Bus Detroit to Knoxville, TN - Compare all Companies

Compare all timetables for the bus from Detroit to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from Detroit to Knoxville, TN from various bus operators like Greyhound US for the next days.

today

$123

tomorrow

Sunday

$93

Monday

Tuesday

$87

Wednesday

$91

Thursday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 45m	8:15 PM	Detroit	Central Bus Station	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$123	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/19/2025 8:15:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/20/2025 6:00:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 21h 45m
Greyhound US	23h 15m	11:25 PM	Detroit	Central Bus Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$123	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/19/2025 11:25:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/20/2025 10:40:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 23h 15m
Greyhound US	20h 50m	10:05 PM	Detroit	Central Bus Station	6:55 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$125	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/19/2025 10:05:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/20/2025 6:55:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 20h 50m

Did you know that if you travel from Detroit to Knoxville, TN via Windsor, ON, you can save more than $28? You will find the corresponding connections below.
- FlixBus
  
  Save more than 23%
  
  22h 20m
  
  Detroit
  
  2 mi
  
  8:35 PM
  
  Windsor, ON
  International Transit Terminal
  
  6:55 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  0 mi
  
  Economy
  
  $95
  
  A Bus from FlixBus goes from International Transit Terminal, Windsor, ON (Canada) at 12/19/2025 8:35:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/20/2025 6:55:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 22h 20m
Did you know that if you travel from Detroit to Knoxville, TN via Cincinnati, you can save more than $27? You can find the corresponding connections below.
- Busbud
  
  23h 25m
  
  0
  
  7:30 PM
  
  Detroit
  Central Bus Station
  
  12:35 AM
  
  Cincinnati
  E Galbraith Rd
  
  0
  
  Economy
  
  $46
  
  A Bus from Busbud goes from Central Bus Station, Detroit (USA) at 12/20/2025 7:30:00 PM to E Galbraith Rd, Cincinnati (USA) arriving at 12/21/2025 12:35:00 AM. 50 Economy ticket for $46 per person are available. Travel duration is 5h 5m
- FlixBus
  
  5h 35m
  
  0
  
  1:20 PM
  
  Cincinnati
  Greyhound Bus Station
  
  6:55 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  0
  
  Economy
  
  $51
  
  A Bus from FlixBus goes from Greyhound Bus Station, Cincinnati (USA) at 12/21/2025 1:20:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/21/2025 6:55:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 5h 35m
Travel time is 2h 35m longer, but you will save $27

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	12h 15m	6:40 AM	Detroit	Central Bus Station	6:55 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$93	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/21/2025 6:40:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/21/2025 6:55:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 12h 15m
Greyhound US	20h 50m	10:05 PM	Detroit	Central Bus Station	6:55 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$144	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/21/2025 10:05:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/22/2025 6:55:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 20h 50m
Greyhound US	21h 45m	8:15 PM	Detroit	Central Bus Station	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$146	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/21/2025 8:15:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/22/2025 6:00:00 PM. 50 Economy ticket for $146 per person are available. Travel duration is 21h 45m
Greyhound US	23h 15m	11:25 PM	Detroit	Central Bus Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$147	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/21/2025 11:25:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/22/2025 10:40:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 23h 15m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	12h 15m	6:40 AM	Detroit	Central Bus Station	6:55 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$87	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/23/2025 6:40:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/23/2025 6:55:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 12h 15m
Greyhound US	20h 50m	10:05 PM	Detroit	Central Bus Station	6:55 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$121	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/23/2025 10:05:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/24/2025 6:55:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 20h 50m
Greyhound US	21h 45m	8:15 PM	Detroit	Central Bus Station	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$122	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/23/2025 8:15:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/24/2025 6:00:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 21h 45m
Greyhound US	23h 15m	11:25 PM	Detroit	Central Bus Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$129	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/23/2025 11:25:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/24/2025 10:40:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 23h 15m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	12h 15m	6:40 AM	Detroit	Central Bus Station	6:55 PM	Knoxville, TN	Greyhound Bus Station	Economy	$91	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/24/2025 6:40:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/24/2025 6:55:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 12h 15m
Greyhound US	21h 45m	8:15 PM	Detroit	Central Bus Station	6:00 PM	Knoxville, TN	Greyhound Bus Station	Economy	$123	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/24/2025 8:15:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/25/2025 6:00:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 21h 45m
Greyhound US	20h 50m	10:05 PM	Detroit	Central Bus Station	6:55 PM	Knoxville, TN	Greyhound Bus Station	Economy	$125	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/24/2025 10:05:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/25/2025 6:55:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 20h 50m
Greyhound US	23h 15m	11:25 PM	Detroit	Central Bus Station	10:40 PM	Knoxville, TN	Greyhound Bus Station	Economy	$126	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/24/2025 11:25:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/25/2025 10:40:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 23h 15m

Best Price Offer: The price for the cheapest bus from Detroit to Knoxville, TN is $66 on 1/6/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Detroit and Knoxville, TN

See here how frequent the connections between Detroit and Knoxville, TN are, during different times and days of the week.

Sunday is the busiest day, with more than 8 daily buses from Detroit to Knoxville, TN. Wednesday has instead the fewest connections, with only 4 daily coaches between Detroit and Knoxville, TN.

The busiest time of the day is the Evening, with 21 buses from Detroit to Knoxville, TN, while Morning sees the fewest connections between Detroit and Knoxville, TN, with 5 offers.

Facts about the bus from Detroit to Knoxville, TN

Compare all providers like Greyhound US that travel 6 times every day by bus from Detroit to Knoxville, TN in one click! Book your bus ticket from Detroit to Knoxville, TN starting from $66!

Cheapest Bus	$66
Fastest Bus	12h 15m
Earliest Bus	8:15 PM
Latest Bus	11:25 PM
Daily Bus Routes	6 Ø
Distance	442.5 miles
Bus Companies	Greyhound US

Cheapest bus connections from Detroit to Knoxville, TN

Every day, 6 buses from 1 bus companies leave Detroit for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/19/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

$94

Saturday 12/20

Sunday 12/21

$102

Monday 12/22

Tuesday 12/23

$130

Wednesday 12/24

$91

Thursday 12/25

Friday 12/26

$118

Saturday 12/27

Sunday 12/28

$105

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

$66

Wednesday 01/07

Thursday 01/08

Friday 01/09

$68

Saturday 01/10

The cheapest time to travel from Detroit to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from Detroit to Knoxville, TN, for the next 30 days.

With a price starting from $66, Tuesday is the cheapest day for a bus from Detroit to Knoxville, TN. Wednesday instead is the most expensive day with prices starting from $91.

Morning is the cheapest day time for bus tickets from Detroit to Knoxville, TN, with $87. Evening is the most expensive time of the day with prices starting from $121.

How to save money travelling from Detroit to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Detroit to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Detroit to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Detroit to Knoxville, TN are also emptier.

Beloved bus companies from Detroit to Knoxville, TN

These are the most booked bus companies between Detroit to Knoxville, TN from our users.

Greyhound US from Detroit to Knoxville, TN

Here you will find the key facts about the Greyhound US bus route Detroit to Knoxville, TN:

Cheapest Price	$87
Fastest Bus	12h 15m
Earliest Bus	8:15 PM
Last Bus	11:25 PM
Daily Connections	6 Ø
Found on	12/16/2025

All bus stations and stops in Detroit and Knoxville, TN

In the map below, you can see where to find all bus stations in Detroit and Knoxville, TN.

Central Bus Station

Howard St 1001

Amtrak

W Baltimore Ave 78

VA Medical Center Blue Deck

East Canfield Street (between John R. and Brush St.) 225

Park Avenue

Rosa Parks TC

Cass Ave 1310

Kingston Pike

Kingston Pike 6927

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Transit Center

E Church Ave 301

Service and Comfort on the bus from Detroit to Knoxville, TN

Want to know which seat classes are available on the buses from Detroit to Knoxville, TN? Or which bus companies serve the route Detroit to Knoxville, TN? Below you will find answers to your questions.

FAQs about the Detroit to Knoxville, TN bus

How much does a Detroit Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $66 and takes 12h 15m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from Detroit to Knoxville, TN?

This route is offered by 1 companies with a range of ticket prices between $66 and $156. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from Detroit to Knoxville, TN each day?

Every day, the Detroit to Knoxville, TN bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Detroit to Knoxville, TN take?

The fastest bus from Detroit to Knoxville, TN is offered by Greyhound US and takes 12h 15m. Bus tickets for this connection cost $93. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Detroit to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from Detroit starts at 8:15 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Detroit to Knoxville, TN?

The latest bus trip departing from Detroit for Knoxville, TN starts at 11:25 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Detroit Knoxville, TN route?

When traveling by bus from Detroit to Knoxville, TN, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Detroit and Knoxville, TN?

You can check all the direct connections between Detroit and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Detroit to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Detroit Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Detroit Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Detroit to Knoxville, TN on your planned travel date.

How does CheckMyBus find the best bus deals from Detroit to Knoxville, TN?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between Detroit and Knoxville, TN. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Detroit to Knoxville, TN?

Prices and availability for 6 trips between Detroit and Knoxville, TN change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Detroit to Knoxville, TN

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Detroit and to Knoxville, TN

Here’s an overview of the most popular bus routes to Detroit and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!