Bus Lafayette, LA to St. Louis, MO - Compare all Companies

Compare all timetables for the bus from Lafayette, LA to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Lafayette, LA to St. Louis, MO from various bus operators like Greyhound US or FlixBus for the next days.

today

tomorrow

$129

Sunday

Monday

Tuesday

Wednesday

Thursday

$145

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	28h 35m	8:20 AM	Lafayette, LA	TA Travel Center	12:55 PM	St. Louis, MO	Gateway Station	Economy	$129	A Bus from FlixBus goes from TA Travel Center, Lafayette, LA (USA) at 12/6/2025 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/7/2025 12:55:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 28h 35m
Greyhound US	23h 35m	9:35 AM	Lafayette, LA	Bus Stop	9:10 AM	St. Louis, MO	Gateway Station	Economy	$129	A Bus from Greyhound US goes from Bus Stop, Lafayette, LA (USA) at 12/6/2025 9:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/7/2025 9:10:00 AM. 50 Economy ticket for $129 per person are available. Travel duration is 23h 35m
Greyhound US	22h 10m	5:35 PM	Lafayette, LA	Bus Stop	3:45 PM	St. Louis, MO	Gateway Station	Economy	$130	A Bus from Greyhound US goes from Bus Stop, Lafayette, LA (USA) at 12/6/2025 5:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/7/2025 3:45:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 22h 10m
Greyhound US	34h 35m	10:35 PM	Lafayette, LA	Bus Stop	9:10 AM	St. Louis, MO	Gateway Station	Economy	$130	A Bus from Greyhound US goes from Bus Stop, Lafayette, LA (USA) at 12/6/2025 10:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/8/2025 9:10:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 34h 35m
FlixBus	18h 55m	8:50 PM	Lafayette, LA	TA Travel Center	3:45 PM	St. Louis, MO	Gateway Station	Economy	$133	A Bus from FlixBus goes from TA Travel Center, Lafayette, LA (USA) at 12/6/2025 8:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/7/2025 3:45:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 18h 55m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	34h 35m	10:35 PM	Lafayette, LA	Bus Stop	9:10 AM	St. Louis, MO	Gateway Station	Economy	$145	A Bus from Greyhound US goes from Bus Stop, Lafayette, LA (USA) at 12/11/2025 10:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/13/2025 9:10:00 AM. 50 Economy ticket for $145 per person are available. Travel duration is 34h 35m
Greyhound US	23h 35m	9:35 AM	Lafayette, LA	Bus Stop	9:10 AM	St. Louis, MO	Gateway Station	Economy	$152	A Bus from Greyhound US goes from Bus Stop, Lafayette, LA (USA) at 12/11/2025 9:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/12/2025 9:10:00 AM. 50 Economy ticket for $152 per person are available. Travel duration is 23h 35m
Greyhound US	22h 10m	5:35 PM	Lafayette, LA	Bus Stop	3:45 PM	St. Louis, MO	Gateway Station	Economy	$152	A Bus from Greyhound US goes from Bus Stop, Lafayette, LA (USA) at 12/11/2025 5:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/12/2025 3:45:00 PM. 50 Economy ticket for $152 per person are available. Travel duration is 22h 10m
FlixBus	18h 55m	8:50 PM	Lafayette, LA	TA Travel Center	3:45 PM	St. Louis, MO	Gateway Station	Economy	$154	A Bus from FlixBus goes from TA Travel Center, Lafayette, LA (USA) at 12/11/2025 8:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/12/2025 3:45:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 18h 55m

Did you know that if you travel from Lafayette, LA to St. Louis, MO via New Orleans, LA, you can save more than $54? You can find the corresponding connections below.
- FlixBus
  
  20h 30m
  
  0
  
  2:30 AM
  
  Lafayette, LA
  TA Travel Center
  
  5:00 AM
  
  New Orleans, LA
  Canal and Charles
  
  0
  
  Economy
  
  $25
  
  A Bus from FlixBus goes from TA Travel Center, Lafayette, LA (USA) at 12/11/2025 2:30:00 AM to Canal and Charles, New Orleans, LA (USA) arriving at 12/11/2025 5:00:00 AM. 50 Economy ticket for $25 per person are available. Travel duration is 2h 30m
- Busbud
  
  14h 40m
  
  0
  
  8:20 AM
  
  New Orleans, LA
  Central Bus Station
  
  11:00 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $66
  
  A Bus from Busbud goes from Central Bus Station, New Orleans, LA (USA) at 12/11/2025 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/11/2025 11:00:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 14h 40m
Travel time is 1h 35m longer, but you will save $54

Best Price Offer: The price for the cheapest bus from Lafayette, LA to St. Louis, MO is $129 on 12/6/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Lafayette, LA and St. Louis, MO

See here how frequent the connections between Lafayette, LA and St. Louis, MO are, during different times and days of the week.

Saturday is the busiest day, with more than 8 daily buses from Lafayette, LA to St. Louis, MO. Thursday has instead the fewest connections, with only 6 daily coaches between Lafayette, LA and St. Louis, MO.

The busiest time of the day is the Evening, with 6 buses from Lafayette, LA to St. Louis, MO, while Afternoon sees the fewest connections between Lafayette, LA and St. Louis, MO, with 2 offers.

Facts about the bus from Lafayette, LA to St. Louis, MO

Compare all providers like Greyhound US and FlixBus that travel 7 times every day by bus from Lafayette, LA to St. Louis, MO in one click! Book your bus ticket from Lafayette, LA to St. Louis, MO starting from $129!

Cheapest Bus	$129
Fastest Bus	18h 55m
Earliest Bus	1:30 AM
Latest Bus	10:35 PM
Daily Bus Routes	7 Ø
Distance	589.7 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Lafayette, LA to St. Louis, MO

Every day, 7 buses from 2 bus companies leave Lafayette, LA for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

Saturday 12/06

$129

Sunday 12/07

Monday 12/08

Tuesday 12/09

Wednesday 12/10

Thursday 12/11

$145

Friday 12/12

Saturday 12/13

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

The cheapest time to travel from Lafayette, LA to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Lafayette, LA to St. Louis, MO, for the next 30 days.

With a price starting from $129, Saturday is the cheapest day for a bus from Lafayette, LA to St. Louis, MO. Thursday instead is the most expensive day with prices starting from $145.

Morning is the cheapest day time for bus tickets from Lafayette, LA to St. Louis, MO, with $129. Afternoon is the most expensive time of the day with prices starting from $130.

How to save money travelling from Lafayette, LA to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Lafayette, LA to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Lafayette, LA to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Lafayette, LA to St. Louis, MO are also emptier.

All bus stations and stops in Lafayette, LA and St. Louis, MO

In the map below, you can see where to find all bus stations in Lafayette, LA and St. Louis, MO.

Bus Stop

Lee Ave 100

TA Travel Center

N University Ave 1701

Cameron Street & Alley Five Bus Stop

Cameron St 2405

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from Lafayette, LA to St. Louis, MO

Want to know which seat classes are available on the buses from Lafayette, LA to St. Louis, MO? Or which bus companies serve the route Lafayette, LA to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Lafayette, LA to St. Louis, MO bus

How much does a Lafayette, LA St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $129 and takes 23h 35m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Lafayette, LA to St. Louis, MO?

This route is offered by 2 companies with a range of ticket prices between $129 and $154. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Lafayette, LA to St. Louis, MO each day?

Every day, the Lafayette, LA to St. Louis, MO bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Lafayette, LA to St. Louis, MO take?

The fastest bus from Lafayette, LA to St. Louis, MO is offered by FlixBus and takes 18h 55m. Bus tickets for this connection cost $133. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Lafayette, LA to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Lafayette, LA starts at 1:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Lafayette, LA to St. Louis, MO?

The latest bus trip departing from Lafayette, LA for St. Louis, MO starts at 10:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Lafayette, LA St. Louis, MO route?

When traveling by bus from Lafayette, LA to St. Louis, MO, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Lafayette, LA and St. Louis, MO?

You can check all the direct connections between Lafayette, LA and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Lafayette, LA to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Lafayette, LA St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Lafayette, LA St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Lafayette, LA to St. Louis, MO on your planned travel date.

Available seat classes which are offered on the bus route Lafayette, LA to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Lafayette, LA and to St. Louis, MO

Here’s an overview of the most popular bus routes to Lafayette, LA and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!