Bus Cleveland to St. Louis, MO - Compare all Companies

Compare all timetables for the bus from Cleveland to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Cleveland to St. Louis, MO from various bus operators like Greyhound US or FlixBus for the next days.

today

$113

tomorrow

$80

Sunday

$104

Monday

Tuesday

$118

Wednesday

$119

Thursday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	19h 10m	12:15 PM	Cleveland	Greyhound Bus Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$113	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/19/2025 12:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/20/2025 6:25:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 19h 10m
Greyhound US	16h 15m	4:40 PM	Cleveland	Greyhound Bus Station	7:55 AM	St. Louis, MO	Gateway Station	Economy	$114	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/19/2025 4:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/20/2025 7:55:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 16h 15m
Greyhound US	23h 30m	4:50 PM	Cleveland	Greyhound Bus Station	3:20 PM	St. Louis, MO	Gateway Station	Economy	$118	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/19/2025 4:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/20/2025 3:20:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 23h 30m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	19h 10m	12:15 PM	Cleveland	Greyhound Bus Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$80	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/20/2025 12:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/21/2025 6:25:00 AM. 50 Economy ticket for $80 per person are available. Travel duration is 19h 10m
FlixBus	16h 10m	8:00 AM	Cleveland	Greyhound Bus Station	11:10 PM	St. Louis, MO	Gateway Station	Economy	$80	A Bus from FlixBus goes from Greyhound Bus Station, Cleveland (USA) at 12/20/2025 8:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/20/2025 11:10:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 16h 10m
Greyhound US	19h 30m	4:55 AM	Cleveland	Greyhound Bus Station	11:25 PM	St. Louis, MO	Gateway Station	Economy	$123	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/20/2025 4:55:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/20/2025 11:25:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 19h 30m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	19h 10m	12:15 PM	Cleveland	Greyhound Bus Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$104	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/21/2025 12:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/22/2025 6:25:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 19h 10m
Greyhound US	16h 15m	4:40 PM	Cleveland	Greyhound Bus Station	7:55 AM	St. Louis, MO	Gateway Station	Economy	$104	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/21/2025 4:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/22/2025 7:55:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 16h 15m
Greyhound US	23h 30m	4:50 PM	Cleveland	Greyhound Bus Station	3:20 PM	St. Louis, MO	Gateway Station	Economy	$108	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/21/2025 4:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/22/2025 3:20:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 23h 30m
Greyhound US	21h 50m	2:35 AM	Cleveland	Greyhound Bus Station	11:25 PM	St. Louis, MO	Gateway Station	Economy	$174	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/21/2025 2:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/21/2025 11:25:00 PM. 50 Economy ticket for $174 per person are available. Travel duration is 21h 50m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	19h 10m	12:15 PM	Cleveland	Greyhound Bus Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$118	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/23/2025 12:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/24/2025 6:25:00 AM. 50 Economy ticket for $118 per person are available. Travel duration is 19h 10m
Greyhound US	23h 30m	4:50 PM	Cleveland	Greyhound Bus Station	3:20 PM	St. Louis, MO	Gateway Station	Economy	$118	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/23/2025 4:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/24/2025 3:20:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 23h 30m
Greyhound US	21h 50m	2:35 AM	Cleveland	Greyhound Bus Station	11:25 PM	St. Louis, MO	Gateway Station	Economy	$133	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/23/2025 2:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/23/2025 11:25:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 21h 50m
Greyhound US	16h 15m	4:40 PM	Cleveland	Greyhound Bus Station	7:55 AM	St. Louis, MO	Gateway Station	Economy	$140	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/23/2025 4:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/24/2025 7:55:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 16h 15m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 30m	4:50 PM	Cleveland	Greyhound Bus Station	3:20 PM	St. Louis, MO	Gateway Station	Economy	$119	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/24/2025 4:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/25/2025 3:20:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 23h 30m
Greyhound US	19h 10m	12:15 PM	Cleveland	Greyhound Bus Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$120	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/24/2025 12:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/25/2025 6:25:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 19h 10m
Greyhound US	16h 15m	4:40 PM	Cleveland	Greyhound Bus Station	7:55 AM	St. Louis, MO	Gateway Station	Economy	$120	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/24/2025 4:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/25/2025 7:55:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 16h 15m
Greyhound US	21h 50m	2:35 AM	Cleveland	Greyhound Bus Station	11:25 PM	St. Louis, MO	Gateway Station	Economy	$139	A Bus from Greyhound US goes from Greyhound Bus Station, Cleveland (USA) at 12/24/2025 2:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/24/2025 11:25:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 21h 50m

Did you know that if you travel from Cleveland to St. Louis, MO via Columbus, OH, you can save more than $12? You can find the corresponding connections below.
- FlixBus
  
  21h 50m
  
  0
  
  2:35 AM
  
  Cleveland
  Greyhound Bus Station
  
  5:25 AM
  
  Columbus, OH
  E Main St & S Lazelle St
  
  0
  
  Economy
  
  $31
  
  A Bus from FlixBus goes from Greyhound Bus Station, Cleveland (USA) at 12/21/2025 2:35:00 AM to E Main St & S Lazelle St, Columbus, OH (USA) arriving at 12/21/2025 5:25:00 AM. 50 Economy ticket for $31 per person are available. Travel duration is 2h 50m
- FlixBus
  
  9h 55m
  
  0
  
  2:30 PM
  
  Columbus, OH
  E Main St & S Lazelle St
  
  11:25 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $76
  
  A Bus from FlixBus goes from E Main St & S Lazelle St, Columbus, OH (USA) at 12/21/2025 2:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/21/2025 11:25:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 9h 55m
Travel time is 6h 35m longer, but you will save $12

Best Price Offer: The price for the cheapest bus from Cleveland to St. Louis, MO is $76 on 1/8/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Cleveland and St. Louis, MO

See here how frequent the connections between Cleveland and St. Louis, MO are, during different times and days of the week.

Tuesday is the busiest day, with more than 8 daily buses from Cleveland to St. Louis, MO. Friday has instead the fewest connections, with only 3 daily coaches between Cleveland and St. Louis, MO.

The busiest time of the day is the Afternoon, with 17 buses from Cleveland to St. Louis, MO, while Morning sees the fewest connections between Cleveland and St. Louis, MO, with 1 offers.

Facts about the bus from Cleveland to St. Louis, MO

Compare all providers like Greyhound US and FlixBus that travel 4 times every day by bus from Cleveland to St. Louis, MO in one click! Book your bus ticket from Cleveland to St. Louis, MO starting from $76!

Cheapest Bus	$76
Fastest Bus	15h 10m
Earliest Bus	12:15 PM
Latest Bus	4:50 PM
Daily Bus Routes	4 Ø
Distance	492.7 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Cleveland to St. Louis, MO

Every day, 4 buses from 2 bus companies leave Cleveland for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/19/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

$113

Saturday 12/20

$80

Sunday 12/21

$104

Monday 12/22

Tuesday 12/23

$118

Wednesday 12/24

$119

Thursday 12/25

Friday 12/26

$105

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

$103

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

$76

Friday 01/09

Saturday 01/10

The cheapest time to travel from Cleveland to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Cleveland to St. Louis, MO, for the next 30 days.

With a price starting from $80, Saturday is the cheapest day for a bus from Cleveland to St. Louis, MO. Wednesday instead is the most expensive day with prices starting from $119.

Night is the cheapest day time for bus tickets from Cleveland to St. Louis, MO, with $69. Afternoon is the most expensive time of the day with prices starting from $80.

How to save money travelling from Cleveland to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Cleveland to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Cleveland to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Cleveland to St. Louis, MO are also emptier.

Beloved bus companies from Cleveland to St. Louis, MO

These are the most booked bus companies between Cleveland to St. Louis, MO from our users.

FlixBus from Cleveland to St. Louis, MO

Here you will find the key facts about the FlixBus bus route Cleveland to St. Louis, MO:

Cheapest Price	$80
Fastest Bus	15h 10m
Earliest Bus	8:00 AM
Last Bus	8:00 AM
Daily Connections	1 Ø
Found on	11/18/2025

All bus stations and stops in Cleveland and St. Louis, MO

In the map below, you can see where to find all bus stations in Cleveland and St. Louis, MO.

Greyhound Bus Station

Chester Ave 1465

Lyndhurst

Cedar Rd 25149

Central Station

Stephanie Tubbs Jones Transit Center

E 22nd St 2115

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from Cleveland to St. Louis, MO

Want to know which seat classes are available on the buses from Cleveland to St. Louis, MO? Or which bus companies serve the route Cleveland to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Cleveland to St. Louis, MO bus

How much does a Cleveland St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $76 and takes 15h 10m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Cleveland to St. Louis, MO?

This route is offered by 2 companies with a range of ticket prices between $76 and $174. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Cleveland to St. Louis, MO each day?

Every day, the Cleveland to St. Louis, MO bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Cleveland to St. Louis, MO take?

The fastest bus from Cleveland to St. Louis, MO is offered by FlixBus and takes 15h 10m. Bus tickets for this connection cost $80. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Cleveland to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Cleveland starts at 12:15 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Cleveland to St. Louis, MO?

The latest bus trip departing from Cleveland for St. Louis, MO starts at 4:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Cleveland St. Louis, MO route?

When traveling by bus from Cleveland to St. Louis, MO, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Cleveland and St. Louis, MO?

You can check all the direct connections between Cleveland and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Cleveland to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Cleveland St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Cleveland St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Cleveland to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Cleveland to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Cleveland and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Cleveland to St. Louis, MO?

Prices and availability for 4 trips between Cleveland and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Cleveland to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Cleveland and to St. Louis, MO

Here’s an overview of the most popular bus routes to Cleveland and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!