Bus from St. Louis, MO to Greenville, SC from $80

Compare all the bus companies and find the best price with CheckMyBus
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from St. Louis, MO to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from St. Louis, MO to Greenville, SC from various bus operators like Greyhound US or FlixBus for the next days.

today
tomorrow
$89
Tuesday
Wednesday
$80
Thursday
$93
Friday
$100
Saturday
$90

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 19h 30m 1:00 AM St. Louis, MO Gateway Station 9:30 PM Greenville, SC Woodruff Rd  Economy $89
Greyhound US 16h 15m 1:45 PM St. Louis, MO Gateway Station 7:00 AM Greenville, SC Woodruff Rd  Economy $90
FlixBus 17h 40m 4:00 PM St. Louis, MO Gateway Station 10:40 AM Greenville, SC Woodruff Rd  Economy $90
Greyhound US 17h 5m 9:00 AM St. Louis, MO Gateway Station 3:05 AM Greenville, SC Woodruff Rd  Economy $91
FlixBus 20h 45m 11:45 PM St. Louis, MO Gateway Station 9:30 PM Greenville, SC Woodruff Rd  Economy $91
  • Did you know that if you travel from St. Louis, MO to Greenville, SC via Atlanta, GA, you can save more than $14? You can find the corresponding connections below.
    • Greyhound US
      17h 5m
      0
      9:00 AM
      St. Louis, MO
      Gateway Station
      9:40 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $54
      • Waiting Time 2h 50m
    • Greyhound US
      2h 35m
      0
      12:30 AM
      Atlanta, GA
      Garnett Transit Station
      3:05 AM
      Greenville, SC
      Woodruff Rd
      0
      Greyhound US
      Economy
      $21
    Travel Time is 0h 10m shorter, and you will save $14

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 19h 30m 1:00 AM St. Louis, MO Gateway Station 9:30 PM Greenville, SC Woodruff Rd  Economy $80
Greyhound US 16h 15m 1:45 PM St. Louis, MO Gateway Station 7:00 AM Greenville, SC Woodruff Rd  Economy $81
Greyhound US 21h 30m 2:05 PM St. Louis, MO Gateway Station 12:35 PM Greenville, SC Woodruff Rd  Economy $81
Greyhound US 17h 5m 9:00 AM St. Louis, MO Gateway Station 3:05 AM Greenville, SC Woodruff Rd  Economy $83
  • Did you know that if you travel from St. Louis, MO to Greenville, SC via Atlanta, GA, you can save more than $11? You can find the corresponding connections below.
    • Greyhound US
      21h 0m
      0
      9:00 AM
      St. Louis, MO
      Gateway Station
      9:40 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $49
      • Waiting Time 7h 0m
    • Greyhound US
      2h 20m
      0
      4:40 AM
      Atlanta, GA
      Garnett Transit Station
      7:00 AM
      Greenville, SC
      Woodruff Rd
      0
      Greyhound US
      Economy
      $20
    Travel time is 3h 45m longer, but you will save $11

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 19h 30m 1:00 AM St. Louis, MO Gateway Station 9:30 PM Greenville, SC Woodruff Rd  Economy $93
Greyhound US 16h 15m 1:45 PM St. Louis, MO Gateway Station 7:00 AM Greenville, SC Woodruff Rd  Economy $93
FlixBus 17h 40m 4:00 PM St. Louis, MO Gateway Station 10:40 AM Greenville, SC Woodruff Rd  Economy $93
FlixBus 15h 25m 11:45 PM St. Louis, MO Gateway Station 4:10 PM Greenville, SC Woodruff Rd  Economy $93
Greyhound US 17h 5m 9:00 AM St. Louis, MO Gateway Station 3:05 AM Greenville, SC Woodruff Rd  Economy $97
  • Did you know that if you travel from St. Louis, MO to Greenville, SC via Atlanta, GA, you can save more than $24? You can find the corresponding connections below.
    • Greyhound US
      21h 0m
      0
      9:00 AM
      St. Louis, MO
      Gateway Station
      9:40 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $49
      • Waiting Time 7h 0m
    • Greyhound US
      2h 20m
      0
      4:40 AM
      Atlanta, GA
      Garnett Transit Station
      7:00 AM
      Greenville, SC
      Woodruff Rd
      0
      Greyhound US
      Economy
      $20
    Travel time is 4h 35m longer, but you will save $24

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 19h 30m 1:00 AM St. Louis, MO Gateway Station 9:30 PM Greenville, SC Woodruff Rd  Economy $100
Greyhound US 17h 5m 9:00 AM St. Louis, MO Gateway Station 3:05 AM Greenville, SC Woodruff Rd  Economy $100
Greyhound US 16h 15m 1:45 PM St. Louis, MO Gateway Station 7:00 AM Greenville, SC Woodruff Rd  Economy $100
FlixBus 15h 25m 11:45 PM St. Louis, MO Gateway Station 4:10 PM Greenville, SC Woodruff Rd  Economy $100
FlixBus 17h 40m 4:00 PM St. Louis, MO Gateway Station 10:40 AM Greenville, SC Woodruff Rd  Economy $101
  • Did you know that if you travel from St. Louis, MO to Greenville, SC via Atlanta, GA, you can save more than $31? You can find the corresponding connections below.
    • Greyhound US
      21h 0m
      0
      9:00 AM
      St. Louis, MO
      Gateway Station
      9:40 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $49
      • Waiting Time 7h 0m
    • Greyhound US
      2h 20m
      0
      4:40 AM
      Atlanta, GA
      Garnett Transit Station
      7:00 AM
      Greenville, SC
      Woodruff Rd
      0
      Greyhound US
      Economy
      $20
    Travel time is 4h 35m longer, but you will save $31

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 17h 40m 4:00 PM St. Louis, MO Gateway Station 10:40 AM Greenville, SC Woodruff Rd  Economy $90
Greyhound US 19h 30m 1:00 AM St. Louis, MO Gateway Station 9:30 PM Greenville, SC Woodruff Rd  Economy $91
Greyhound US 17h 15m 9:00 AM St. Louis, MO Gateway Station 3:15 AM Greenville, SC Woodruff Rd  Economy $91
Greyhound US 16h 15m 1:45 PM St. Louis, MO Gateway Station 7:00 AM Greenville, SC Woodruff Rd  Economy $91
FlixBus 15h 25m 11:45 PM St. Louis, MO Gateway Station 4:10 PM Greenville, SC Woodruff Rd  Economy $91
  • Did you know that if you travel from St. Louis, MO to Greenville, SC via Atlanta, GA, you can save more than $21? You can find the corresponding connections below.
    • Greyhound US
      21h 0m
      0
      9:00 AM
      St. Louis, MO
      Gateway Station
      9:40 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $49
      • Waiting Time 7h 0m
    • Greyhound US
      2h 20m
      0
      4:40 AM
      Atlanta, GA
      Garnett Transit Station
      7:00 AM
      Greenville, SC
      Woodruff Rd
      0
      Greyhound US
      Economy
      $20
    Travel time is 4h 35m longer, but you will save $21

Best Price Offer: The price for the cheapest bus from St. Louis, MO to Greenville, SC is $80 on 10/21/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between St. Louis, MO and Greenville, SC

See here how frequent the connections between St. Louis, MO and Greenville, SC are, during different times and days of the week.
Friday is the busiest day, with more than 10 daily buses from St. Louis, MO to Greenville, SC. Monday has instead the fewest connections, with only 5 daily coaches between St. Louis, MO and Greenville, SC.
The busiest time of the day is the Afternoon, with 16 buses from St. Louis, MO to Greenville, SC, while Evening sees the fewest connections between St. Louis, MO and Greenville, SC, with 6 offers.

Facts about the bus from St. Louis, MO to Greenville, SC

Compare all providers like Greyhound US and FlixBus that travel 7 times every day by bus from St. Louis, MO to Greenville, SC in one click! Book your bus ticket from St. Louis, MO to Greenville, SC starting from $80!

Cheapest Bus $80
Fastest Bus 16h 25m
Earliest Bus 1:00 AM
Latest Bus 11:45 PM
Daily Bus Routes 7 Ø
Distance 504.7 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from St. Louis, MO to Greenville, SC

Every day, 7 buses from 2 bus companies leave St. Louis, MO for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/18/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 10/18
Monday 10/19
$89
Tuesday 10/20
Wednesday 10/21
$80
Thursday 10/22
$93
Friday 10/23
$104
Saturday 10/24
$90
Sunday 10/25
Monday 10/26
$99
Tuesday 10/27
$104
Wednesday 10/28
$100
Thursday 10/29
Friday 10/30
$108
Saturday 10/31
$102
Sunday 11/01
Monday 11/02
$93
Tuesday 11/03
Wednesday 11/04
Thursday 11/05
Friday 11/06
Saturday 11/07
Sunday 11/08
Monday 11/09
Tuesday 11/10
Wednesday 11/11
Thursday 11/12
Friday 11/13
Saturday 11/14

The cheapest time to travel from St. Louis, MO to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from St. Louis, MO to Greenville, SC, for the next 30 days.
With a price starting from $80, Wednesday is the cheapest day for a bus from St. Louis, MO to Greenville, SC. Friday instead is the most expensive day with prices starting from $100.
Night is the cheapest day time for bus tickets from St. Louis, MO to Greenville, SC, with $80. Evening is the most expensive time of the day with prices starting from $91.

How to save money travelling from St. Louis, MO to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from St. Louis, MO to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from St. Louis, MO to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from St. Louis, MO to Greenville, SC are also emptier.

Beloved bus companies from St. Louis, MO to Greenville, SC

These are the most booked bus companies between St. Louis, MO to Greenville, SC from our users.

Greyhound US from St. Louis, MO to Greenville, SC

Greyhound US

Here you will find the key facts about the Greyhound US bus route St. Louis, MO to Greenville, SC:

Cheapest Price $80
Fastest Bus 17h 15m
Earliest Bus 1:00 AM
Last Bus 1:45 PM
Daily Connections 5 Ø
Found on 9/23/2026

All bus stations and stops in St. Louis, MO and Greenville, SC

In the map below, you can see where to find all bus stations in St. Louis, MO and Greenville, SC.

Service and Comfort on the bus from St. Louis, MO to Greenville, SC

Want to know which seat classes are available on the buses from St. Louis, MO to Greenville, SC? Or which bus companies serve the route St. Louis, MO to Greenville, SC? Below you will find answers to your questions.

FAQs about the St. Louis, MO to Greenville, SC bus

How much does a St. Louis, MO Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $80 and takes 20h 30m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from St. Louis, MO to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $80 and $107. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from St. Louis, MO to Greenville, SC each day?

Every day, the St. Louis, MO to Greenville, SC bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from St. Louis, MO to Greenville, SC take?

The fastest bus from St. Louis, MO to Greenville, SC is offered by FlixBus and takes 16h 25m. Bus tickets for this connection cost $93. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from St. Louis, MO to Greenville, SC?

The earliest bus arriving in Greenville, SC from St. Louis, MO starts at 1:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from St. Louis, MO to Greenville, SC?

The latest bus trip departing from St. Louis, MO for Greenville, SC starts at 11:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the St. Louis, MO Greenville, SC route?

When traveling by bus from St. Louis, MO to Greenville, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between St. Louis, MO and Greenville, SC?

You can check all the direct connections between St. Louis, MO and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the St. Louis, MO to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the St. Louis, MO Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the St. Louis, MO Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from St. Louis, MO to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from St. Louis, MO to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between St. Louis, MO and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from St. Louis, MO to Greenville, SC?

Prices and availability for 7 trips between St. Louis, MO and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route St. Louis, MO to Greenville, SC

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to St. Louis, MO and to Greenville, SC

Here’s an overview of the most popular bus routes to St. Louis, MO and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
From Jefferson City, MO to St. Louis, MO bus From Jefferson City, MO to St. Louis, MO bus
Buses Battle Creek, MI - St. Louis, MO Buses Battle Creek, MI - St. Louis, MO
Buses from Cheyenne, WY to St. Louis, MO Buses from Cheyenne, WY to St. Louis, MO
Bus to St. Louis, MO from Lubbock, TX Bus to St. Louis, MO from Lubbock, TX
Bus Veracruz - Greenville, SC Bus Veracruz - Greenville, SC
Bus from Milwaukee to Greenville, SC Bus from Milwaukee to Greenville, SC
Bus Las Vegas - Greenville, SC Bus Las Vegas - Greenville, SC
Bus to Greenville, SC from Phoenix, AZ Bus to Greenville, SC from Phoenix, AZ
Popular Airport Shuttles to St. Louis, MO and to Greenville, SC
CheckMyBus › Buses in USA › Bus to St. Louis, MO › Bus to Greenville, SC

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.