Bus Detroit to Greenville, SC - Compare all Companies

Compare all timetables for the bus from Detroit to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Detroit to Greenville, SC from various bus operators like Greyhound US or FlixBus for the next days.

today

tomorrow

$102

Sunday

Monday

$120

Tuesday

Wednesday

$111

Thursday

$117

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	27h 40m	8:20 AM	Detroit	Central Bus Station	12:00 PM	Greenville, SC	Woodruff Rd	Economy	$102	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/6/2025 8:20:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/7/2025 12:00:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 27h 40m
Greyhound US	18h 20m	8:15 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$102	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/6/2025 8:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/7/2025 2:35:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 18h 20m
Greyhound US	31h 40m	11:25 PM	Detroit	Central Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$102	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/6/2025 11:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/8/2025 7:05:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 31h 40m
FlixBus	27h 25m	7:15 AM	Detroit	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$110	A Bus from FlixBus goes from Central Bus Station, Detroit (USA) at 12/6/2025 7:15:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/7/2025 10:40:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 27h 25m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	18h 20m	8:15 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$120	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/8/2025 8:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/9/2025 2:35:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 18h 20m
Greyhound US	24h 25m	6:40 AM	Detroit	Central Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$122	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/8/2025 6:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/9/2025 7:05:00 AM. 50 Economy ticket for $122 per person are available. Travel duration is 24h 25m
FlixBus	27h 25m	7:15 AM	Detroit	Central Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$122	A Bus from FlixBus goes from Central Bus Station, Detroit (USA) at 12/8/2025 7:15:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/9/2025 10:40:00 AM. 50 Economy ticket for $122 per person are available. Travel duration is 27h 25m
Greyhound US	31h 40m	11:25 PM	Detroit	Central Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$129	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/8/2025 11:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/10/2025 7:05:00 AM. 50 Economy ticket for $129 per person are available. Travel duration is 31h 40m

Did you know that if you travel from Detroit to Greenville, SC via Charlotte, you can save more than $20? You can find the corresponding connections below.
- Busbud
  
  18h 20m
  
  0
  
  8:15 PM
  
  Detroit
  Central Bus Station
  
  11:55 AM
  
  Charlotte
  W Trade St
  
  0
  
  Economy
  
  $78
  
  A Bus from Busbud goes from Central Bus Station, Detroit (USA) at 12/7/2025 8:15:00 PM to W Trade St, Charlotte (USA) arriving at 12/8/2025 11:55:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 15h 40m
- FlixBus
  
  1h 45m
  
  0
  
  12:50 PM
  
  Charlotte
  W Trade St
  
  2:35 PM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $22
  
  A Bus from FlixBus goes from W Trade St, Charlotte (USA) at 12/8/2025 12:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/8/2025 2:35:00 PM. 50 Economy ticket for $22 per person are available. Travel duration is 1h 45m
Travel time is the same as the direct connection, but you will save $20

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	18h 20m	8:15 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$111	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/10/2025 8:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/11/2025 2:35:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 18h 20m
Greyhound US	31h 40m	11:25 PM	Detroit	Central Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$112	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/10/2025 11:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/12/2025 7:05:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 31h 40m
Greyhound US	24h 25m	6:40 AM	Detroit	Central Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$114	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/10/2025 6:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/11/2025 7:05:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 24h 25m

Did you know that if you travel from Detroit to Greenville, SC via Charlotte, you can save more than $11? You can find the corresponding connections below.
- Busbud
  
  18h 20m
  
  0
  
  8:15 PM
  
  Detroit
  Central Bus Station
  
  11:55 AM
  
  Charlotte
  W Trade St
  
  0
  
  Economy
  
  $78
  
  A Bus from Busbud goes from Central Bus Station, Detroit (USA) at 12/7/2025 8:15:00 PM to W Trade St, Charlotte (USA) arriving at 12/8/2025 11:55:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 15h 40m
- FlixBus
  
  1h 45m
  
  0
  
  12:50 PM
  
  Charlotte
  W Trade St
  
  2:35 PM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $22
  
  A Bus from FlixBus goes from W Trade St, Charlotte (USA) at 12/8/2025 12:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/8/2025 2:35:00 PM. 50 Economy ticket for $22 per person are available. Travel duration is 1h 45m
Travel time is the same as the direct connection, but you will save $11

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	18h 20m	8:15 PM	Detroit	Central Bus Station	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$117	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/11/2025 8:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/12/2025 2:35:00 PM. 50 Economy ticket for $117 per person are available. Travel duration is 18h 20m
Greyhound US	24h 25m	6:40 AM	Detroit	Central Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$118	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/11/2025 6:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/12/2025 7:05:00 AM. 50 Economy ticket for $118 per person are available. Travel duration is 24h 25m
Greyhound US	31h 40m	11:25 PM	Detroit	Central Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$126	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/11/2025 11:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/13/2025 7:05:00 AM. 50 Economy ticket for $126 per person are available. Travel duration is 31h 40m

Did you know that if you travel from Detroit to Greenville, SC via Charlotte, you can save more than $21? You can find the corresponding connections below.
- Busbud
  
  23h 25m
  
  0
  
  8:15 PM
  
  Detroit
  Central Bus Station
  
  11:50 AM
  
  Charlotte
  W Trade St
  
  0
  
  Economy
  
  $78
  
  A Bus from Busbud goes from Central Bus Station, Detroit (USA) at 12/12/2025 8:15:00 PM to W Trade St, Charlotte (USA) arriving at 12/13/2025 11:50:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 15h 35m
- Busbud
  
  2h 0m
  
  0
  
  5:40 PM
  
  Charlotte
  W Trade St
  
  7:40 PM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $18
  
  A Bus from Busbud goes from W Trade St, Charlotte (USA) at 12/13/2025 5:40:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/13/2025 7:40:00 PM. 50 Economy ticket for $18 per person are available. Travel duration is 2h 0m
Travel time is 5h 5m longer, but you will save $21

Best Price Offer: The price for the cheapest bus from Detroit to Greenville, SC is $92 on 12/4/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Detroit and Greenville, SC

See here how frequent the connections between Detroit and Greenville, SC are, during different times and days of the week.

Saturday is the busiest day, with more than 10 daily buses from Detroit to Greenville, SC. Wednesday has instead the fewest connections, with only 3 daily coaches between Detroit and Greenville, SC.

The busiest time of the day is the Morning, with 12 buses from Detroit to Greenville, SC, while Morning sees the fewest connections between Detroit and Greenville, SC, with 12 offers.

Facts about the bus from Detroit to Greenville, SC

Compare all providers like Greyhound US and FlixBus that travel 6 times every day by bus from Detroit to Greenville, SC in one click! Book your bus ticket from Detroit to Greenville, SC starting from $92!

Cheapest Bus	$92
Fastest Bus	18h 20m
Earliest Bus	6:40 AM
Latest Bus	11:25 PM
Daily Bus Routes	6 Ø
Distance	518.2 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Detroit to Greenville, SC

Every day, 6 buses from 2 bus companies leave Detroit for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

Saturday 12/06

$109

Sunday 12/07

Monday 12/08

$120

Tuesday 12/09

Wednesday 12/10

$111

Thursday 12/11

$117

Friday 12/12

Saturday 12/13

$118

Sunday 12/14

$97

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

$146

Saturday 12/20

$158

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

The cheapest time to travel from Detroit to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Detroit to Greenville, SC, for the next 30 days.

With a price starting from $102, Saturday is the cheapest day for a bus from Detroit to Greenville, SC. Monday instead is the most expensive day with prices starting from $120.

Evening is the cheapest day time for bus tickets from Detroit to Greenville, SC, with $102. Morning is the most expensive time of the day with prices starting from $102.

How to save money travelling from Detroit to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Detroit to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Detroit to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Detroit to Greenville, SC are also emptier.

Beloved bus companies from Detroit to Greenville, SC

These are the most booked bus companies between Detroit to Greenville, SC from our users.

Greyhound US from Detroit to Greenville, SC

Here you will find the key facts about the Greyhound US bus route Detroit to Greenville, SC:

Cheapest Price	$102
Fastest Bus	18h 20m
Earliest Bus	6:40 AM
Last Bus	11:25 PM
Daily Connections	5 Ø
Found on	12/2/2025

All bus stations and stops in Detroit and Greenville, SC

In the map below, you can see where to find all bus stations in Detroit and Greenville, SC.

Central Bus Station

Howard St 1001

Amtrak

W Baltimore Ave 78

VA Medical Center Blue Deck

East Canfield Street (between John R. and Brush St.) 225

Park Avenue

Rosa Parks TC

Cass Ave 1310

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

Service and Comfort on the bus from Detroit to Greenville, SC

Want to know which seat classes are available on the buses from Detroit to Greenville, SC? Or which bus companies serve the route Detroit to Greenville, SC? Below you will find answers to your questions.

FAQs about the Detroit to Greenville, SC bus

How much does a Detroit Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $92 and takes 18h 20m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Detroit to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $92 and $130. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Detroit to Greenville, SC each day?

Every day, the Detroit to Greenville, SC bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Detroit to Greenville, SC take?

The fastest bus from Detroit to Greenville, SC is offered by Greyhound US and takes 18h 20m. Bus tickets for this connection cost $102. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Detroit to Greenville, SC?

The earliest bus arriving in Greenville, SC from Detroit starts at 6:40 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Detroit to Greenville, SC?

The latest bus trip departing from Detroit for Greenville, SC starts at 11:25 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Detroit Greenville, SC route?

When traveling by bus from Detroit to Greenville, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Detroit and Greenville, SC?

You can check all the direct connections between Detroit and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Detroit to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Detroit Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Detroit Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Detroit to Greenville, SC on your planned travel date.

Available seat classes which are offered on the bus route Detroit to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Detroit and to Greenville, SC

Here’s an overview of the most popular bus routes to Detroit and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!