Bus Houston to Greenville, SC: Compare prices and save money

Compare all timetables for the bus from Houston to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Houston to Greenville, SC from various bus operators like FlixBus, Greyhound US or Valley Transit for the next days.

today

tomorrow

Tuesday

$129

Wednesday

Thursday

Friday

Saturday

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	36h 0m	6:00 PM	Houston	Downtown Houston	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$129	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 3/24/2026 6:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 3/26/2026 7:00:00 AM. 50 Economy ticket for $129 per person are available. Travel duration is 36h 0m
Greyhound US	25h 0m	5:00 AM	Houston	Harrisburg Blvd Station	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$130	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 3/24/2026 5:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 3/25/2026 7:00:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 25h 0m
Greyhound US	22h 55m	10:00 PM	Houston	Harrisburg Blvd Station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$130	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 3/24/2026 10:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 3/25/2026 9:55:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 22h 55m
FlixBus	34h 10m	7:50 PM	Houston	Uptown/Upper Kirby	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$130	A Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 3/24/2026 7:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 3/26/2026 7:00:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 34h 10m
Valley Transit	38h 20m	6:35 AM	Houston	SW Agencia Autobuses	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$141	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 3/24/2026 6:35:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 3/25/2026 9:55:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 38h 20m

Did you know that if you travel from Houston to Greenville, SC via Atlanta, GA, you can save more than $57? You can find the corresponding connections below.
- Greyhound US
  
  25h 0m
  
  0
  
  5:00 AM
  
  Houston
  Harrisburg Blvd Station
  
  10:55 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $49
  
  A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 3/24/2026 5:00:00 AM to Garnett Transit Station, Atlanta, GA (USA) arriving at 3/24/2026 10:55:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 16h 55m
- Greyhound US
  
  2h 20m
  
  0
  
  4:40 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  7:00 AM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $23
  
  A Bus from Greyhound US goes from Garnett Transit Station, Atlanta, GA (USA) at 3/25/2026 4:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 3/25/2026 7:00:00 AM. 50 Economy ticket for $23 per person are available. Travel duration is 2h 20m
Travel time is 1h 5m longer, but you will save $57

Best Price Offer: The price for the cheapest bus from Houston to Greenville, SC is $73 on 4/13/2026. Flexible travelers save on ticket prices.

Facts about the bus from Houston to Greenville, SC

Compare all providers like FlixBus, Greyhound US and Valley Transit that travel 20 times every day by bus from Houston to Greenville, SC in one click! Book your bus ticket from Houston to Greenville, SC starting from $73!

Cheapest Bus	$73
Fastest Bus	21h 35m
Earliest Bus	5:00 AM
Latest Bus	10:00 PM
Daily Bus Routes	20 Ø
Distance	835.2 miles
Bus Companies	FlixBus, Greyhound US, Valley Transit and Tornado Bus Company

Cheapest bus connections from Houston to Greenville, SC

Every day, 20 buses from 4 bus companies leave Houston for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/22/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 03/22

Monday 03/23

Tuesday 03/24

$129

Wednesday 03/25

Thursday 03/26

Friday 03/27

Saturday 03/28

Sunday 03/29

$106

Monday 03/30

Tuesday 03/31

$115

Wednesday 04/01

$134

Thursday 04/02

$94

Friday 04/03

Saturday 04/04

$105

Sunday 04/05

$100

Monday 04/06

$110

Tuesday 04/07

$122

Wednesday 04/08

$113

Thursday 04/09

$116

Friday 04/10

$108

Saturday 04/11

$74

Sunday 04/12

$74

Monday 04/13

$73

Tuesday 04/14

$122

Wednesday 04/15

$112

Thursday 04/16

$106

Friday 04/17

$108

Saturday 04/18

How to save money travelling from Houston to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Houston to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Houston to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Houston to Greenville, SC are also emptier.

Beloved bus companies from Houston to Greenville, SC

These are the most booked bus companies between Houston to Greenville, SC from our users.

Tornado Bus Company from Houston to Greenville, SC

Here you will find the key facts about the Tornado Bus Company bus route Houston to Greenville, SC:

Cheapest Price	$211
Fastest Bus	23h 4m
Earliest Bus	1:30 PM
Last Bus	1:30 PM
Daily Connections	1 Ø
Found on	3/12/2026

All bus stations and stops in Houston and Greenville, SC

In the map below, you can see where to find all bus stations in Houston and Greenville, SC.

Downtown Houston

Gray St 605

Harrisburg Blvd Station

Harrisburg Blvd 7000

Main Street

Main St 2121

Chase Bank

Milam Street 212

Uptown/Upper Kirby

Southwest Fwy 2525

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Greyhound Bus Station

Hendrix Dr 9

N Church St

Guadalajara Supermarket

White Horse Rd 2803

Service and Comfort on the bus from Houston to Greenville, SC

Want to know which seat classes are available on the buses from Houston to Greenville, SC? Or which bus companies serve the route Houston to Greenville, SC? Below you will find answers to your questions.

FAQs about the Houston to Greenville, SC bus

How much does a Houston Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $73 and takes 37h 0m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Houston to Greenville, SC?

This route is offered by 4 companies with a range of ticket prices between $73 and $211. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Houston to Greenville, SC each day?

Every day, the Houston to Greenville, SC bus route is served by approximately 20 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Houston to Greenville, SC take?

The fastest bus from Houston to Greenville, SC is offered by Greyhound US and takes 21h 35m. Bus tickets for this connection cost $137. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Houston to Greenville, SC?

The earliest bus arriving in Greenville, SC from Houston starts at 5:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Houston to Greenville, SC?

The latest bus trip departing from Houston for Greenville, SC starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Houston Greenville, SC route?

When traveling by bus from Houston to Greenville, SC, passengers can travel with FlixBus, Greyhound US and Valley Transit. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Houston and Greenville, SC?

You can check all the direct connections between Houston and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Greyhound US and Valley Transit.

What can I take with me on the Houston to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Houston Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Houston Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Houston to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Houston to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 20 daily trips between Houston and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Houston to Greenville, SC?

Prices and availability for 20 trips between Houston and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Houston to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Houston and to Greenville, SC

Here’s an overview of the most popular bus routes to Houston and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!