Bus Houston to Greenville, SC: Compare prices and save money

Compare all timetables for the bus from Houston to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Houston to Greenville, SC from various bus operators like FlixBus, Greyhound US or Valley Transit for the next days.

today

$103

tomorrow

$99

Monday

$102

Tuesday

Wednesday

$94

Thursday

$96

Friday

$100

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 15m	5:00 AM	Houston	Harrisburg Blvd Station	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$103	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/20/2026 5:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/21/2026 3:15:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 21h 15m
Greyhound US	20h 35m	1:05 PM	Houston	Harrisburg Blvd Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$103	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/20/2026 1:05:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/21/2026 10:40:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 20h 35m
FlixBus	30h 20m	2:10 PM	Houston	Downtown Houston	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$103	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/20/2026 2:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/21/2026 9:30:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 30h 20m
FlixBus	20h 10m	1:30 PM	Houston	Downtown Houston	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$104	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/20/2026 1:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/21/2026 10:40:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 20h 10m
Valley Transit	37h 55m	6:35 AM	Houston	SW Agencia Autobuses	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$105	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/20/2026 6:35:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/21/2026 9:30:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 37h 55m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 35m	1:05 PM	Houston	Harrisburg Blvd Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$99	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/21/2026 1:05:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/22/2026 10:40:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 20h 35m
Greyhound US	22h 30m	10:00 PM	Houston	Harrisburg Blvd Station	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$99	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/21/2026 10:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/22/2026 9:30:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 22h 30m
FlixBus	30h 20m	2:10 PM	Houston	Downtown Houston	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$99	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/21/2026 2:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/22/2026 9:30:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 30h 20m
Valley Transit	37h 55m	6:35 AM	Houston	SW Agencia Autobuses	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$101	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/21/2026 6:35:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/22/2026 9:30:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 37h 55m
FlixBus	27h 25m	10:50 PM	Houston	Downtown Houston	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$102	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/21/2026 10:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/23/2026 3:15:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 27h 25m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	20h 10m	1:30 PM	Houston	Downtown Houston	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$102	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/22/2026 1:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/23/2026 10:40:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 20h 10m
Greyhound US	20h 35m	1:05 PM	Houston	Harrisburg Blvd Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$103	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/22/2026 1:05:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/23/2026 10:40:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 20h 35m
Greyhound US	22h 30m	10:00 PM	Houston	Harrisburg Blvd Station	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$103	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/22/2026 10:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/23/2026 9:30:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 22h 30m
Valley Transit	37h 55m	6:35 AM	Houston	SW Agencia Autobuses	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$103	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/22/2026 6:35:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/23/2026 9:30:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 37h 55m
FlixBus	27h 25m	10:50 PM	Houston	Downtown Houston	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$103	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/22/2026 10:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/24/2026 3:15:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 27h 25m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	30h 20m	2:10 PM	Houston	Downtown Houston	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$94	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/24/2026 2:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/25/2026 9:30:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 30h 20m
Greyhound US	21h 15m	5:00 AM	Houston	Harrisburg Blvd Station	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$96	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/24/2026 5:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/25/2026 3:15:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 21h 15m
Greyhound US	20h 35m	1:05 PM	Houston	Harrisburg Blvd Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$96	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/24/2026 1:05:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/25/2026 10:40:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 20h 35m
FlixBus	24h 40m	9:00 AM	Houston	Downtown Houston	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$96	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/24/2026 9:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/25/2026 10:40:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 24h 40m
Valley Transit	37h 55m	6:35 AM	Houston	SW Agencia Autobuses	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$98	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/24/2026 6:35:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/25/2026 9:30:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 37h 55m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 15m	5:00 AM	Houston	Harrisburg Blvd Station	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$96	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/25/2026 5:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/26/2026 3:15:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 21h 15m
Greyhound US	20h 35m	1:05 PM	Houston	Harrisburg Blvd Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$96	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/25/2026 1:05:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/26/2026 10:40:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 20h 35m
FlixBus	20h 10m	1:30 PM	Houston	Downtown Houston	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$96	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/25/2026 1:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/26/2026 10:40:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 20h 10m
FlixBus	30h 20m	2:10 PM	Houston	Downtown Houston	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$96	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/25/2026 2:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/26/2026 9:30:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 30h 20m
Valley Transit	37h 55m	6:35 AM	Houston	SW Agencia Autobuses	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$98	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/25/2026 6:35:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/26/2026 9:30:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 37h 55m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 15m	5:00 AM	Houston	Harrisburg Blvd Station	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$100	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/26/2026 5:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/27/2026 3:15:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 21h 15m
Greyhound US	20h 35m	1:05 PM	Houston	Harrisburg Blvd Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$100	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/26/2026 1:05:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/27/2026 10:40:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 20h 35m
Greyhound US	22h 30m	10:00 PM	Houston	Harrisburg Blvd Station	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$100	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/26/2026 10:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/27/2026 9:30:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 22h 30m
FlixBus	20h 10m	1:30 PM	Houston	Downtown Houston	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$101	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/26/2026 1:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/27/2026 10:40:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 20h 10m
FlixBus	30h 20m	2:10 PM	Houston	Downtown Houston	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$101	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/26/2026 2:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/27/2026 9:30:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 30h 20m

Best Price Offer: The price for the cheapest bus from Houston to Greenville, SC is $74 on 6/21/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Houston and Greenville, SC

See here how frequent the connections between Houston and Greenville, SC are, during different times and days of the week.

Sunday is the busiest day, with more than 15 daily buses from Houston to Greenville, SC. Monday has instead the fewest connections, with only 7 daily coaches between Houston and Greenville, SC.

The busiest time of the day is the Afternoon, with 24 buses from Houston to Greenville, SC, while Night sees the fewest connections between Houston and Greenville, SC, with 7 offers.

Facts about the bus from Houston to Greenville, SC

Compare all providers like FlixBus, Greyhound US and Valley Transit that travel 8 times every day by bus from Houston to Greenville, SC in one click! Book your bus ticket from Houston to Greenville, SC starting from $74!

Cheapest Bus	$74
Fastest Bus	21h 10m
Earliest Bus	5:00 AM
Latest Bus	10:50 PM
Daily Bus Routes	8 Ø
Distance	835.2 miles
Bus Companies	FlixBus, Greyhound US, Valley Transit and Tornado Bus Company

Cheapest bus connections from Houston to Greenville, SC

Every day, 8 buses from 4 bus companies leave Houston for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 06/14

Monday 06/15

Tuesday 06/16

Wednesday 06/17

Thursday 06/18

Friday 06/19

Saturday 06/20

$103

Sunday 06/21

$74

Monday 06/22

$74

Tuesday 06/23

$90

Wednesday 06/24

$94

Thursday 06/25

$74

Friday 06/26

$74

Saturday 06/27

$74

Sunday 06/28

$74

Monday 06/29

Tuesday 06/30

Wednesday 07/01

Thursday 07/02

Friday 07/03

Saturday 07/04

Sunday 07/05

Monday 07/06

Tuesday 07/07

Wednesday 07/08

Thursday 07/09

Friday 07/10

$94

Saturday 07/11

The cheapest time to travel from Houston to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Houston to Greenville, SC, for the next 30 days.

With a price starting from $74, Sunday is the cheapest day for a bus from Houston to Greenville, SC. Wednesday instead is the most expensive day with prices starting from $90.

Night is the cheapest day time for bus tickets from Houston to Greenville, SC, with $74. Morning is the most expensive time of the day with prices starting from $96.

How to save money travelling from Houston to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Houston to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Houston to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Houston to Greenville, SC are also emptier.

All bus stations and stops in Houston and Greenville, SC

In the map below, you can see where to find all bus stations in Houston and Greenville, SC.

Downtown Houston

Gray St 605

Harrisburg Blvd Station

Harrisburg Blvd 7000

Main Street

Main St 2121

Chase Bank

Milam Street 212

Uptown/Upper Kirby

Southwest Fwy 2525

Woodruff Rd

Woodruff Rd 1116

N Church St

Greyhound Bus Station

Hendrix Dr 9

Guadalajara Supermarket

White Horse Rd 2803

McDonald's

Woodruff Rd 1111

Service and Comfort on the bus from Houston to Greenville, SC

Want to know which seat classes are available on the buses from Houston to Greenville, SC? Or which bus companies serve the route Houston to Greenville, SC? Below you will find answers to your questions.

FAQs about the Houston to Greenville, SC bus

How much does a Houston Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $74 and takes 31h 20m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Houston to Greenville, SC?

This route is offered by 4 companies with a range of ticket prices between $74 and $205. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Houston to Greenville, SC each day?

Every day, the Houston to Greenville, SC bus route is served by approximately 8 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Houston to Greenville, SC take?

The fastest bus from Houston to Greenville, SC is offered by FlixBus and takes 21h 10m. Bus tickets for this connection cost $104. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Houston to Greenville, SC?

The earliest bus arriving in Greenville, SC from Houston starts at 5:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Houston to Greenville, SC?

The latest bus trip departing from Houston for Greenville, SC starts at 10:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Houston Greenville, SC route?

When traveling by bus from Houston to Greenville, SC, passengers can travel with FlixBus, Greyhound US and Valley Transit. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Houston and Greenville, SC?

You can check all the direct connections between Houston and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Greyhound US and Valley Transit.

What can I take with me on the Houston to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Houston Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Houston Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Houston to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Houston to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 8 daily trips between Houston and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Houston to Greenville, SC?

Prices and availability for 8 trips between Houston and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Houston to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Houston and to Greenville, SC

Here’s an overview of the most popular bus routes to Houston and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!