Bus Houston to Knoxville, TN - Compare all Companies

Compare all timetables for the bus from Houston to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from Houston to Knoxville, TN from various bus operators like FlixBus, Greyhound US or Valley Transit for the next days.

today

$114

tomorrow

$122

Sunday

Monday

$137

Tuesday

$115

Wednesday

$122

Thursday

$125

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	27h 5m	5:45 PM	Houston	Downtown Houston	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$114	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/16/2026 5:45:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/17/2026 9:50:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 27h 5m
Greyhound US	22h 50m	10:00 PM	Houston	Harrisburg Blvd Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$115	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/16/2026 10:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/17/2026 9:50:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 22h 50m
FlixBus	31h 5m	1:45 PM	Houston	SW Agencia Autobuses	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$120	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 10/16/2026 1:45:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/17/2026 9:50:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 31h 5m
FlixBus	27h 30m	6:00 PM	Houston	Downtown Houston	10:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$121	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/16/2026 6:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/17/2026 10:30:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 27h 30m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	31h 5m	1:45 PM	Houston	SW Agencia Autobuses	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$122	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 10/17/2026 1:45:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/18/2026 9:50:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 31h 5m
FlixBus	27h 5m	5:45 PM	Houston	Downtown Houston	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$122	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/17/2026 5:45:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/18/2026 9:50:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 27h 5m
Greyhound US	22h 50m	10:00 PM	Houston	Harrisburg Blvd Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$123	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/17/2026 10:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/18/2026 9:50:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 22h 50m
FlixBus	27h 30m	6:00 PM	Houston	Downtown Houston	10:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$134	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/17/2026 6:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/18/2026 10:30:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 27h 30m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	27h 5m	5:45 PM	Houston	Downtown Houston	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$137	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/19/2026 5:45:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/20/2026 9:50:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 27h 5m
Greyhound US	22h 50m	10:00 PM	Houston	Harrisburg Blvd Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$140	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/19/2026 10:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/20/2026 9:50:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 22h 50m
FlixBus	27h 55m	5:35 PM	Houston	SW Agencia Autobuses	10:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$163	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 10/19/2026 5:35:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/20/2026 10:30:00 PM. 50 Economy ticket for $163 per person are available. Travel duration is 27h 55m
Valley Transit	38h 15m	6:35 AM	Houston	SW Agencia Autobuses	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$177	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 10/19/2026 6:35:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/20/2026 9:50:00 PM. 50 Economy ticket for $177 per person are available. Travel duration is 38h 15m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	27h 30m	6:00 PM	Houston	Downtown Houston	10:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$115	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/20/2026 6:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/21/2026 10:30:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 27h 30m
Greyhound US	22h 50m	10:00 PM	Houston	Harrisburg Blvd Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$115	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/20/2026 10:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/21/2026 9:50:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 22h 50m
FlixBus	27h 55m	5:35 PM	Houston	SW Agencia Autobuses	10:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$117	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 10/20/2026 5:35:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/21/2026 10:30:00 PM. 50 Economy ticket for $117 per person are available. Travel duration is 27h 55m
Valley Transit	38h 15m	6:35 AM	Houston	SW Agencia Autobuses	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$127	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 10/20/2026 6:35:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/21/2026 9:50:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 38h 15m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 50m	10:00 PM	Houston	Harrisburg Blvd Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$122	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/21/2026 10:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/22/2026 9:50:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 22h 50m
FlixBus	31h 5m	1:45 PM	Houston	SW Agencia Autobuses	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$123	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 10/21/2026 1:45:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/22/2026 9:50:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 31h 5m
FlixBus	30h 40m	2:10 PM	Houston	Downtown Houston	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$123	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/21/2026 2:10:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/22/2026 9:50:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 30h 40m
FlixBus	27h 55m	5:35 PM	Houston	SW Agencia Autobuses	10:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$124	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 10/21/2026 5:35:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 10/22/2026 10:30:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 27h 55m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	31h 5m	1:45 PM	Houston	SW Agencia Autobuses	9:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$125	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 10/22/2026 1:45:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 10/23/2026 9:50:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 31h 5m
FlixBus	27h 5m	5:45 PM	Houston	Downtown Houston	9:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$125	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/22/2026 5:45:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 10/23/2026 9:50:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 27h 5m
Greyhound US	22h 50m	10:00 PM	Houston	Harrisburg Blvd Station	9:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$125	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/22/2026 10:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 10/23/2026 9:50:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 22h 50m
FlixBus	27h 55m	5:35 PM	Houston	SW Agencia Autobuses	10:30 PM	Knoxville, TN	Greyhound Bus Station	Economy	$144	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 10/22/2026 5:35:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 10/23/2026 10:30:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 27h 55m

Best Price Offer: The price for the cheapest bus from Houston to Knoxville, TN is $111 on 11/5/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Houston and Knoxville, TN

See here how frequent the connections between Houston and Knoxville, TN are, during different times and days of the week.

Monday is the busiest day, with more than 10 daily buses from Houston to Knoxville, TN. Thursday has instead the fewest connections, with only 4 daily coaches between Houston and Knoxville, TN.

The busiest time of the day is the Afternoon, with 19 buses from Houston to Knoxville, TN, while Morning sees the fewest connections between Houston and Knoxville, TN, with 3 offers.

Facts about the bus from Houston to Knoxville, TN

Compare all providers like FlixBus, Greyhound US and Valley Transit that travel 5 times every day by bus from Houston to Knoxville, TN in one click! Book your bus ticket from Houston to Knoxville, TN starting from $111!

Cheapest Bus	$111
Fastest Bus	23h 50m
Earliest Bus	1:45 PM
Latest Bus	10:00 PM
Daily Bus Routes	5 Ø
Distance	791.0 miles
Bus Companies	FlixBus, Greyhound US and Valley Transit

Cheapest bus connections from Houston to Knoxville, TN

Every day, 5 buses from 3 bus companies leave Houston for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/16/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 10/11

Monday 10/12

Tuesday 10/13

Wednesday 10/14

Thursday 10/15

Friday 10/16

$114

Saturday 10/17

$122

Sunday 10/18

Monday 10/19

$137

Tuesday 10/20

$115

Wednesday 10/21

$122

Thursday 10/22

$125

Friday 10/23

$122

Saturday 10/24

Sunday 10/25

$117

Monday 10/26

$118

Tuesday 10/27

Wednesday 10/28

$119

Thursday 10/29

$122

Friday 10/30

$116

Saturday 10/31

$129

Sunday 11/01

Monday 11/02

$117

Tuesday 11/03

$133

Wednesday 11/04

$128

Thursday 11/05

$111

Friday 11/06

$121

Saturday 11/07

The cheapest time to travel from Houston to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from Houston to Knoxville, TN, for the next 30 days.

With a price starting from $111, Thursday is the cheapest day for a bus from Houston to Knoxville, TN. Monday instead is the most expensive day with prices starting from $117.

Afternoon is the cheapest day time for bus tickets from Houston to Knoxville, TN, with $114. Morning is the most expensive time of the day with prices starting from $127.

How to save money travelling from Houston to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Houston to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Houston to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Houston to Knoxville, TN are also emptier.

All bus stations and stops in Houston and Knoxville, TN

In the map below, you can see where to find all bus stations in Houston and Knoxville, TN.

Downtown Houston

Gray St 605

Harrisburg Blvd Station

Harrisburg Blvd 7000

Main Street

Main St 2121

Uptown/Upper Kirby

Southwest Fwy 2525

SW Agencia Autobuses

Southwest Fwy 6590

Kingston Pike

Kingston Pike 6927

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Transit Center

E Church Ave 301

Service and Comfort on the bus from Houston to Knoxville, TN

Want to know which seat classes are available on the buses from Houston to Knoxville, TN? Or which bus companies serve the route Houston to Knoxville, TN? Below you will find answers to your questions.

FAQs about the Houston to Knoxville, TN bus

How much does a Houston Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $111 and takes 28h 5m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from Houston to Knoxville, TN?

This route is offered by 3 companies with a range of ticket prices between $111 and $181. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from Houston to Knoxville, TN each day?

Every day, the Houston to Knoxville, TN bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Houston to Knoxville, TN take?

The fastest bus from Houston to Knoxville, TN is offered by Greyhound US and takes 23h 50m. Bus tickets for this connection cost $115. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Houston to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from Houston starts at 1:45 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Houston to Knoxville, TN?

The latest bus trip departing from Houston for Knoxville, TN starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Houston Knoxville, TN route?

When traveling by bus from Houston to Knoxville, TN, passengers can travel with FlixBus, Greyhound US and Valley Transit. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Houston and Knoxville, TN?

You can check all the direct connections between Houston and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Greyhound US and Valley Transit.

What can I take with me on the Houston to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Houston Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Houston Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Houston to Knoxville, TN on your planned travel date.

How does CheckMyBus find the best bus deals from Houston to Knoxville, TN?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between Houston and Knoxville, TN. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Houston to Knoxville, TN?

Prices and availability for 5 trips between Houston and Knoxville, TN change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Houston to Knoxville, TN

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Houston and to Knoxville, TN

Here’s an overview of the most popular bus routes to Houston and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!