Compare all timetables for the bus from Houston to Knoxville, TN
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Valley Transit | 38h 15m | 6:35 AM | Houston | SW Agencia Autobuses | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $122 |
A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 4/22/2026 6:35:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/23/2026 9:50:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 38h 15m
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| Greyhound Lines Mexico | 36h 10m | 9:30 AM | Houston | SW Agencia Autobuses | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $122 |
A Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 4/22/2026 9:30:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/23/2026 10:40:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 36h 10m
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| Greyhound US | 22h 50m | 10:00 PM | Houston | Harrisburg Blvd Station | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $122 |
A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/22/2026 10:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/23/2026 9:50:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 22h 50m
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| FlixBus | 31h 0m | 1:50 PM | Houston | Uptown/Upper Kirby | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $123 |
A Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/22/2026 1:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/23/2026 9:50:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 31h 0m
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| FlixBus | 30h 40m | 2:10 PM | Houston | Downtown Houston | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $123 |
A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 4/22/2026 2:10:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/23/2026 9:50:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 30h 40m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 31h 0m | 1:50 PM | Houston | Uptown/Upper Kirby | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $109 |
A Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/23/2026 1:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/24/2026 9:50:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 31h 0m
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| FlixBus | 30h 40m | 2:10 PM | Houston | Downtown Houston | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $109 |
A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 4/23/2026 2:10:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/24/2026 9:50:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 30h 40m
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| Greyhound US | 22h 50m | 10:00 PM | Houston | Harrisburg Blvd Station | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $109 |
A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/23/2026 10:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/24/2026 9:50:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 22h 50m
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| Valley Transit | 38h 15m | 6:35 AM | Houston | SW Agencia Autobuses | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $110 |
A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 4/23/2026 6:35:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/24/2026 9:50:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 38h 15m
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| Greyhound Lines Mexico | 36h 10m | 9:30 AM | Houston | SW Agencia Autobuses | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $111 |
A Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 4/23/2026 9:30:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/24/2026 10:40:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 36h 10m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound Lines Mexico | 36h 10m | 9:30 AM | Houston | SW Agencia Autobuses | 10:40 PM | Knoxville, TN | Greyhound Bus Station | Economy | $130 |
A Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 4/25/2026 9:30:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 4/26/2026 10:40:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 36h 10m
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| Valley Transit | 38h 15m | 6:35 AM | Houston | SW Agencia Autobuses | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $130 |
A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 4/25/2026 6:35:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/26/2026 9:50:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 38h 15m
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| FlixBus | 31h 0m | 1:50 PM | Houston | Uptown/Upper Kirby | 9:50 PM | Knoxville, TN | Greyhound Bus Station | Economy | $130 |
A Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/25/2026 1:50:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 4/26/2026 9:50:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 31h 0m
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| FlixBus | 28h 5m | 5:35 PM | Houston | Uptown/Upper Kirby | 10:40 PM | Knoxville, TN | Greyhound Bus Station | Economy | $130 |
A Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/25/2026 5:35:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 4/26/2026 10:40:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 28h 5m
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| Greyhound US | 22h 50m | 10:00 PM | Houston | Harrisburg Blvd Station | 9:50 PM | Knoxville, TN | Greyhound Bus Station | Economy | $130 |
A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/25/2026 10:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 4/26/2026 9:50:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 22h 50m
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FlixBus30h 40m02:10 PMHoustonDowntown Houston3:15 PMAtlanta, GAGarnett Transit Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 4/26/2026 2:10:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 4/27/2026 3:15:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 24h 5m
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Greyhound US3h 45m06:05 PMAtlanta, GAGarnett Transit Station9:50 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Garnett Transit Station, Atlanta, GA (USA) at 4/27/2026 6:05:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 4/27/2026 9:50:00 PM. 50 Economy ticket for $31 per person are available. Travel duration is 3h 45m
Waiting Time 2h 50m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 28h 5m | 5:35 PM | Houston | Uptown/Upper Kirby | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $115 |
A Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/26/2026 5:35:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/27/2026 10:40:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 28h 5m
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| FlixBus | 27h 40m | 6:00 PM | Houston | Downtown Houston | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $115 |
A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 4/26/2026 6:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/27/2026 10:40:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 27h 40m
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| Valley Transit | 38h 15m | 6:35 AM | Houston | SW Agencia Autobuses | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $116 |
A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 4/26/2026 6:35:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/27/2026 9:50:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 38h 15m
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| Greyhound US | 22h 50m | 10:00 PM | Houston | Harrisburg Blvd Station | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $116 |
A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/26/2026 10:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/27/2026 9:50:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 22h 50m
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| Greyhound Lines Mexico | 36h 10m | 9:30 AM | Houston | SW Agencia Autobuses | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $117 |
A Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 4/26/2026 9:30:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/27/2026 10:40:00 PM. 50 Economy ticket for $117 per person are available. Travel duration is 36h 10m
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FlixBus30h 40m02:10 PMHoustonDowntown Houston3:15 PMAtlanta, GAGarnett Transit Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 4/26/2026 2:10:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 4/27/2026 3:15:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 24h 5m
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Greyhound US3h 45m06:05 PMAtlanta, GAGarnett Transit Station9:50 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Garnett Transit Station, Atlanta, GA (USA) at 4/27/2026 6:05:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 4/27/2026 9:50:00 PM. 50 Economy ticket for $31 per person are available. Travel duration is 3h 45m
Waiting Time 2h 50m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Valley Transit | 38h 15m | 6:35 AM | Houston | SW Agencia Autobuses | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $97 |
A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 4/27/2026 6:35:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/28/2026 9:50:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 38h 15m
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| FlixBus | 31h 35m | 1:15 PM | Houston | Uptown/Upper Kirby | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $98 |
A Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/27/2026 1:15:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/28/2026 9:50:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 31h 35m
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| FlixBus | 28h 5m | 5:35 PM | Houston | Uptown/Upper Kirby | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $98 |
A Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/27/2026 5:35:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/28/2026 10:40:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 28h 5m
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| Greyhound US | 22h 50m | 10:00 PM | Houston | Harrisburg Blvd Station | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $98 |
A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/27/2026 10:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/28/2026 9:50:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 22h 50m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Valley Transit | 38h 15m | 6:35 AM | Houston | SW Agencia Autobuses | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $117 |
A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 4/28/2026 6:35:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/29/2026 9:50:00 PM. 50 Economy ticket for $117 per person are available. Travel duration is 38h 15m
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| FlixBus | 33h 25m | 11:25 AM | Houston | Uptown/Upper Kirby | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $117 |
A Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/28/2026 11:25:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/29/2026 9:50:00 PM. 50 Economy ticket for $117 per person are available. Travel duration is 33h 25m
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| FlixBus | 31h 35m | 1:15 PM | Houston | Downtown Houston | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $118 |
A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 4/28/2026 1:15:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/29/2026 9:50:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 31h 35m
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| Greyhound US | 22h 50m | 10:00 PM | Houston | Harrisburg Blvd Station | 9:50 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $118 |
A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/28/2026 10:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/29/2026 9:50:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 22h 50m
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FlixBus30h 40m02:10 PMHoustonDowntown Houston3:15 PMAtlanta, GAGarnett Transit Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 4/26/2026 2:10:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 4/27/2026 3:15:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 24h 5m
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Greyhound US3h 45m06:05 PMAtlanta, GAGarnett Transit Station9:50 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Garnett Transit Station, Atlanta, GA (USA) at 4/27/2026 6:05:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 4/27/2026 9:50:00 PM. 50 Economy ticket for $31 per person are available. Travel duration is 3h 45m
Waiting Time 2h 50m -
Best Price Offer: The price for the cheapest bus from Houston to Knoxville, TN is $97 on 4/27/2026. Flexible travelers save on ticket prices.
Frequency of bus connections between Houston and Knoxville, TN
Facts about the bus from Houston to Knoxville, TN
Compare all providers like FlixBus, Greyhound US and Greyhound Lines Mexico that travel 10 times every day by bus from Houston to Knoxville, TN in one click! Book your bus ticket from Houston to Knoxville, TN starting from $97!
| Cheapest Bus | $97 |
| Fastest Bus | 23h 50m |
| Earliest Bus | 6:35 AM |
| Latest Bus | 10:00 PM |
| Daily Bus Routes | 10 Ø |
| Distance | 791.0 miles |
| Bus Companies | FlixBus, Greyhound US, Greyhound Lines Mexico and Valley Transit |
Cheapest bus connections from Houston to Knoxville, TN
Every day, 10 buses from 4 bus companies leave Houston for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/22/2026 and for the following days.
The cheapest time to travel from Houston to Knoxville, TN
How to save money travelling from Houston to Knoxville, TN
Book the ticket from Houston to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Houston to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Houston to Knoxville, TN are also emptier.All bus stations and stops in Houston and Knoxville, TN
In the map below, you can see where to find all bus stations in Houston and Knoxville, TN.
Service and Comfort on the bus from Houston to Knoxville, TN
FAQs about the Houston to Knoxville, TN bus
How much does a Houston Knoxville, TN bus trip cost?
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What time is the last bus from Houston to Knoxville, TN?
Which bus companies operate the Houston Knoxville, TN route?
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Available seat classes which are offered on the bus route Houston to Knoxville, TN
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
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