Which bus from Fort Myers, FL to Greenville, SC is the cheapest?

Compare all bus companies and find the best price: Bus tickets from $104
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Fort Myers, FL to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Fort Myers, FL to Greenville, SC from various bus operators like FlixBus for the next days.

today
$104
tomorrow
$176
Sunday
$126
Monday
Tuesday
Wednesday
Thursday

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 16h 30m 2:35 PM Fort Myers, FL Rosa Parks Transit Center 7:05 AM Greenville, SC Woodruff Rd  Economy $104
FlixBus 25h 5m 6:20 PM Fort Myers, FL Rosa Parks Transit Center 7:25 PM Greenville, SC Woodruff Rd  Economy $105

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 24h 55m 6:30 PM Fort Myers, FL Rosa Parks Transit Center 7:25 PM Greenville, SC Woodruff Rd  Economy $176
FlixBus 16h 30m 2:35 PM Fort Myers, FL Rosa Parks Transit Center 7:05 AM Greenville, SC Woodruff Rd  Economy $177
  • Did you know that if you travel from Fort Myers, FL to Greenville, SC via Orlando, FL, you can save more than $75? You can find the corresponding connections below.
    • Busbud
      16h 30m
      0
      2:35 PM
      Fort Myers, FL
      Rosa Parks Transit Center
      8:25 PM
      Orlando, FL
      Florida Mall
      0
      Busbud
      Economy
      $31
      • Waiting Time 0h 15m
    • Busbud
      10h 25m
      0
      8:40 PM
      Orlando, FL
      Bus Station
      7:05 AM
      Greenville, SC
      Woodruff Rd
      0
      Busbud
      Economy
      $70
    Travel time is the same as the direct connection, but you will save $75

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 16h 30m 2:35 PM Fort Myers, FL Rosa Parks Transit Center 7:05 AM Greenville, SC Woodruff Rd  Economy $126
FlixBus 24h 55m 6:30 PM Fort Myers, FL Rosa Parks Transit Center 7:25 PM Greenville, SC Woodruff Rd  Economy $127
  • Did you know that if you travel from Fort Myers, FL to Greenville, SC via Orlando, FL, you can save more than $25? You can find the corresponding connections below.
    • Busbud
      16h 30m
      0
      2:35 PM
      Fort Myers, FL
      Rosa Parks Transit Center
      8:25 PM
      Orlando, FL
      Florida Mall
      0
      Busbud
      Economy
      $31
      • Waiting Time 0h 15m
    • Busbud
      10h 25m
      0
      8:40 PM
      Orlando, FL
      Bus Station
      7:05 AM
      Greenville, SC
      Woodruff Rd
      0
      Busbud
      Economy
      $70
    Travel time is the same as the direct connection, but you will save $25

Best Price Offer: The price for the cheapest bus from Fort Myers, FL to Greenville, SC is $104 on 2/6/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Fort Myers, FL and Greenville, SC

See here how frequent the connections between Fort Myers, FL and Greenville, SC are, during different times and days of the week.
Sunday is the busiest day, with more than 4 daily buses from Fort Myers, FL to Greenville, SC. Saturday has instead the fewest connections, with only 2 daily coaches between Fort Myers, FL and Greenville, SC.
The busiest time of the day is the Afternoon, with 5 buses from Fort Myers, FL to Greenville, SC, while Afternoon sees the fewest connections between Fort Myers, FL and Greenville, SC, with 5 offers.

Facts about the bus from Fort Myers, FL to Greenville, SC

Compare all providers like FlixBus that travel 3 times every day by bus from Fort Myers, FL to Greenville, SC in one click! Book your bus ticket from Fort Myers, FL to Greenville, SC starting from $104!

Cheapest Bus $104
Fastest Bus 16h 30m
Earliest Bus 2:35 PM
Latest Bus 6:30 PM
Daily Bus Routes 3 Ø
Distance 568.4 miles
Bus Companies FlixBus

Cheapest bus connections from Fort Myers, FL to Greenville, SC

Every day, 3 buses from 1 bus companies leave Fort Myers, FL for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/06/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 02/01
Monday 02/02
Tuesday 02/03
Wednesday 02/04
Thursday 02/05
Friday 02/06
$104
Saturday 02/07
$176
Sunday 02/08
$126
Monday 02/09
Tuesday 02/10
Wednesday 02/11
Thursday 02/12
Friday 02/13
$125
Saturday 02/14
Sunday 02/15
Monday 02/16
Tuesday 02/17
Wednesday 02/18
Thursday 02/19
Friday 02/20
Saturday 02/21
Sunday 02/22
Monday 02/23
Tuesday 02/24
Wednesday 02/25
Thursday 02/26
Friday 02/27
Saturday 02/28

The cheapest time to travel from Fort Myers, FL to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Fort Myers, FL to Greenville, SC, for the next 30 days.
With a price starting from $104, Friday is the cheapest day for a bus from Fort Myers, FL to Greenville, SC. Saturday instead is the most expensive day with prices starting from $176.
Afternoon is the cheapest day time for bus tickets from Fort Myers, FL to Greenville, SC, with $104. Evening is the most expensive time of the day with prices starting from $105.

How to save money travelling from Fort Myers, FL to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Fort Myers, FL to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Fort Myers, FL to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Fort Myers, FL to Greenville, SC are also emptier.

All bus stations and stops in Fort Myers, FL and Greenville, SC

In the map below, you can see where to find all bus stations in Fort Myers, FL and Greenville, SC.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Fort Myers, FL to Greenville, SC? Compare all modes of transports from Fort Myers, FL to Greenville, SC.

Service and Comfort on the bus from Fort Myers, FL to Greenville, SC

Want to know which seat classes are available on the buses from Fort Myers, FL to Greenville, SC? Or which bus companies serve the route Fort Myers, FL to Greenville, SC? Below you will find answers to your questions.

FAQs about the Fort Myers, FL to Greenville, SC bus

How much does a Fort Myers, FL Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $104 and takes 16h 30m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Fort Myers, FL to Greenville, SC?

This route is offered by 1 companies with a range of ticket prices between $104 and $177. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Fort Myers, FL to Greenville, SC each day?

Every day, the Fort Myers, FL to Greenville, SC bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Fort Myers, FL to Greenville, SC take?

The fastest bus from Fort Myers, FL to Greenville, SC is offered by FlixBus and takes 16h 30m. Bus tickets for this connection cost $117. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Fort Myers, FL to Greenville, SC?

The earliest bus arriving in Greenville, SC from Fort Myers, FL starts at 2:35 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Fort Myers, FL to Greenville, SC?

The latest bus trip departing from Fort Myers, FL for Greenville, SC starts at 6:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Fort Myers, FL Greenville, SC route?

When traveling by bus from Fort Myers, FL to Greenville, SC, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Fort Myers, FL and Greenville, SC?

You can check all the direct connections between Fort Myers, FL and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Fort Myers, FL to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Fort Myers, FL Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Fort Myers, FL Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Fort Myers, FL to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Fort Myers, FL to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Fort Myers, FL and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Fort Myers, FL to Greenville, SC?

Prices and availability for 3 trips between Fort Myers, FL and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Fort Myers, FL to Greenville, SC

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Fort Myers, FL and to Greenville, SC

Here’s an overview of the most popular bus routes to Fort Myers, FL and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus from Palm Coast, FL to Fort Myers, FL Bus from Palm Coast, FL to Fort Myers, FL
Bus from Cambridge, MA to Fort Myers, FL Bus from Cambridge, MA to Fort Myers, FL
Bus from Toledo, OH to Fort Myers, FL Bus from Toledo, OH to Fort Myers, FL
Bus Dothan, AL to Fort Myers, FL Bus Dothan, AL to Fort Myers, FL
Buses from Charleston, SC to Greenville, SC Buses from Charleston, SC to Greenville, SC
Buses from Port Saint Lucie, FL to Greenville, SC Buses from Port Saint Lucie, FL to Greenville, SC
Buses Lexington, KY to Greenville, SC Buses Lexington, KY to Greenville, SC
Bus to Greenville, SC from San Luis Potosí Bus to Greenville, SC from San Luis Potosí
Popular Airport Shuttles to Fort Myers, FL and to Greenville, SC
CheckMyBus › Buses in USA › Bus to Fort Myers, FL › Bus to Greenville, SC

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.