What is the best way to travel from Buffalo, NY to Chicago?
Looking for a trip? Compare all the available Flights and Buses for the journey to Chicago from Buffalo, NY. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Chicago from Buffalo, NY?
You can get to Chicago with just $78 by taking a Bus from Greyhound US, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
-
Allegiant Air22h 13m09:00 PMNiagara Falls AirportNiagara Falls Airport6:13 PMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Allegiant Air goes from Niagara Falls Airport, Niagara Falls Airport (USA) at 3/16/2026 9:00:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 3/17/2026 6:13:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 22h 13m
Cheapest Flights Monday
-
Greyhound US25h 5m07:55 AMBuffalo, NYCentral Bus Station8:00 AMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 3/22/2026 7:55:00 AM to Union Station, Chicago (USA) arriving at 3/23/2026 8:00:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 25h 5m
-
Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 3/22/2026 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 3/22/2026 8:05:00 PM. 50 Economy ticket for $78 per person are available. Travel duration is 13h 10m
-
Frontier Airlines23h 7m012:45 PMBuffalo AirportBuffalo Airport10:52 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 3/22/2026 12:45:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 3/23/2026 10:52:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 23h 7m
-
Frontier Airlines19h 53m08:42 PMBuffalo AirportBuffalo Airport3:35 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 3/22/2026 8:42:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 3/23/2026 3:35:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 19h 53m
-
Frontier Airlines28h 2m08:42 PMBuffalo AirportBuffalo Airport11:44 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 3/22/2026 8:42:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 3/23/2026 11:44:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 28h 2m
-
United Airlines2h 3m06:51 AMBuffalo AirportBuffalo Airport7:54 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 3/22/2026 6:51:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 3/22/2026 7:54:00 AM. 50 Economy ticket for $154 per person are available. Travel duration is 2h 3m
-
United Airlines2h 9m05:46 PMBuffalo AirportBuffalo Airport6:55 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 3/22/2026 5:46:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 3/22/2026 6:55:00 PM. 50 Economy ticket for $184 per person are available. Travel duration is 2h 9m
Cheapest Buses Sunday
Cheapest Flights Sunday
What are the fastest trips from Buffalo, NY to Chicago?
You can get to Chicago from Buffalo, NY in just 2h 3m with a Flight from United Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
-
Allegiant Air22h 13m09:00 PMNiagara Falls AirportNiagara Falls Airport6:13 PMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Allegiant Air goes from Niagara Falls Airport, Niagara Falls Airport (USA) at 3/16/2026 9:00:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 3/17/2026 6:13:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 22h 13m
Fastest Flights Monday
-
United Airlines2h 3m06:51 AMBuffalo AirportBuffalo Airport7:54 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 3/22/2026 6:51:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 3/22/2026 7:54:00 AM. 50 Economy ticket for $154 per person are available. Travel duration is 2h 3m
-
United Airlines2h 9m05:46 PMBuffalo AirportBuffalo Airport6:55 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 3/22/2026 5:46:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 3/22/2026 6:55:00 PM. 50 Economy ticket for $184 per person are available. Travel duration is 2h 9m
-
Frontier Airlines19h 53m08:42 PMBuffalo AirportBuffalo Airport3:35 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 3/22/2026 8:42:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 3/23/2026 3:35:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 19h 53m
-
Frontier Airlines23h 7m012:45 PMBuffalo AirportBuffalo Airport10:52 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 3/22/2026 12:45:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 3/23/2026 10:52:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 23h 7m
-
Frontier Airlines28h 2m08:42 PMBuffalo AirportBuffalo Airport11:44 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Frontier Airlines goes from Buffalo Airport, Buffalo Airport (USA) at 3/22/2026 8:42:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 3/23/2026 11:44:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 28h 2m
-
Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 3/22/2026 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 3/22/2026 8:05:00 PM. 50 Economy ticket for $78 per person are available. Travel duration is 13h 10m
-
Greyhound US25h 5m07:55 AMBuffalo, NYCentral Bus Station8:00 AMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 3/22/2026 7:55:00 AM to Union Station, Chicago (USA) arriving at 3/23/2026 8:00:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 25h 5m
Fastest Flights Sunday
Fastest Buses Sunday
Here you will find all operators and timetables for a
Bus from Buffalo, NY to Chicago
What are the most popular stations in Buffalo, NY and Chicago?
In Buffalo, NY, you will usually depart from Central Bus Station, Exchange Street Train Station or Maple Road Gulf, while in Chicago you will be arriving at California & 35th Street Bus Stop, Downtown Bus Station or 95th Red Line Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Chicago from Buffalo, NY? With 4 connections between 1 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Buffalo, NY and Chicago, you can pay as low as $78 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to Chicago in just 2h 3m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Buffalo, NY and Chicago are Frontier Airlines, Greyhound US and United Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Buffalo, NY and Chicago is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Sloan, NY or to Cicero, IL, and look at flights from Niagara Falls Airport, and landing at Chicago Midway Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Buffalo, NY to Chicago?
The most popular companies between Buffalo, NY and Chicago, are Frontier Airlines, Greyhound US and United Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US
Airlines: Frontier Airlines, United Airlines and Allegiant Air
All you need to know when you travel from Buffalo, NY to Chicago
Check all information on comfort and services on all modes of transports from Buffalo, NY to Chicago. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Buffalo, NY to Chicago
How can I reach Chicago from Buffalo, NY?
Every day, there are on average 4 connections between Flight and Bus, with which you can get to Chicago from Buffalo, NY.
How far is Chicago from Buffalo, NY?
The distance between Buffalo, NY and Chicago is 452.7 miles.
What is the most ecofriendly mode of transport between Buffalo, NY and Chicago?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 20 kgs of CO2, a train 26 kgs, a car 124 kgs, and a flight 179 kgs.
What is the cheapest mode of transport from Buffalo, NY to Chicago?
You can get to Chicago with just $78 by taking a Bus from Greyhound US.
What is the fastest way to get from Buffalo, NY to Chicago?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Chicago in just 2h 3m with a Flight from United Airlines.
More routes to Buffalo, NY and to Chicago
Looking for more options? Here you can see the most popular routes to Buffalo, NY and to Chicago. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Buffalo, NY
- Atlanta, GA to Buffalo, NY
- Birmingham, AL to Buffalo, NY
- New York to Buffalo, NY
- Trips to Chicago
- Atlanta, GA to Chicago
- Boston, MA to Chicago
- Cincinnati to Chicago
- Dallas to Chicago
- El Paso, TX to Chicago
- Houston to Chicago
- Little Rock, AR to Chicago
- Los Angeles to Chicago
- Louisville, KY to Chicago
- Matamoros to Chicago
- Memphis to Chicago
- Monterrey, NL to Chicago
- Nashville to Chicago
- New York to Chicago
- Oklahoma City, OK to Chicago
- Pearson Toronto Airport to Chicago
- Philadelphia to Chicago
- San Antonio, TX to Chicago
- St. Louis, MO to Chicago
- Toronto, ON to Chicago
