What is the best way to travel from Fort Myers, FL to Greenville, SC?
Looking for a trip? Compare all the available Buses and Flights for the journey to Greenville, SC from Fort Myers, FL. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Greenville, SC from Fort Myers, FL?
You can get to Greenville, SC with just $112 by taking a Bus from FlixBus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus16h 30m02:35 PMFort Myers, FLRosa Parks Transit Center7:05 AMGreenville, SCWoodruff Rd0EconomyA Bus from FlixBus goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/10/2025 2:35:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/11/2025 7:05:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 16h 30m
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FlixBus27h 35m06:20 PMFort Myers, FLRosa Parks Transit Center9:55 PMGreenville, SCWoodruff Rd0EconomyA Bus from FlixBus goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/10/2025 6:20:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/11/2025 9:55:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 27h 35m
Cheapest Buses Wednesday
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FlixBus16h 30m02:35 PMFort Myers, FLRosa Parks Transit Center7:05 AMGreenville, SCWoodruff Rd0EconomyA Bus from FlixBus goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/11/2025 2:35:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/12/2025 7:05:00 AM. 50 Economy ticket for $129 per person are available. Travel duration is 16h 30m
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FlixBus25h 10m06:30 PMFort Myers, FLRosa Parks Transit Center7:40 PMGreenville, SCWoodruff Rd0EconomyA Bus from FlixBus goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/11/2025 6:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/12/2025 7:40:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 25h 10m
Cheapest Buses Thursday
What are the fastest trips from Fort Myers, FL to Greenville, SC?
You can get to Greenville, SC from Fort Myers, FL in just 16h 30m with a Bus from FlixBus. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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FlixBus16h 30m02:35 PMFort Myers, FLRosa Parks Transit Center7:05 AMGreenville, SCWoodruff Rd0EconomyA Bus from FlixBus goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/10/2025 2:35:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/11/2025 7:05:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 16h 30m
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FlixBus27h 35m06:20 PMFort Myers, FLRosa Parks Transit Center9:55 PMGreenville, SCWoodruff Rd0EconomyA Bus from FlixBus goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/10/2025 6:20:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/11/2025 9:55:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 27h 35m
Fastest Buses Wednesday
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FlixBus16h 30m02:35 PMFort Myers, FLRosa Parks Transit Center7:05 AMGreenville, SCWoodruff Rd0EconomyA Bus from FlixBus goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/11/2025 2:35:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/12/2025 7:05:00 AM. 50 Economy ticket for $129 per person are available. Travel duration is 16h 30m
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FlixBus25h 10m06:30 PMFort Myers, FLRosa Parks Transit Center7:40 PMGreenville, SCWoodruff Rd0EconomyA Bus from FlixBus goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/11/2025 6:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/12/2025 7:40:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 25h 10m
Fastest Buses Thursday
Here you will find all operators and timetables for a
Bus from Fort Myers, FL to Greenville, SC
What are the most popular stations in Fort Myers, FL and Greenville, SC?
In Fort Myers, FL, you will usually depart from Cleveland Ave, Rosa Parks Transit Center or Daniels Pkwy, while in Greenville, SC you will be arriving at Woodruff Rd, McDonald's or Greyhound Bus Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Greenville, SC from Fort Myers, FL? With 2 connections between 1 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Fort Myers, FL and Greenville, SC, you can pay as low as $112 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from FlixBus: you will get to Greenville, SC in just 16h 30m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Fort Myers, FL and Greenville, SC are FlixBus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Fort Myers, FL and Greenville, SC is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Palmona Park, FL or to Welcome, SC, and look at flights from Southwest Florida - Fort Myers Airport, and landing at . Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Fort Myers, FL to Greenville, SC?
The most popular companies between Fort Myers, FL and Greenville, SC, are FlixBus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus
All you need to know when you travel from Fort Myers, FL to Greenville, SC
Check all information on comfort and services on all modes of transports from Fort Myers, FL to Greenville, SC. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Fort Myers, FL to Greenville, SC
How can I reach Greenville, SC from Fort Myers, FL?
Every day, there are on average 2 connections between Bus and Flight, with which you can get to Greenville, SC from Fort Myers, FL.
How far is Greenville, SC from Fort Myers, FL?
The distance between Fort Myers, FL and Greenville, SC is 568.4 miles.
What is the most ecofriendly mode of transport between Fort Myers, FL and Greenville, SC?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 25 kgs of CO2, a train 32 kgs, a car 156 kgs, and a flight 225 kgs.
What is the cheapest mode of transport from Fort Myers, FL to Greenville, SC?
You can get to Greenville, SC with just $112 by taking a Bus from FlixBus.
What is the fastest way to get from Fort Myers, FL to Greenville, SC?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Greenville, SC in just 16h 30m with a Bus from FlixBus.
More routes to Fort Myers, FL and to Greenville, SC
Looking for more options? Here you can see the most popular routes to Fort Myers, FL and to Greenville, SC. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Fort Myers, FL
- Greenville, SC to Fort Myers, FL
