Which bus from Detroit to Greenville, SC is the cheapest?

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Compare all timetables for the bus from Detroit to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Detroit to Greenville, SC from various bus operators like Greyhound US for the next days.

today
tomorrow
$154
Sunday
$107
Monday
Tuesday
$118
Wednesday
Thursday

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 23h 50m 7:15 AM Detroit Central Bus Station 7:05 AM Greenville, SC Woodruff Rd  Economy $154
Greyhound US 27h 40m 8:20 AM Detroit Central Bus Station 12:00 PM Greenville, SC Woodruff Rd  Economy $154
Greyhound US 31h 50m 11:15 PM Detroit Central Bus Station 7:05 AM Greenville, SC Woodruff Rd  Economy $154
Greyhound US 18h 20m 8:15 PM Detroit Central Bus Station 2:35 PM Greenville, SC Woodruff Rd  Economy $157
  • Did you know that if you travel from Detroit to Greenville, SC via Charlotte, you can save more than $52? You can find the corresponding connections below.
    • FlixBus
      23h 10m
      0
      8:15 PM
      Detroit
      Central Bus Station
      11:55 AM
      Charlotte
      W Trade St
      0
      FlixBus
      Economy
      $78
      • Waiting Time 5h 40m
    • Busbud
      1h 50m
      0
      5:35 PM
      Charlotte
      W Trade St
      7:25 PM
      Greenville, SC
      Woodruff Rd
      0
      Busbud
      Economy
      $24
    Travel time is 4h 50m longer, but you will save $52

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 18h 20m 8:15 PM Detroit Central Bus Station 2:35 PM Greenville, SC Woodruff Rd  Economy $107
Greyhound US 23h 50m 7:15 AM Detroit Central Bus Station 7:05 AM Greenville, SC Woodruff Rd  Economy $108
Greyhound US 31h 50m 11:15 PM Detroit Central Bus Station 7:05 AM Greenville, SC Woodruff Rd  Economy $108
  • Did you know that if you travel from Detroit to Greenville, SC via Charlotte, you can save more than $19? You can find the corresponding connections below.
    • Busbud
      18h 20m
      0
      8:15 PM
      Detroit
      Central Bus Station
      11:55 AM
      Charlotte
      W Trade St
      0
      Busbud
      Economy
      $65
      • Waiting Time 0h 55m
    • FlixBus
      1h 45m
      0
      12:50 PM
      Charlotte
      W Trade St
      2:35 PM
      Greenville, SC
      Woodruff Rd
      0
      FlixBus
      Economy
      $23
    Travel time is the same as the direct connection, but you will save $19

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 31h 50m 11:15 PM Detroit Central Bus Station 7:05 AM Greenville, SC Woodruff Rd  Economy $118
Greyhound US 18h 20m 8:15 PM Detroit Central Bus Station 2:35 PM Greenville, SC Woodruff Rd  Economy $132
Greyhound US 23h 50m 7:15 AM Detroit Central Bus Station 7:05 AM Greenville, SC Woodruff Rd  Economy $133
  • Did you know that if you travel from Detroit to Greenville, SC via Charlotte, you can save more than $30? You can find the corresponding connections below.
    • Busbud
      18h 20m
      0
      8:15 PM
      Detroit
      Central Bus Station
      11:55 AM
      Charlotte
      W Trade St
      0
      Busbud
      Economy
      $65
      • Waiting Time 0h 55m
    • FlixBus
      1h 45m
      0
      12:50 PM
      Charlotte
      W Trade St
      2:35 PM
      Greenville, SC
      Woodruff Rd
      0
      FlixBus
      Economy
      $23
    Travel time is the same as the direct connection, but you will save $30

Best Price Offer: The price for the cheapest bus from Detroit to Greenville, SC is $84 on 2/19/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Detroit and Greenville, SC

See here how frequent the connections between Detroit and Greenville, SC are, during different times and days of the week.
Saturday is the busiest day, with more than 4 daily buses from Detroit to Greenville, SC. Sunday has instead the fewest connections, with only 3 daily coaches between Detroit and Greenville, SC.
The busiest time of the day is the Evening, with 6 buses from Detroit to Greenville, SC, while Morning sees the fewest connections between Detroit and Greenville, SC, with 4 offers.

Facts about the bus from Detroit to Greenville, SC

Compare all providers like Greyhound US that travel 3 times every day by bus from Detroit to Greenville, SC in one click! Book your bus ticket from Detroit to Greenville, SC starting from $84!

Cheapest Bus $84
Fastest Bus 18h 20m
Earliest Bus 7:15 AM
Latest Bus 11:15 PM
Daily Bus Routes 3 Ø
Distance 518.2 miles
Bus Companies Greyhound US

Cheapest bus connections from Detroit to Greenville, SC

Every day, 3 buses from 1 bus companies leave Detroit for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/06/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 02/01
Monday 02/02
Tuesday 02/03
Wednesday 02/04
Thursday 02/05
Friday 02/06
Saturday 02/07
$154
Sunday 02/08
$107
Monday 02/09
Tuesday 02/10
$118
Wednesday 02/11
Thursday 02/12
Friday 02/13
$102
Saturday 02/14
Sunday 02/15
$95
Monday 02/16
$90
Tuesday 02/17
Wednesday 02/18
Thursday 02/19
$84
Friday 02/20
Saturday 02/21
$118
Sunday 02/22
$85
Monday 02/23
Tuesday 02/24
Wednesday 02/25
Thursday 02/26
Friday 02/27
Saturday 02/28

The cheapest time to travel from Detroit to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Detroit to Greenville, SC, for the next 30 days.
With a price starting from $81, Sunday is the cheapest day for a bus from Detroit to Greenville, SC. Tuesday instead is the most expensive day with prices starting from $118.
Evening is the cheapest day time for bus tickets from Detroit to Greenville, SC, with $107. Morning is the most expensive time of the day with prices starting from $108.

How to save money travelling from Detroit to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Detroit to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Detroit to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Detroit to Greenville, SC are also emptier.

Beloved bus companies from Detroit to Greenville, SC

These are the most booked bus companies between Detroit to Greenville, SC from our users.

Greyhound US from Detroit to Greenville, SC

Greyhound US

Here you will find the key facts about the Greyhound US bus route Detroit to Greenville, SC:

Cheapest Price $107
Fastest Bus 18h 20m
Earliest Bus 7:15 AM
Last Bus 11:15 PM
Daily Connections 3 Ø
Found on 2/1/2026

All bus stations and stops in Detroit and Greenville, SC

In the map below, you can see where to find all bus stations in Detroit and Greenville, SC.

Service and Comfort on the bus from Detroit to Greenville, SC

Want to know which seat classes are available on the buses from Detroit to Greenville, SC? Or which bus companies serve the route Detroit to Greenville, SC? Below you will find answers to your questions.

FAQs about the Detroit to Greenville, SC bus

How much does a Detroit Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $84 and takes 18h 20m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Detroit to Greenville, SC?

This route is offered by 1 companies with a range of ticket prices between $84 and $157. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Detroit to Greenville, SC each day?

Every day, the Detroit to Greenville, SC bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Detroit to Greenville, SC take?

The fastest bus from Detroit to Greenville, SC is offered by Greyhound US and takes 18h 20m. Bus tickets for this connection cost $157. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Detroit to Greenville, SC?

The earliest bus arriving in Greenville, SC from Detroit starts at 7:15 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Detroit to Greenville, SC?

The latest bus trip departing from Detroit for Greenville, SC starts at 11:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Detroit Greenville, SC route?

When traveling by bus from Detroit to Greenville, SC, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Detroit and Greenville, SC?

You can check all the direct connections between Detroit and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Detroit to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Detroit Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Detroit Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Detroit to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Detroit to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Detroit and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Detroit to Greenville, SC?

Prices and availability for 3 trips between Detroit and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Detroit to Greenville, SC

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Detroit and to Greenville, SC

Here’s an overview of the most popular bus routes to Detroit and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Popular Airport Shuttles to Detroit and to Greenville, SC
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