Bus Chicago to St. Louis, MO - Compare all Companies

Compare all timetables for the bus from Chicago to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Chicago to St. Louis, MO from various bus operators like FlixBus or Greyhound US for the next days.

today

$37

tomorrow

$43

Saturday

$36

Sunday

$44

Monday

$37

Tuesday

$40

Wednesday

$51

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	6h 40m	4:30 PM	Chicago	Downtown Bus Station	11:10 PM	St. Louis, MO	Gateway Station	Economy	$37	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/4/2025 4:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/4/2025 11:10:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 6h 40m
FlixBus	6h 10m	12:15 AM	Chicago	Downtown Bus Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$38	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/4/2025 12:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/4/2025 6:25:00 AM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 10m
FlixBus	6h 0m	9:45 AM	Chicago	Downtown Bus Station	3:45 PM	St. Louis, MO	Gateway Station	Economy	$38	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/4/2025 9:45:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/4/2025 3:45:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 0m
Greyhound US	7h 55m	10:30 PM	Chicago	95th Red Line Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$40	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/4/2025 10:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/5/2025 6:25:00 AM. 50 Economy ticket for $40 per person are available. Travel duration is 7h 55m
Greyhound US	9h 10m	6:10 AM	Chicago	Downtown Bus Station	3:20 PM	St. Louis, MO	Gateway Station	Economy	$46	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/4/2025 6:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/4/2025 3:20:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 9h 10m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	6h 10m	12:15 AM	Chicago	Downtown Bus Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$43	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/5/2025 12:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/5/2025 6:25:00 AM. 50 Economy ticket for $43 per person are available. Travel duration is 6h 10m
FlixBus	6h 40m	4:30 PM	Chicago	Downtown Bus Station	11:10 PM	St. Louis, MO	Gateway Station	Economy	$43	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/5/2025 4:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/5/2025 11:10:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 6h 40m
FlixBus	6h 0m	9:45 AM	Chicago	Downtown Bus Station	3:45 PM	St. Louis, MO	Gateway Station	Economy	$45	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/5/2025 9:45:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/5/2025 3:45:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 6h 0m
Greyhound US	9h 10m	6:10 AM	Chicago	Downtown Bus Station	3:20 PM	St. Louis, MO	Gateway Station	Economy	$50	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/5/2025 6:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/5/2025 3:20:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 9h 10m
Greyhound US	8h 45m	9:40 PM	Chicago	Downtown Bus Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$58	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/5/2025 9:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/6/2025 6:25:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 8h 45m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	6h 40m	4:30 PM	Chicago	Downtown Bus Station	11:10 PM	St. Louis, MO	Gateway Station	Economy	$36	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/6/2025 4:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/6/2025 11:10:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 6h 40m
FlixBus	5h 35m	10:10 AM	Chicago	95th Red Line Station	3:45 PM	St. Louis, MO	Gateway Station	Economy	$36	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/6/2025 10:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/6/2025 3:45:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 5h 35m
FlixBus	5h 45m	12:40 AM	Chicago	95th Red Line Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$37	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/6/2025 12:40:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/6/2025 6:25:00 AM. 50 Economy ticket for $37 per person are available. Travel duration is 5h 45m
Greyhound US	7h 55m	10:30 PM	Chicago	95th Red Line Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$47	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/6/2025 10:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/7/2025 6:25:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 7h 55m
Greyhound US	9h 10m	6:10 AM	Chicago	Downtown Bus Station	3:20 PM	St. Louis, MO	Gateway Station	Economy	$48	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/6/2025 6:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/6/2025 3:20:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 9h 10m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 45m	12:40 AM	Chicago	95th Red Line Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$44	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/7/2025 12:40:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/7/2025 6:25:00 AM. 50 Economy ticket for $44 per person are available. Travel duration is 5h 45m
FlixBus	6h 10m	12:15 AM	Chicago	Downtown Bus Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$45	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/7/2025 12:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/7/2025 6:25:00 AM. 50 Economy ticket for $45 per person are available. Travel duration is 6h 10m
FlixBus	6h 0m	9:45 AM	Chicago	Downtown Bus Station	3:45 PM	St. Louis, MO	Gateway Station	Economy	$45	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/7/2025 9:45:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/7/2025 3:45:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 6h 0m
Greyhound US	7h 55m	10:30 PM	Chicago	95th Red Line Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$56	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/7/2025 10:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/8/2025 6:25:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 7h 55m
Greyhound US	9h 10m	6:10 AM	Chicago	Downtown Bus Station	3:20 PM	St. Louis, MO	Gateway Station	Economy	$63	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/7/2025 6:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/7/2025 3:20:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 9h 10m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	6h 40m	4:30 PM	Chicago	Downtown Bus Station	11:10 PM	St. Louis, MO	Gateway Station	Economy	$37	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/8/2025 4:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/8/2025 11:10:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 6h 40m
FlixBus	6h 10m	12:15 AM	Chicago	Downtown Bus Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$39	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/8/2025 12:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/8/2025 6:25:00 AM. 50 Economy ticket for $39 per person are available. Travel duration is 6h 10m
FlixBus	5h 45m	12:40 AM	Chicago	95th Red Line Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$40	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/8/2025 12:40:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/8/2025 6:25:00 AM. 50 Economy ticket for $40 per person are available. Travel duration is 5h 45m
Greyhound US	7h 55m	10:30 PM	Chicago	95th Red Line Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$43	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/8/2025 10:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/9/2025 6:25:00 AM. 50 Economy ticket for $43 per person are available. Travel duration is 7h 55m
Greyhound US	9h 10m	6:10 AM	Chicago	Downtown Bus Station	3:20 PM	St. Louis, MO	Gateway Station	Economy	$50	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/8/2025 6:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/8/2025 3:20:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 9h 10m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	9h 15m	2:10 PM	Chicago	95th Red Line Station	11:25 PM	St. Louis, MO	Gateway Station	Economy	$40	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/9/2025 2:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/9/2025 11:25:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 9h 15m
Greyhound US	7h 55m	10:30 PM	Chicago	95th Red Line Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$40	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/9/2025 10:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/10/2025 6:25:00 AM. 50 Economy ticket for $40 per person are available. Travel duration is 7h 55m
FlixBus	9h 55m	5:25 AM	Chicago	95th Red Line Station	3:20 PM	St. Louis, MO	Gateway Station	Economy	$42	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/9/2025 5:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/9/2025 3:20:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 9h 55m
Greyhound US	9h 10m	6:10 AM	Chicago	Downtown Bus Station	3:20 PM	St. Louis, MO	Gateway Station	Economy	$44	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/9/2025 6:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/9/2025 3:20:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 9h 10m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	9h 10m	6:10 AM	Chicago	Downtown Bus Station	3:20 PM	St. Louis, MO	Gateway Station	Economy	$51	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/10/2025 6:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/10/2025 3:20:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 9h 10m
Greyhound US	8h 40m	2:45 PM	Chicago	Downtown Bus Station	11:25 PM	St. Louis, MO	Gateway Station	Economy	$51	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/10/2025 2:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/10/2025 11:25:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 8h 40m
Greyhound US	8h 45m	9:40 PM	Chicago	Downtown Bus Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$51	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/10/2025 9:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/11/2025 6:25:00 AM. 50 Economy ticket for $51 per person are available. Travel duration is 8h 45m
Greyhound US	13h 25m	10:00 AM	Chicago	Union Station	11:25 PM	St. Louis, MO	Gateway Station	Economy	$51	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/10/2025 10:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/10/2025 11:25:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 13h 25m
Greyhound US	8h 25m	10:00 PM	Chicago	Union Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$51	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/10/2025 10:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/11/2025 6:25:00 AM. 50 Economy ticket for $51 per person are available. Travel duration is 8h 25m

Best Price Offer: The price for the cheapest bus from Chicago to St. Louis, MO is $36 on 12/11/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Chicago and St. Louis, MO

See here how frequent the connections between Chicago and St. Louis, MO are, during different times and days of the week.

Sunday is the busiest day, with more than 22 daily buses from Chicago to St. Louis, MO. Wednesday has instead the fewest connections, with only 5 daily coaches between Chicago and St. Louis, MO.

The busiest time of the day is the Evening, with 34 buses from Chicago to St. Louis, MO, while Afternoon sees the fewest connections between Chicago and St. Louis, MO, with 22 offers.

Facts about the bus from Chicago to St. Louis, MO

Compare all providers like FlixBus and Greyhound US that travel 16 times every day by bus from Chicago to St. Louis, MO in one click! Book your bus ticket from Chicago to St. Louis, MO starting from $36!

Cheapest Bus	$36
Fastest Bus	5h 35m
Earliest Bus	12:15 AM
Latest Bus	10:00 PM
Daily Bus Routes	16 Ø
Distance	262.3 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Chicago to St. Louis, MO

Every day, 16 buses from 2 bus companies leave Chicago for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/04/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

$37

Friday 12/05

$43

Saturday 12/06

$43

Sunday 12/07

$44

Monday 12/08

$37

Tuesday 12/09

$40

Wednesday 12/10

$51

Thursday 12/11

$36

Friday 12/12

Saturday 12/13

Sunday 12/14

Monday 12/15

$38

Tuesday 12/16

$39

Wednesday 12/17

$40

Thursday 12/18

Friday 12/19

$45

Saturday 12/20

$42

Sunday 12/21

$45

Monday 12/22

Tuesday 12/23

$52

Wednesday 12/24

Thursday 12/25

$47

Friday 12/26

Saturday 12/27

The cheapest time to travel from Chicago to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to St. Louis, MO, for the next 30 days.

With a price starting from $36, Saturday is the cheapest day for a bus from Chicago to St. Louis, MO. Sunday instead is the most expensive day with prices starting from $44.

Morning is the cheapest day time for bus tickets from Chicago to St. Louis, MO, with $36. Evening is the most expensive time of the day with prices starting from $40.

How to save money travelling from Chicago to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to St. Louis, MO are also emptier.

Beloved bus companies from Chicago to St. Louis, MO

These are the most booked bus companies between Chicago to St. Louis, MO from our users.

FlixBus from Chicago to St. Louis, MO

Here you will find the key facts about the FlixBus bus route Chicago to St. Louis, MO:

Cheapest Price	$36
Fastest Bus	5h 35m
Earliest Bus	12:15 AM
Last Bus	5:25 AM
Daily Connections	9 Ø
Found on	12/2/2025

All bus stations and stops in Chicago and St. Louis, MO

In the map below, you can see where to find all bus stations in Chicago and St. Louis, MO.

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

California & Cermak Bus Stop

S California Ave 2139

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from Chicago to St. Louis, MO

Want to know which seat classes are available on the buses from Chicago to St. Louis, MO? Or which bus companies serve the route Chicago to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Chicago to St. Louis, MO bus

How much does a Chicago St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $36 and takes 6h 40m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Chicago to St. Louis, MO?

This route is offered by 2 companies with a range of ticket prices between $36 and $66. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Chicago to St. Louis, MO each day?

Every day, the Chicago to St. Louis, MO bus route is served by approximately 16 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to St. Louis, MO take?

The fastest bus from Chicago to St. Louis, MO is offered by FlixBus and takes 5h 35m. Bus tickets for this connection cost $39. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Chicago starts at 12:15 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to St. Louis, MO?

The latest bus trip departing from Chicago for St. Louis, MO starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago St. Louis, MO route?

When traveling by bus from Chicago to St. Louis, MO, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and St. Louis, MO?

You can check all the direct connections between Chicago and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Chicago to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to St. Louis, MO on your planned travel date.

Available seat classes which are offered on the bus route Chicago to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to St. Louis, MO

Here’s an overview of the most popular bus routes to Chicago and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!