Bus Fort Myers, FL to Greenville, SC

Compare all timetables for the bus from Fort Myers, FL to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Fort Myers, FL to Greenville, SC from various bus operators like FlixBus for the next days.

today

tomorrow

Wednesday

Thursday

Friday

$172

Saturday

Sunday

Cheapest bus trips Friday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	25h 10m	6:30 PM	Fort Myers, FL	Rosa Parks Transit Center	7:40 PM	Greenville, SC	Woodruff Rd		Economy	$172	A Bus from FlixBus goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/26/2025 6:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/27/2025 7:40:00 PM. 50 Economy ticket for $172 per person are available. Travel duration is 25h 10m
	FlixBus	16h 30m	2:35 PM	Fort Myers, FL	Rosa Parks Transit Center	7:05 AM	Greenville, SC	Woodruff Rd		Economy	$205	A Bus from FlixBus goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/26/2025 2:35:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/27/2025 7:05:00 AM. 50 Economy ticket for $205 per person are available. Travel duration is 16h 30m

Did you know that if you travel from Fort Myers, FL to Greenville, SC via Orlando, FL, you can save more than $45? You can find the corresponding connections below.
- Busbud
  
  18h 15m
  
  0
  
  4:25 PM
  
  Fort Myers, FL
  Rosa Parks Transit Center
  
  10:10 PM
  
  Orlando, FL
  Bus Station
  
  0
  
  Economy
  
  $46
  
  A Bus from Busbud goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/23/2025 4:25:00 PM to Bus Station, Orlando, FL (USA) arriving at 12/23/2025 10:10:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 5h 45m
- Busbud
  
  11h 45m
  
  0
  
  10:55 PM
  
  Orlando, FL
  Bus Station
  
  10:40 AM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $81
  
  A Bus from Busbud goes from Bus Station, Orlando, FL (USA) at 12/23/2025 10:55:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 10:40:00 AM. 50 Economy ticket for $81 per person are available. Travel duration is 11h 45m
Travel time is 1h 45m longer, but you will save $45

Best Price Offer: The price for the cheapest bus from Fort Myers, FL to Greenville, SC is $124 on 1/6/2026. Flexible travelers save on ticket prices.

Facts about the bus from Fort Myers, FL to Greenville, SC

Compare all providers like FlixBus that travel 2 times every day by bus from Fort Myers, FL to Greenville, SC in one click! Book your bus ticket from Fort Myers, FL to Greenville, SC starting from $124!

Cheapest Bus	$124
Fastest Bus	16h 30m
Earliest Bus	2:35 PM
Latest Bus	6:30 PM
Daily Bus Routes	2 Ø
Distance	568.4 miles
Bus Companies	FlixBus

Cheapest bus connections from Fort Myers, FL to Greenville, SC

Every day, 2 buses from 1 bus companies leave Fort Myers, FL for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/22/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

$172

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

$124

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

Sunday 01/11

Monday 01/12

Tuesday 01/13

Wednesday 01/14

Thursday 01/15

Friday 01/16

Saturday 01/17

How to save money travelling from Fort Myers, FL to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Fort Myers, FL to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Fort Myers, FL to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Fort Myers, FL to Greenville, SC are also emptier.

All bus stations and stops in Fort Myers, FL and Greenville, SC

In the map below, you can see where to find all bus stations in Fort Myers, FL and Greenville, SC.

Bus Station

Plaza Drive 6050

Rosa Parks Transit Center

Widman Way 2250

Daniels Pkwy

Florida Gulf Coast University

Parking Lot Five

Cleveland Ave

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Fort Myers, FL to Greenville, SC? Compare all modes of transports from Fort Myers, FL to Greenville, SC.

Service and Comfort on the bus from Fort Myers, FL to Greenville, SC

Want to know which seat classes are available on the buses from Fort Myers, FL to Greenville, SC? Or which bus companies serve the route Fort Myers, FL to Greenville, SC? Below you will find answers to your questions.

FAQs about the Fort Myers, FL to Greenville, SC bus

How much does a Fort Myers, FL Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $124 and takes 25h 10m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Fort Myers, FL to Greenville, SC?

This route is offered by 1 companies with a range of ticket prices between $124 and $205. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Fort Myers, FL to Greenville, SC each day?

Every day, the Fort Myers, FL to Greenville, SC bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Fort Myers, FL to Greenville, SC take?

The fastest bus from Fort Myers, FL to Greenville, SC is offered by FlixBus and takes 16h 30m. Bus tickets for this connection cost $205. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Fort Myers, FL to Greenville, SC?

The earliest bus arriving in Greenville, SC from Fort Myers, FL starts at 2:35 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Fort Myers, FL to Greenville, SC?

The latest bus trip departing from Fort Myers, FL for Greenville, SC starts at 6:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Fort Myers, FL Greenville, SC route?

When traveling by bus from Fort Myers, FL to Greenville, SC, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Fort Myers, FL and Greenville, SC?

You can check all the direct connections between Fort Myers, FL and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Fort Myers, FL to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Fort Myers, FL Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Fort Myers, FL Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Fort Myers, FL to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Fort Myers, FL to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 2 daily trips between Fort Myers, FL and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Fort Myers, FL to Greenville, SC?

Prices and availability for 2 trips between Fort Myers, FL and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Fort Myers, FL to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Fort Myers, FL and to Greenville, SC

Here’s an overview of the most popular bus routes to Fort Myers, FL and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!