Bus Jacksonville, FL to Greenville, SC: Compare prices and save money

Compare all timetables for the bus from Jacksonville, FL to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Jacksonville, FL to Greenville, SC from various bus operators like FlixBus or Greyhound US for the next days.

today

$76

tomorrow

$75

Wednesday

$72

Thursday

$65

Friday

Saturday

$75

Sunday

$72

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	9h 35m	9:25 PM	Jacksonville, FL	Amtrak Train Station	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$76	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 6/22/2026 9:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/23/2026 7:00:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 9h 35m
FlixBus	11h 10m	8:15 AM	Jacksonville, FL	Amtrak Train Station	7:25 PM	Greenville, SC	Woodruff Rd	Economy	$77	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 6/22/2026 8:15:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/22/2026 7:25:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 11h 10m
Greyhound US	12h 0m	9:30 AM	Jacksonville, FL	Amtrak Train Station	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$77	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 6/22/2026 9:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/22/2026 9:30:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 12h 0m
FlixBus	10h 45m	4:30 PM	Jacksonville, FL	Amtrak Train Station	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$78	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 6/22/2026 4:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/23/2026 3:15:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 10h 45m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	9h 35m	9:25 PM	Jacksonville, FL	Downtown Bus Stop	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$75	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 6/23/2026 9:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/24/2026 7:00:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 9h 35m
FlixBus	11h 10m	8:15 AM	Jacksonville, FL	Downtown Bus Stop	7:25 PM	Greenville, SC	Woodruff Rd	Economy	$76	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 6/23/2026 8:15:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/23/2026 7:25:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 11h 10m
Greyhound US	12h 0m	9:30 AM	Jacksonville, FL	Downtown Bus Stop	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$76	A Bus from Greyhound US goes from Downtown Bus Stop, Jacksonville, FL (USA) at 6/23/2026 9:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/23/2026 9:30:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 12h 0m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	10h 45m	4:30 PM	Jacksonville, FL	Amtrak Train Station	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$72	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 6/24/2026 4:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/25/2026 3:15:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 10h 45m
FlixBus	9h 35m	9:25 PM	Jacksonville, FL	Amtrak Train Station	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$72	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 6/24/2026 9:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/25/2026 7:00:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 9h 35m
FlixBus	11h 55m	8:15 AM	Jacksonville, FL	Amtrak Train Station	8:10 PM	Greenville, SC	Woodruff Rd	Economy	$73	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 6/24/2026 8:15:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/24/2026 8:10:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 11h 55m
Greyhound US	12h 0m	9:30 AM	Jacksonville, FL	Amtrak Train Station	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$74	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 6/24/2026 9:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/24/2026 9:30:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 12h 0m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	11h 55m	8:15 AM	Jacksonville, FL	Downtown Bus Stop	8:10 PM	Greenville, SC	Woodruff Rd	Economy	$65	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 6/25/2026 8:15:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/25/2026 8:10:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 11h 55m
FlixBus	10h 45m	4:30 PM	Jacksonville, FL	Downtown Bus Stop	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$65	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 6/25/2026 4:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/26/2026 3:15:00 AM. 50 Economy ticket for $65 per person are available. Travel duration is 10h 45m
FlixBus	9h 35m	9:25 PM	Jacksonville, FL	Downtown Bus Stop	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$65	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 6/25/2026 9:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/26/2026 7:00:00 AM. 50 Economy ticket for $65 per person are available. Travel duration is 9h 35m
Greyhound US	12h 0m	9:30 AM	Jacksonville, FL	Downtown Bus Stop	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$66	A Bus from Greyhound US goes from Downtown Bus Stop, Jacksonville, FL (USA) at 6/25/2026 9:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/25/2026 9:30:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 12h 0m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	11h 10m	8:15 AM	Jacksonville, FL	Amtrak Train Station	7:25 PM	Greenville, SC	Woodruff Rd	Economy	$75	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 6/27/2026 8:15:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/27/2026 7:25:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 11h 10m
FlixBus	10h 45m	4:30 PM	Jacksonville, FL	Amtrak Train Station	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$76	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 6/27/2026 4:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/28/2026 3:15:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 10h 45m
FlixBus	9h 35m	9:25 PM	Jacksonville, FL	Amtrak Train Station	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$76	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 6/27/2026 9:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/28/2026 7:00:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 9h 35m
Greyhound US	12h 0m	9:30 AM	Jacksonville, FL	Amtrak Train Station	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$76	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 6/27/2026 9:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/27/2026 9:30:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 12h 0m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	11h 10m	8:15 AM	Jacksonville, FL	Downtown Bus Stop	7:25 PM	Greenville, SC	Woodruff Rd	Economy	$72	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 6/28/2026 8:15:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/28/2026 7:25:00 PM. 50 Economy ticket for $72 per person are available. Travel duration is 11h 10m
FlixBus	9h 35m	9:25 PM	Jacksonville, FL	Downtown Bus Stop	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$72	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 6/28/2026 9:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/29/2026 7:00:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 9h 35m
Greyhound US	12h 0m	9:30 AM	Jacksonville, FL	Downtown Bus Stop	9:30 PM	Greenville, SC	Woodruff Rd	Economy	$73	A Bus from Greyhound US goes from Downtown Bus Stop, Jacksonville, FL (USA) at 6/28/2026 9:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 6/28/2026 9:30:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 12h 0m
FlixBus	10h 45m	4:30 PM	Jacksonville, FL	Downtown Bus Stop	3:15 AM	Greenville, SC	Woodruff Rd	Economy	$77	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 6/28/2026 4:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 6/29/2026 3:15:00 AM. 50 Economy ticket for $77 per person are available. Travel duration is 10h 45m

Best Price Offer: The price for the cheapest bus from Jacksonville, FL to Greenville, SC is $65 on 6/25/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Jacksonville, FL and Greenville, SC

See here how frequent the connections between Jacksonville, FL and Greenville, SC are, during different times and days of the week.

Tuesday is the busiest day, with more than 6 daily buses from Jacksonville, FL to Greenville, SC. Sunday has instead the fewest connections, with only 4 daily coaches between Jacksonville, FL and Greenville, SC.

The busiest time of the day is the Morning, with 14 buses from Jacksonville, FL to Greenville, SC, while Afternoon sees the fewest connections between Jacksonville, FL and Greenville, SC, with 5 offers.

Facts about the bus from Jacksonville, FL to Greenville, SC

Compare all providers like FlixBus and Greyhound US that travel 4 times every day by bus from Jacksonville, FL to Greenville, SC in one click! Book your bus ticket from Jacksonville, FL to Greenville, SC starting from $65!

Cheapest Bus	$65
Fastest Bus	9h 35m
Earliest Bus	8:15 AM
Latest Bus	9:25 PM
Daily Bus Routes	4 Ø
Distance	315.5 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Jacksonville, FL to Greenville, SC

Every day, 4 buses from 2 bus companies leave Jacksonville, FL for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/22/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 06/21

Monday 06/22

$76

Tuesday 06/23

$79

Wednesday 06/24

$72

Thursday 06/25

$65

Friday 06/26

Saturday 06/27

$118

Sunday 06/28

$72

Monday 06/29

Tuesday 06/30

Wednesday 07/01

Thursday 07/02

Friday 07/03

Saturday 07/04

Sunday 07/05

Monday 07/06

Tuesday 07/07

Wednesday 07/08

Thursday 07/09

Friday 07/10

$73

Saturday 07/11

$80

Sunday 07/12

$115

Monday 07/13

$118

Tuesday 07/14

$71

Wednesday 07/15

$118

Thursday 07/16

Friday 07/17

$118

Saturday 07/18

The cheapest time to travel from Jacksonville, FL to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Jacksonville, FL to Greenville, SC, for the next 30 days.

With a price starting from $65, Thursday is the cheapest day for a bus from Jacksonville, FL to Greenville, SC. Monday instead is the most expensive day with prices starting from $76.

Morning is the cheapest day time for bus tickets from Jacksonville, FL to Greenville, SC, with $65. Morning is the most expensive time of the day with prices starting from $65.

How to save money travelling from Jacksonville, FL to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Jacksonville, FL to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Jacksonville, FL to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Jacksonville, FL to Greenville, SC are also emptier.

Beloved bus companies from Jacksonville, FL to Greenville, SC

These are the most booked bus companies between Jacksonville, FL to Greenville, SC from our users.

Greyhound US from Jacksonville, FL to Greenville, SC

Here you will find the key facts about the Greyhound US bus route Jacksonville, FL to Greenville, SC:

Cheapest Price	$66
Fastest Bus	12h 0m
Earliest Bus	9:30 AM
Last Bus	9:30 AM
Daily Connections	1 Ø
Found on	5/29/2026

All bus stations and stops in Jacksonville, FL and Greenville, SC

In the map below, you can see where to find all bus stations in Jacksonville, FL and Greenville, SC.

Downtown Bus Stop

West Forsyth Street 1111

Beaver St. & Ocean St. Bus Stop

Central Bus Station

Old St. Augustine Rd

Old St. Augustine Rd 10584-13

Southpoint Bus Stop

Woodruff Rd

Woodruff Rd 1116

N Church St

Greyhound Bus Station

Hendrix Dr 9

Guadalajara Supermarket

White Horse Rd 2803

McDonald's

Woodruff Rd 1111

Service and Comfort on the bus from Jacksonville, FL to Greenville, SC

Want to know which seat classes are available on the buses from Jacksonville, FL to Greenville, SC? Or which bus companies serve the route Jacksonville, FL to Greenville, SC? Below you will find answers to your questions.

FAQs about the Jacksonville, FL to Greenville, SC bus

How much does a Jacksonville, FL Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $65 and takes 11h 55m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Jacksonville, FL to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $65 and $80. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Jacksonville, FL to Greenville, SC each day?

Every day, the Jacksonville, FL to Greenville, SC bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Jacksonville, FL to Greenville, SC take?

The fastest bus from Jacksonville, FL to Greenville, SC is offered by FlixBus and takes 9h 35m. Bus tickets for this connection cost $76. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Jacksonville, FL to Greenville, SC?

The earliest bus arriving in Greenville, SC from Jacksonville, FL starts at 8:15 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Jacksonville, FL to Greenville, SC?

The latest bus trip departing from Jacksonville, FL for Greenville, SC starts at 9:25 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Jacksonville, FL Greenville, SC route?

When traveling by bus from Jacksonville, FL to Greenville, SC, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Jacksonville, FL and Greenville, SC?

You can check all the direct connections between Jacksonville, FL and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Jacksonville, FL to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Jacksonville, FL Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Jacksonville, FL Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Jacksonville, FL to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Jacksonville, FL to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Jacksonville, FL and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Jacksonville, FL to Greenville, SC?

Prices and availability for 4 trips between Jacksonville, FL and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Jacksonville, FL to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Jacksonville, FL and to Greenville, SC

Here’s an overview of the most popular bus routes to Jacksonville, FL and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!