Compare all timetables for the bus from Chicago to Knoxville, TN
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 15h 30m | 6:10 AM | Chicago | Downtown Bus Station | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $90 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 6/10/2026 6:10:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/10/2026 10:40:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 15h 30m
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| FlixBus | 16h 15m | 5:25 AM | Chicago | 95th Red Line Station | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $105 |
A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 6/10/2026 5:25:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/10/2026 10:40:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 16h 15m
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| FlixBus | 21h 50m | 11:50 PM | Chicago | 95th Red Line Station | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $105 |
A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 6/10/2026 11:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/11/2026 10:40:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 21h 50m
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| Greyhound US | 19h 40m | 10:50 PM | Chicago | Downtown Bus Station | 7:30 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $113 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 6/10/2026 10:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/11/2026 7:30:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 19h 40m
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| Greyhound US | 19h 20m | 11:10 PM | Chicago | Canal & Van Buren | 7:30 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $113 |
A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 6/10/2026 11:10:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/11/2026 7:30:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 19h 20m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 15h 30m | 6:10 AM | Chicago | Downtown Bus Station | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $86 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 6/11/2026 6:10:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/11/2026 10:40:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 15h 30m
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| Greyhound US | 19h 40m | 10:50 PM | Chicago | Downtown Bus Station | 7:30 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $90 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 6/11/2026 10:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/12/2026 7:30:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 19h 40m
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| FlixBus | 16h 15m | 5:25 AM | Chicago | 95th Red Line Station | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $91 |
A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 6/11/2026 5:25:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/11/2026 10:40:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 16h 15m
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| FlixBus | 21h 50m | 11:50 PM | Chicago | 95th Red Line Station | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $91 |
A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 6/11/2026 11:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/12/2026 10:40:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 21h 50m
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| Greyhound US | 19h 20m | 11:10 PM | Chicago | Canal & Van Buren | 7:30 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $92 |
A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 6/11/2026 11:10:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/12/2026 7:30:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 19h 20m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 21h 50m | 11:50 PM | Chicago | 95th Red Line Station | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $118 |
A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 6/12/2026 11:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/13/2026 10:40:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 21h 50m
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| FlixBus | 16h 15m | 5:25 AM | Chicago | 95th Red Line Station | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $121 |
A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 6/12/2026 5:25:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/12/2026 10:40:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 16h 15m
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| Greyhound US | 18h 45m | 11:45 PM | Chicago | 95th Red Line Station | 7:30 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $123 |
A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 6/12/2026 11:45:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/13/2026 7:30:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 18h 45m
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| Greyhound US | 15h 30m | 6:10 AM | Chicago | Downtown Bus Station | 10:40 PM | Knoxville, TN | Greyhound Bus Station | Economy | $133 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 6/12/2026 6:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 6/12/2026 10:40:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 15h 30m
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| Greyhound US | 19h 40m | 10:50 PM | Chicago | Downtown Bus Station | 7:30 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $134 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 6/12/2026 10:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/13/2026 7:30:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 19h 40m
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Greyhound US19h 20m011:10 PMChicagoCanal & Van Buren3:35 PMLexington, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 6/13/2026 11:10:00 PM to Greyhound Bus Station, Lexington, KY (USA) arriving at 6/14/2026 3:35:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 15h 25m
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Greyhound US3h 45m03:45 PMLexington, KYGreyhound Bus Station7:30 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Lexington, KY (USA) at 6/14/2026 3:45:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/14/2026 7:30:00 PM. 50 Economy ticket for $31 per person are available. Travel duration is 3h 45m
Waiting Time 0h 10m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 15h 30m | 6:10 AM | Chicago | Downtown Bus Station | 10:40 PM | Knoxville, TN | Greyhound Bus Station | Economy | $97 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 6/13/2026 6:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 6/13/2026 10:40:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 15h 30m
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| Greyhound US | 19h 40m | 10:50 PM | Chicago | Downtown Bus Station | 7:30 PM | Knoxville, TN | Greyhound Bus Station | Economy | $97 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 6/13/2026 10:50:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 6/14/2026 7:30:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 19h 40m
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| Greyhound US | 19h 20m | 11:10 PM | Chicago | Union Station | 7:30 PM | Knoxville, TN | Greyhound Bus Station | Economy | $97 |
A Bus from Greyhound US goes from Union Station, Chicago (USA) at 6/13/2026 11:10:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 6/14/2026 7:30:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 19h 20m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 15h 30m | 6:10 AM | Chicago | Downtown Bus Station | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $108 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 6/14/2026 6:10:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/14/2026 10:40:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 15h 30m
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| FlixBus | 16h 15m | 5:25 AM | Chicago | 95th Red Line Station | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $111 |
A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 6/14/2026 5:25:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/14/2026 10:40:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 16h 15m
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| FlixBus | 21h 50m | 11:50 PM | Chicago | 95th Red Line Station | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $111 |
A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 6/14/2026 11:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/15/2026 10:40:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 21h 50m
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| Greyhound US | 19h 40m | 10:50 PM | Chicago | Downtown Bus Station | 7:30 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $121 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 6/14/2026 10:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/15/2026 7:30:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 19h 40m
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| Greyhound US | 19h 20m | 11:10 PM | Chicago | Canal & Van Buren | 7:30 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $121 |
A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 6/14/2026 11:10:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/15/2026 7:30:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 19h 20m
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Greyhound US19h 20m011:10 PMChicagoCanal & Van Buren3:35 PMLexington, KYGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 6/13/2026 11:10:00 PM to Greyhound Bus Station, Lexington, KY (USA) arriving at 6/14/2026 3:35:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 15h 25m
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Greyhound US3h 45m03:45 PMLexington, KYGreyhound Bus Station7:30 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Lexington, KY (USA) at 6/14/2026 3:45:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/14/2026 7:30:00 PM. 50 Economy ticket for $31 per person are available. Travel duration is 3h 45m
Waiting Time 0h 10m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 15h 30m | 6:10 AM | Chicago | Downtown Bus Station | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $90 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 6/16/2026 6:10:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/16/2026 10:40:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 15h 30m
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| FlixBus | 16h 15m | 5:25 AM | Chicago | 95th Red Line Station | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $99 |
A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 6/16/2026 5:25:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/16/2026 10:40:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 16h 15m
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| FlixBus | 21h 50m | 11:50 PM | Chicago | 95th Red Line Station | 10:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $99 |
A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 6/16/2026 11:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/17/2026 10:40:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 21h 50m
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| Greyhound US | 19h 40m | 10:50 PM | Chicago | Downtown Bus Station | 7:30 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $101 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 6/16/2026 10:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/17/2026 7:30:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 19h 40m
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| Greyhound US | 19h 20m | 11:10 PM | Chicago | Canal & Van Buren | 7:30 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | Economy | $101 |
A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 6/16/2026 11:10:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/17/2026 7:30:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 19h 20m
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Best Price Offer: The price for the cheapest bus from Chicago to Knoxville, TN is $85 on 6/8/2026. Flexible travelers save on ticket prices.
Frequency of bus connections between Chicago and Knoxville, TN
Facts about the bus from Chicago to Knoxville, TN
Compare all providers like Greyhound US and FlixBus that travel 8 times every day by bus from Chicago to Knoxville, TN in one click! Book your bus ticket from Chicago to Knoxville, TN starting from $85!
| Cheapest Bus | $85 |
| Fastest Bus | 16h 30m |
| Earliest Bus | 5:25 AM |
| Latest Bus | 11:50 PM |
| Daily Bus Routes | 8 Ø |
| Distance | 455.0 miles |
| Bus Companies | Greyhound US and FlixBus |
Cheapest bus connections from Chicago to Knoxville, TN
Every day, 8 buses from 2 bus companies leave Chicago for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/10/2026 and for the following days.
The cheapest time to travel from Chicago to Knoxville, TN
How to save money travelling from Chicago to Knoxville, TN
Book the ticket from Chicago to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to Knoxville, TN are also emptier.Beloved bus companies from Chicago to Knoxville, TN
FlixBus from Chicago to Knoxville, TN
Here you will find the key facts about the FlixBus bus route Chicago to Knoxville, TN:
| Cheapest Price | $91 |
| Fastest Bus | 17h 15m |
| Earliest Bus | 5:25 AM |
| Last Bus | 11:50 PM |
| Daily Connections | 3 Ø |
| Found on | 6/4/2026 |
Greyhound US from Chicago to Knoxville, TN
Here you will find the key facts about the Greyhound US bus route Chicago to Knoxville, TN:
| Cheapest Price | $86 |
| Fastest Bus | 16h 30m |
| Earliest Bus | 6:10 AM |
| Last Bus | 11:45 PM |
| Daily Connections | 6 Ø |
| Found on | 6/4/2026 |
All bus stations and stops in Chicago and Knoxville, TN
In the map below, you can see where to find all bus stations in Chicago and Knoxville, TN.
Service and Comfort on the bus from Chicago to Knoxville, TN
FAQs about the Chicago to Knoxville, TN bus
How much does a Chicago Knoxville, TN bus trip cost?
How much could I save by comparing buses from Chicago to Knoxville, TN?
On average, how many connections are available from Chicago to Knoxville, TN each day?
How long does a bus journey from Chicago to Knoxville, TN take?
What time is the first bus from Chicago to Knoxville, TN?
What time is the last bus from Chicago to Knoxville, TN?
Which bus companies operate the Chicago Knoxville, TN route?
Is there a direct bus between Chicago and Knoxville, TN?
What can I take with me on the Chicago to Knoxville, TN bus route?
What equipment is available for the Chicago Knoxville, TN bus route?
How does CheckMyBus find the best bus deals from Chicago to Knoxville, TN?
How does CheckMyBus technology work for trips from Chicago to Knoxville, TN?
Available seat classes which are offered on the bus route Chicago to Knoxville, TN
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
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