Bus Durham, NC to Greenville, SC - Compare all Companies

Compare all timetables for the bus from Durham, NC to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Durham, NC to Greenville, SC from various bus operators like Wanda Coach, FlixBus or Greyhound US for the next days.

today

tomorrow

$50

Saturday

$50

Sunday

$50

Monday

$50

Tuesday

$50

Wednesday

$53

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Wanda Coach	4h 40m	1:30 AM	Durham, NC	BP Hillandale Rd	6:10 AM	Greenville, SC	McDonald's		Economy	$50	A Bus from Wanda Coach goes from BP Hillandale Rd, Durham, NC (USA) at 12/19/2025 1:30:00 AM to McDonald's, Greenville, SC (USA) arriving at 12/19/2025 6:10:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 4h 40m
	Wanda Coach	4h 40m	4:20 AM	Durham, NC	BP Hillandale Rd	9:00 AM	Greenville, SC	McDonald's		Economy	$50	A Bus from Wanda Coach goes from BP Hillandale Rd, Durham, NC (USA) at 12/19/2025 4:20:00 AM to McDonald's, Greenville, SC (USA) arriving at 12/19/2025 9:00:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 4h 40m

Cheapest bus trips Saturday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Wanda Coach	4h 40m	1:30 AM	Durham, NC	BP Guess Road	6:10 AM	Greenville, SC	McDonald's		Economy	$50	A Bus from Wanda Coach goes from BP Guess Road, Durham, NC (USA) at 12/20/2025 1:30:00 AM to McDonald's, Greenville, SC (USA) arriving at 12/20/2025 6:10:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 4h 40m
	Wanda Coach	4h 40m	4:20 AM	Durham, NC	BP Guess Road	9:00 AM	Greenville, SC	McDonald's		Economy	$50	A Bus from Wanda Coach goes from BP Guess Road, Durham, NC (USA) at 12/20/2025 4:20:00 AM to McDonald's, Greenville, SC (USA) arriving at 12/20/2025 9:00:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 4h 40m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Wanda Coach	4h 40m	1:30 AM	Durham, NC	BP Hillandale Rd	6:10 AM	Greenville, SC	McDonald's	Economy	$50	A Bus from Wanda Coach goes from BP Hillandale Rd, Durham, NC (USA) at 12/21/2025 1:30:00 AM to McDonald's, Greenville, SC (USA) arriving at 12/21/2025 6:10:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 4h 40m
Wanda Coach	4h 40m	4:20 AM	Durham, NC	BP Hillandale Rd	9:00 AM	Greenville, SC	McDonald's	Economy	$50	A Bus from Wanda Coach goes from BP Hillandale Rd, Durham, NC (USA) at 12/21/2025 4:20:00 AM to McDonald's, Greenville, SC (USA) arriving at 12/21/2025 9:00:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 4h 40m
Greyhound US	5h 55m	4:55 AM	Durham, NC	Exxon	10:50 AM	Greenville, SC	Woodruff Rd	Economy	$55	A Bus from Greyhound US goes from Exxon, Durham, NC (USA) at 12/21/2025 4:55:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/21/2025 10:50:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 5h 55m
FlixBus	4h 50m	2:50 PM	Durham, NC	Exxon	7:40 PM	Greenville, SC	Woodruff Rd	Economy	$56	A Bus from FlixBus goes from Exxon, Durham, NC (USA) at 12/21/2025 2:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/21/2025 7:40:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 4h 50m
FlixBus	4h 40m	3:55 AM	Durham, NC	Exxon	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$58	A Bus from FlixBus goes from Exxon, Durham, NC (USA) at 12/21/2025 3:55:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/21/2025 8:35:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 4h 40m

Cheapest bus trips Monday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Wanda Coach	4h 40m	1:30 AM	Durham, NC	BP Guess Road	6:10 AM	Greenville, SC	McDonald's		Economy	$50	A Bus from Wanda Coach goes from BP Guess Road, Durham, NC (USA) at 12/22/2025 1:30:00 AM to McDonald's, Greenville, SC (USA) arriving at 12/22/2025 6:10:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 4h 40m
	Wanda Coach	4h 40m	4:20 AM	Durham, NC	BP Guess Road	9:00 AM	Greenville, SC	McDonald's		Economy	$50	A Bus from Wanda Coach goes from BP Guess Road, Durham, NC (USA) at 12/22/2025 4:20:00 AM to McDonald's, Greenville, SC (USA) arriving at 12/22/2025 9:00:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 4h 40m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Wanda Coach	4h 40m	1:30 AM	Durham, NC	BP Hillandale Rd	6:10 AM	Greenville, SC	McDonald's	Economy	$50	A Bus from Wanda Coach goes from BP Hillandale Rd, Durham, NC (USA) at 12/23/2025 1:30:00 AM to McDonald's, Greenville, SC (USA) arriving at 12/23/2025 6:10:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 4h 40m
Wanda Coach	4h 40m	4:20 AM	Durham, NC	BP Hillandale Rd	9:00 AM	Greenville, SC	McDonald's	Economy	$50	A Bus from Wanda Coach goes from BP Hillandale Rd, Durham, NC (USA) at 12/23/2025 4:20:00 AM to McDonald's, Greenville, SC (USA) arriving at 12/23/2025 9:00:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 4h 40m
FlixBus	4h 40m	3:55 AM	Durham, NC	Exxon	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$55	A Bus from FlixBus goes from Exxon, Durham, NC (USA) at 12/23/2025 3:55:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/23/2025 8:35:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 4h 40m
Greyhound US	5h 55m	4:55 AM	Durham, NC	Exxon	10:50 AM	Greenville, SC	Woodruff Rd	Economy	$61	A Bus from Greyhound US goes from Exxon, Durham, NC (USA) at 12/23/2025 4:55:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/23/2025 10:50:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 5h 55m
FlixBus	4h 45m	8:30 AM	Durham, NC	Exxon	1:15 PM	Greenville, SC	Woodruff Rd	Economy	$69	A Bus from FlixBus goes from Exxon, Durham, NC (USA) at 12/23/2025 8:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/23/2025 1:15:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 4h 45m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	4h 50m	2:50 PM	Durham, NC	Exxon	7:40 PM	Greenville, SC	Woodruff Rd	Economy	$53	A Bus from FlixBus goes from Exxon, Durham, NC (USA) at 12/24/2025 2:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 7:40:00 PM. 50 Economy ticket for $53 per person are available. Travel duration is 4h 50m
Greyhound US	5h 55m	4:55 AM	Durham, NC	Exxon	10:50 AM	Greenville, SC	Woodruff Rd	Economy	$56	A Bus from Greyhound US goes from Exxon, Durham, NC (USA) at 12/24/2025 4:55:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 10:50:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 5h 55m
FlixBus	4h 45m	8:30 AM	Durham, NC	Exxon	1:15 PM	Greenville, SC	Woodruff Rd	Economy	$63	A Bus from FlixBus goes from Exxon, Durham, NC (USA) at 12/24/2025 8:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 1:15:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 4h 45m
FlixBus	4h 40m	3:55 AM	Durham, NC	Exxon	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$120	A Bus from FlixBus goes from Exxon, Durham, NC (USA) at 12/24/2025 3:55:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 8:35:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 4h 40m

Best Price Offer: The price for the cheapest bus from Durham, NC to Greenville, SC is $50 on 12/19/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Durham, NC and Greenville, SC

See here how frequent the connections between Durham, NC and Greenville, SC are, during different times and days of the week.

Tuesday is the busiest day, with more than 8 daily buses from Durham, NC to Greenville, SC. Monday has instead the fewest connections, with only 2 daily coaches between Durham, NC and Greenville, SC.

The busiest time of the day is the Night, with 18 buses from Durham, NC to Greenville, SC, while Morning sees the fewest connections between Durham, NC and Greenville, SC, with 3 offers.

Facts about the bus from Durham, NC to Greenville, SC

Compare all providers like Wanda Coach, FlixBus and Greyhound US that travel 4 times every day by bus from Durham, NC to Greenville, SC in one click! Book your bus ticket from Durham, NC to Greenville, SC starting from $50!

Cheapest Bus	$50
Fastest Bus	4h 40m
Earliest Bus	1:30 AM
Latest Bus	2:50 PM
Daily Bus Routes	4 Ø
Distance	211.7 miles
Bus Companies	Wanda Coach, FlixBus and Greyhound US

Cheapest bus connections from Durham, NC to Greenville, SC

Every day, 4 buses from 3 bus companies leave Durham, NC for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/18/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

$50

Friday 12/19

$50

Saturday 12/20

$50

Sunday 12/21

$50

Monday 12/22

$50

Tuesday 12/23

$50

Wednesday 12/24

$53

Thursday 12/25

$50

Friday 12/26

$50

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

The cheapest time to travel from Durham, NC to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Durham, NC to Greenville, SC, for the next 30 days.

With a price starting from $49, Monday is the cheapest day for a bus from Durham, NC to Greenville, SC. Wednesday instead is the most expensive day with prices starting from $53.

Night is the cheapest day time for bus tickets from Durham, NC to Greenville, SC, with $50. Morning is the most expensive time of the day with prices starting from $63.

How to save money travelling from Durham, NC to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Durham, NC to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Durham, NC to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Durham, NC to Greenville, SC are also emptier.

All bus stations and stops in Durham, NC and Greenville, SC

In the map below, you can see where to find all bus stations in Durham, NC and Greenville, SC.

Transportation Center

W Pettigrew St 515

Exxon

Hillsborough Rd 3454

BP Guess Road

Guess Road 2918

BP Hillandale Rd

Hillandale Rd 1815

Chapel Hill and Willard St

W Chapel Hill

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

Service and Comfort on the bus from Durham, NC to Greenville, SC

Want to know which seat classes are available on the buses from Durham, NC to Greenville, SC? Or which bus companies serve the route Durham, NC to Greenville, SC? Below you will find answers to your questions.

FAQs about the Durham, NC to Greenville, SC bus

How much does a Durham, NC Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $50 and takes 4h 40m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Durham, NC to Greenville, SC?

This route is offered by 3 companies with a range of ticket prices between $50 and $120. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Durham, NC to Greenville, SC each day?

Every day, the Durham, NC to Greenville, SC bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Durham, NC to Greenville, SC take?

The fastest bus from Durham, NC to Greenville, SC is offered by Wanda Coach and takes 4h 40m. Bus tickets for this connection cost $50. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Durham, NC to Greenville, SC?

The earliest bus arriving in Greenville, SC from Durham, NC starts at 1:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Durham, NC to Greenville, SC?

The latest bus trip departing from Durham, NC for Greenville, SC starts at 2:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Durham, NC Greenville, SC route?

When traveling by bus from Durham, NC to Greenville, SC, passengers can travel with Wanda Coach, FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Durham, NC and Greenville, SC?

You can check all the direct connections between Durham, NC and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Wanda Coach, FlixBus and Greyhound US.

What can I take with me on the Durham, NC to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Durham, NC Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Durham, NC Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Durham, NC to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Durham, NC to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Durham, NC and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Durham, NC to Greenville, SC?

Prices and availability for 4 trips between Durham, NC and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Durham, NC to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Durham, NC and to Greenville, SC

Here’s an overview of the most popular bus routes to Durham, NC and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!