Bus Fort Myers, FL to Greenville, SC

Compare all timetables for the bus from Fort Myers, FL to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Fort Myers, FL to Greenville, SC from various bus operators like FlixBus for the next days.

today

tomorrow

Sunday

Monday

Tuesday

Wednesday

$112

Thursday

$129

Cheapest bus trips Wednesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	16h 30m	2:35 PM	Fort Myers, FL	Rosa Parks Transit Center	7:05 AM	Greenville, SC	Woodruff Rd		Economy	$112	A Bus from FlixBus goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/10/2025 2:35:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/11/2025 7:05:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 16h 30m
	FlixBus	27h 35m	6:20 PM	Fort Myers, FL	Rosa Parks Transit Center	9:55 PM	Greenville, SC	Woodruff Rd		Economy	$114	A Bus from FlixBus goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/10/2025 6:20:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/11/2025 9:55:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 27h 35m

Did you know that if you travel from Fort Myers, FL to Greenville, SC via Orlando, FL, you can save more than $13? You can find the corresponding connections below.
- Busbud
  
  18h 45m
  
  0
  
  12:20 PM
  
  Fort Myers, FL
  Rosa Parks Transit Center
  
  6:00 PM
  
  Orlando, FL
  Bus Station
  
  0
  
  Economy
  
  $24
  
  A Bus from Busbud goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/8/2025 12:20:00 PM to Bus Station, Orlando, FL (USA) arriving at 12/8/2025 6:00:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 5h 40m
- Busbud
  
  10h 25m
  
  0
  
  8:40 PM
  
  Orlando, FL
  Bus Station
  
  7:05 AM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $75
  
  A Bus from Busbud goes from Bus Station, Orlando, FL (USA) at 12/8/2025 8:40:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/9/2025 7:05:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 10h 25m
Travel time is 2h 15m longer, but you will save $13

Cheapest bus trips Thursday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	16h 30m	2:35 PM	Fort Myers, FL	Rosa Parks Transit Center	7:05 AM	Greenville, SC	Woodruff Rd		Economy	$129	A Bus from FlixBus goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/11/2025 2:35:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/12/2025 7:05:00 AM. 50 Economy ticket for $129 per person are available. Travel duration is 16h 30m
	FlixBus	25h 10m	6:30 PM	Fort Myers, FL	Rosa Parks Transit Center	7:40 PM	Greenville, SC	Woodruff Rd		Economy	$131	A Bus from FlixBus goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/11/2025 6:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/12/2025 7:40:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 25h 10m

Did you know that if you travel from Fort Myers, FL to Greenville, SC via Orlando, FL, you can save more than $30? You can find the corresponding connections below.
- Busbud
  
  18h 45m
  
  0
  
  12:20 PM
  
  Fort Myers, FL
  Rosa Parks Transit Center
  
  6:00 PM
  
  Orlando, FL
  Bus Station
  
  0
  
  Economy
  
  $24
  
  A Bus from Busbud goes from Rosa Parks Transit Center, Fort Myers, FL (USA) at 12/8/2025 12:20:00 PM to Bus Station, Orlando, FL (USA) arriving at 12/8/2025 6:00:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 5h 40m
- Busbud
  
  10h 25m
  
  0
  
  8:40 PM
  
  Orlando, FL
  Bus Station
  
  7:05 AM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $75
  
  A Bus from Busbud goes from Bus Station, Orlando, FL (USA) at 12/8/2025 8:40:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/9/2025 7:05:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 10h 25m
Travel time is 2h 15m longer, but you will save $30

Best Price Offer: The price for the cheapest bus from Fort Myers, FL to Greenville, SC is $90 on 12/13/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Fort Myers, FL and Greenville, SC

See here how frequent the connections between Fort Myers, FL and Greenville, SC are, during different times and days of the week.

Wednesday is the busiest day, with more than 2 daily buses from Fort Myers, FL to Greenville, SC. Wednesday has instead the fewest connections, with only 2 daily coaches between Fort Myers, FL and Greenville, SC.

The busiest time of the day is the Afternoon, with 2 buses from Fort Myers, FL to Greenville, SC, while Afternoon sees the fewest connections between Fort Myers, FL and Greenville, SC, with 2 offers.

Facts about the bus from Fort Myers, FL to Greenville, SC

Compare all providers like FlixBus that travel 2 times every day by bus from Fort Myers, FL to Greenville, SC in one click! Book your bus ticket from Fort Myers, FL to Greenville, SC starting from $90!

Cheapest Bus	$90
Fastest Bus	16h 30m
Earliest Bus	2:35 PM
Latest Bus	6:30 PM
Daily Bus Routes	2 Ø
Distance	568.4 miles
Bus Companies	FlixBus

Cheapest bus connections from Fort Myers, FL to Greenville, SC

Every day, 2 buses from 1 bus companies leave Fort Myers, FL for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

Saturday 12/06

Sunday 12/07

Monday 12/08

Tuesday 12/09

Wednesday 12/10

$112

Thursday 12/11

$129

Friday 12/12

Saturday 12/13

$90

Sunday 12/14

$104

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

The cheapest time to travel from Fort Myers, FL to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Fort Myers, FL to Greenville, SC, for the next 30 days.

With a price starting from $112, Wednesday is the cheapest day for a bus from Fort Myers, FL to Greenville, SC. Thursday instead is the most expensive day with prices starting from $129.

Afternoon is the cheapest day time for bus tickets from Fort Myers, FL to Greenville, SC, with $112. Evening is the most expensive time of the day with prices starting from $114.

How to save money travelling from Fort Myers, FL to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Fort Myers, FL to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Fort Myers, FL to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Fort Myers, FL to Greenville, SC are also emptier.

All bus stations and stops in Fort Myers, FL and Greenville, SC

In the map below, you can see where to find all bus stations in Fort Myers, FL and Greenville, SC.

Bus Station

Plaza Drive 6050

Rosa Parks Transit Center

Widman Way 2250

Daniels Pkwy

Florida Gulf Coast University

Parking Lot Five

Cleveland Ave

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Fort Myers, FL to Greenville, SC? Compare all modes of transports from Fort Myers, FL to Greenville, SC.

Service and Comfort on the bus from Fort Myers, FL to Greenville, SC

Want to know which seat classes are available on the buses from Fort Myers, FL to Greenville, SC? Or which bus companies serve the route Fort Myers, FL to Greenville, SC? Below you will find answers to your questions.

FAQs about the Fort Myers, FL to Greenville, SC bus

How much does a Fort Myers, FL Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $90 and takes 16h 30m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Fort Myers, FL to Greenville, SC?

This route is offered by 1 companies with a range of ticket prices between $90 and $131. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Fort Myers, FL to Greenville, SC each day?

Every day, the Fort Myers, FL to Greenville, SC bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Fort Myers, FL to Greenville, SC take?

The fastest bus from Fort Myers, FL to Greenville, SC is offered by FlixBus and takes 16h 30m. Bus tickets for this connection cost $112. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Fort Myers, FL to Greenville, SC?

The earliest bus arriving in Greenville, SC from Fort Myers, FL starts at 2:35 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Fort Myers, FL to Greenville, SC?

The latest bus trip departing from Fort Myers, FL for Greenville, SC starts at 6:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Fort Myers, FL Greenville, SC route?

When traveling by bus from Fort Myers, FL to Greenville, SC, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Fort Myers, FL and Greenville, SC?

You can check all the direct connections between Fort Myers, FL and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Fort Myers, FL to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Fort Myers, FL Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Fort Myers, FL Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Fort Myers, FL to Greenville, SC on your planned travel date.

Available seat classes which are offered on the bus route Fort Myers, FL to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Fort Myers, FL and to Greenville, SC

Here’s an overview of the most popular bus routes to Fort Myers, FL and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!