What is the best way to travel from Buffalo, NY to Chicago?
Looking for a trip? Compare all the available Buses and Flights for the journey to Chicago from Buffalo, NY. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Chicago from Buffalo, NY?
You can get to Chicago with just $73 by taking a Bus from Greyhound US, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Greyhound US15h 30m07:55 AMBuffalo, NYCentral Bus Station10:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/5/2025 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/5/2025 10:25:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 15h 30m
Cheapest Buses Friday
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Greyhound US25h 5m07:55 AMBuffalo, NYCentral Bus Station8:00 AMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/6/2025 7:55:00 AM to Union Station, Chicago (USA) arriving at 12/7/2025 8:00:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 25h 5m
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/6/2025 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/6/2025 8:05:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 13h 10m
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Greyhound US15h 30m07:55 AMBuffalo, NYCentral Bus Station10:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/6/2025 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/6/2025 10:25:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 15h 30m
Cheapest Buses Saturday
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Greyhound US25h 5m07:55 AMBuffalo, NYCentral Bus Station8:00 AMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/8/2025 7:55:00 AM to Union Station, Chicago (USA) arriving at 12/9/2025 8:00:00 AM. 50 Economy ticket for $73 per person are available. Travel duration is 25h 5m
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/8/2025 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/8/2025 8:05:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 13h 10m
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Greyhound US15h 30m07:55 AMBuffalo, NYCentral Bus Station10:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/8/2025 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/8/2025 10:25:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 15h 30m
Cheapest Buses Monday
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/10/2025 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/10/2025 8:05:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 13h 10m
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Greyhound US25h 5m07:55 AMBuffalo, NYCentral Bus Station8:00 AMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/10/2025 7:55:00 AM to Union Station, Chicago (USA) arriving at 12/11/2025 8:00:00 AM. 50 Economy ticket for $81 per person are available. Travel duration is 25h 5m
Cheapest Buses Wednesday
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/11/2025 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/11/2025 8:05:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 13h 10m
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Greyhound US25h 5m07:55 AMBuffalo, NYCentral Bus Station8:00 AMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/11/2025 7:55:00 AM to Union Station, Chicago (USA) arriving at 12/12/2025 8:00:00 AM. 50 Economy ticket for $87 per person are available. Travel duration is 25h 5m
Cheapest Buses Thursday
What are the fastest trips from Buffalo, NY to Chicago?
You can get to Chicago from Buffalo, NY in just 13h 10m with a Bus from Greyhound US. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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Greyhound US15h 30m07:55 AMBuffalo, NYCentral Bus Station10:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/5/2025 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/5/2025 10:25:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 15h 30m
Fastest Buses Friday
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/6/2025 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/6/2025 8:05:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 13h 10m
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Greyhound US15h 30m07:55 AMBuffalo, NYCentral Bus Station10:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/6/2025 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/6/2025 10:25:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 15h 30m
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Greyhound US25h 5m07:55 AMBuffalo, NYCentral Bus Station8:00 AMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/6/2025 7:55:00 AM to Union Station, Chicago (USA) arriving at 12/7/2025 8:00:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 25h 5m
Fastest Buses Saturday
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/8/2025 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/8/2025 8:05:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 13h 10m
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Greyhound US15h 30m07:55 AMBuffalo, NYCentral Bus Station10:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/8/2025 7:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/8/2025 10:25:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 15h 30m
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Greyhound US25h 5m07:55 AMBuffalo, NYCentral Bus Station8:00 AMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/8/2025 7:55:00 AM to Union Station, Chicago (USA) arriving at 12/9/2025 8:00:00 AM. 50 Economy ticket for $73 per person are available. Travel duration is 25h 5m
Fastest Buses Monday
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/10/2025 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/10/2025 8:05:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 13h 10m
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Greyhound US25h 5m07:55 AMBuffalo, NYCentral Bus Station8:00 AMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/10/2025 7:55:00 AM to Union Station, Chicago (USA) arriving at 12/11/2025 8:00:00 AM. 50 Economy ticket for $81 per person are available. Travel duration is 25h 5m
Fastest Buses Wednesday
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Greyhound US13h 10m07:55 AMBuffalo, NYCentral Bus Station8:05 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/11/2025 7:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/11/2025 8:05:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 13h 10m
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Greyhound US25h 5m07:55 AMBuffalo, NYCentral Bus Station8:00 AMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 12/11/2025 7:55:00 AM to Union Station, Chicago (USA) arriving at 12/12/2025 8:00:00 AM. 50 Economy ticket for $87 per person are available. Travel duration is 25h 5m
Fastest Buses Thursday
Here you will find all operators and timetables for a
Bus from Buffalo, NY to Chicago
What are the most popular stations in Buffalo, NY and Chicago?
In Buffalo, NY, you will usually depart from Central Bus Station, Maple Road Gulf or Exchange Street Train Station, while in Chicago you will be arriving at California & 35th Street Bus Stop, Downtown Bus Station or 95th Red Line Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Chicago from Buffalo, NY? With 2 connections between 1 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Buffalo, NY and Chicago, you can pay as low as $73 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from Greyhound US: you will get to Chicago in just 13h 10m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Buffalo, NY and Chicago are Greyhound US, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Buffalo, NY and Chicago is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Sloan, NY or to Cicero, IL, and look at flights from Niagara Falls Airport, and landing at Chicago Midway Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Buffalo, NY to Chicago?
The most popular companies between Buffalo, NY and Chicago, are Greyhound US. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US
All you need to know when you travel from Buffalo, NY to Chicago
Check all information on comfort and services on all modes of transports from Buffalo, NY to Chicago. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Buffalo, NY to Chicago
How can I reach Chicago from Buffalo, NY?
Every day, there are on average 2 connections between Bus and Flight, with which you can get to Chicago from Buffalo, NY.
How far is Chicago from Buffalo, NY?
The distance between Buffalo, NY and Chicago is 452.7 miles.
What is the most ecofriendly mode of transport between Buffalo, NY and Chicago?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 20 kgs of CO2, a train 26 kgs, a car 124 kgs, and a flight 179 kgs.
What is the cheapest mode of transport from Buffalo, NY to Chicago?
You can get to Chicago with just $73 by taking a Bus from Greyhound US.
What is the fastest way to get from Buffalo, NY to Chicago?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Chicago in just 13h 10m with a Bus from Greyhound US.
More routes to Buffalo, NY and to Chicago
Looking for more options? Here you can see the most popular routes to Buffalo, NY and to Chicago. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Buffalo, NY
- Atlanta, GA to Buffalo, NY
- Birmingham, AL to Buffalo, NY
- New York to Buffalo, NY
- Philadelphia to Buffalo, NY
- Trips to Chicago
- Atlanta, GA to Chicago
- Bloomington, IN to Chicago
- Ciudad Juárez to Chicago
- Dallas to Chicago
- Durango, DG to Chicago
- El Paso, TX to Chicago
- Guadalajara, JC to Chicago
- Houston to Chicago
- London, ON to Chicago
- Los Angeles to Chicago
- Memphis to Chicago
- Mexico City to Chicago
- Monterrey, NL to Chicago
- New York to Chicago
- Niagara Falls, ON to Chicago
- Nuevo Laredo to Chicago
- Pearson Toronto Airport to Chicago
- San Antonio, TX to Chicago
- San Diego to Chicago
- San Luis Potosí to Chicago
- St. Louis, MO to Chicago
- Toronto, ON to Chicago
- Tulsa to Chicago

