Compare all timetables for the bus from Port Saint Lucie, FL to North Charleston, SC
Here is a selection of the cheapest bus trips from the schedule from Port Saint Lucie, FL to North Charleston, SC from various bus operators like Greyhound US or FlixBus for the next days.
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 26h 45m | 3:45 PM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 6:30 PM | North Charleston, SC | Bus Station | Economy | $103 |
A Bus from Greyhound US goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 12/14/2025 3:45:00 PM to Bus Station, North Charleston, SC (USA) arriving at 12/15/2025 6:30:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 26h 45m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 16h 50m | 1:40 AM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 6:30 PM | North Charleston, SC | Bus Station | Economy | $90 |
A Bus from FlixBus goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 12/15/2025 1:40:00 AM to Bus Station, North Charleston, SC (USA) arriving at 12/15/2025 6:30:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 16h 50m
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| Greyhound US | 26h 45m | 3:45 PM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 6:30 PM | North Charleston, SC | Bus Station | Economy | $108 |
A Bus from Greyhound US goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 12/15/2025 3:45:00 PM to Bus Station, North Charleston, SC (USA) arriving at 12/16/2025 6:30:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 26h 45m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 16h 50m | 1:40 AM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 6:30 PM | North Charleston, SC | Bus Station | Economy | $90 |
A Bus from FlixBus goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 12/20/2025 1:40:00 AM to Bus Station, North Charleston, SC (USA) arriving at 12/20/2025 6:30:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 16h 50m
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| Greyhound US | 26h 45m | 3:45 PM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 6:30 PM | North Charleston, SC | Bus Station | Economy | $108 |
A Bus from Greyhound US goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 12/20/2025 3:45:00 PM to Bus Station, North Charleston, SC (USA) arriving at 12/21/2025 6:30:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 26h 45m
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Best Price Offer: The price for the cheapest bus from Port Saint Lucie, FL to North Charleston, SC is $90 on 12/15/2025. Flexible travelers save on ticket prices.
Frequency of bus connections between Port Saint Lucie, FL and North Charleston, SC
Monday
is the busiest day, with more than 2 daily buses from Port Saint Lucie, FL to North Charleston, SC. Sunday has instead the fewest connections, with only 1 daily coaches between Port Saint Lucie, FL and North Charleston, SC.
The busiest time of the day is the Afternoon, with 3 buses from Port Saint Lucie, FL to North Charleston, SC, while Night sees the fewest connections between Port Saint Lucie, FL and North Charleston, SC, with 2 offers.
Facts about the bus from Port Saint Lucie, FL to North Charleston, SC
Compare all providers like Greyhound US and FlixBus that travel 1 times every day by bus from Port Saint Lucie, FL to North Charleston, SC in one click! Book your bus ticket from Port Saint Lucie, FL to North Charleston, SC starting from $90!
| Cheapest Bus | $90 |
| Fastest Bus | 16h 50m |
| Earliest Bus | 3:45 PM |
| Latest Bus | 3:45 PM |
| Daily Bus Routes | 1 Ø |
| Distance | 386.5 miles |
| Bus Companies | Greyhound US and FlixBus |
Cheapest bus connections from Port Saint Lucie, FL to North Charleston, SC
Every day, 1 buses from 2 bus companies leave Port Saint Lucie, FL for North Charleston, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/14/2025 and for the following days.
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday
12/14
$100
Monday
12/15
$90
Tuesday
12/16
Wednesday
12/17
Thursday
12/18
Friday
12/19
Saturday
12/20
$90
Sunday
12/21
Monday
12/22
$97
Tuesday
12/23
Wednesday
12/24
Thursday
12/25
Friday
12/26
Saturday
12/27
Sunday
12/28
Monday
12/29
Tuesday
12/30
Wednesday
12/31
Thursday
01/01
Friday
01/02
Saturday
01/03
Sunday
01/04
Monday
01/05
Tuesday
01/06
Wednesday
01/07
Thursday
01/08
Friday
01/09
Saturday
01/10
The cheapest time to travel from Port Saint Lucie, FL to North Charleston, SC
With a price starting from $90, Monday is the cheapest day for a bus from Port Saint Lucie, FL to North Charleston, SC. Sunday instead is the most expensive day with prices starting from $100.
Night
is the cheapest day time for bus tickets from Port Saint Lucie, FL to North Charleston, SC, with $90. Afternoon is the most expensive time of the day with prices starting from $103.
How to save money travelling from Port Saint Lucie, FL to North Charleston, SC
Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:
Book the ticket from Port Saint Lucie, FL to North Charleston, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Port Saint Lucie, FL to North Charleston, SC, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Port Saint Lucie, FL to North Charleston, SC are also emptier.Beloved bus companies from Port Saint Lucie, FL to North Charleston, SC
These are the most booked bus companies between Port Saint Lucie, FL to North Charleston, SC from our users.
FlixBus from Port Saint Lucie, FL to North Charleston, SC
Here you will find the key facts about the FlixBus bus route Port Saint Lucie, FL to North Charleston, SC:
| Cheapest Price | $90 |
| Fastest Bus | 16h 50m |
| Earliest Bus | 1:40 AM |
| Last Bus | 1:40 AM |
| Daily Connections | 1 Ø |
| Found on | 12/11/2025 |
All bus stations and stops in Port Saint Lucie, FL and North Charleston, SC
In the map below, you can see where to find all bus stations in Port Saint Lucie, FL and North Charleston, SC.
Service and Comfort on the bus from Port Saint Lucie, FL to North Charleston, SC
Want to know which seat classes are available on the buses from Port Saint Lucie, FL to North Charleston, SC? Or which bus companies serve the route Port Saint Lucie, FL to North Charleston, SC? Below you will find answers to your questions.
FAQs about the Port Saint Lucie, FL to North Charleston, SC bus
How much does a Port Saint Lucie, FL North Charleston, SC bus trip cost?
This depends on, among other things, the day and time of travel. The cheapest trip is available from $90 and takes 16h 50m to reach North Charleston, SC. Compare offers to save money!
How much could I save by comparing buses from Port Saint Lucie, FL to North Charleston, SC?
This route is offered by 2 companies with a range of ticket prices between $90 and $108. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to North Charleston, SC.
On average, how many connections are available from Port Saint Lucie, FL to North Charleston, SC each day?
Every day, the Port Saint Lucie, FL to North Charleston, SC bus route is served by approximately 1 connections. With our search, you can compare bus times to find the perfect trip.
How long does a bus journey from Port Saint Lucie, FL to North Charleston, SC take?
The fastest bus from Port Saint Lucie, FL to North Charleston, SC is offered by FlixBus and takes 16h 50m. Bus tickets for this connection cost $90. In this context, bear in mind that the journey can take longer due to traffic.
What time is the first bus from Port Saint Lucie, FL to North Charleston, SC?
The earliest bus arriving in North Charleston, SC from Port Saint Lucie, FL starts at 3:45 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.
What time is the last bus from Port Saint Lucie, FL to North Charleston, SC?
The latest bus trip departing from Port Saint Lucie, FL for North Charleston, SC starts at 3:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.
Which bus companies operate the Port Saint Lucie, FL North Charleston, SC route?
When traveling by bus from Port Saint Lucie, FL to North Charleston, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.
Is there a direct bus between Port Saint Lucie, FL and North Charleston, SC?
You can check all the direct connections between Port Saint Lucie, FL and North Charleston, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.
What can I take with me on the Port Saint Lucie, FL to North Charleston, SC bus route?
Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Port Saint Lucie, FL North Charleston, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.
What equipment is available for the Port Saint Lucie, FL North Charleston, SC bus route?
The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Port Saint Lucie, FL to North Charleston, SC on your planned travel date.
Available seat classes which are offered on the bus route Port Saint Lucie, FL to North Charleston, SC
Economy
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
More bus routes to Port Saint Lucie, FL and to North Charleston, SC
Here’s an overview of the most popular bus routes to Port Saint Lucie, FL and to North Charleston, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
- Bus Routes to Port Saint Lucie, FL
- Buses Atlanta, GA to Port Saint Lucie, FL
- Bus to Port Saint Lucie, FL from Boca Raton, FL
- Buses Coconut Creek, FL - Port Saint Lucie, FL
- Bus to Port Saint Lucie, FL from Denver
- Buses from Fort Lauderdale, FL to Port Saint Lucie, FL
- Buses to Port Saint Lucie, FL from Gainesville, FL
- Bus Jacksonville, FL - Port Saint Lucie, FL
- Bus Kissimmee, FL - Port Saint Lucie, FL
- From New York to Port Saint Lucie, FL bus
- Buses Portland, OR - Port Saint Lucie, FL
- Buses Rockledge, FL - Port Saint Lucie, FL
- Buses Tallahassee, FL to Port Saint Lucie, FL
- Buses Tampa - Port Saint Lucie, FL
- Venice, FL to Port Saint Lucie, FL bus
- Bus West Palm Beach, FL - Port Saint Lucie, FL
- Buses to Port Saint Lucie, FL from Winter Haven, FL
- Bus Routes to North Charleston, SC
- Bus Albany, NY - North Charleston, SC
- Buses to North Charleston, SC from Atlanta, GA
- Bus Charlotte - North Charleston, SC
- Buses Clarksville, TN to North Charleston, SC
- Buses from Columbia, SC to North Charleston, SC
- Buses from Dallas to North Charleston, SC
- Buses Florence, SC to North Charleston, SC
- Bus to North Charleston, SC from Jacksonville, FL
- Buses Norfolk, VA - North Charleston, SC
- Bus from Savannah, GA to North Charleston, SC
Popular Airport Shuttles to Port Saint Lucie, FL and to North Charleston, SC
