What is the best way to travel from Buffalo, NY to Chicago?
Looking for a trip? Compare all the available Flights and Buses for the journey to Chicago from Buffalo, NY. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Chicago from Buffalo, NY?
You can get to Chicago with just $62 by taking a Bus from Greyhound US, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Greyhound US15h 20m011:05 PMBuffalo, NYCentral Bus Station1:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/23/2026 11:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/24/2026 1:25:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 15h 20m
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Greyhound US11h 55m011:05 PMBuffalo, NYCentral Bus Station10:00 AMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/23/2026 11:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 6/24/2026 10:00:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 11h 55m
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Greyhound US18h 55m011:05 PMBuffalo, NYCentral Bus Station5:00 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/23/2026 11:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/24/2026 5:00:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 18h 55m
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Frontier Airlines11h 21m011:50 AMBuffalo AirportBuffalo Airport10:11 PMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/23/2026 11:50:00 AM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/23/2026 10:11:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 11h 21m
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Frontier Airlines9h 0m011:50 AMBuffalo AirportBuffalo Airport7:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/23/2026 11:50:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/23/2026 7:50:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 9h 0m
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United Airlines1h 59m06:02 PMBuffalo AirportBuffalo Airport7:01 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/23/2026 6:02:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/23/2026 7:01:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 1h 59m
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Frontier Airlines24h 19m011:50 AMBuffalo AirportBuffalo Airport11:09 AMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/23/2026 11:50:00 AM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/24/2026 11:09:00 AM. 50 Economy ticket for $165 per person are available. Travel duration is 24h 19m
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Frontier Airlines21h 13m011:50 AMBuffalo AirportBuffalo Airport8:03 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/23/2026 11:50:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/24/2026 8:03:00 AM. 50 Economy ticket for $177 per person are available. Travel duration is 21h 13m
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Skyscanner2h 3m010:50 AMBuffalo AirportBuffalo Airport11:53 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 6/23/2026 10:50:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/23/2026 11:53:00 AM. 50 Economy ticket for $178 per person are available. Travel duration is 2h 3m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
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Greyhound US16h 40m07:55 AMBuffalo, NYCentral Bus Station11:35 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/24/2026 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/24/2026 11:35:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 16h 40m
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Greyhound US15h 20m011:05 PMBuffalo, NYCentral Bus Station1:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/24/2026 11:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/25/2026 1:25:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 15h 20m
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/24/2026 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 6/24/2026 8:05:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 13h 10m
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Greyhound US11h 55m011:05 PMBuffalo, NYCentral Bus Station10:00 AMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/24/2026 11:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 6/25/2026 10:00:00 AM. 50 Economy ticket for $65 per person are available. Travel duration is 11h 55m
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Frontier Airlines8h 21m02:50 PMBuffalo AirportBuffalo Airport10:11 PMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/24/2026 2:50:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/24/2026 10:11:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 8h 21m
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Frontier Airlines6h 0m02:50 PMBuffalo AirportBuffalo Airport7:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/24/2026 2:50:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/24/2026 7:50:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 6h 0m
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United Airlines1h 59m07:00 AMBuffalo AirportBuffalo Airport7:59 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/24/2026 7:00:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/24/2026 7:59:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 1h 59m
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United Airlines1h 59m06:04 PMBuffalo AirportBuffalo Airport7:03 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/24/2026 6:04:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/24/2026 7:03:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 1h 59m
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Skyscanner2h 3m010:50 AMBuffalo AirportBuffalo Airport11:53 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 6/24/2026 10:50:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/24/2026 11:53:00 AM. 50 Economy ticket for $162 per person are available. Travel duration is 2h 3m
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JetBlue Airways6h 39m03:50 PMBuffalo AirportBuffalo Airport9:29 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from JetBlue Airways goes from Buffalo Airport, Buffalo Airport (USA) at 6/24/2026 3:50:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/24/2026 9:29:00 PM. 50 Economy ticket for $174 per person are available. Travel duration is 6h 39m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
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Greyhound US16h 40m07:55 AMBuffalo, NYCentral Bus Station11:35 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/25/2026 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/25/2026 11:35:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 16h 40m
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Greyhound US15h 20m011:05 PMBuffalo, NYCentral Bus Station1:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/25/2026 11:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/26/2026 1:25:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 15h 20m
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/25/2026 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 6/25/2026 8:05:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 13h 10m
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Greyhound US11h 55m011:05 PMBuffalo, NYCentral Bus Station10:00 AMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/25/2026 11:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 6/26/2026 10:00:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 11h 55m
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United Airlines1h 59m07:00 AMBuffalo AirportBuffalo Airport7:59 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/25/2026 7:00:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/25/2026 7:59:00 AM. 50 Economy ticket for $175 per person are available. Travel duration is 1h 59m
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United Airlines2h 0m010:57 AMBuffalo AirportBuffalo Airport11:57 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/25/2026 10:57:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/25/2026 11:57:00 AM. 50 Economy ticket for $175 per person are available. Travel duration is 2h 0m
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JetBlue Airways6h 40m03:50 PMBuffalo AirportBuffalo Airport9:30 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from JetBlue Airways goes from Buffalo Airport, Buffalo Airport (USA) at 6/25/2026 3:50:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/25/2026 9:30:00 PM. 50 Economy ticket for $233 per person are available. Travel duration is 6h 40m
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Frontier Airlines11h 36m011:35 AMBuffalo AirportBuffalo Airport10:11 PMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/25/2026 11:35:00 AM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/25/2026 10:11:00 PM. 50 Economy ticket for $238 per person are available. Travel duration is 11h 36m
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Frontier Airlines9h 15m011:35 AMBuffalo AirportBuffalo Airport7:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/25/2026 11:35:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/25/2026 7:50:00 PM. 50 Economy ticket for $238 per person are available. Travel duration is 9h 15m
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Frontier Airlines24h 34m011:35 AMBuffalo AirportBuffalo Airport11:09 AMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/25/2026 11:35:00 AM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/26/2026 11:09:00 AM. 50 Economy ticket for $241 per person are available. Travel duration is 24h 34m
Cheapest Buses Thursday
Cheapest Flights Thursday
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Greyhound US16h 40m07:55 AMBuffalo, NYCentral Bus Station11:35 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/26/2026 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/26/2026 11:35:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 16h 40m
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Greyhound US15h 20m011:05 PMBuffalo, NYCentral Bus Station1:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/26/2026 11:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/27/2026 1:25:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 15h 20m
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/26/2026 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 6/26/2026 8:05:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 13h 10m
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Greyhound US11h 55m011:05 PMBuffalo, NYCentral Bus Station10:00 AMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/26/2026 11:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 6/27/2026 10:00:00 AM. 50 Economy ticket for $65 per person are available. Travel duration is 11h 55m
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Frontier Airlines8h 21m02:50 PMBuffalo AirportBuffalo Airport10:11 PMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/26/2026 2:50:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/26/2026 10:11:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 8h 21m
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Frontier Airlines6h 0m02:50 PMBuffalo AirportBuffalo Airport7:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/26/2026 2:50:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/26/2026 7:50:00 PM. 50 Economy ticket for $152 per person are available. Travel duration is 6h 0m
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United Airlines1h 59m07:00 AMBuffalo AirportBuffalo Airport7:59 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/26/2026 7:00:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/26/2026 7:59:00 AM. 50 Economy ticket for $175 per person are available. Travel duration is 1h 59m
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JetBlue Airways26h 22m08:07 PMBuffalo AirportBuffalo Airport9:29 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from JetBlue Airways goes from Buffalo Airport, Buffalo Airport (USA) at 6/26/2026 8:07:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/27/2026 9:29:00 PM. 50 Economy ticket for $203 per person are available. Travel duration is 26h 22m
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Frontier Airlines21h 14m02:50 PMBuffalo AirportBuffalo Airport11:04 AMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/26/2026 2:50:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/27/2026 11:04:00 AM. 50 Economy ticket for $221 per person are available. Travel duration is 21h 14m
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Sun Country Airlines6h 4m012:20 PMBuffalo AirportBuffalo Airport5:24 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Sun Country Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/26/2026 12:20:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/26/2026 5:24:00 PM. 50 Economy ticket for $231 per person are available. Travel duration is 6h 4m
Cheapest Buses Friday
Cheapest Flights Friday
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Greyhound US16h 40m07:55 AMBuffalo, NYCentral Bus Station11:35 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/27/2026 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/27/2026 11:35:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 40m
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Greyhound US15h 20m011:05 PMBuffalo, NYCentral Bus Station1:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/27/2026 11:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/28/2026 1:25:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 15h 20m
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Greyhound US11h 55m011:05 PMBuffalo, NYCentral Bus Station10:00 AMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/27/2026 11:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 6/28/2026 10:00:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 11h 55m
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/27/2026 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 6/27/2026 8:05:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 13h 10m
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Frontier Airlines8h 21m012:29 PMBuffalo AirportBuffalo Airport7:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/27/2026 12:29:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/27/2026 7:50:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 8h 21m
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Frontier Airlines10h 42m012:29 PMBuffalo AirportBuffalo Airport10:11 PMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/27/2026 12:29:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/27/2026 10:11:00 PM. 50 Economy ticket for $160 per person are available. Travel duration is 10h 42m
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United Airlines1h 59m07:00 AMBuffalo AirportBuffalo Airport7:59 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/27/2026 7:00:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/27/2026 7:59:00 AM. 50 Economy ticket for $174 per person are available. Travel duration is 1h 59m
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United Airlines2h 0m010:57 AMBuffalo AirportBuffalo Airport11:57 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/27/2026 10:57:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/27/2026 11:57:00 AM. 50 Economy ticket for $174 per person are available. Travel duration is 2h 0m
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Allegiant Air13h 14m08:07 PMNiagara Falls AirportNiagara Falls Airport8:21 AMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Allegiant Air goes from Niagara Falls Airport, Niagara Falls Airport (USA) at 6/27/2026 8:07:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/28/2026 8:21:00 AM. 50 Economy ticket for $222 per person are available. Travel duration is 13h 14m
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Skyscanner2h 1m01:54 PMBuffalo AirportBuffalo Airport2:55 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 6/27/2026 1:54:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/27/2026 2:55:00 PM. 50 Economy ticket for $263 per person are available. Travel duration is 2h 1m
Cheapest Buses Saturday
Cheapest Flights Saturday
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Greyhound US16h 40m07:55 AMBuffalo, NYCentral Bus Station11:35 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/28/2026 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/28/2026 11:35:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 16h 40m
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Greyhound US15h 20m011:05 PMBuffalo, NYCentral Bus Station1:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/28/2026 11:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/29/2026 1:25:00 PM. 50 Economy ticket for $78 per person are available. Travel duration is 15h 20m
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United Airlines1h 59m07:00 AMBuffalo AirportBuffalo Airport7:59 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/28/2026 7:00:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/28/2026 7:59:00 AM. 50 Economy ticket for $195 per person are available. Travel duration is 1h 59m
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JetBlue Airways27h 13m06:32 AMBuffalo AirportBuffalo Airport8:45 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from JetBlue Airways goes from Buffalo Airport, Buffalo Airport (USA) at 6/28/2026 6:32:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/29/2026 8:45:00 AM. 50 Economy ticket for $203 per person are available. Travel duration is 27h 13m
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Frontier Airlines13h 19m09:02 PMBuffalo AirportBuffalo Airport9:21 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/28/2026 9:02:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/29/2026 9:21:00 AM. 50 Economy ticket for $231 per person are available. Travel duration is 13h 19m
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Sun Country Airlines8h 43m011:41 AMBuffalo AirportBuffalo Airport7:24 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Sun Country Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/28/2026 11:41:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/28/2026 7:24:00 PM. 50 Economy ticket for $273 per person are available. Travel duration is 8h 43m
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Allegiant Air23h 47m07:01 PMNiagara Falls AirportNiagara Falls Airport5:48 PMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Allegiant Air goes from Niagara Falls Airport, Niagara Falls Airport (USA) at 6/28/2026 7:01:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/29/2026 5:48:00 PM. 50 Economy ticket for $286 per person are available. Travel duration is 23h 47m
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Skyscanner2h 1m01:54 PMBuffalo AirportBuffalo Airport2:55 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 6/28/2026 1:54:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/28/2026 2:55:00 PM. 50 Economy ticket for $294 per person are available. Travel duration is 2h 1m
Cheapest Buses Sunday
Cheapest Flights Sunday
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/29/2026 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 6/29/2026 8:05:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 13h 10m
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Greyhound US16h 40m07:55 AMBuffalo, NYCentral Bus Station11:35 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/29/2026 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/29/2026 11:35:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 16h 40m
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Greyhound US15h 20m011:05 PMBuffalo, NYCentral Bus Station1:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/29/2026 11:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/30/2026 1:25:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 15h 20m
Cheapest Buses Monday
What are the fastest trips from Buffalo, NY to Chicago?
You can get to Chicago from Buffalo, NY in just 1h 59m with a Flight from United Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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United Airlines1h 59m06:02 PMBuffalo AirportBuffalo Airport7:01 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/23/2026 6:02:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/23/2026 7:01:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 1h 59m
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Skyscanner2h 3m010:50 AMBuffalo AirportBuffalo Airport11:53 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 6/23/2026 10:50:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/23/2026 11:53:00 AM. 50 Economy ticket for $178 per person are available. Travel duration is 2h 3m
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Frontier Airlines9h 0m011:50 AMBuffalo AirportBuffalo Airport7:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/23/2026 11:50:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/23/2026 7:50:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 9h 0m
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Frontier Airlines11h 21m011:50 AMBuffalo AirportBuffalo Airport10:11 PMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/23/2026 11:50:00 AM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/23/2026 10:11:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 11h 21m
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JetBlue Airways16h 2m08:07 PMBuffalo AirportBuffalo Airport11:09 AMChicago Midway AirportChicago Midway Airport0EconomyA Flight from JetBlue Airways goes from Buffalo Airport, Buffalo Airport (USA) at 6/23/2026 8:07:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/24/2026 11:09:00 AM. 50 Economy ticket for $236 per person are available. Travel duration is 16h 2m
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JetBlue Airways20h 19m03:50 PMBuffalo AirportBuffalo Airport11:09 AMChicago Midway AirportChicago Midway Airport0EconomyA Flight from JetBlue Airways goes from Buffalo Airport, Buffalo Airport (USA) at 6/23/2026 3:50:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/24/2026 11:09:00 AM. 50 Economy ticket for $236 per person are available. Travel duration is 20h 19m
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Greyhound US11h 55m011:05 PMBuffalo, NYCentral Bus Station10:00 AMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/23/2026 11:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 6/24/2026 10:00:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 11h 55m
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Greyhound US15h 20m011:05 PMBuffalo, NYCentral Bus Station1:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/23/2026 11:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/24/2026 1:25:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 15h 20m
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Greyhound US18h 55m011:05 PMBuffalo, NYCentral Bus Station5:00 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/23/2026 11:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/24/2026 5:00:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 18h 55m
Fastest Flights Tuesday
Fastest Buses Tuesday
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United Airlines1h 59m07:00 AMBuffalo AirportBuffalo Airport7:59 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/24/2026 7:00:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/24/2026 7:59:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 1h 59m
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United Airlines1h 59m06:04 PMBuffalo AirportBuffalo Airport7:03 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/24/2026 6:04:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/24/2026 7:03:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 1h 59m
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Skyscanner2h 3m010:50 AMBuffalo AirportBuffalo Airport11:53 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 6/24/2026 10:50:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/24/2026 11:53:00 AM. 50 Economy ticket for $162 per person are available. Travel duration is 2h 3m
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Frontier Airlines6h 0m02:50 PMBuffalo AirportBuffalo Airport7:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/24/2026 2:50:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/24/2026 7:50:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 6h 0m
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JetBlue Airways6h 39m03:50 PMBuffalo AirportBuffalo Airport9:29 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from JetBlue Airways goes from Buffalo Airport, Buffalo Airport (USA) at 6/24/2026 3:50:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/24/2026 9:29:00 PM. 50 Economy ticket for $174 per person are available. Travel duration is 6h 39m
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Frontier Airlines8h 21m02:50 PMBuffalo AirportBuffalo Airport10:11 PMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/24/2026 2:50:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/24/2026 10:11:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 8h 21m
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Greyhound US11h 55m011:05 PMBuffalo, NYCentral Bus Station10:00 AMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/24/2026 11:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 6/25/2026 10:00:00 AM. 50 Economy ticket for $65 per person are available. Travel duration is 11h 55m
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/24/2026 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 6/24/2026 8:05:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 13h 10m
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Greyhound US15h 20m011:05 PMBuffalo, NYCentral Bus Station1:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/24/2026 11:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/25/2026 1:25:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 15h 20m
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Greyhound US16h 40m07:55 AMBuffalo, NYCentral Bus Station11:35 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/24/2026 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/24/2026 11:35:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 16h 40m
Fastest Flights Wednesday
Fastest Buses Wednesday
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United Airlines1h 59m07:00 AMBuffalo AirportBuffalo Airport7:59 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/25/2026 7:00:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/25/2026 7:59:00 AM. 50 Economy ticket for $175 per person are available. Travel duration is 1h 59m
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United Airlines2h 0m010:57 AMBuffalo AirportBuffalo Airport11:57 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/25/2026 10:57:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/25/2026 11:57:00 AM. 50 Economy ticket for $175 per person are available. Travel duration is 2h 0m
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JetBlue Airways6h 40m03:50 PMBuffalo AirportBuffalo Airport9:30 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from JetBlue Airways goes from Buffalo Airport, Buffalo Airport (USA) at 6/25/2026 3:50:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/25/2026 9:30:00 PM. 50 Economy ticket for $233 per person are available. Travel duration is 6h 40m
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Frontier Airlines9h 15m011:35 AMBuffalo AirportBuffalo Airport7:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/25/2026 11:35:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/25/2026 7:50:00 PM. 50 Economy ticket for $238 per person are available. Travel duration is 9h 15m
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Frontier Airlines11h 36m011:35 AMBuffalo AirportBuffalo Airport10:11 PMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/25/2026 11:35:00 AM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/25/2026 10:11:00 PM. 50 Economy ticket for $238 per person are available. Travel duration is 11h 36m
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Frontier Airlines21h 28m011:35 AMBuffalo AirportBuffalo Airport8:03 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/25/2026 11:35:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/26/2026 8:03:00 AM. 50 Economy ticket for $241 per person are available. Travel duration is 21h 28m
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Greyhound US11h 55m011:05 PMBuffalo, NYCentral Bus Station10:00 AMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/25/2026 11:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 6/26/2026 10:00:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 11h 55m
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/25/2026 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 6/25/2026 8:05:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 13h 10m
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Greyhound US15h 20m011:05 PMBuffalo, NYCentral Bus Station1:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/25/2026 11:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/26/2026 1:25:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 15h 20m
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Greyhound US16h 40m07:55 AMBuffalo, NYCentral Bus Station11:35 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/25/2026 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/25/2026 11:35:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 16h 40m
Fastest Flights Thursday
Fastest Buses Thursday
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United Airlines1h 59m07:00 AMBuffalo AirportBuffalo Airport7:59 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/26/2026 7:00:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/26/2026 7:59:00 AM. 50 Economy ticket for $175 per person are available. Travel duration is 1h 59m
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Skyscanner2h 1m01:54 PMBuffalo AirportBuffalo Airport2:55 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 6/26/2026 1:54:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/26/2026 2:55:00 PM. 50 Economy ticket for $332 per person are available. Travel duration is 2h 1m
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Frontier Airlines6h 0m02:50 PMBuffalo AirportBuffalo Airport7:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/26/2026 2:50:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/26/2026 7:50:00 PM. 50 Economy ticket for $152 per person are available. Travel duration is 6h 0m
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Sun Country Airlines6h 4m012:20 PMBuffalo AirportBuffalo Airport5:24 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Sun Country Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/26/2026 12:20:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/26/2026 5:24:00 PM. 50 Economy ticket for $231 per person are available. Travel duration is 6h 4m
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Frontier Airlines8h 21m02:50 PMBuffalo AirportBuffalo Airport10:11 PMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/26/2026 2:50:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/26/2026 10:11:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 8h 21m
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Frontier Airlines21h 14m02:50 PMBuffalo AirportBuffalo Airport11:04 AMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/26/2026 2:50:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/27/2026 11:04:00 AM. 50 Economy ticket for $221 per person are available. Travel duration is 21h 14m
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Greyhound US11h 55m011:05 PMBuffalo, NYCentral Bus Station10:00 AMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/26/2026 11:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 6/27/2026 10:00:00 AM. 50 Economy ticket for $65 per person are available. Travel duration is 11h 55m
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/26/2026 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 6/26/2026 8:05:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 13h 10m
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Greyhound US15h 20m011:05 PMBuffalo, NYCentral Bus Station1:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/26/2026 11:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/27/2026 1:25:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 15h 20m
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Greyhound US16h 40m07:55 AMBuffalo, NYCentral Bus Station11:35 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/26/2026 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/26/2026 11:35:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 16h 40m
Fastest Flights Friday
Fastest Buses Friday
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United Airlines1h 59m07:00 AMBuffalo AirportBuffalo Airport7:59 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/27/2026 7:00:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/27/2026 7:59:00 AM. 50 Economy ticket for $174 per person are available. Travel duration is 1h 59m
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United Airlines2h 0m010:57 AMBuffalo AirportBuffalo Airport11:57 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/27/2026 10:57:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/27/2026 11:57:00 AM. 50 Economy ticket for $174 per person are available. Travel duration is 2h 0m
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Skyscanner2h 1m01:54 PMBuffalo AirportBuffalo Airport2:55 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 6/27/2026 1:54:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/27/2026 2:55:00 PM. 50 Economy ticket for $263 per person are available. Travel duration is 2h 1m
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Frontier Airlines8h 21m012:29 PMBuffalo AirportBuffalo Airport7:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/27/2026 12:29:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/27/2026 7:50:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 8h 21m
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Frontier Airlines10h 42m012:29 PMBuffalo AirportBuffalo Airport10:11 PMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/27/2026 12:29:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/27/2026 10:11:00 PM. 50 Economy ticket for $160 per person are available. Travel duration is 10h 42m
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Allegiant Air13h 14m08:07 PMNiagara Falls AirportNiagara Falls Airport8:21 AMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Allegiant Air goes from Niagara Falls Airport, Niagara Falls Airport (USA) at 6/27/2026 8:07:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/28/2026 8:21:00 AM. 50 Economy ticket for $222 per person are available. Travel duration is 13h 14m
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Greyhound US11h 55m011:05 PMBuffalo, NYCentral Bus Station10:00 AMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/27/2026 11:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 6/28/2026 10:00:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 11h 55m
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/27/2026 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 6/27/2026 8:05:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 13h 10m
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Greyhound US15h 20m011:05 PMBuffalo, NYCentral Bus Station1:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/27/2026 11:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/28/2026 1:25:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 15h 20m
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Greyhound US16h 40m07:55 AMBuffalo, NYCentral Bus Station11:35 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/27/2026 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/27/2026 11:35:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 40m
Fastest Flights Saturday
Fastest Buses Saturday
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United Airlines1h 59m07:00 AMBuffalo AirportBuffalo Airport7:59 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/28/2026 7:00:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/28/2026 7:59:00 AM. 50 Economy ticket for $195 per person are available. Travel duration is 1h 59m
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Skyscanner2h 1m01:54 PMBuffalo AirportBuffalo Airport2:55 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from Buffalo Airport, Buffalo Airport (USA) at 6/28/2026 1:54:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/28/2026 2:55:00 PM. 50 Economy ticket for $294 per person are available. Travel duration is 2h 1m
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Sun Country Airlines8h 43m011:41 AMBuffalo AirportBuffalo Airport7:24 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Sun Country Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/28/2026 11:41:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/28/2026 7:24:00 PM. 50 Economy ticket for $273 per person are available. Travel duration is 8h 43m
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Frontier Airlines11h 36m011:35 AMBuffalo AirportBuffalo Airport10:11 PMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/28/2026 11:35:00 AM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/28/2026 10:11:00 PM. 50 Economy ticket for $368 per person are available. Travel duration is 11h 36m
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Frontier Airlines13h 19m09:02 PMBuffalo AirportBuffalo Airport9:21 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 6/28/2026 9:02:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 6/29/2026 9:21:00 AM. 50 Economy ticket for $231 per person are available. Travel duration is 13h 19m
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JetBlue Airways16h 2m08:07 PMBuffalo AirportBuffalo Airport11:09 AMChicago Midway AirportChicago Midway Airport0EconomyA Flight from JetBlue Airways goes from Buffalo Airport, Buffalo Airport (USA) at 6/28/2026 8:07:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 6/29/2026 11:09:00 AM. 50 Economy ticket for $348 per person are available. Travel duration is 16h 2m
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Greyhound US15h 20m011:05 PMBuffalo, NYCentral Bus Station1:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/28/2026 11:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/29/2026 1:25:00 PM. 50 Economy ticket for $78 per person are available. Travel duration is 15h 20m
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Greyhound US16h 40m07:55 AMBuffalo, NYCentral Bus Station11:35 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/28/2026 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/28/2026 11:35:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 16h 40m
Fastest Flights Sunday
Fastest Buses Sunday
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/29/2026 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 6/29/2026 8:05:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 13h 10m
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Greyhound US15h 20m011:05 PMBuffalo, NYCentral Bus Station1:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/29/2026 11:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/30/2026 1:25:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 15h 20m
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Greyhound US16h 40m07:55 AMBuffalo, NYCentral Bus Station11:35 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 6/29/2026 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/29/2026 11:35:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 16h 40m
Fastest Buses Monday
Here you will find all operators and timetables for a
Bus from Buffalo, NY to Chicago
What are the most popular stations in Buffalo, NY and Chicago?
In Buffalo, NY, you will usually depart from Central Bus Station, Maple Road Gulf or Exchange Street Train Station, while in Chicago you will be arriving at California & 35th Street Bus Stop, Downtown Bus Station or 95th Red Line Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Chicago from Buffalo, NY? With 12 connections between 1 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Buffalo, NY and Chicago, you can pay as low as $62 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to Chicago in just 1h 59m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Buffalo, NY and Chicago are Greyhound US, Frontier Airlines and United Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Buffalo, NY and Chicago is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Sloan, NY or to Cicero, IL, and look at flights from Niagara Falls Airport, and landing at Chicago Midway Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Buffalo, NY to Chicago?
The most popular companies between Buffalo, NY and Chicago, are Greyhound US, Frontier Airlines and United Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US
Airlines: Frontier Airlines, United Airlines, JetBlue Airways and 3 more.
All you need to know when you travel from Buffalo, NY to Chicago
Check all information on comfort and services on all modes of transports from Buffalo, NY to Chicago. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Buffalo, NY to Chicago
How can I reach Chicago from Buffalo, NY?
Every day, there are on average 12 connections between Flight and Bus, with which you can get to Chicago from Buffalo, NY.
How far is Chicago from Buffalo, NY?
The distance between Buffalo, NY and Chicago is 452.7 miles.
What is the most ecofriendly mode of transport between Buffalo, NY and Chicago?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 20 kgs of CO2, a train 26 kgs, a car 124 kgs, and a flight 179 kgs.
What is the cheapest mode of transport from Buffalo, NY to Chicago?
You can get to Chicago with just $62 by taking a Bus from Greyhound US.
What is the fastest way to get from Buffalo, NY to Chicago?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Chicago in just 1h 59m with a Flight from United Airlines.
More routes to Buffalo, NY and to Chicago
Looking for more options? Here you can see the most popular routes to Buffalo, NY and to Chicago. Simply click on a connection, and you’ll find all the details about the route!
