Bus Louisville, KY to St. Louis, MO - Compare all Companies

Compare all timetables for the bus from Louisville, KY to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Louisville, KY to St. Louis, MO from various bus operators like Greyhound US for the next days.

today

tomorrow

Thursday

Friday

Saturday

Sunday

$65

Monday

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	8h 10m	8:00 AM	Louisville, KY	Greyhound Bus Station	3:10 PM	St. Louis, MO	Gateway Station	Economy	$65	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/29/2026 8:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/29/2026 3:10:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 8h 10m
Greyhound US	14h 0m	10:10 AM	Louisville, KY	Greyhound Bus Station	11:10 PM	St. Louis, MO	Gateway Station	Economy	$65	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/29/2026 10:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/29/2026 11:10:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 14h 0m
Greyhound US	9h 50m	2:35 PM	Louisville, KY	Greyhound Bus Station	11:25 PM	St. Louis, MO	Gateway Station	Economy	$65	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/29/2026 2:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 3/29/2026 11:25:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 9h 50m
Greyhound US	11h 15m	10:55 PM	Louisville, KY	Greyhound Bus Station	9:10 AM	St. Louis, MO	Gateway Station	Economy	$65	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/29/2026 10:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 3/30/2026 9:10:00 AM. 50 Economy ticket for $65 per person are available. Travel duration is 11h 15m

Best Price Offer: The price for the cheapest bus from Louisville, KY to St. Louis, MO is $43 on 4/7/2026. Flexible travelers save on ticket prices.

Facts about the bus from Louisville, KY to St. Louis, MO

Compare all providers like Greyhound US that travel 4 times every day by bus from Louisville, KY to St. Louis, MO in one click! Book your bus ticket from Louisville, KY to St. Louis, MO starting from $43!

Cheapest Bus	$43
Fastest Bus	7h 10m
Earliest Bus	8:00 AM
Latest Bus	10:55 PM
Daily Bus Routes	4 Ø
Distance	241.6 miles
Bus Companies	Greyhound US

Cheapest bus connections from Louisville, KY to St. Louis, MO

Every day, 4 buses from 1 bus companies leave Louisville, KY for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/24/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 03/22

Monday 03/23

Tuesday 03/24

Wednesday 03/25

Thursday 03/26

Friday 03/27

Saturday 03/28

Sunday 03/29

$65

Monday 03/30

Tuesday 03/31

Wednesday 04/01

$54

Thursday 04/02

$46

Friday 04/03

Saturday 04/04

$53

Sunday 04/05

Monday 04/06

$52

Tuesday 04/07

$43

Wednesday 04/08

$47

Thursday 04/09

Friday 04/10

Saturday 04/11

$50

Sunday 04/12

$58

Monday 04/13

Tuesday 04/14

$48

Wednesday 04/15

$52

Thursday 04/16

$49

Friday 04/17

$55

Saturday 04/18

How to save money travelling from Louisville, KY to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Louisville, KY to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Louisville, KY to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Louisville, KY to St. Louis, MO are also emptier.

Beloved bus companies from Louisville, KY to St. Louis, MO

These are the most booked bus companies between Louisville, KY to St. Louis, MO from our users.

Greyhound US from Louisville, KY to St. Louis, MO

Here you will find the key facts about the Greyhound US bus route Louisville, KY to St. Louis, MO:

Cheapest Price	$65
Fastest Bus	7h 10m
Earliest Bus	8:00 AM
Last Bus	10:55 PM
Daily Connections	4 Ø
Found on	2/26/2026

All bus stations and stops in Louisville, KY and St. Louis, MO

In the map below, you can see where to find all bus stations in Louisville, KY and St. Louis, MO.

Greyhound Bus Station

W Muhammad Ali Blvd 720

Convention Center

S 3rd St 300

BP Gas Station

Newburg Rd 3301

W Muhammad Ali Blvd

East Broadway, under the I-65 overpass between S 1st Street and S Brook Street

International Airport

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from Louisville, KY to St. Louis, MO

Want to know which seat classes are available on the buses from Louisville, KY to St. Louis, MO? Or which bus companies serve the route Louisville, KY to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Louisville, KY to St. Louis, MO bus

How much does a Louisville, KY St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $43 and takes 13h 0m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Louisville, KY to St. Louis, MO?

This route is offered by 1 companies with a range of ticket prices between $43 and $65. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Louisville, KY to St. Louis, MO each day?

Every day, the Louisville, KY to St. Louis, MO bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Louisville, KY to St. Louis, MO take?

The fastest bus from Louisville, KY to St. Louis, MO is offered by Greyhound US and takes 7h 10m. Bus tickets for this connection cost $65. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Louisville, KY to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Louisville, KY starts at 8:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Louisville, KY to St. Louis, MO?

The latest bus trip departing from Louisville, KY for St. Louis, MO starts at 10:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Louisville, KY St. Louis, MO route?

When traveling by bus from Louisville, KY to St. Louis, MO, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Louisville, KY and St. Louis, MO?

You can check all the direct connections between Louisville, KY and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Louisville, KY to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Louisville, KY St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Louisville, KY St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Louisville, KY to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Louisville, KY to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Louisville, KY and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Louisville, KY to St. Louis, MO?

Prices and availability for 4 trips between Louisville, KY and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Louisville, KY to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Louisville, KY and to St. Louis, MO

Here’s an overview of the most popular bus routes to Louisville, KY and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!