Bus Tampa to Knoxville, TN: Compare prices and save money

Compare all timetables for the bus from Tampa to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from Tampa to Knoxville, TN from various bus operators like FlixBus for the next days.

today

tomorrow

$111

Tuesday

$111

Wednesday

Thursday

Friday

Saturday

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	24h 0m	9:50 PM	Tampa	USF	9:50 PM	Knoxville, TN	Greyhound Bus Station		Economy	$111	A Bus from FlixBus goes from USF, Tampa (USA) at 12/15/2025 9:50:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/16/2025 9:50:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 24h 0m
	FlixBus	23h 15m	10:35 PM	Tampa	Marion Street	9:50 PM	Knoxville, TN	Greyhound Bus Station		Economy	$111	A Bus from FlixBus goes from Marion Street, Tampa (USA) at 12/15/2025 10:35:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/16/2025 9:50:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 23h 15m

Did you know that if you travel from Tampa to Knoxville, TN via Atlanta, GA, you can save more than $29? You can find the corresponding connections below.
- Busbud
  
  28h 25m
  
  0
  
  5:25 PM
  
  Tampa
  Marion Street
  
  4:10 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $44
  
  A Bus from Busbud goes from Marion Street, Tampa (USA) at 12/17/2025 5:25:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 12/18/2025 4:10:00 AM. 50 Economy ticket for $44 per person are available. Travel duration is 10h 45m
- FlixBus
  
  3h 45m
  
  0
  
  6:05 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:50 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  0
  
  Economy
  
  $38
  
  A Bus from FlixBus goes from Garnett Transit Station, Atlanta, GA (USA) at 12/18/2025 6:05:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/18/2025 9:50:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 3h 45m
Travel time is 5h 10m longer, but you will save $29

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	28h 45m	5:55 PM	Tampa	USF	10:40 PM	Knoxville, TN	Greyhound Bus Station	Economy	$111	A Bus from FlixBus goes from USF, Tampa (USA) at 12/16/2025 5:55:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/17/2025 10:40:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 28h 45m
FlixBus	23h 15m	10:35 PM	Tampa	Marion Street	9:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$112	A Bus from FlixBus goes from Marion Street, Tampa (USA) at 12/16/2025 10:35:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/17/2025 9:50:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 23h 15m
FlixBus	31h 10m	2:40 PM	Tampa	USF	9:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$116	A Bus from FlixBus goes from USF, Tampa (USA) at 12/16/2025 2:40:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/17/2025 9:50:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 31h 10m

Did you know that if you travel from Tampa to Knoxville, TN via Atlanta, GA, you can save more than $29? You can find the corresponding connections below.
- Busbud
  
  28h 25m
  
  0
  
  5:25 PM
  
  Tampa
  Marion Street
  
  4:10 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $44
  
  A Bus from Busbud goes from Marion Street, Tampa (USA) at 12/17/2025 5:25:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 12/18/2025 4:10:00 AM. 50 Economy ticket for $44 per person are available. Travel duration is 10h 45m
- FlixBus
  
  3h 45m
  
  0
  
  6:05 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:50 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  0
  
  Economy
  
  $38
  
  A Bus from FlixBus goes from Garnett Transit Station, Atlanta, GA (USA) at 12/18/2025 6:05:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/18/2025 9:50:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 3h 45m
Travel time is 5h 10m longer, but you will save $29

Best Price Offer: The price for the cheapest bus from Tampa to Knoxville, TN is $111 on 12/16/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Tampa and Knoxville, TN

See here how frequent the connections between Tampa and Knoxville, TN are, during different times and days of the week.

Tuesday is the busiest day, with more than 3 daily buses from Tampa to Knoxville, TN. Monday has instead the fewest connections, with only 2 daily coaches between Tampa and Knoxville, TN.

The busiest time of the day is the Evening, with 3 buses from Tampa to Knoxville, TN, while Afternoon sees the fewest connections between Tampa and Knoxville, TN, with 2 offers.

Facts about the bus from Tampa to Knoxville, TN

Compare all providers like FlixBus that travel 2 times every day by bus from Tampa to Knoxville, TN in one click! Book your bus ticket from Tampa to Knoxville, TN starting from $111!

Cheapest Bus	$111
Fastest Bus	23h 15m
Earliest Bus	9:50 PM
Latest Bus	10:35 PM
Daily Bus Routes	2 Ø
Distance	560.1 miles
Bus Companies	FlixBus

Cheapest bus connections from Tampa to Knoxville, TN

Every day, 2 buses from 1 bus companies leave Tampa for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/14/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

$111

Tuesday 12/16

$111

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

$170

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

The cheapest time to travel from Tampa to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from Tampa to Knoxville, TN, for the next 30 days.

With a price starting from $110, Monday is the cheapest day for a bus from Tampa to Knoxville, TN. Tuesday instead is the most expensive day with prices starting from $111.

Afternoon is the cheapest day time for bus tickets from Tampa to Knoxville, TN, with $111. Evening is the most expensive time of the day with prices starting from $111.

How to save money travelling from Tampa to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Tampa to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Tampa to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Tampa to Knoxville, TN are also emptier.

All bus stations and stops in Tampa and Knoxville, TN

In the map below, you can see where to find all bus stations in Tampa and Knoxville, TN.

Marion Street

N Marion St 1211

USF

USF Holly Drive 3755

Greyhound Bus Station

East Polk Street 602

Western Union

Tampa Gateway Blvd, I 4 Exit 10 11706

Port of Tampa Cruise Terminals

Channelside Dr. 1101

Kingston Pike

Kingston Pike 6927

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Transit Center

E Church Ave 301

Service and Comfort on the bus from Tampa to Knoxville, TN

Want to know which seat classes are available on the buses from Tampa to Knoxville, TN? Or which bus companies serve the route Tampa to Knoxville, TN? Below you will find answers to your questions.

FAQs about the Tampa to Knoxville, TN bus

How much does a Tampa Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $111 and takes 28h 45m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from Tampa to Knoxville, TN?

This route is offered by 1 companies with a range of ticket prices between $111 and $116. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from Tampa to Knoxville, TN each day?

Every day, the Tampa to Knoxville, TN bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Tampa to Knoxville, TN take?

The fastest bus from Tampa to Knoxville, TN is offered by FlixBus and takes 23h 15m. Bus tickets for this connection cost $111. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Tampa to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from Tampa starts at 9:50 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Tampa to Knoxville, TN?

The latest bus trip departing from Tampa for Knoxville, TN starts at 10:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Tampa Knoxville, TN route?

When traveling by bus from Tampa to Knoxville, TN, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Tampa and Knoxville, TN?

You can check all the direct connections between Tampa and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Tampa to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Tampa Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Tampa Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Tampa to Knoxville, TN on your planned travel date.

Available seat classes which are offered on the bus route Tampa to Knoxville, TN

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Tampa and to Knoxville, TN

Here’s an overview of the most popular bus routes to Tampa and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!