Which bus from Knoxville, TN to St. Louis, MO is the cheapest?

Compare all bus companies and find the best price: Bus tickets from $88
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Compare all timetables for the bus from Knoxville, TN to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Knoxville, TN to St. Louis, MO from various bus operators like Greyhound US for the next days.

today
$94
tomorrow
Sunday
$94
Monday
$97
Tuesday
$89
Wednesday
$126
Thursday

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 19h 15m 8:00 PM Knoxville, TN Greyhound Bus Station 2:15 PM St. Louis, MO Gateway Station  Economy $94
Greyhound US 18h 10m 10:00 PM Knoxville, TN Greyhound Bus Station 3:10 PM St. Louis, MO Gateway Station  Economy $94
  • Did you know that if you travel from Knoxville, TN to St. Louis, MO via Nashville, you can save more than $16? You can find the corresponding connections below.
    • Greyhound US
      16h 10m
      0
      6:10 PM
      Knoxville, TN
      Knoxville Area Transit Bus Stop
      7:55 PM
      Nashville
      5th Ave South Station
      0
      Greyhound US
      Economy
      $41
      • Waiting Time 7h 30m
    • FlixBus
      5h 55m
      0
      3:25 AM
      Nashville
      5th Ave South Station
      9:20 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $37
    Travel Time is 1h 0m shorter, and you will save $16

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 19h 15m 8:00 PM Knoxville, TN Knoxville Area Transit Bus Stop 2:15 PM St. Louis, MO Gateway Station  Economy $94
Greyhound US 18h 10m 10:00 PM Knoxville, TN Knoxville Area Transit Bus Stop 3:10 PM St. Louis, MO Gateway Station  Economy $95
  • Did you know that if you travel from Knoxville, TN to St. Louis, MO via Nashville, you can save more than $22? You can find the corresponding connections below.
    • Greyhound US
      23h 0m
      0
      5:55 PM
      Knoxville, TN
      Greyhound Bus Station
      7:55 PM
      Nashville
      5th Ave South Station
      0
      Greyhound US
      Economy
      $36
      • Waiting Time 13h 15m
    • Greyhound US
      6h 45m
      0
      9:10 AM
      Nashville
      5th Ave South Station
      3:55 PM
      St. Louis, MO
      Gateway Station
      0
      Greyhound US
      Economy
      $36
    Travel time is 5h 50m longer, but you will save $22

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 19h 15m 8:00 PM Knoxville, TN Greyhound Bus Station 2:15 PM St. Louis, MO Gateway Station  Economy $97
Greyhound US 18h 10m 10:00 PM Knoxville, TN Greyhound Bus Station 3:10 PM St. Louis, MO Gateway Station  Economy $97
  • Did you know that if you travel from Knoxville, TN to St. Louis, MO via Nashville, you can save more than $27? You can find the corresponding connections below.
    • Greyhound US
      23h 0m
      0
      5:55 PM
      Knoxville, TN
      Greyhound Bus Station
      7:55 PM
      Nashville
      5th Ave South Station
      0
      Greyhound US
      Economy
      $34
      • Waiting Time 13h 15m
    • Greyhound US
      6h 45m
      0
      9:10 AM
      Nashville
      5th Ave South Station
      3:55 PM
      St. Louis, MO
      Gateway Station
      0
      Greyhound US
      Economy
      $36
    Travel time is 5h 50m longer, but you will save $27

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 18h 10m 10:00 PM Knoxville, TN Greyhound Bus Station 3:10 PM St. Louis, MO Gateway Station  Economy $89
  • Did you know that if you travel from Knoxville, TN to St. Louis, MO via Nashville, you can save more than $19? You can find the corresponding connections below.
    • Greyhound US
      16h 25m
      0
      5:55 PM
      Knoxville, TN
      Greyhound Bus Station
      7:55 PM
      Nashville
      5th Ave South Station
      0
      Greyhound US
      Economy
      $34
      • Waiting Time 7h 30m
    • FlixBus
      5h 55m
      0
      3:25 AM
      Nashville
      5th Ave South Station
      9:20 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $36
    Travel Time is 0h 45m shorter, and you will save $19

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 18h 10m 10:00 PM Knoxville, TN Greyhound Bus Station 3:10 PM St. Louis, MO Gateway Station  Economy $126
  • Did you know that if you travel from Knoxville, TN to St. Louis, MO via Nashville, you can save more than $56? You can find the corresponding connections below.
    • Greyhound US
      16h 25m
      0
      5:55 PM
      Knoxville, TN
      Greyhound Bus Station
      7:55 PM
      Nashville
      5th Ave South Station
      0
      Greyhound US
      Economy
      $34
      • Waiting Time 7h 30m
    • FlixBus
      5h 55m
      0
      3:25 AM
      Nashville
      5th Ave South Station
      9:20 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $36
    Travel Time is 0h 45m shorter, and you will save $56

Best Price Offer: The price for the cheapest bus from Knoxville, TN to St. Louis, MO is $88 on 11/6/2026. Flexible travelers save on ticket prices.


Facts about the bus from Knoxville, TN to St. Louis, MO

Compare all providers like Greyhound US that travel 2 times every day by bus from Knoxville, TN to St. Louis, MO in one click! Book your bus ticket from Knoxville, TN to St. Louis, MO starting from $88!

Cheapest Bus $88
Fastest Bus 17h 10m
Earliest Bus 8:00 PM
Latest Bus 10:00 PM
Daily Bus Routes 2 Ø
Distance 391.5 miles
Bus Companies Greyhound US

Cheapest bus connections from Knoxville, TN to St. Louis, MO

Every day, 2 buses from 1 bus companies leave Knoxville, TN for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/16/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 10/11
Monday 10/12
Tuesday 10/13
Wednesday 10/14
Thursday 10/15
Friday 10/16
$94
Saturday 10/17
Sunday 10/18
$94
Monday 10/19
$101
Tuesday 10/20
$89
Wednesday 10/21
$126
Thursday 10/22
Friday 10/23
$113
Saturday 10/24
Sunday 10/25
$101
Monday 10/26
$116
Tuesday 10/27
$153
Wednesday 10/28
$114
Thursday 10/29
$110
Friday 10/30
$106
Saturday 10/31
$101
Sunday 11/01
Monday 11/02
$105
Tuesday 11/03
$111
Wednesday 11/04
$108
Thursday 11/05
Friday 11/06
$88
Saturday 11/07

How to save money travelling from Knoxville, TN to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Knoxville, TN to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Knoxville, TN to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Knoxville, TN to St. Louis, MO are also emptier.

Beloved bus companies from Knoxville, TN to St. Louis, MO

These are the most booked bus companies between Knoxville, TN to St. Louis, MO from our users.

Greyhound US from Knoxville, TN to St. Louis, MO

Greyhound US

Here you will find the key facts about the Greyhound US bus route Knoxville, TN to St. Louis, MO:

Cheapest Price $89
Fastest Bus 17h 10m
Earliest Bus 8:00 PM
Last Bus 10:00 PM
Daily Connections 2 Ø
Found on 9/21/2026

All bus stations and stops in Knoxville, TN and St. Louis, MO

In the map below, you can see where to find all bus stations in Knoxville, TN and St. Louis, MO.

Service and Comfort on the bus from Knoxville, TN to St. Louis, MO

Want to know which seat classes are available on the buses from Knoxville, TN to St. Louis, MO? Or which bus companies serve the route Knoxville, TN to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Knoxville, TN to St. Louis, MO bus

How much does a Knoxville, TN St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $88 and takes 17h 10m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Knoxville, TN to St. Louis, MO?

This route is offered by 1 companies with a range of ticket prices between $88 and $126. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Knoxville, TN to St. Louis, MO each day?

Every day, the Knoxville, TN to St. Louis, MO bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Knoxville, TN to St. Louis, MO take?

The fastest bus from Knoxville, TN to St. Louis, MO is offered by Greyhound US and takes 17h 10m. Bus tickets for this connection cost $94. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Knoxville, TN to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Knoxville, TN starts at 8:00 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Knoxville, TN to St. Louis, MO?

The latest bus trip departing from Knoxville, TN for St. Louis, MO starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Knoxville, TN St. Louis, MO route?

When traveling by bus from Knoxville, TN to St. Louis, MO, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Knoxville, TN and St. Louis, MO?

You can check all the direct connections between Knoxville, TN and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Knoxville, TN to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Knoxville, TN St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Knoxville, TN St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Knoxville, TN to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Knoxville, TN to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 2 daily trips between Knoxville, TN and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Knoxville, TN to St. Louis, MO?

Prices and availability for 2 trips between Knoxville, TN and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Knoxville, TN to St. Louis, MO

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Knoxville, TN and to St. Louis, MO

Here’s an overview of the most popular bus routes to Knoxville, TN and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Popular Airport Shuttles to Knoxville, TN and to St. Louis, MO
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