Bus Detroit to Greenville, SC - Compare all Companies

Compare all timetables for the bus from Detroit to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Detroit to Greenville, SC from various bus operators like Greyhound US for the next days.

today

$92

tomorrow

$102

Saturday

$94

Sunday

$84

Monday

$91

Tuesday

$93

Wednesday

$87

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 50m	1:50 PM	Detroit	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$92	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/6/2026 1:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/7/2026 10:40:00 AM. 50 Economy ticket for $92 per person are available. Travel duration is 20h 50m
Greyhound US	18h 40m	7:55 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$92	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/6/2026 7:55:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/7/2026 2:35:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 18h 40m
Greyhound US	20h 0m	7:15 AM	Detroit	Central Bus Station	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$100	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/6/2026 7:15:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/7/2026 3:15:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 20h 0m
Greyhound US	35h 25m	11:15 PM	Detroit	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$112	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/6/2026 11:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/8/2026 10:40:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 35h 25m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 0m	7:15 AM	Detroit	Central Bus Station	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$102	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/7/2026 7:15:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/8/2026 3:15:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 20h 0m
Greyhound US	20h 50m	1:50 PM	Detroit	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$102	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/7/2026 1:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/8/2026 10:40:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 20h 50m
Greyhound US	18h 40m	7:55 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$102	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/7/2026 7:55:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/8/2026 2:35:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 18h 40m
Greyhound US	35h 25m	11:15 PM	Detroit	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$112	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/7/2026 11:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/9/2026 10:40:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 35h 25m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 50m	1:50 PM	Detroit	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$94	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/8/2026 1:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/9/2026 10:40:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 20h 50m
Greyhound US	20h 0m	7:15 AM	Detroit	Central Bus Station	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$99	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/8/2026 7:15:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/9/2026 3:15:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 20h 0m
Greyhound US	18h 40m	7:55 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$101	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/8/2026 7:55:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/9/2026 2:35:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 18h 40m
Greyhound US	35h 25m	11:15 PM	Detroit	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$117	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/8/2026 11:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/10/2026 10:40:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 35h 25m

Did you know that if you travel from Detroit to Greenville, SC via Toledo, OH, you can save more than $9? You can find the corresponding connections below.
- Greyhound US
  
  20h 50m
  
  0
  
  1:50 PM
  
  Detroit
  Central Bus Station
  
  2:55 PM
  
  Toledo, OH
  Amtrak Station
  
  0
  
  Economy
  
  $9
  
  A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/9/2026 1:50:00 PM to Amtrak Station, Toledo, OH (USA) arriving at 8/9/2026 2:55:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 1h 5m
- Greyhound US
  
  19h 35m
  
  0
  
  3:05 PM
  
  Toledo, OH
  Amtrak Station
  
  10:40 AM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $76
  
  A Bus from Greyhound US goes from Amtrak Station, Toledo, OH (USA) at 8/9/2026 3:05:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/10/2026 10:40:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 19h 35m
Travel time is 2h 10m longer, but you will save $9

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 50m	1:50 PM	Detroit	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$84	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/9/2026 1:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/10/2026 10:40:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 20h 50m
Greyhound US	18h 40m	7:55 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$84	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/9/2026 7:55:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/10/2026 2:35:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 18h 40m
Greyhound US	20h 0m	7:15 AM	Detroit	Central Bus Station	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$88	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/9/2026 7:15:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/10/2026 3:15:00 AM. 50 Economy ticket for $88 per person are available. Travel duration is 20h 0m
Greyhound US	35h 25m	11:15 PM	Detroit	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$99	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/9/2026 11:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/11/2026 10:40:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 35h 25m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 50m	1:50 PM	Detroit	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$91	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/10/2026 1:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/11/2026 10:40:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 20h 50m
Greyhound US	18h 40m	7:55 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$92	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/10/2026 7:55:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/11/2026 2:35:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 18h 40m
Greyhound US	20h 0m	7:15 AM	Detroit	Central Bus Station	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$93	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/10/2026 7:15:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/11/2026 3:15:00 AM. 50 Economy ticket for $93 per person are available. Travel duration is 20h 0m
Greyhound US	35h 25m	11:15 PM	Detroit	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$95	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/10/2026 11:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/12/2026 10:40:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 35h 25m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 0m	7:15 AM	Detroit	Central Bus Station	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$93	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/11/2026 7:15:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/12/2026 3:15:00 AM. 50 Economy ticket for $93 per person are available. Travel duration is 20h 0m
Greyhound US	18h 40m	7:55 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$93	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/11/2026 7:55:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/12/2026 2:35:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 18h 40m
Greyhound US	20h 50m	1:50 PM	Detroit	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$94	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/11/2026 1:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/12/2026 10:40:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 20h 50m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 10m	1:50 PM	Detroit	Central Bus Station	12:00 PM	Greenville, SC	Woodruff Rd	Economy	$87	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/12/2026 1:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/13/2026 12:00:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 22h 10m
Greyhound US	18h 40m	7:55 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$88	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/12/2026 7:55:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/13/2026 2:35:00 PM. 50 Economy ticket for $88 per person are available. Travel duration is 18h 40m
Greyhound US	20h 0m	7:15 AM	Detroit	Central Bus Station	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$89	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/12/2026 7:15:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/13/2026 3:15:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 20h 0m
Greyhound US	35h 25m	11:15 PM	Detroit	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$91	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 8/12/2026 11:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/14/2026 10:40:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 35h 25m

Best Price Offer: The price for the cheapest bus from Detroit to Greenville, SC is $79 on 8/25/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Detroit and Greenville, SC

See here how frequent the connections between Detroit and Greenville, SC are, during different times and days of the week.

Sunday is the busiest day, with more than 8 daily buses from Detroit to Greenville, SC. Tuesday has instead the fewest connections, with only 6 daily coaches between Detroit and Greenville, SC.

The busiest time of the day is the Evening, with 25 buses from Detroit to Greenville, SC, while Morning sees the fewest connections between Detroit and Greenville, SC, with 14 offers.

Facts about the bus from Detroit to Greenville, SC

Compare all providers like Greyhound US that travel 7 times every day by bus from Detroit to Greenville, SC in one click! Book your bus ticket from Detroit to Greenville, SC starting from $79!

Cheapest Bus	$79
Fastest Bus	18h 40m
Earliest Bus	7:15 AM
Latest Bus	11:15 PM
Daily Bus Routes	7 Ø
Distance	518.2 miles
Bus Companies	Greyhound US

Cheapest bus connections from Detroit to Greenville, SC

Every day, 7 buses from 1 bus companies leave Detroit for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 08/06/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 08/02

Monday 08/03

Tuesday 08/04

Wednesday 08/05

Thursday 08/06

$92

Friday 08/07

$102

Saturday 08/08

$94

Sunday 08/09

$129

Monday 08/10

$91

Tuesday 08/11

$93

Wednesday 08/12

$87

Thursday 08/13

$98

Friday 08/14

$129

Saturday 08/15

$129

Sunday 08/16

$129

Monday 08/17

$129

Tuesday 08/18

$90

Wednesday 08/19

$79

Thursday 08/20

$88

Friday 08/21

$86

Saturday 08/22

Sunday 08/23

$96

Monday 08/24

$86

Tuesday 08/25

$79

Wednesday 08/26

$84

Thursday 08/27

$90

Friday 08/28

$95

Saturday 08/29

The cheapest time to travel from Detroit to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Detroit to Greenville, SC, for the next 30 days.

With a price starting from $79, Tuesday is the cheapest day for a bus from Detroit to Greenville, SC. Saturday instead is the most expensive day with prices starting from $91.

Afternoon is the cheapest day time for bus tickets from Detroit to Greenville, SC, with $84. Morning is the most expensive time of the day with prices starting from $88.

How to save money travelling from Detroit to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Detroit to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Detroit to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Detroit to Greenville, SC are also emptier.

Beloved bus companies from Detroit to Greenville, SC

These are the most booked bus companies between Detroit to Greenville, SC from our users.

Greyhound US from Detroit to Greenville, SC

Here you will find the key facts about the Greyhound US bus route Detroit to Greenville, SC:

Cheapest Price	$84
Fastest Bus	18h 40m
Earliest Bus	7:15 AM
Last Bus	11:15 PM
Daily Connections	7 Ø
Found on	7/29/2026

All bus stations and stops in Detroit and Greenville, SC

In the map below, you can see where to find all bus stations in Detroit and Greenville, SC.

Central Bus Station

Howard St 1001

Amtrak

W Baltimore Ave 78

VA Medical Center Blue Deck

East Canfield Street (between John R. and Brush St.) 225

Park Avenue

Rosa Parks TC

Cass Ave 1310

McDonald's

Woodruff Rd 1111

N Church St

Woodruff Rd

Woodruff Rd 1116

Greyhound Bus Station

Hendrix Dr 9

Guadalajara Supermarket

White Horse Rd 2803

Service and Comfort on the bus from Detroit to Greenville, SC

Want to know which seat classes are available on the buses from Detroit to Greenville, SC? Or which bus companies serve the route Detroit to Greenville, SC? Below you will find answers to your questions.

FAQs about the Detroit to Greenville, SC bus

How much does a Detroit Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $79 and takes 20h 50m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Detroit to Greenville, SC?

This route is offered by 1 companies with a range of ticket prices between $79 and $168. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Detroit to Greenville, SC each day?

Every day, the Detroit to Greenville, SC bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Detroit to Greenville, SC take?

The fastest bus from Detroit to Greenville, SC is offered by Greyhound US and takes 18h 40m. Bus tickets for this connection cost $92. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Detroit to Greenville, SC?

The earliest bus arriving in Greenville, SC from Detroit starts at 7:15 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Detroit to Greenville, SC?

The latest bus trip departing from Detroit for Greenville, SC starts at 11:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Detroit Greenville, SC route?

When traveling by bus from Detroit to Greenville, SC, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Detroit and Greenville, SC?

You can check all the direct connections between Detroit and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Detroit to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Detroit Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Detroit Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Detroit to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Detroit to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between Detroit and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Detroit to Greenville, SC?

Prices and availability for 7 trips between Detroit and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Detroit to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Detroit and to Greenville, SC

Here’s an overview of the most popular bus routes to Detroit and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!