What is the best way to travel from Chicago to Louisville, KY?
Looking for a trip? Compare all the available Flights and Buses for the journey to Louisville, KY from Chicago. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Louisville, KY from Chicago?
You can get to Louisville, KY with just $34 by taking a Bus from FlixBus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus7h 0m05:25 AMChicago95th Red Line Station1:25 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 1/31/2026 5:25:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 1/31/2026 1:25:00 PM. 50 Economy ticket for $34 per person are available. Travel duration is 7h 0m
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FlixBus11h 0m05:45 AMChicago95th Red Line Station5:45 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 1/31/2026 5:45:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 1/31/2026 5:45:00 PM. 50 Economy ticket for $34 per person are available. Travel duration is 11h 0m
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Greyhound US6h 5m011:40 PMChicago95th Red Line Station6:45 AMLouisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 1/31/2026 11:40:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/1/2026 6:45:00 AM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 5m
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Greyhound US6h 15m06:10 AMChicagoDowntown Bus Station1:25 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 1/31/2026 6:10:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 1/31/2026 1:25:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 15m
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Spirit Airlines20h 9m05:32 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:41 PMLouisville AirportLouisville Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 1/31/2026 5:32:00 PM to Louisville Airport, Louisville Airport (USA) arriving at 2/1/2026 2:41:00 PM. 50 Economy ticket for $211 per person are available. Travel duration is 20h 9m
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Frontier Airlines25h 41m012:00 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:41 PMLouisville AirportLouisville Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 1/31/2026 12:00:00 PM to Louisville Airport, Louisville Airport (USA) arriving at 2/1/2026 2:41:00 PM. 50 Economy ticket for $211 per person are available. Travel duration is 25h 41m
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Frontier Airlines29h 24m09:25 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center3:49 PMLouisville AirportLouisville Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 1/31/2026 9:25:00 AM to Louisville Airport, Louisville Airport (USA) arriving at 2/1/2026 3:49:00 PM. 50 Economy ticket for $222 per person are available. Travel duration is 29h 24m
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Spirit Airlines30h 21m07:20 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:41 PMLouisville AirportLouisville Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 1/31/2026 7:20:00 AM to Louisville Airport, Louisville Airport (USA) arriving at 2/1/2026 2:41:00 PM. 50 Economy ticket for $252 per person are available. Travel duration is 30h 21m
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United Airlines4h 56m08:52 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:48 PMLouisville AirportLouisville Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 1/31/2026 8:52:00 AM to Louisville Airport, Louisville Airport (USA) arriving at 1/31/2026 2:48:00 PM. 50 Economy ticket for $318 per person are available. Travel duration is 4h 56m
Cheapest Buses Saturday
Cheapest Flights Saturday
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Greyhound US7h 5m09:40 AMChicagoDowntown Bus Station5:45 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 2/1/2026 9:40:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/1/2026 5:45:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 7h 5m
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Greyhound US6h 55m010:50 PMChicagoDowntown Bus Station6:45 AMLouisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 2/1/2026 10:50:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/2/2026 6:45:00 AM. 50 Economy ticket for $49 per person are available. Travel duration is 6h 55m
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Greyhound US6h 45m010:00 AMChicagoUnion Station5:45 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 2/1/2026 10:00:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/1/2026 5:45:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 6h 45m
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FlixBus6h 25m06:00 PMChicagoDowntown Bus Station1:25 AMLouisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 2/1/2026 6:00:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/2/2026 1:25:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 6h 25m
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FlixBus7h 50m01:00 PMChicagoDowntown Bus Station9:50 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 2/1/2026 1:00:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/1/2026 9:50:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 7h 50m
Cheapest Buses Sunday
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Spirit Airlines30h 21m07:20 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:41 PMLouisville AirportLouisville Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/2/2026 7:20:00 AM to Louisville Airport, Louisville Airport (USA) arriving at 2/3/2026 2:41:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 30h 21m
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Spirit Airlines20h 9m05:32 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:41 PMLouisville AirportLouisville Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/2/2026 5:32:00 PM to Louisville Airport, Louisville Airport (USA) arriving at 2/3/2026 2:41:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 20h 9m
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Spirit Airlines16h 58m08:43 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:41 PMLouisville AirportLouisville Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/2/2026 8:43:00 PM to Louisville Airport, Louisville Airport (USA) arriving at 2/3/2026 2:41:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 16h 58m
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United Airlines1h 39m010:45 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center1:24 PMLouisville AirportLouisville Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/2/2026 10:45:00 AM to Louisville Airport, Louisville Airport (USA) arriving at 2/2/2026 1:24:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 39m
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United Airlines1h 37m03:00 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center5:37 PMLouisville AirportLouisville Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/2/2026 3:00:00 PM to Louisville Airport, Louisville Airport (USA) arriving at 2/2/2026 5:37:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 37m
Cheapest Flights Monday
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Greyhound US7h 5m09:40 AMChicagoDowntown Bus Station5:45 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 2/3/2026 9:40:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/3/2026 5:45:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 7h 5m
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Greyhound US6h 45m010:00 AMChicagoUnion Station5:45 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 2/3/2026 10:00:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/3/2026 5:45:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 6h 45m
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Greyhound US6h 15m06:10 AMChicagoDowntown Bus Station1:25 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 2/3/2026 6:10:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/3/2026 1:25:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 6h 15m
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FlixBus7h 50m01:00 PMChicagoDowntown Bus Station9:50 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 2/3/2026 1:00:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/3/2026 9:50:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 7h 50m
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Spirit Airlines25h 12m010:48 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center1:00 PMLouisville AirportLouisville Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/3/2026 10:48:00 AM to Louisville Airport, Louisville Airport (USA) arriving at 2/4/2026 1:00:00 PM. 50 Economy ticket for $225 per person are available. Travel duration is 25h 12m
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Spirit Airlines23h 16m012:44 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center1:00 PMLouisville AirportLouisville Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/3/2026 12:44:00 PM to Louisville Airport, Louisville Airport (USA) arriving at 2/4/2026 1:00:00 PM. 50 Economy ticket for $225 per person are available. Travel duration is 23h 16m
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Spirit Airlines8h 26m05:15 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:41 PMLouisville AirportLouisville Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/3/2026 5:15:00 AM to Louisville Airport, Louisville Airport (USA) arriving at 2/3/2026 2:41:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 8h 26m
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United Airlines1h 38m010:50 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center1:28 PMLouisville AirportLouisville Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/3/2026 10:50:00 AM to Louisville Airport, Louisville Airport (USA) arriving at 2/3/2026 1:28:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 38m
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United Airlines1h 38m05:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:28 PMLouisville AirportLouisville Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/3/2026 5:50:00 PM to Louisville Airport, Louisville Airport (USA) arriving at 2/3/2026 8:28:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 38m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
What are the fastest trips from Chicago to Louisville, KY?
You can get to Louisville, KY from Chicago in just 1h 37m with a Flight from United Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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United Airlines4h 56m08:52 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:48 PMLouisville AirportLouisville Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 1/31/2026 8:52:00 AM to Louisville Airport, Louisville Airport (USA) arriving at 1/31/2026 2:48:00 PM. 50 Economy ticket for $318 per person are available. Travel duration is 4h 56m
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Spirit Airlines20h 9m05:32 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:41 PMLouisville AirportLouisville Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 1/31/2026 5:32:00 PM to Louisville Airport, Louisville Airport (USA) arriving at 2/1/2026 2:41:00 PM. 50 Economy ticket for $211 per person are available. Travel duration is 20h 9m
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Frontier Airlines25h 41m012:00 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:41 PMLouisville AirportLouisville Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 1/31/2026 12:00:00 PM to Louisville Airport, Louisville Airport (USA) arriving at 2/1/2026 2:41:00 PM. 50 Economy ticket for $211 per person are available. Travel duration is 25h 41m
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Frontier Airlines29h 24m09:25 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center3:49 PMLouisville AirportLouisville Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 1/31/2026 9:25:00 AM to Louisville Airport, Louisville Airport (USA) arriving at 2/1/2026 3:49:00 PM. 50 Economy ticket for $222 per person are available. Travel duration is 29h 24m
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Spirit Airlines30h 21m07:20 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:41 PMLouisville AirportLouisville Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 1/31/2026 7:20:00 AM to Louisville Airport, Louisville Airport (USA) arriving at 2/1/2026 2:41:00 PM. 50 Economy ticket for $252 per person are available. Travel duration is 30h 21m
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Greyhound US6h 5m011:40 PMChicago95th Red Line Station6:45 AMLouisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 1/31/2026 11:40:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/1/2026 6:45:00 AM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 5m
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Greyhound US6h 15m06:10 AMChicagoDowntown Bus Station1:25 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 1/31/2026 6:10:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 1/31/2026 1:25:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 15m
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FlixBus7h 0m05:25 AMChicago95th Red Line Station1:25 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 1/31/2026 5:25:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 1/31/2026 1:25:00 PM. 50 Economy ticket for $34 per person are available. Travel duration is 7h 0m
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FlixBus11h 0m05:45 AMChicago95th Red Line Station5:45 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 1/31/2026 5:45:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 1/31/2026 5:45:00 PM. 50 Economy ticket for $34 per person are available. Travel duration is 11h 0m
Fastest Flights Saturday
Fastest Buses Saturday
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FlixBus6h 25m06:00 PMChicagoDowntown Bus Station1:25 AMLouisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 2/1/2026 6:00:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/2/2026 1:25:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 6h 25m
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Greyhound US6h 45m010:00 AMChicagoUnion Station5:45 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 2/1/2026 10:00:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/1/2026 5:45:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 6h 45m
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Greyhound US6h 55m010:50 PMChicagoDowntown Bus Station6:45 AMLouisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 2/1/2026 10:50:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/2/2026 6:45:00 AM. 50 Economy ticket for $49 per person are available. Travel duration is 6h 55m
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Greyhound US7h 5m09:40 AMChicagoDowntown Bus Station5:45 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 2/1/2026 9:40:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/1/2026 5:45:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 7h 5m
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FlixBus7h 50m01:00 PMChicagoDowntown Bus Station9:50 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 2/1/2026 1:00:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/1/2026 9:50:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 7h 50m
Fastest Buses Sunday
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United Airlines1h 37m03:00 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center5:37 PMLouisville AirportLouisville Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/2/2026 3:00:00 PM to Louisville Airport, Louisville Airport (USA) arriving at 2/2/2026 5:37:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 37m
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United Airlines1h 39m010:45 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center1:24 PMLouisville AirportLouisville Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/2/2026 10:45:00 AM to Louisville Airport, Louisville Airport (USA) arriving at 2/2/2026 1:24:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 39m
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Spirit Airlines16h 58m08:43 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:41 PMLouisville AirportLouisville Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/2/2026 8:43:00 PM to Louisville Airport, Louisville Airport (USA) arriving at 2/3/2026 2:41:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 16h 58m
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Spirit Airlines20h 9m05:32 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:41 PMLouisville AirportLouisville Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/2/2026 5:32:00 PM to Louisville Airport, Louisville Airport (USA) arriving at 2/3/2026 2:41:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 20h 9m
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Spirit Airlines30h 21m07:20 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:41 PMLouisville AirportLouisville Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/2/2026 7:20:00 AM to Louisville Airport, Louisville Airport (USA) arriving at 2/3/2026 2:41:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 30h 21m
Fastest Flights Monday
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United Airlines1h 38m010:50 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center1:28 PMLouisville AirportLouisville Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/3/2026 10:50:00 AM to Louisville Airport, Louisville Airport (USA) arriving at 2/3/2026 1:28:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 38m
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United Airlines1h 38m05:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:28 PMLouisville AirportLouisville Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/3/2026 5:50:00 PM to Louisville Airport, Louisville Airport (USA) arriving at 2/3/2026 8:28:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 38m
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Spirit Airlines8h 26m05:15 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:41 PMLouisville AirportLouisville Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/3/2026 5:15:00 AM to Louisville Airport, Louisville Airport (USA) arriving at 2/3/2026 2:41:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 8h 26m
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Spirit Airlines23h 16m012:44 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center1:00 PMLouisville AirportLouisville Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/3/2026 12:44:00 PM to Louisville Airport, Louisville Airport (USA) arriving at 2/4/2026 1:00:00 PM. 50 Economy ticket for $225 per person are available. Travel duration is 23h 16m
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Spirit Airlines25h 12m010:48 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center1:00 PMLouisville AirportLouisville Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 2/3/2026 10:48:00 AM to Louisville Airport, Louisville Airport (USA) arriving at 2/4/2026 1:00:00 PM. 50 Economy ticket for $225 per person are available. Travel duration is 25h 12m
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Greyhound US6h 15m06:10 AMChicagoDowntown Bus Station1:25 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 2/3/2026 6:10:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/3/2026 1:25:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 6h 15m
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Greyhound US6h 45m010:00 AMChicagoUnion Station5:45 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 2/3/2026 10:00:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/3/2026 5:45:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 6h 45m
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Greyhound US7h 5m09:40 AMChicagoDowntown Bus Station5:45 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 2/3/2026 9:40:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/3/2026 5:45:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 7h 5m
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FlixBus7h 50m01:00 PMChicagoDowntown Bus Station9:50 PMLouisville, KYGreyhound Bus Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 2/3/2026 1:00:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 2/3/2026 9:50:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 7h 50m
Fastest Flights Tuesday
Fastest Buses Tuesday
Here you will find all operators and timetables for a
Bus from Chicago to Louisville, KY
What are the most popular stations in Chicago and Louisville, KY?
In Chicago, you will usually depart from California & 35th Street Bus Stop, Downtown Bus Station or 95th Red Line Station, while in Louisville, KY you will be arriving at Greyhound Bus Station, International Airport or Convention Center, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Louisville, KY from Chicago? With 7 connections between 2 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Chicago and Louisville, KY, you can pay as low as $34 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to Louisville, KY in just 1h 37m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Chicago and Louisville, KY are Greyhound US, Spirit Airlines and FlixBus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Chicago and Louisville, KY is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Cicero, IL or to New Albany, IN, and look at flights from Chicago Midway Airport, and landing at Louisville Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Chicago to Louisville, KY?
The most popular companies between Chicago and Louisville, KY, are Greyhound US, Spirit Airlines and FlixBus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US and FlixBus
Airlines: Spirit Airlines, United Airlines and Frontier Airlines
All you need to know when you travel from Chicago to Louisville, KY
Check all information on comfort and services on all modes of transports from Chicago to Louisville, KY. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Chicago to Louisville, KY
How can I reach Louisville, KY from Chicago?
Every day, there are on average 7 connections between Flight and Bus, with which you can get to Louisville, KY from Chicago.
How far is Louisville, KY from Chicago?
The distance between Chicago and Louisville, KY is 269.3 miles.
What is the most ecofriendly mode of transport between Chicago and Louisville, KY?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 12 kgs of CO2, a train 15 kgs, a car 74 kgs, and a flight 107 kgs.
What is the cheapest mode of transport from Chicago to Louisville, KY?
You can get to Louisville, KY with just $34 by taking a Bus from FlixBus.
What is the fastest way to get from Chicago to Louisville, KY?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Louisville, KY in just 1h 37m with a Flight from United Airlines.
More routes to Chicago and to Louisville, KY
Looking for more options? Here you can see the most popular routes to Chicago and to Louisville, KY. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Chicago
- Aguascalientes to Chicago
- Atlanta, GA to Chicago
- Buffalo, NY to Chicago
- Cincinnati to Chicago
- Dallas to Chicago
- Durango, DG to Chicago
- El Paso, TX to Chicago
- Guadalajara, JC to Chicago
- Houston to Chicago
- Los Angeles to Chicago
- Louisville, KY to Chicago
- Memphis to Chicago
- Mexico City to Chicago
- Monterrey, NL to Chicago
- Nashville to Chicago
- New York to Chicago
- Nuevo Laredo to Chicago
- Pearson Toronto Airport to Chicago
- San Antonio, TX to Chicago
- Santiago de Queretaro to Chicago
- St. Louis, MO to Chicago
- Toronto, ON to Chicago
- Tulsa to Chicago
