Bus from Port Saint Lucie, FL to North Charleston, SC from $90

Compare all the bus companies and find the best price with CheckMyBus
Compare & Save Millions of buses in one click. Save up to 70%!
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Port Saint Lucie, FL to North Charleston, SC

Here is a selection of the cheapest bus trips from the schedule from Port Saint Lucie, FL to North Charleston, SC from various bus operators like Greyhound US or FlixBus for the next days.

today
tomorrow
Saturday
Sunday
$90
Monday
$90
Tuesday
Wednesday
$102

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 16h 50m 1:40 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop 6:30 PM North Charleston, SC Bus Station  Economy $90
Greyhound US 26h 45m 3:45 PM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop 6:30 PM North Charleston, SC Bus Station  Economy $101
  • Did you know that if you travel from Port Saint Lucie, FL to North Charleston, SC via Orlando, FL, you can save more than $18? You can find the corresponding connections below.
    • Busbud
      16h 45m
      0
      9:05 PM
      Port Saint Lucie, FL
      Fort Pierce Service Plaza
      11:15 PM
      Orlando, FL
      Jet Set Express Orlando Terminal
      0
      Busbud
      Economy
      $27
      • Waiting Time 4h 45m
    • Busbud
      9h 50m
      0
      4:00 AM
      Orlando, FL
      Bus Station
      1:50 PM
      North Charleston, SC
      Bus Station
      0
      Busbud
      Economy
      $45
    Travel Time is 0h 5m shorter, and you will save $18

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 16h 50m 1:40 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop 6:30 PM North Charleston, SC Bus Station  Economy $90
Greyhound US 26h 45m 3:45 PM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop 6:30 PM North Charleston, SC Bus Station  Economy $101
  • Did you know that if you travel from Port Saint Lucie, FL to North Charleston, SC via Orlando, FL, you can save more than $18? You can find the corresponding connections below.
    • Busbud
      16h 45m
      0
      9:05 PM
      Port Saint Lucie, FL
      Fort Pierce Service Plaza
      11:15 PM
      Orlando, FL
      Jet Set Express Orlando Terminal
      0
      Busbud
      Economy
      $27
      • Waiting Time 4h 45m
    • Busbud
      9h 50m
      0
      4:00 AM
      Orlando, FL
      Bus Station
      1:50 PM
      North Charleston, SC
      Bus Station
      0
      Busbud
      Economy
      $45
    Travel Time is 0h 5m shorter, and you will save $18

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 26h 45m 3:45 PM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop 6:30 PM North Charleston, SC Bus Station  Economy $102
  • Did you know that if you travel from Port Saint Lucie, FL to North Charleston, SC via Orlando, FL, you can save more than $33? You can find the corresponding connections below.
    • FlixBus
      36h 10m
      0
      1:40 AM
      Port Saint Lucie, FL
      RaceTrac Gas Station
      3:40 AM
      Orlando, FL
      Florida Mall
      0
      FlixBus
      Economy
      $23
      • Waiting Time 24h 20m
    • Busbud
      9h 50m
      0
      4:00 AM
      Orlando, FL
      Bus Station
      1:50 PM
      North Charleston, SC
      Bus Station
      0
      Busbud
      Economy
      $45
    Travel time is 9h 25m longer, but you will save $33

Best Price Offer: The price for the cheapest bus from Port Saint Lucie, FL to North Charleston, SC is $90 on 12/8/2025. Flexible travelers save on ticket prices.


Frequency of bus connections between Port Saint Lucie, FL and North Charleston, SC

See here how frequent the connections between Port Saint Lucie, FL and North Charleston, SC are, during different times and days of the week.
Sunday is the busiest day, with more than 2 daily buses from Port Saint Lucie, FL to North Charleston, SC. Wednesday has instead the fewest connections, with only 1 daily coaches between Port Saint Lucie, FL and North Charleston, SC.
The busiest time of the day is the Afternoon, with 3 buses from Port Saint Lucie, FL to North Charleston, SC, while Night sees the fewest connections between Port Saint Lucie, FL and North Charleston, SC, with 2 offers.

Facts about the bus from Port Saint Lucie, FL to North Charleston, SC

Compare all providers like Greyhound US and FlixBus that travel 1 times every day by bus from Port Saint Lucie, FL to North Charleston, SC in one click! Book your bus ticket from Port Saint Lucie, FL to North Charleston, SC starting from $90!

Cheapest Bus $90
Fastest Bus 16h 50m
Earliest Bus 1:40 AM
Latest Bus 3:45 PM
Daily Bus Routes 1 Ø
Distance 386.5 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from Port Saint Lucie, FL to North Charleston, SC

Every day, 1 buses from 2 bus companies leave Port Saint Lucie, FL for North Charleston, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/04/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 11/30
Monday 12/01
Tuesday 12/02
Wednesday 12/03
Thursday 12/04
Friday 12/05
Saturday 12/06
Sunday 12/07
$90
Monday 12/08
$90
Tuesday 12/09
Wednesday 12/10
$102
Thursday 12/11
Friday 12/12
Saturday 12/13
Sunday 12/14
Monday 12/15
Tuesday 12/16
Wednesday 12/17
Thursday 12/18
Friday 12/19
Saturday 12/20
Sunday 12/21
Monday 12/22
Tuesday 12/23
Wednesday 12/24
Thursday 12/25
Friday 12/26
Saturday 12/27

The cheapest time to travel from Port Saint Lucie, FL to North Charleston, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Port Saint Lucie, FL to North Charleston, SC, for the next 30 days.
With a price starting from $90, Monday is the cheapest day for a bus from Port Saint Lucie, FL to North Charleston, SC. Wednesday instead is the most expensive day with prices starting from $101.
Night is the cheapest day time for bus tickets from Port Saint Lucie, FL to North Charleston, SC, with $90. Afternoon is the most expensive time of the day with prices starting from $101.

How to save money travelling from Port Saint Lucie, FL to North Charleston, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Port Saint Lucie, FL to North Charleston, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Port Saint Lucie, FL to North Charleston, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Port Saint Lucie, FL to North Charleston, SC are also emptier.

Beloved bus companies from Port Saint Lucie, FL to North Charleston, SC

These are the most booked bus companies between Port Saint Lucie, FL to North Charleston, SC from our users.

FlixBus from Port Saint Lucie, FL to North Charleston, SC

FlixBus

Here you will find the key facts about the FlixBus bus route Port Saint Lucie, FL to North Charleston, SC:

Cheapest Price $90
Fastest Bus 16h 50m
Earliest Bus 1:40 AM
Last Bus 1:40 AM
Daily Connections 1 Ø
Found on 11/30/2025

All bus stations and stops in Port Saint Lucie, FL and North Charleston, SC

In the map below, you can see where to find all bus stations in Port Saint Lucie, FL and North Charleston, SC.

Service and Comfort on the bus from Port Saint Lucie, FL to North Charleston, SC

Want to know which seat classes are available on the buses from Port Saint Lucie, FL to North Charleston, SC? Or which bus companies serve the route Port Saint Lucie, FL to North Charleston, SC? Below you will find answers to your questions.

FAQs about the Port Saint Lucie, FL to North Charleston, SC bus

How much does a Port Saint Lucie, FL North Charleston, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $90 and takes 16h 50m to reach North Charleston, SC. Compare offers to save money!

How much could I save by comparing buses from Port Saint Lucie, FL to North Charleston, SC?

This route is offered by 2 companies with a range of ticket prices between $90 and $102. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to North Charleston, SC.

On average, how many connections are available from Port Saint Lucie, FL to North Charleston, SC each day?

Every day, the Port Saint Lucie, FL to North Charleston, SC bus route is served by approximately 1 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Port Saint Lucie, FL to North Charleston, SC take?

The fastest bus from Port Saint Lucie, FL to North Charleston, SC is offered by FlixBus and takes 16h 50m. Bus tickets for this connection cost $90. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Port Saint Lucie, FL to North Charleston, SC?

The earliest bus arriving in North Charleston, SC from Port Saint Lucie, FL starts at 1:40 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Port Saint Lucie, FL to North Charleston, SC?

The latest bus trip departing from Port Saint Lucie, FL for North Charleston, SC starts at 3:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Port Saint Lucie, FL North Charleston, SC route?

When traveling by bus from Port Saint Lucie, FL to North Charleston, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Port Saint Lucie, FL and North Charleston, SC?

You can check all the direct connections between Port Saint Lucie, FL and North Charleston, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Port Saint Lucie, FL to North Charleston, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Port Saint Lucie, FL North Charleston, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Port Saint Lucie, FL North Charleston, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Port Saint Lucie, FL to North Charleston, SC on your planned travel date.

Available seat classes which are offered on the bus route Port Saint Lucie, FL to North Charleston, SC

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Port Saint Lucie, FL and to North Charleston, SC

Here’s an overview of the most popular bus routes to Port Saint Lucie, FL and to North Charleston, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus West Palm Beach, FL - Port Saint Lucie, FL Bus West Palm Beach, FL - Port Saint Lucie, FL
Buses Tampa - Port Saint Lucie, FL Buses Tampa - Port Saint Lucie, FL
Buses from Fort Lauderdale, FL to Port Saint Lucie, FL Buses from Fort Lauderdale, FL to Port Saint Lucie, FL
Bus Jacksonville, FL - Port Saint Lucie, FL Bus Jacksonville, FL - Port Saint Lucie, FL
Myrtle Beach, SC to North Charleston, SC bus Myrtle Beach, SC to North Charleston, SC bus
From Augusta, GA to North Charleston, SC bus From Augusta, GA to North Charleston, SC bus
Buses from Washington, DC to North Charleston, SC Buses from Washington, DC to North Charleston, SC
New York to North Charleston, SC bus New York to North Charleston, SC bus
Popular Airport Shuttles to Port Saint Lucie, FL and to North Charleston, SC
CheckMyBus › Buses in USA › Bus to Port Saint Lucie, FL › Bus to North Charleston, SC

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.