Downtown Bus Stop

West Forsyth Street 1111

Central Bus Station

Old St. Augustine Rd

Old St. Augustine Rd 10584-13

Beaver St. & Ocean St. Bus Stop

Friendship Fountain

Service and Comfort on the bus from Key West, FL to Jacksonville, FL

Want to know which seat classes are available on the buses from Key West, FL to Jacksonville, FL? Or which bus companies serve the route Key West, FL to Jacksonville, FL? Below you will find answers to your questions.

FAQs about the Key West, FL to Jacksonville, FL bus

How much does a Key West, FL Jacksonville, FL bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $81 and takes 14h 45m to reach Jacksonville, FL. Compare offers to save money!

How much could I save by comparing buses from Key West, FL to Jacksonville, FL?

This route is offered by 1 companies with a range of ticket prices between $81 and $95. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Jacksonville, FL.

On average, how many connections are available from Key West, FL to Jacksonville, FL each day?

Every day, the Key West, FL to Jacksonville, FL bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Key West, FL to Jacksonville, FL take?

The fastest bus from Key West, FL to Jacksonville, FL is offered by Greyhound US and takes 14h 45m. Bus tickets for this connection cost $95. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Key West, FL to Jacksonville, FL?

The earliest bus arriving in Jacksonville, FL from Key West, FL starts at 10:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Key West, FL to Jacksonville, FL?

The latest bus trip departing from Key West, FL for Jacksonville, FL starts at 5:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Key West, FL Jacksonville, FL route?

When traveling by bus from Key West, FL to Jacksonville, FL, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Key West, FL and Jacksonville, FL?

You can check all the direct connections between Key West, FL and Jacksonville, FL by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Key West, FL to Jacksonville, FL bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Key West, FL Jacksonville, FL bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Key West, FL Jacksonville, FL bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Key West, FL to Jacksonville, FL on your planned travel date.

Available seat classes which are offered on the bus route Key West, FL to Jacksonville, FL

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Key West, FL and to Jacksonville, FL

Here’s an overview of the most popular bus routes to Key West, FL and to Jacksonville, FL. Simply click on the connection of your choice, and you will find all the details about your bus route!