Bus San Antonio, TX to Knoxville, TN: Compare prices and save money

Compare all timetables for the bus from San Antonio, TX to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from San Antonio, TX to Knoxville, TN from various bus operators like Greyhound US, FlixBus or Greyhound Lines Mexico for the next days.

today

$114

tomorrow

$125

Wednesday

Thursday

$107

Friday

$118

Saturday

Sunday

$119

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	26h 25m	7:15 PM	San Antonio, TX	Bus Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$114	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 4/27/2026 7:15:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/28/2026 10:40:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 26h 25m
Greyhound US	31h 20m	1:30 PM	San Antonio, TX	Bus Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$115	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 4/27/2026 1:30:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/28/2026 9:50:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 31h 20m
FlixBus	37h 5m	7:45 AM	San Antonio, TX	Pearl District	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$116	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 4/27/2026 7:45:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/28/2026 9:50:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 37h 5m

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	31h 20m	1:30 PM	San Antonio, TX	Bus Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop		Economy	$125	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 4/28/2026 1:30:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/29/2026 9:50:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 31h 20m
	Greyhound Lines Mexico	26h 25m	7:15 PM	San Antonio, TX	Bus Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop		Economy	$125	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 4/28/2026 7:15:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/29/2026 10:40:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 26h 25m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	37h 5m	7:45 AM	San Antonio, TX	Pearl District	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$107	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 4/30/2026 7:45:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 5/1/2026 9:50:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 37h 5m
Greyhound US	31h 20m	1:30 PM	San Antonio, TX	Bus Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$107	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 4/30/2026 1:30:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 5/1/2026 9:50:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 31h 20m
Valley Transit	24h 25m	9:15 PM	San Antonio, TX	Bus Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$107	A Bus from Valley Transit goes from Bus Station, San Antonio, TX (USA) at 4/30/2026 9:15:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 5/1/2026 10:40:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 24h 25m

Cheapest bus trips Friday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	31h 20m	1:30 PM	San Antonio, TX	Bus Station	9:50 PM	Knoxville, TN	Greyhound Bus Station		Economy	$118	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 5/1/2026 1:30:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 5/2/2026 9:50:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 31h 20m
	FlixBus	37h 5m	7:45 AM	San Antonio, TX	Pearl District	9:50 PM	Knoxville, TN	Greyhound Bus Station		Economy	$119	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 5/1/2026 7:45:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 5/2/2026 9:50:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 37h 5m

Cheapest bus trips Sunday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	31h 20m	1:30 PM	San Antonio, TX	Bus Station	9:50 PM	Knoxville, TN	Greyhound Bus Station		Economy	$119	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 5/3/2026 1:30:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 5/4/2026 9:50:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 31h 20m
	FlixBus	37h 5m	7:45 AM	San Antonio, TX	Pearl District	9:50 PM	Knoxville, TN	Greyhound Bus Station		Economy	$120	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 5/3/2026 7:45:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 5/4/2026 9:50:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 37h 5m

Best Price Offer: The price for the cheapest bus from San Antonio, TX to Knoxville, TN is $95 on 5/17/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Antonio, TX and Knoxville, TN

See here how frequent the connections between San Antonio, TX and Knoxville, TN are, during different times and days of the week.

Tuesday is the busiest day, with more than 4 daily buses from San Antonio, TX to Knoxville, TN. Sunday has instead the fewest connections, with only 2 daily coaches between San Antonio, TX and Knoxville, TN.

The busiest time of the day is the Afternoon, with 6 buses from San Antonio, TX to Knoxville, TN, while Morning sees the fewest connections between San Antonio, TX and Knoxville, TN, with 4 offers.

Facts about the bus from San Antonio, TX to Knoxville, TN

Compare all providers like Greyhound US, FlixBus and Greyhound Lines Mexico that travel 2 times every day by bus from San Antonio, TX to Knoxville, TN in one click! Book your bus ticket from San Antonio, TX to Knoxville, TN starting from $95!

Cheapest Bus	$95
Fastest Bus	25h 25m
Earliest Bus	7:45 AM
Latest Bus	1:30 PM
Daily Bus Routes	2 Ø
Distance	958.9 miles
Bus Companies	Greyhound US, FlixBus, Greyhound Lines Mexico and Valley Transit

Cheapest bus connections from San Antonio, TX to Knoxville, TN

Every day, 2 buses from 4 bus companies leave San Antonio, TX for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/27/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/26

Monday 04/27

$114

Tuesday 04/28

$129

Wednesday 04/29

Thursday 04/30

$107

Friday 05/01

$118

Saturday 05/02

Sunday 05/03

$119

Monday 05/04

Tuesday 05/05

$126

Wednesday 05/06

Thursday 05/07

Friday 05/08

$115

Saturday 05/09

$125

Sunday 05/10

$114

Monday 05/11

Tuesday 05/12

$128

Wednesday 05/13

$114

Thursday 05/14

$107

Friday 05/15

$112

Saturday 05/16

Sunday 05/17

$95

Monday 05/18

$107

Tuesday 05/19

Wednesday 05/20

Thursday 05/21

Friday 05/22

$131

Saturday 05/23

The cheapest time to travel from San Antonio, TX to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from San Antonio, TX to Knoxville, TN, for the next 30 days.

With a price starting from $95, Sunday is the cheapest day for a bus from San Antonio, TX to Knoxville, TN. Tuesday instead is the most expensive day with prices starting from $125.

Evening is the cheapest day time for bus tickets from San Antonio, TX to Knoxville, TN, with $107. Afternoon is the most expensive time of the day with prices starting from $107.

How to save money travelling from San Antonio, TX to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Antonio, TX to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Antonio, TX to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Antonio, TX to Knoxville, TN are also emptier.

Beloved bus companies from San Antonio, TX to Knoxville, TN

These are the most booked bus companies between San Antonio, TX to Knoxville, TN from our users.

FlixBus from San Antonio, TX to Knoxville, TN

Here you will find the key facts about the FlixBus bus route San Antonio, TX to Knoxville, TN:

Cheapest Price	$107
Fastest Bus	38h 5m
Earliest Bus	7:45 AM
Last Bus	7:45 AM
Daily Connections	1 Ø
Found on	4/2/2026

All bus stations and stops in San Antonio, TX and Knoxville, TN

In the map below, you can see where to find all bus stations in San Antonio, TX and Knoxville, TN.

Bus Station

N St Mary's St 500

San Antonio

Commerce & Bowie Bus Stop

W. Southcross & Buffalo Bus Stop

La Cantera

La Cantera Pkwy 15900

Kingston Pike

Kingston Pike 6927

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Transit Center

E Church Ave 301

Service and Comfort on the bus from San Antonio, TX to Knoxville, TN

Want to know which seat classes are available on the buses from San Antonio, TX to Knoxville, TN? Or which bus companies serve the route San Antonio, TX to Knoxville, TN? Below you will find answers to your questions.

FAQs about the San Antonio, TX to Knoxville, TN bus

How much does a San Antonio, TX Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $95 and takes 25h 25m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from San Antonio, TX to Knoxville, TN?

This route is offered by 4 companies with a range of ticket prices between $95 and $129. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from San Antonio, TX to Knoxville, TN each day?

Every day, the San Antonio, TX to Knoxville, TN bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Antonio, TX to Knoxville, TN take?

The fastest bus from San Antonio, TX to Knoxville, TN is offered by Valley Transit and takes 25h 25m. Bus tickets for this connection cost $107. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Antonio, TX to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from San Antonio, TX starts at 7:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Antonio, TX to Knoxville, TN?

The latest bus trip departing from San Antonio, TX for Knoxville, TN starts at 1:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Antonio, TX Knoxville, TN route?

When traveling by bus from San Antonio, TX to Knoxville, TN, passengers can travel with Greyhound US, FlixBus and Greyhound Lines Mexico. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Antonio, TX and Knoxville, TN?

You can check all the direct connections between San Antonio, TX and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US, FlixBus and Greyhound Lines Mexico.

What can I take with me on the San Antonio, TX to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Antonio, TX Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Antonio, TX Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Antonio, TX to Knoxville, TN on your planned travel date.

How does CheckMyBus find the best bus deals from San Antonio, TX to Knoxville, TN?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 2 daily trips between San Antonio, TX and Knoxville, TN. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Antonio, TX to Knoxville, TN?

Prices and availability for 2 trips between San Antonio, TX and Knoxville, TN change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Antonio, TX to Knoxville, TN

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Antonio, TX and to Knoxville, TN

Here’s an overview of the most popular bus routes to San Antonio, TX and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!