Compare all timetables for the bus from Knoxville, TN to St. Louis, MO
Here is a selection of the cheapest bus trips from the schedule from Knoxville, TN to St. Louis, MO from various bus operators like Greyhound US for the next days.
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 15h 5m | 7:05 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | 9:10 AM | St. Louis, MO | Gateway Station | Economy | $171 |
A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 12/18/2025 7:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/19/2025 9:10:00 AM. 50 Economy ticket for $171 per person are available. Travel duration is 15h 5m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 15h 5m | 7:05 PM | Knoxville, TN | Greyhound Bus Station | 9:10 AM | St. Louis, MO | Gateway Station | Economy | $220 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/19/2025 7:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/20/2025 9:10:00 AM. 50 Economy ticket for $220 per person are available. Travel duration is 15h 5m
|
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 15h 5m | 7:05 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | 9:10 AM | St. Louis, MO | Gateway Station | Economy | $167 |
A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 12/20/2025 7:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/21/2025 9:10:00 AM. 50 Economy ticket for $167 per person are available. Travel duration is 15h 5m
|
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 15h 5m | 7:05 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | 9:10 AM | St. Louis, MO | Gateway Station | Economy | $221 |
A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 12/22/2025 7:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/23/2025 9:10:00 AM. 50 Economy ticket for $221 per person are available. Travel duration is 15h 5m
|
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 15h 5m | 7:05 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | 9:10 AM | St. Louis, MO | Gateway Station | Economy | $201 |
A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 12/23/2025 7:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/24/2025 9:10:00 AM. 50 Economy ticket for $201 per person are available. Travel duration is 15h 5m
|
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 15h 5m | 7:05 PM | Knoxville, TN | Greyhound Bus Station | 9:10 AM | St. Louis, MO | Gateway Station | Economy | $167 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/24/2025 7:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/25/2025 9:10:00 AM. 50 Economy ticket for $167 per person are available. Travel duration is 15h 5m
|
Best Price Offer: The price for the cheapest bus from Knoxville, TN to St. Louis, MO is $149 on 12/15/2025. Flexible travelers save on ticket prices.
Facts about the bus from Knoxville, TN to St. Louis, MO
Compare all providers like Greyhound US that travel 1 times every day by bus from Knoxville, TN to St. Louis, MO in one click! Book your bus ticket from Knoxville, TN to St. Louis, MO starting from $149!
| Cheapest Bus | $149 |
| Fastest Bus | 14h 5m |
| Earliest Bus | 7:05 PM |
| Latest Bus | 7:05 PM |
| Daily Bus Routes | 1 Ø |
| Distance | 391.5 miles |
| Bus Companies | Greyhound US |
Cheapest bus connections from Knoxville, TN to St. Louis, MO
Every day, 1 buses from 1 bus companies leave Knoxville, TN for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/18/2025 and for the following days.
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday
12/14
Monday
12/15
Tuesday
12/16
Wednesday
12/17
Thursday
12/18
$171
Friday
12/19
$220
Saturday
12/20
$167
Sunday
12/21
Monday
12/22
$221
Tuesday
12/23
$205
Wednesday
12/24
$167
Thursday
12/25
$159
Friday
12/26
$213
Saturday
12/27
Sunday
12/28
Monday
12/29
Tuesday
12/30
Wednesday
12/31
Thursday
01/01
Friday
01/02
Saturday
01/03
Sunday
01/04
Monday
01/05
Tuesday
01/06
Wednesday
01/07
Thursday
01/08
Friday
01/09
Saturday
01/10
How to save money travelling from Knoxville, TN to St. Louis, MO
Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:
Book the ticket from Knoxville, TN to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Knoxville, TN to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Knoxville, TN to St. Louis, MO are also emptier.All bus stations and stops in Knoxville, TN and St. Louis, MO
In the map below, you can see where to find all bus stations in Knoxville, TN and St. Louis, MO.
Service and Comfort on the bus from Knoxville, TN to St. Louis, MO
Want to know which seat classes are available on the buses from Knoxville, TN to St. Louis, MO? Or which bus companies serve the route Knoxville, TN to St. Louis, MO? Below you will find answers to your questions.
FAQs about the Knoxville, TN to St. Louis, MO bus
How much does a Knoxville, TN St. Louis, MO bus trip cost?
This depends on, among other things, the day and time of travel. The cheapest trip is available from $149 and takes 14h 5m to reach St. Louis, MO. Compare offers to save money!
How much could I save by comparing buses from Knoxville, TN to St. Louis, MO?
This route is offered by 1 companies with a range of ticket prices between $149 and $221. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.
On average, how many connections are available from Knoxville, TN to St. Louis, MO each day?
Every day, the Knoxville, TN to St. Louis, MO bus route is served by approximately 1 connections. With our search, you can compare bus times to find the perfect trip.
How long does a bus journey from Knoxville, TN to St. Louis, MO take?
The fastest bus from Knoxville, TN to St. Louis, MO is offered by Greyhound US and takes 14h 5m. Bus tickets for this connection cost $171. In this context, bear in mind that the journey can take longer due to traffic.
What time is the first bus from Knoxville, TN to St. Louis, MO?
The earliest bus arriving in St. Louis, MO from Knoxville, TN starts at 7:05 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.
What time is the last bus from Knoxville, TN to St. Louis, MO?
The latest bus trip departing from Knoxville, TN for St. Louis, MO starts at 7:05 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.
Which bus companies operate the Knoxville, TN St. Louis, MO route?
When traveling by bus from Knoxville, TN to St. Louis, MO, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.
Is there a direct bus between Knoxville, TN and St. Louis, MO?
You can check all the direct connections between Knoxville, TN and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.
What can I take with me on the Knoxville, TN to St. Louis, MO bus route?
Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Knoxville, TN St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.
What equipment is available for the Knoxville, TN St. Louis, MO bus route?
The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Knoxville, TN to St. Louis, MO on your planned travel date.
How does CheckMyBus find the best bus deals from Knoxville, TN to St. Louis, MO?
CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 1 daily trips between Knoxville, TN and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.
How does CheckMyBus technology work for trips from Knoxville, TN to St. Louis, MO?
Prices and availability for 1 trips between Knoxville, TN and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.
Available seat classes which are offered on the bus route Knoxville, TN to St. Louis, MO
Economy
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
More bus routes to Knoxville, TN and to St. Louis, MO
Here’s an overview of the most popular bus routes to Knoxville, TN and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!
- Bus Routes to Knoxville, TN
- Buses from Athens, TN to Knoxville, TN
- From Atlanta, GA to Knoxville, TN bus
- From Baton Rouge to Knoxville, TN bus
- Bus from Beaumont, TX to Knoxville, TN
- Buses to Knoxville, TN from Huntsville, AL
- Bus from Jacksonville, FL to Knoxville, TN
- From Lexington, KY to Knoxville, TN bus
- Bus Louisville, KY to Knoxville, TN
- Buses to Knoxville, TN from Memphis
- Buses from Miami to Knoxville, TN
- Buses Nashville - Knoxville, TN
- Bus to Knoxville, TN from New York
- Norcross, GA to Knoxville, TN bus
- Bus Raleigh, NC - Knoxville, TN
- From Richmond, VA to Knoxville, TN bus
- Buses Roanoke, VA - Knoxville, TN
- Buses San Bernardino, CA to Knoxville, TN
- Buses to Knoxville, TN from Shreveport, LA
- Bus to Knoxville, TN from Warner Robins, GA
- Bus Washington, DC to Knoxville, TN
- Bus Routes to St. Louis, MO
- Bus Atlanta, GA - St. Louis, MO
- Buses Clarksville, TN to St. Louis, MO
- Bus to St. Louis, MO from Cleveland
- Buses Conroe, TX - St. Louis, MO
- Buses Dallas - St. Louis, MO
- Bus Denver to St. Louis, MO
- Bus to St. Louis, MO from Des Moines, IA
- Buses to St. Louis, MO from Houston
- Buses to St. Louis, MO from Indianapolis
- Buses to St. Louis, MO from Jacksonville, FL
- Buses to St. Louis, MO from Kansas City
- Bus to St. Louis, MO from Lafayette, LA
- Buses to St. Louis, MO from Memphis
- From Miami to St. Louis, MO bus
- Buses Minneapolis to St. Louis, MO
- Buses Nashville - St. Louis, MO
- Bus Newark to St. Louis, MO
- From Springfield, MO to St. Louis, MO bus
- Bus The Woodlands, TX - St. Louis, MO
- Toledo, OH to St. Louis, MO bus
Popular Airport Shuttles to Knoxville, TN and to St. Louis, MO
