Which bus from Chicago to Knoxville, TN is the cheapest?

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Compare all timetables for the bus from Chicago to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from Chicago to Knoxville, TN from various bus operators like Greyhound US or FlixBus for the next days.

today
$161
tomorrow
Monday
Tuesday
$124
Wednesday
Thursday
Friday
$113

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 15h 30m 6:10 AM Chicago Downtown Bus Station 10:40 PM Knoxville, TN Greyhound Bus Station  Economy $161
Greyhound US 19h 40m 10:50 PM Chicago Downtown Bus Station 7:30 PM Knoxville, TN Greyhound Bus Station  Economy $162
Greyhound US 26h 15m 2:45 PM Chicago Downtown Bus Station 6:00 PM Knoxville, TN Greyhound Bus Station  Economy $163
Greyhound US 19h 20m 11:10 PM Chicago Union Station 7:30 PM Knoxville, TN Greyhound Bus Station  Economy $163
  • Did you know that if you travel from Chicago to Knoxville, TN via Indianapolis, you can save more than $52? You can find the corresponding connections below.
    • Busbud
      15h 30m
      0
      6:10 AM
      Chicago
      Downtown Bus Station
      10:55 AM
      Indianapolis
      Central Bus Station
      0
      Busbud
      Economy
      $33
      • Waiting Time 0h 30m
    • FlixBus
      11h 15m
      0
      11:25 AM
      Indianapolis
      Central Bus Station
      10:40 PM
      Knoxville, TN
      Greyhound Bus Station
      0
      FlixBus
      Economy
      $76
    Travel Time is 1h 0m shorter, and you will save $52

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 15h 30m 6:10 AM Chicago Downtown Bus Station 10:40 PM Knoxville, TN Knoxville Area Transit Bus Stop  Economy $124
Greyhound US 19h 40m 10:50 PM Chicago Downtown Bus Station 7:30 PM Knoxville, TN Knoxville Area Transit Bus Stop  Economy $124
Greyhound US 26h 15m 2:45 PM Chicago Downtown Bus Station 6:00 PM Knoxville, TN Knoxville Area Transit Bus Stop  Economy $125
FlixBus 16h 15m 5:25 AM Chicago 95th Red Line Station 10:40 PM Knoxville, TN Greyhound Bus Station  Economy $128
FlixBus 21h 50m 11:50 PM Chicago 95th Red Line Station 10:40 PM Knoxville, TN Greyhound Bus Station  Economy $128
  • Did you know that if you travel from Chicago to Knoxville, TN via Indianapolis, you can save more than $15? You can find the corresponding connections below.
    • Busbud
      15h 30m
      0
      6:10 AM
      Chicago
      Downtown Bus Station
      10:55 AM
      Indianapolis
      Central Bus Station
      0
      Busbud
      Economy
      $33
      • Waiting Time 0h 30m
    • FlixBus
      11h 15m
      0
      11:25 AM
      Indianapolis
      Central Bus Station
      10:40 PM
      Knoxville, TN
      Greyhound Bus Station
      0
      FlixBus
      Economy
      $76
    Travel Time is 1h 0m shorter, and you will save $15

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 26h 15m 2:45 PM Chicago Downtown Bus Station 6:00 PM Knoxville, TN Greyhound Bus Station  Economy $113
Greyhound US 19h 20m 11:10 PM Chicago Union Station 7:30 PM Knoxville, TN Greyhound Bus Station  Economy $116
Greyhound US 19h 40m 10:50 PM Chicago Downtown Bus Station 7:30 PM Knoxville, TN Greyhound Bus Station  Economy $118
Greyhound US 15h 30m 6:10 AM Chicago Downtown Bus Station 10:40 PM Knoxville, TN Greyhound Bus Station  Economy $119
  • Did you know that if you travel from Chicago to Knoxville, TN via Louisville, KY, you can save more than $11? You can find the corresponding connections below.
    • FlixBus
      15h 30m
      0
      6:10 AM
      Chicago
      Downtown Bus Station
      1:25 PM
      Louisville, KY
      Greyhound Bus Station
      0
      FlixBus
      Economy
      $50
      • Waiting Time 0h 55m
    • FlixBus
      8h 20m
      0
      2:20 PM
      Louisville, KY
      Greyhound Bus Station
      10:40 PM
      Knoxville, TN
      Greyhound Bus Station
      0
      FlixBus
      Economy
      $52
    Travel Time is 1h 0m shorter, and you will save $11

Best Price Offer: The price for the cheapest bus from Chicago to Knoxville, TN is $75 on 2/23/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Chicago and Knoxville, TN

See here how frequent the connections between Chicago and Knoxville, TN are, during different times and days of the week.
Tuesday is the busiest day, with more than 14 daily buses from Chicago to Knoxville, TN. Friday has instead the fewest connections, with only 4 daily coaches between Chicago and Knoxville, TN.
The busiest time of the day is the Evening, with 12 buses from Chicago to Knoxville, TN, while Night sees the fewest connections between Chicago and Knoxville, TN, with 2 offers.

Facts about the bus from Chicago to Knoxville, TN

Compare all providers like Greyhound US and FlixBus that travel 7 times every day by bus from Chicago to Knoxville, TN in one click! Book your bus ticket from Chicago to Knoxville, TN starting from $75!

Cheapest Bus $75
Fastest Bus 16h 30m
Earliest Bus 6:10 AM
Latest Bus 11:10 PM
Daily Bus Routes 7 Ø
Distance 455.0 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from Chicago to Knoxville, TN

Every day, 7 buses from 2 bus companies leave Chicago for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/07/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 02/01
Monday 02/02
Tuesday 02/03
Wednesday 02/04
Thursday 02/05
Friday 02/06
Saturday 02/07
$161
Sunday 02/08
Monday 02/09
Tuesday 02/10
$152
Wednesday 02/11
Thursday 02/12
Friday 02/13
$113
Saturday 02/14
$142
Sunday 02/15
$86
Monday 02/16
Tuesday 02/17
Wednesday 02/18
Thursday 02/19
Friday 02/20
$87
Saturday 02/21
Sunday 02/22
$86
Monday 02/23
$75
Tuesday 02/24
Wednesday 02/25
Thursday 02/26
Friday 02/27
$89
Saturday 02/28

The cheapest time to travel from Chicago to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to Knoxville, TN, for the next 30 days.
With a price starting from $87, Friday is the cheapest day for a bus from Chicago to Knoxville, TN. Saturday instead is the most expensive day with prices starting from $142.
Night is the cheapest day time for bus tickets from Chicago to Knoxville, TN, with $75. Morning is the most expensive time of the day with prices starting from $119.

How to save money travelling from Chicago to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to Knoxville, TN are also emptier.

Beloved bus companies from Chicago to Knoxville, TN

These are the most booked bus companies between Chicago to Knoxville, TN from our users.

Greyhound US from Chicago to Knoxville, TN

Greyhound US

Here you will find the key facts about the Greyhound US bus route Chicago to Knoxville, TN:

Cheapest Price $113
Fastest Bus 16h 30m
Earliest Bus 6:10 AM
Last Bus 11:10 PM
Daily Connections 6 Ø
Found on 2/4/2026

FlixBus from Chicago to Knoxville, TN

FlixBus

Here you will find the key facts about the FlixBus bus route Chicago to Knoxville, TN:

Cheapest Price $128
Fastest Bus 17h 15m
Earliest Bus 5:25 AM
Last Bus 11:50 PM
Daily Connections 4 Ø
Found on 1/20/2026

All bus stations and stops in Chicago and Knoxville, TN

In the map below, you can see where to find all bus stations in Chicago and Knoxville, TN.

Service and Comfort on the bus from Chicago to Knoxville, TN

Want to know which seat classes are available on the buses from Chicago to Knoxville, TN? Or which bus companies serve the route Chicago to Knoxville, TN? Below you will find answers to your questions.

FAQs about the Chicago to Knoxville, TN bus

How much does a Chicago Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $75 and takes 27h 15m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from Chicago to Knoxville, TN?

This route is offered by 2 companies with a range of ticket prices between $75 and $163. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from Chicago to Knoxville, TN each day?

Every day, the Chicago to Knoxville, TN bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to Knoxville, TN take?

The fastest bus from Chicago to Knoxville, TN is offered by Greyhound US and takes 16h 30m. Bus tickets for this connection cost $161. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from Chicago starts at 6:10 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to Knoxville, TN?

The latest bus trip departing from Chicago for Knoxville, TN starts at 11:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago Knoxville, TN route?

When traveling by bus from Chicago to Knoxville, TN, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and Knoxville, TN?

You can check all the direct connections between Chicago and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Chicago to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to Knoxville, TN on your planned travel date.

How does CheckMyBus find the best bus deals from Chicago to Knoxville, TN?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between Chicago and Knoxville, TN. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Chicago to Knoxville, TN?

Prices and availability for 7 trips between Chicago and Knoxville, TN change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Chicago to Knoxville, TN

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to Knoxville, TN

Here’s an overview of the most popular bus routes to Chicago and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Bus Biloxi, MS to Knoxville, TN Bus Biloxi, MS to Knoxville, TN
Bus Hempstead, NY to Knoxville, TN Bus Hempstead, NY to Knoxville, TN
Bus Murfreesboro, TN to Knoxville, TN Bus Murfreesboro, TN to Knoxville, TN
Bus Toronto, ON to Knoxville, TN Bus Toronto, ON to Knoxville, TN
Popular Airport Shuttles to Chicago and to Knoxville, TN
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