What is the best way to travel from Florence to Lyon?
Looking for a trip? Compare all the available Buses and Flights for the journey to Lyon from Florence. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Lyon from Florence?
You can get to Lyon with just $28 by taking a Bus from Itabus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus10h 40m012:00 PMFlorenceVilla Costanza Bus Station10:40 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/13/2025 12:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/13/2025 10:40:00 PM. 50 Economy ticket for $32 per person are available. Travel duration is 10h 40m
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FlixBus11h 15m012:30 PMFlorenceVilla Costanza Bus Station11:45 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/13/2025 12:30:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/13/2025 11:45:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 11h 15m
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FlixBus13h 0m06:45 PMFlorenceVilla Costanza Bus Station7:45 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/13/2025 6:45:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/14/2025 7:45:00 AM. 50 Economy ticket for $35 per person are available. Travel duration is 13h 0m
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Itabus15h 35m01:20 PMFlorenceVilla Costanza Bus Station4:55 AMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/13/2025 1:20:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/14/2025 4:55:00 AM. 50 Premium Economy ticket for $52 per person are available. Travel duration is 15h 35m
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Itabus11h 10m010:20 AMFlorenceVilla Costanza Bus Station9:30 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/13/2025 10:20:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/13/2025 9:30:00 PM. 50 Premium Economy ticket for $53 per person are available. Travel duration is 11h 10m
Cheapest Buses Saturday
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FlixBus10h 40m012:00 PMFlorenceVilla Costanza Bus Station10:40 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/14/2025 12:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/14/2025 10:40:00 PM. 50 Economy ticket for $31 per person are available. Travel duration is 10h 40m
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FlixBus11h 40m09:05 PMFlorenceVilla Costanza Bus Station8:45 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/14/2025 9:05:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/15/2025 8:45:00 AM. 50 Economy ticket for $35 per person are available. Travel duration is 11h 40m
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FlixBus11h 50m06:45 PMFlorenceVilla Costanza Bus Station6:35 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/14/2025 6:45:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/15/2025 6:35:00 AM. 50 Economy ticket for $39 per person are available. Travel duration is 11h 50m
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Itabus11h 10m010:20 AMFlorenceVilla Costanza Bus Station9:30 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/14/2025 10:20:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/14/2025 9:30:00 PM. 50 Premium Economy ticket for $41 per person are available. Travel duration is 11h 10m
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Itabus11h 50m01:05 AMFlorenceVilla Costanza Bus Station12:55 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/14/2025 1:05:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/14/2025 12:55:00 PM. 50 Premium Economy ticket for $47 per person are available. Travel duration is 11h 50m
Cheapest Buses Sunday
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FlixBus10h 40m012:00 PMFlorenceVilla Costanza Bus Station10:40 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/15/2025 12:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/15/2025 10:40:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 10h 40m
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FlixBus10h 40m07:30 AMFlorenceVilla Costanza Bus Station6:10 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/15/2025 7:30:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/15/2025 6:10:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 10h 40m
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Itabus11h 10m010:20 AMFlorenceVilla Costanza Bus Station9:30 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/15/2025 10:20:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/15/2025 9:30:00 PM. 50 Premium Economy ticket for $47 per person are available. Travel duration is 11h 10m
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Itabus11h 50m01:05 AMFlorenceVilla Costanza Bus Station12:55 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/15/2025 1:05:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/15/2025 12:55:00 PM. 50 Premium Economy ticket for $48 per person are available. Travel duration is 11h 50m
Cheapest Buses Monday
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Itabus11h 10m010:20 AMFlorenceVilla Costanza Bus Station9:30 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/16/2025 10:20:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/16/2025 9:30:00 PM. 50 Premium Economy ticket for $28 per person are available. Travel duration is 11h 10m
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Itabus11h 50m01:05 AMFlorenceVilla Costanza Bus Station12:55 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/16/2025 1:05:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/16/2025 12:55:00 PM. 50 Premium Economy ticket for $41 per person are available. Travel duration is 11h 50m
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FlixBus10h 40m07:30 AMFlorenceVilla Costanza Bus Station6:10 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/16/2025 7:30:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/16/2025 6:10:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 10h 40m
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FlixBus11h 15m012:30 PMFlorenceVilla Costanza Bus Station11:45 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/16/2025 12:30:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/16/2025 11:45:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 11h 15m
Cheapest Buses Tuesday
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FlixBus11h 40m09:05 PMFlorenceVilla Costanza Bus Station8:45 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/17/2025 9:05:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/18/2025 8:45:00 AM. 50 Economy ticket for $35 per person are available. Travel duration is 11h 40m
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Itabus11h 50m01:05 AMFlorenceVilla Costanza Bus Station12:55 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/17/2025 1:05:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/17/2025 12:55:00 PM. 50 Premium Economy ticket for $47 per person are available. Travel duration is 11h 50m
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Itabus11h 10m010:20 AMFlorenceVilla Costanza Bus Station9:30 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/17/2025 10:20:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/17/2025 9:30:00 PM. 50 Premium Economy ticket for $47 per person are available. Travel duration is 11h 10m
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FlixBus11h 50m06:45 PMFlorenceVilla Costanza Bus Station6:35 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/17/2025 6:45:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/18/2025 6:35:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 11h 50m
Cheapest Buses Wednesday
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Itabus11h 50m01:05 AMFlorenceVilla Costanza Bus Station12:55 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/18/2025 1:05:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/18/2025 12:55:00 PM. 50 Premium Economy ticket for $47 per person are available. Travel duration is 11h 50m
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Itabus11h 10m010:20 AMFlorenceVilla Costanza Bus Station9:30 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/18/2025 10:20:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/18/2025 9:30:00 PM. 50 Premium Economy ticket for $47 per person are available. Travel duration is 11h 10m
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FlixBus10h 40m07:30 AMFlorenceVilla Costanza Bus Station6:10 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/18/2025 7:30:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/18/2025 6:10:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 10h 40m
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FlixBus10h 40m012:00 PMFlorenceVilla Costanza Bus Station10:40 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/18/2025 12:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/18/2025 10:40:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 10h 40m
Cheapest Buses Thursday
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Itabus11h 50m01:05 AMFlorenceVilla Costanza Bus Station12:55 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/19/2025 1:05:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/19/2025 12:55:00 PM. 50 Premium Economy ticket for $28 per person are available. Travel duration is 11h 50m
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Itabus11h 10m010:20 AMFlorenceVilla Costanza Bus Station9:30 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/19/2025 10:20:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/19/2025 9:30:00 PM. 50 Premium Economy ticket for $28 per person are available. Travel duration is 11h 10m
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FlixBus11h 15m012:30 PMFlorenceVilla Costanza Bus Station11:45 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/19/2025 12:30:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/19/2025 11:45:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 11h 15m
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FlixBus10h 40m07:30 AMFlorenceVilla Costanza Bus Station6:10 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/19/2025 7:30:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/19/2025 6:10:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 10h 40m
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Volotea1h 20m010:25 AMFlorence AirportFlorence Airport11:45 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station0EconomyA Flight from Volotea goes from Florence Airport, Florence Airport (Italy) at 12/19/2025 10:25:00 AM to Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) arriving at 12/19/2025 11:45:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 1h 20m
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Vueling Airlines7h 25m09:50 AMFlorence AirportFlorence Airport5:15 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station0EconomyA Flight from Vueling Airlines goes from Florence Airport, Florence Airport (Italy) at 12/19/2025 9:50:00 AM to Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) arriving at 12/19/2025 5:15:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 7h 25m
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Air Dolomiti4h 25m08:00 AMFlorence AirportFlorence Airport12:25 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station0EconomyA Flight from Air Dolomiti goes from Florence Airport, Florence Airport (Italy) at 12/19/2025 8:00:00 AM to Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) arriving at 12/19/2025 12:25:00 PM. 50 Economy ticket for $150 per person are available. Travel duration is 4h 25m
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KLM Cityhopper6h 45m06:40 AMFlorence AirportFlorence Airport1:25 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station0EconomyA Flight from KLM Cityhopper goes from Florence Airport, Florence Airport (Italy) at 12/19/2025 6:40:00 AM to Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) arriving at 12/19/2025 1:25:00 PM. 50 Economy ticket for $186 per person are available. Travel duration is 6h 45m
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Air France14h 20m08:45 PMFlorence AirportFlorence Airport11:05 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station0EconomyA Flight from Air France goes from Florence Airport, Florence Airport (Italy) at 12/19/2025 8:45:00 PM to Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) arriving at 12/20/2025 11:05:00 AM. 50 Economy ticket for $187 per person are available. Travel duration is 14h 20m
Cheapest Buses Friday
Cheapest Flights Friday
What are the fastest trips from Florence to Lyon?
You can get to Lyon from Florence in just 1h 20m with a Flight from Volotea. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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FlixBus10h 40m012:00 PMFlorenceVilla Costanza Bus Station10:40 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/13/2025 12:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/13/2025 10:40:00 PM. 50 Economy ticket for $32 per person are available. Travel duration is 10h 40m
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Itabus11h 10m010:20 AMFlorenceVilla Costanza Bus Station9:30 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/13/2025 10:20:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/13/2025 9:30:00 PM. 50 Premium Economy ticket for $53 per person are available. Travel duration is 11h 10m
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FlixBus11h 15m012:30 PMFlorenceVilla Costanza Bus Station11:45 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/13/2025 12:30:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/13/2025 11:45:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 11h 15m
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FlixBus13h 0m06:45 PMFlorenceVilla Costanza Bus Station7:45 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/13/2025 6:45:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/14/2025 7:45:00 AM. 50 Economy ticket for $35 per person are available. Travel duration is 13h 0m
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Itabus15h 35m01:20 PMFlorenceVilla Costanza Bus Station4:55 AMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/13/2025 1:20:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/14/2025 4:55:00 AM. 50 Premium Economy ticket for $52 per person are available. Travel duration is 15h 35m
Fastest Buses Saturday
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FlixBus10h 40m012:00 PMFlorenceVilla Costanza Bus Station10:40 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/14/2025 12:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/14/2025 10:40:00 PM. 50 Economy ticket for $31 per person are available. Travel duration is 10h 40m
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Itabus11h 10m010:20 AMFlorenceVilla Costanza Bus Station9:30 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/14/2025 10:20:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/14/2025 9:30:00 PM. 50 Premium Economy ticket for $41 per person are available. Travel duration is 11h 10m
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FlixBus11h 40m09:05 PMFlorenceVilla Costanza Bus Station8:45 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/14/2025 9:05:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/15/2025 8:45:00 AM. 50 Economy ticket for $35 per person are available. Travel duration is 11h 40m
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FlixBus11h 50m06:45 PMFlorenceVilla Costanza Bus Station6:35 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/14/2025 6:45:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/15/2025 6:35:00 AM. 50 Economy ticket for $39 per person are available. Travel duration is 11h 50m
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Itabus11h 50m01:05 AMFlorenceVilla Costanza Bus Station12:55 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/14/2025 1:05:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/14/2025 12:55:00 PM. 50 Premium Economy ticket for $47 per person are available. Travel duration is 11h 50m
Fastest Buses Sunday
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FlixBus10h 40m012:00 PMFlorenceVilla Costanza Bus Station10:40 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/15/2025 12:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/15/2025 10:40:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 10h 40m
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FlixBus10h 40m07:30 AMFlorenceVilla Costanza Bus Station6:10 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/15/2025 7:30:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/15/2025 6:10:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 10h 40m
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Itabus11h 10m010:20 AMFlorenceVilla Costanza Bus Station9:30 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/15/2025 10:20:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/15/2025 9:30:00 PM. 50 Premium Economy ticket for $47 per person are available. Travel duration is 11h 10m
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Itabus11h 50m01:05 AMFlorenceVilla Costanza Bus Station12:55 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/15/2025 1:05:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/15/2025 12:55:00 PM. 50 Premium Economy ticket for $48 per person are available. Travel duration is 11h 50m
Fastest Buses Monday
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FlixBus10h 40m07:30 AMFlorenceVilla Costanza Bus Station6:10 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/16/2025 7:30:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/16/2025 6:10:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 10h 40m
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Itabus11h 10m010:20 AMFlorenceVilla Costanza Bus Station9:30 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/16/2025 10:20:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/16/2025 9:30:00 PM. 50 Premium Economy ticket for $28 per person are available. Travel duration is 11h 10m
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FlixBus11h 15m012:30 PMFlorenceVilla Costanza Bus Station11:45 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/16/2025 12:30:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/16/2025 11:45:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 11h 15m
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Itabus11h 50m01:05 AMFlorenceVilla Costanza Bus Station12:55 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/16/2025 1:05:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/16/2025 12:55:00 PM. 50 Premium Economy ticket for $41 per person are available. Travel duration is 11h 50m
Fastest Buses Tuesday
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Itabus11h 10m010:20 AMFlorenceVilla Costanza Bus Station9:30 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/17/2025 10:20:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/17/2025 9:30:00 PM. 50 Premium Economy ticket for $47 per person are available. Travel duration is 11h 10m
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FlixBus11h 40m09:05 PMFlorenceVilla Costanza Bus Station8:45 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/17/2025 9:05:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/18/2025 8:45:00 AM. 50 Economy ticket for $35 per person are available. Travel duration is 11h 40m
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Itabus11h 50m01:05 AMFlorenceVilla Costanza Bus Station12:55 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/17/2025 1:05:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/17/2025 12:55:00 PM. 50 Premium Economy ticket for $47 per person are available. Travel duration is 11h 50m
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FlixBus11h 50m06:45 PMFlorenceVilla Costanza Bus Station6:35 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/17/2025 6:45:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/18/2025 6:35:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 11h 50m
Fastest Buses Wednesday
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FlixBus10h 40m07:30 AMFlorenceVilla Costanza Bus Station6:10 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/18/2025 7:30:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/18/2025 6:10:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 10h 40m
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FlixBus10h 40m012:00 PMFlorenceVilla Costanza Bus Station10:40 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/18/2025 12:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/18/2025 10:40:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 10h 40m
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Itabus11h 10m010:20 AMFlorenceVilla Costanza Bus Station9:30 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/18/2025 10:20:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/18/2025 9:30:00 PM. 50 Premium Economy ticket for $47 per person are available. Travel duration is 11h 10m
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Itabus11h 50m01:05 AMFlorenceVilla Costanza Bus Station12:55 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/18/2025 1:05:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/18/2025 12:55:00 PM. 50 Premium Economy ticket for $47 per person are available. Travel duration is 11h 50m
Fastest Buses Thursday
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Volotea1h 20m010:25 AMFlorence AirportFlorence Airport11:45 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station0EconomyA Flight from Volotea goes from Florence Airport, Florence Airport (Italy) at 12/19/2025 10:25:00 AM to Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) arriving at 12/19/2025 11:45:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 1h 20m
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Air Dolomiti4h 25m08:00 AMFlorence AirportFlorence Airport12:25 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station0EconomyA Flight from Air Dolomiti goes from Florence Airport, Florence Airport (Italy) at 12/19/2025 8:00:00 AM to Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) arriving at 12/19/2025 12:25:00 PM. 50 Economy ticket for $150 per person are available. Travel duration is 4h 25m
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KLM Cityhopper6h 45m06:40 AMFlorence AirportFlorence Airport1:25 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station0EconomyA Flight from KLM Cityhopper goes from Florence Airport, Florence Airport (Italy) at 12/19/2025 6:40:00 AM to Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) arriving at 12/19/2025 1:25:00 PM. 50 Economy ticket for $186 per person are available. Travel duration is 6h 45m
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Vueling Airlines7h 25m09:50 AMFlorence AirportFlorence Airport5:15 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station0EconomyA Flight from Vueling Airlines goes from Florence Airport, Florence Airport (Italy) at 12/19/2025 9:50:00 AM to Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) arriving at 12/19/2025 5:15:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 7h 25m
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Air France14h 20m08:45 PMFlorence AirportFlorence Airport11:05 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station0EconomyA Flight from Air France goes from Florence Airport, Florence Airport (Italy) at 12/19/2025 8:45:00 PM to Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) arriving at 12/20/2025 11:05:00 AM. 50 Economy ticket for $187 per person are available. Travel duration is 14h 20m
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FlixBus10h 40m07:30 AMFlorenceVilla Costanza Bus Station6:10 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/19/2025 7:30:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/19/2025 6:10:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 10h 40m
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Itabus11h 10m010:20 AMFlorenceVilla Costanza Bus Station9:30 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/19/2025 10:20:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/19/2025 9:30:00 PM. 50 Premium Economy ticket for $28 per person are available. Travel duration is 11h 10m
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FlixBus11h 15m012:30 PMFlorenceVilla Costanza Bus Station11:45 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/19/2025 12:30:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/19/2025 11:45:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 11h 15m
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Itabus11h 50m01:05 AMFlorenceVilla Costanza Bus Station12:55 PMLyonPerrache Bus Stop0Premium EconomyA Bus from Itabus goes from Villa Costanza Bus Station, Florence (Italy) at 12/19/2025 1:05:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/19/2025 12:55:00 PM. 50 Premium Economy ticket for $28 per person are available. Travel duration is 11h 50m
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Here you will find all operators and timetables for a
Bus from Florence to Lyon
What are the most popular stations in Florence and Lyon?
In Florence, you will usually depart from Santa Maria Novella Central Station, Villa Costanza Bus Station or Piazzale Montelungo Bus Stop, while in Lyon you will be arriving at Perrache Bus Stop, Part-Dieu Train Station or Perrache Train Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Lyon from Florence? With 5 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Florence and Lyon, you can pay as low as $28 with a Bus from Itabus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Volotea: you will get to Lyon in just 1h 20m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Florence and Lyon are Itabus, FlixBus and Volotea, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Florence and Lyon is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Scandicci or to Caluire-et-Cuire, and look at flights from Florence Airport, and landing at Lyons St. Exupery Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Florence to Lyon?
The most popular companies between Florence and Lyon, are Itabus, FlixBus and Volotea. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Itabus and FlixBus
Airlines: Volotea, Vueling Airlines, Air Dolomiti and 2 more.
All you need to know when you travel from Florence to Lyon
Check all information on comfort and services on all modes of transports from Florence to Lyon. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Florence to Lyon
How can I reach Lyon from Florence?
Every day, there are on average 5 connections between Bus and Flight, with which you can get to Lyon from Florence.
How far is Lyon from Florence?
The distance between Florence and Lyon is 343.2 miles.
What is the most ecofriendly mode of transport between Florence and Lyon?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 15 kgs of CO2, a train 19 kgs, a car 94 kgs, and a flight 136 kgs.
What is the cheapest mode of transport from Florence to Lyon?
You can get to Lyon with just $28 by taking a Bus from Itabus.
What is the fastest way to get from Florence to Lyon?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Lyon in just 1h 20m with a Flight from Volotea.
More routes to Florence and to Lyon
Looking for more options? Here you can see the most popular routes to Florence and to Lyon. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Florence
- Bologna Airport to Florence
- Bologna to Florence
- Castrovillari to Florence
- Cosenza to Florence
- Foligno to Florence
- Frascineto to Florence
- Genoa to Florence
- Lagonegro to Florence
- Marseille to Florence
- Milan Malpensa Airport to Florence
- Milan to Florence
- Modena to Florence
- Naples to Florence
- Perugia to Florence
- Pescara to Florence
- Pisa Airport to Florence
- Pisa to Florence
- Rimini to Florence
- Rome Fiumicino Airport to Florence
- Rome to Florence
- Siena to Florence
- Venice to Florence
- Vibo Valentia to Florence
- Zurich to Florence
- Trips to Lyon
- Alicante to Lyon
- Annecy to Lyon
- Barcelona to Lyon
- Basel to Lyon
- Bern to Lyon
- Bologna to Lyon
- Bordeaux to Lyon
- Braga to Lyon
- Caen to Lyon
- Dusseldorf to Lyon
- Geneva to Lyon
- Genoa to Lyon
- Grenoble to Lyon
- Lisbon to Lyon
- Lloret de Mar to Lyon
- London to Lyon
- Lyons St. Exupery Airport to Lyon
- Marseille to Lyon
- Milan to Lyon
- Paris to Lyon
- Rome to Lyon
- Toulouse to Lyon
- Turin to Lyon
- Valencia to Lyon

