Bus Chicago to Knoxville, TN - Compare all Companies

Compare all timetables for the bus from Chicago to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from Chicago to Knoxville, TN from various bus operators like Greyhound US or FlixBus for the next days.

today

$106

tomorrow

$94

Tuesday

Wednesday

$78

Thursday

Friday

$78

Saturday

$77

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 20m	6:10 AM	Chicago	Downtown Bus Station	10:30 PM	Knoxville, TN	Greyhound Bus Station	Economy	$106	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/20/2026 6:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 9/20/2026 10:30:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 15h 20m
Greyhound US	20h 0m	10:50 PM	Chicago	Downtown Bus Station	7:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$124	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/20/2026 10:50:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 9/21/2026 7:50:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 20h 0m
Greyhound US	19h 40m	11:10 PM	Chicago	Union Station	7:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$124	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 9/20/2026 11:10:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 9/21/2026 7:50:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 19h 40m

Did you know that if you travel from Chicago to Knoxville, TN via Nashville, you can save more than $20? You can find the corresponding connections below.
- Greyhound US
  
  15h 20m
  
  0
  
  6:10 AM
  
  Chicago
  Downtown Bus Station
  
  4:05 PM
  
  Nashville
  5th Ave South Station
  
  0
  
  Economy
  
  $52
  
  A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/21/2026 6:10:00 AM to 5th Ave South Station, Nashville (USA) arriving at 9/21/2026 4:05:00 PM. 50 Economy ticket for $52 per person are available. Travel duration is 9h 55m
- Greyhound US
  
  3h 15m
  
  0
  
  6:15 PM
  
  Nashville
  5th Ave South Station
  
  10:30 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  0
  
  Economy
  
  $34
  
  A Bus from Greyhound US goes from 5th Ave South Station, Nashville (USA) at 9/21/2026 6:15:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 9/21/2026 10:30:00 PM. 50 Economy ticket for $34 per person are available. Travel duration is 3h 15m
Travel Time is 1h 0m shorter, and you will save $20

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 20m	6:10 AM	Chicago	Downtown Bus Station	10:30 PM	Knoxville, TN	Greyhound Bus Station	Economy	$94	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/21/2026 6:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 9/21/2026 10:30:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 15h 20m
Greyhound US	19h 40m	11:10 PM	Chicago	Union Station	7:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$105	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 9/21/2026 11:10:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 9/22/2026 7:50:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 19h 40m
Greyhound US	20h 0m	10:50 PM	Chicago	Downtown Bus Station	7:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$106	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/21/2026 10:50:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 9/22/2026 7:50:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 20h 0m

Did you know that if you travel from Chicago to Knoxville, TN via Indianapolis, you can save more than $9? You can find the corresponding connections below.
- Greyhound US
  
  15h 20m
  
  0
  
  6:10 AM
  
  Chicago
  Downtown Bus Station
  
  10:45 AM
  
  Indianapolis
  Central Bus Station
  
  0
  
  Economy
  
  $27
  
  A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/23/2026 6:10:00 AM to Central Bus Station, Indianapolis (USA) arriving at 9/23/2026 10:45:00 AM. 50 Economy ticket for $27 per person are available. Travel duration is 3h 35m
- Greyhound US
  
  11h 15m
  
  0
  
  11:15 AM
  
  Indianapolis
  Central Bus Station
  
  10:30 PM
  
  Knoxville, TN
  Knoxville Area Transit Bus Stop
  
  0
  
  Economy
  
  $58
  
  A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 9/23/2026 11:15:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 9/23/2026 10:30:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 11h 15m
Travel Time is 1h 0m shorter, and you will save $9

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 35m	11:55 PM	Chicago	95th Red Line Station	10:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$78	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/23/2026 11:55:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 9/24/2026 10:30:00 PM. 50 Economy ticket for $78 per person are available. Travel duration is 21h 35m
Greyhound US	15h 20m	6:10 AM	Chicago	Downtown Bus Station	10:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$87	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/23/2026 6:10:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 9/23/2026 10:30:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 15h 20m
Greyhound US	19h 10m	11:40 PM	Chicago	95th Red Line Station	7:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$89	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 9/23/2026 11:40:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 9/24/2026 7:50:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 19h 10m
Greyhound US	20h 0m	10:50 PM	Chicago	Downtown Bus Station	7:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$100	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/23/2026 10:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 9/24/2026 7:50:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 20h 0m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	16h 15m	5:15 AM	Chicago	95th Red Line Station	10:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$78	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/25/2026 5:15:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 9/25/2026 10:30:00 PM. 50 Economy ticket for $78 per person are available. Travel duration is 16h 15m
Greyhound US	19h 5m	11:45 PM	Chicago	95th Red Line Station	7:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$90	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 9/25/2026 11:45:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 9/26/2026 7:50:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 19h 5m
Greyhound US	15h 20m	6:10 AM	Chicago	Downtown Bus Station	10:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$91	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/25/2026 6:10:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 9/25/2026 10:30:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 15h 20m
Greyhound US	20h 0m	10:50 PM	Chicago	Downtown Bus Station	7:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$102	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/25/2026 10:50:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 9/26/2026 7:50:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 20h 0m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	16h 15m	5:15 AM	Chicago	95th Red Line Station	10:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$77	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/26/2026 5:15:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 9/26/2026 10:30:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 16h 15m
FlixBus	21h 35m	11:55 PM	Chicago	95th Red Line Station	10:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$77	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 9/26/2026 11:55:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 9/27/2026 10:30:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 21h 35m
Greyhound US	19h 10m	11:40 PM	Chicago	95th Red Line Station	7:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$81	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 9/26/2026 11:40:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 9/27/2026 7:50:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 19h 10m
Greyhound US	15h 20m	6:10 AM	Chicago	Downtown Bus Station	10:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$93	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 9/26/2026 6:10:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 9/26/2026 10:30:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 15h 20m
Greyhound US	19h 40m	11:10 PM	Chicago	Canal & Van Buren	7:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$97	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 9/26/2026 11:10:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 9/27/2026 7:50:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 19h 40m

Best Price Offer: The price for the cheapest bus from Chicago to Knoxville, TN is $77 on 9/26/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Chicago and Knoxville, TN

See here how frequent the connections between Chicago and Knoxville, TN are, during different times and days of the week.

Saturday is the busiest day, with more than 12 daily buses from Chicago to Knoxville, TN. Sunday has instead the fewest connections, with only 3 daily coaches between Chicago and Knoxville, TN.

The busiest time of the day is the Evening, with 26 buses from Chicago to Knoxville, TN, while Night sees the fewest connections between Chicago and Knoxville, TN, with 4 offers.

Facts about the bus from Chicago to Knoxville, TN

Compare all providers like Greyhound US and FlixBus that travel 7 times every day by bus from Chicago to Knoxville, TN in one click! Book your bus ticket from Chicago to Knoxville, TN starting from $77!

Cheapest Bus	$77
Fastest Bus	16h 20m
Earliest Bus	6:10 AM
Latest Bus	11:55 PM
Daily Bus Routes	7 Ø
Distance	455.0 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Chicago to Knoxville, TN

Every day, 7 buses from 2 bus companies leave Chicago for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 09/20

$106

Monday 09/21

$94

Tuesday 09/22

Wednesday 09/23

$78

Thursday 09/24

Friday 09/25

$78

Saturday 09/26

$77

Sunday 09/27

$79

Monday 09/28

Tuesday 09/29

Wednesday 09/30

Thursday 10/01

$87

Friday 10/02

$93

Saturday 10/03

$79

Sunday 10/04

Monday 10/05

Tuesday 10/06

Wednesday 10/07

$95

Thursday 10/08

$86

Friday 10/09

$94

Saturday 10/10

$106

Sunday 10/11

$106

Monday 10/12

Tuesday 10/13

Wednesday 10/14

$97

Thursday 10/15

$90

Friday 10/16

$99

Saturday 10/17

The cheapest time to travel from Chicago to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to Knoxville, TN, for the next 30 days.

With a price starting from $77, Saturday is the cheapest day for a bus from Chicago to Knoxville, TN. Monday instead is the most expensive day with prices starting from $94.

Evening is the cheapest day time for bus tickets from Chicago to Knoxville, TN, with $77. Morning is the most expensive time of the day with prices starting from $87.

How to save money travelling from Chicago to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to Knoxville, TN are also emptier.

Beloved bus companies from Chicago to Knoxville, TN

These are the most booked bus companies between Chicago to Knoxville, TN from our users.

Greyhound US from Chicago to Knoxville, TN

Here you will find the key facts about the Greyhound US bus route Chicago to Knoxville, TN:

Cheapest Price	$81
Fastest Bus	16h 20m
Earliest Bus	6:10 AM
Last Bus	11:40 PM
Daily Connections	6 Ø
Found on	9/13/2026

FlixBus from Chicago to Knoxville, TN

Here you will find the key facts about the FlixBus bus route Chicago to Knoxville, TN:

Cheapest Price	$77
Fastest Bus	17h 15m
Earliest Bus	11:55 PM
Last Bus	11:55 PM
Daily Connections	2 Ø
Found on	9/13/2026

All bus stations and stops in Chicago and Knoxville, TN

In the map below, you can see where to find all bus stations in Chicago and Knoxville, TN.

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Kingston Pike

Kingston Pike 6927

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Transit Center

E Church Ave 301

Greyhound Bus Station

E Magnolia Ave 100

Service and Comfort on the bus from Chicago to Knoxville, TN

Want to know which seat classes are available on the buses from Chicago to Knoxville, TN? Or which bus companies serve the route Chicago to Knoxville, TN? Below you will find answers to your questions.

FAQs about the Chicago to Knoxville, TN bus

How much does a Chicago Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $77 and takes 17h 15m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from Chicago to Knoxville, TN?

This route is offered by 2 companies with a range of ticket prices between $77 and $124. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from Chicago to Knoxville, TN each day?

Every day, the Chicago to Knoxville, TN bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to Knoxville, TN take?

The fastest bus from Chicago to Knoxville, TN is offered by Greyhound US and takes 16h 20m. Bus tickets for this connection cost $106. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from Chicago starts at 6:10 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to Knoxville, TN?

The latest bus trip departing from Chicago for Knoxville, TN starts at 11:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago Knoxville, TN route?

When traveling by bus from Chicago to Knoxville, TN, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and Knoxville, TN?

You can check all the direct connections between Chicago and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Chicago to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to Knoxville, TN on your planned travel date.

How does CheckMyBus find the best bus deals from Chicago to Knoxville, TN?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between Chicago and Knoxville, TN. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Chicago to Knoxville, TN?

Prices and availability for 7 trips between Chicago and Knoxville, TN change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Chicago to Knoxville, TN

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to Knoxville, TN

Here’s an overview of the most popular bus routes to Chicago and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!