Bus Chicago to Knoxville, TN - Compare all Companies

Compare all timetables for the bus from Chicago to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from Chicago to Knoxville, TN from various bus operators like Greyhound US or FlixBus for the next days.

today

$118

tomorrow

$100

Tuesday

$97

Wednesday

Thursday

Friday

$138

Saturday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	18h 45m	11:10 PM	Chicago	Canal & Van Buren	6:55 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$118	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 12/14/2025 11:10:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/15/2025 6:55:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 18h 45m
Greyhound US	19h 5m	10:50 PM	Chicago	Downtown Bus Station	6:55 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$119	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/14/2025 10:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/15/2025 6:55:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 19h 5m
Greyhound US	15h 30m	6:10 AM	Chicago	Downtown Bus Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$123	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/14/2025 6:10:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/14/2025 10:40:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 15h 30m
FlixBus	21h 50m	11:50 PM	Chicago	95th Red Line Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$132	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/14/2025 11:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/15/2025 10:40:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 21h 50m
FlixBus	16h 15m	5:25 AM	Chicago	95th Red Line Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$133	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/14/2025 5:25:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/14/2025 10:40:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 16h 15m

Did you know that if you travel from Chicago to Knoxville, TN via Cincinnati, you can save more than $21? You can find the corresponding connections below.
- Busbud
  
  18h 15m
  
  0
  
  11:40 PM
  
  Chicago
  95th Red Line Station
  
  12:40 PM
  
  Cincinnati
  E Galbraith Rd
  
  0
  
  Economy
  
  $53
  
  A Bus from Busbud goes from 95th Red Line Station, Chicago (USA) at 12/15/2025 11:40:00 PM to E Galbraith Rd, Cincinnati (USA) arriving at 12/16/2025 12:40:00 PM. 50 Economy ticket for $53 per person are available. Travel duration is 12h 0m
- FlixBus
  
  5h 35m
  
  0
  
  1:20 PM
  
  Cincinnati
  Greyhound Bus Station
  
  6:55 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  0
  
  Economy
  
  $44
  
  A Bus from FlixBus goes from Greyhound Bus Station, Cincinnati (USA) at 12/16/2025 1:20:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/16/2025 6:55:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 5h 35m
Travel time is 1h 45m longer, but you will save $21

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 30m	6:10 AM	Chicago	Downtown Bus Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$100	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/15/2025 6:10:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/15/2025 10:40:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 15h 30m
Greyhound US	18h 45m	11:10 PM	Chicago	Canal & Van Buren	6:55 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$101	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 12/15/2025 11:10:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/16/2025 6:55:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 18h 45m
Greyhound US	19h 5m	10:50 PM	Chicago	Downtown Bus Station	6:55 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$102	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/15/2025 10:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/16/2025 6:55:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 19h 5m
FlixBus	16h 15m	5:25 AM	Chicago	95th Red Line Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$125	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/15/2025 5:25:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/15/2025 10:40:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 16h 15m
FlixBus	21h 50m	11:50 PM	Chicago	95th Red Line Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$125	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/15/2025 11:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/16/2025 10:40:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 21h 50m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	18h 45m	11:10 PM	Chicago	Union Station	6:55 PM	Knoxville, TN	Greyhound Bus Station	Economy	$97	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/16/2025 11:10:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/17/2025 6:55:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 18h 45m
Greyhound US	19h 5m	10:50 PM	Chicago	Downtown Bus Station	6:55 PM	Knoxville, TN	Greyhound Bus Station	Economy	$98	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/16/2025 10:50:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/17/2025 6:55:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 19h 5m
Greyhound US	15h 30m	6:10 AM	Chicago	Downtown Bus Station	10:40 PM	Knoxville, TN	Greyhound Bus Station	Economy	$112	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/16/2025 6:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/16/2025 10:40:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 15h 30m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	18h 45m	11:10 PM	Chicago	Union Station	6:55 PM	Knoxville, TN	Greyhound Bus Station	Economy	$138	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/19/2025 11:10:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/20/2025 6:55:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 18h 45m
Greyhound US	19h 5m	10:50 PM	Chicago	Downtown Bus Station	6:55 PM	Knoxville, TN	Greyhound Bus Station	Economy	$139	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/19/2025 10:50:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/20/2025 6:55:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 19h 5m
Greyhound US	15h 30m	6:10 AM	Chicago	Downtown Bus Station	10:40 PM	Knoxville, TN	Greyhound Bus Station	Economy	$152	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/19/2025 6:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/19/2025 10:40:00 PM. 50 Economy ticket for $152 per person are available. Travel duration is 15h 30m

Did you know that if you travel from Chicago to Knoxville, TN via Cincinnati, you can save more than $42? You can find the corresponding connections below.
- Busbud
  
  18h 15m
  
  0
  
  11:40 PM
  
  Chicago
  95th Red Line Station
  
  12:40 PM
  
  Cincinnati
  E Galbraith Rd
  
  0
  
  Economy
  
  $46
  
  A Bus from Busbud goes from 95th Red Line Station, Chicago (USA) at 12/18/2025 11:40:00 PM to E Galbraith Rd, Cincinnati (USA) arriving at 12/19/2025 12:40:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 12h 0m
- FlixBus
  
  5h 35m
  
  0
  
  1:20 PM
  
  Cincinnati
  Greyhound Bus Station
  
  6:55 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  0
  
  Economy
  
  $50
  
  A Bus from FlixBus goes from Greyhound Bus Station, Cincinnati (USA) at 12/19/2025 1:20:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/19/2025 6:55:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 5h 35m
Travel time is 1h 45m longer, but you will save $42

Best Price Offer: The price for the cheapest bus from Chicago to Knoxville, TN is $90 on 1/9/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Chicago and Knoxville, TN

See here how frequent the connections between Chicago and Knoxville, TN are, during different times and days of the week.

Sunday is the busiest day, with more than 12 daily buses from Chicago to Knoxville, TN. Tuesday has instead the fewest connections, with only 3 daily coaches between Chicago and Knoxville, TN.

The busiest time of the day is the Evening, with 20 buses from Chicago to Knoxville, TN, while Night sees the fewest connections between Chicago and Knoxville, TN, with 4 offers.

Facts about the bus from Chicago to Knoxville, TN

Compare all providers like Greyhound US and FlixBus that travel 7 times every day by bus from Chicago to Knoxville, TN in one click! Book your bus ticket from Chicago to Knoxville, TN starting from $90!

Cheapest Bus	$90
Fastest Bus	16h 30m
Earliest Bus	5:25 AM
Latest Bus	11:10 PM
Daily Bus Routes	7 Ø
Distance	455.0 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Chicago to Knoxville, TN

Every day, 7 buses from 2 bus companies leave Chicago for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/14/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

$118

Monday 12/15

$100

Tuesday 12/16

$97

Wednesday 12/17

Thursday 12/18

Friday 12/19

$138

Saturday 12/20

Sunday 12/21

$172

Monday 12/22

Tuesday 12/23

$162

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

$124

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

$90

Friday 01/09

$90

Saturday 01/10

The cheapest time to travel from Chicago to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to Knoxville, TN, for the next 30 days.

With a price starting from $90, Friday is the cheapest day for a bus from Chicago to Knoxville, TN. Sunday instead is the most expensive day with prices starting from $118.

Night is the cheapest day time for bus tickets from Chicago to Knoxville, TN, with $90. Morning is the most expensive time of the day with prices starting from $100.

How to save money travelling from Chicago to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to Knoxville, TN are also emptier.

Beloved bus companies from Chicago to Knoxville, TN

These are the most booked bus companies between Chicago to Knoxville, TN from our users.

Greyhound US from Chicago to Knoxville, TN

Here you will find the key facts about the Greyhound US bus route Chicago to Knoxville, TN:

Cheapest Price	$97
Fastest Bus	16h 30m
Earliest Bus	6:10 AM
Last Bus	11:10 PM
Daily Connections	5 Ø
Found on	12/12/2025

All bus stations and stops in Chicago and Knoxville, TN

In the map below, you can see where to find all bus stations in Chicago and Knoxville, TN.

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Kingston Pike

Kingston Pike 6927

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Transit Center

E Church Ave 301

Service and Comfort on the bus from Chicago to Knoxville, TN

Want to know which seat classes are available on the buses from Chicago to Knoxville, TN? Or which bus companies serve the route Chicago to Knoxville, TN? Below you will find answers to your questions.

FAQs about the Chicago to Knoxville, TN bus

How much does a Chicago Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $90 and takes 19h 45m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from Chicago to Knoxville, TN?

This route is offered by 2 companies with a range of ticket prices between $90 and $152. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from Chicago to Knoxville, TN each day?

Every day, the Chicago to Knoxville, TN bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to Knoxville, TN take?

The fastest bus from Chicago to Knoxville, TN is offered by Greyhound US and takes 16h 30m. Bus tickets for this connection cost $127. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from Chicago starts at 5:25 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to Knoxville, TN?

The latest bus trip departing from Chicago for Knoxville, TN starts at 11:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago Knoxville, TN route?

When traveling by bus from Chicago to Knoxville, TN, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and Knoxville, TN?

You can check all the direct connections between Chicago and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Chicago to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to Knoxville, TN on your planned travel date.

How does CheckMyBus find the best bus deals from Chicago to Knoxville, TN?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between Chicago and Knoxville, TN. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Chicago to Knoxville, TN?

Prices and availability for 7 trips between Chicago and Knoxville, TN change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Chicago to Knoxville, TN

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to Knoxville, TN

Here’s an overview of the most popular bus routes to Chicago and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!