Bus Columbus, OH to Knoxville, TN - Compare all Companies

Compare all timetables for the bus from Columbus, OH to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from Columbus, OH to Knoxville, TN from various bus operators like Greyhound US or FlixBus for the next days.

today

$71

tomorrow

Tuesday

$60

Wednesday

Thursday

$58

Friday

Saturday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	16h 55m	12:50 AM	Columbus, OH	E Main St & S Lazelle St	5:45 PM	Knoxville, TN	Greyhound Bus Station	Economy	$71	A Bus from Greyhound US goes from E Main St & S Lazelle St, Columbus, OH (USA) at 9/6/2026 12:50:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 9/6/2026 5:45:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 16h 55m
Greyhound US	14h 30m	5:20 AM	Columbus, OH	E Main St & S Lazelle St	7:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$71	A Bus from Greyhound US goes from E Main St & S Lazelle St, Columbus, OH (USA) at 9/6/2026 5:20:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 9/6/2026 7:50:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 14h 30m
FlixBus	10h 5m	9:45 AM	Columbus, OH	ABM Public Parking	7:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$72	A Bus from FlixBus goes from ABM Public Parking, Columbus, OH (USA) at 9/6/2026 9:45:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 9/6/2026 7:50:00 PM. 50 Economy ticket for $72 per person are available. Travel duration is 10h 5m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	10h 5m	9:45 AM	Columbus, OH	ABM Public Parking	7:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$60	A Bus from FlixBus goes from ABM Public Parking, Columbus, OH (USA) at 9/8/2026 9:45:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 9/8/2026 7:50:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 10h 5m
Greyhound US	16h 55m	12:50 AM	Columbus, OH	E Main St & S Lazelle St	5:45 PM	Knoxville, TN	Greyhound Bus Station	Economy	$63	A Bus from Greyhound US goes from E Main St & S Lazelle St, Columbus, OH (USA) at 9/8/2026 12:50:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 9/8/2026 5:45:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 16h 55m
Greyhound US	14h 30m	5:20 AM	Columbus, OH	E Main St & S Lazelle St	7:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$63	A Bus from Greyhound US goes from E Main St & S Lazelle St, Columbus, OH (USA) at 9/8/2026 5:20:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 9/8/2026 7:50:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 14h 30m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 30m	5:20 AM	Columbus, OH	E Main St & S Lazelle St	7:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$58	A Bus from Greyhound US goes from E Main St & S Lazelle St, Columbus, OH (USA) at 9/10/2026 5:20:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 9/10/2026 7:50:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 14h 30m
FlixBus	10h 5m	9:45 AM	Columbus, OH	ABM Public Parking	7:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$58	A Bus from FlixBus goes from ABM Public Parking, Columbus, OH (USA) at 9/10/2026 9:45:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 9/10/2026 7:50:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 10h 5m
Greyhound US	16h 55m	12:50 AM	Columbus, OH	E Main St & S Lazelle St	5:45 PM	Knoxville, TN	Greyhound Bus Station	Economy	$59	A Bus from Greyhound US goes from E Main St & S Lazelle St, Columbus, OH (USA) at 9/10/2026 12:50:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 9/10/2026 5:45:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 16h 55m

Best Price Offer: The price for the cheapest bus from Columbus, OH to Knoxville, TN is $48 on 9/23/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Columbus, OH and Knoxville, TN

See here how frequent the connections between Columbus, OH and Knoxville, TN are, during different times and days of the week.

Tuesday is the busiest day, with more than 4 daily buses from Columbus, OH to Knoxville, TN. Sunday has instead the fewest connections, with only 3 daily coaches between Columbus, OH and Knoxville, TN.

The busiest time of the day is the Night, with 6 buses from Columbus, OH to Knoxville, TN, while Morning sees the fewest connections between Columbus, OH and Knoxville, TN, with 4 offers.

Facts about the bus from Columbus, OH to Knoxville, TN

Compare all providers like Greyhound US and FlixBus that travel 3 times every day by bus from Columbus, OH to Knoxville, TN in one click! Book your bus ticket from Columbus, OH to Knoxville, TN starting from $48!

Cheapest Bus	$48
Fastest Bus	10h 5m
Earliest Bus	12:50 AM
Latest Bus	9:45 AM
Daily Bus Routes	3 Ø
Distance	281.1 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Columbus, OH to Knoxville, TN

Every day, 3 buses from 2 bus companies leave Columbus, OH for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/06/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 09/06

$71

Monday 09/07

Tuesday 09/08

$59

Wednesday 09/09

Thursday 09/10

$58

Friday 09/11

Saturday 09/12

Sunday 09/13

Monday 09/14

$62

Tuesday 09/15

$51

Wednesday 09/16

Thursday 09/17

$58

Friday 09/18

Saturday 09/19

Sunday 09/20

Monday 09/21

$62

Tuesday 09/22

$58

Wednesday 09/23

$48

Thursday 09/24

Friday 09/25

Saturday 09/26

Sunday 09/27

$56

Monday 09/28

$57

Tuesday 09/29

Wednesday 09/30

Thursday 10/01

Friday 10/02

Saturday 10/03

The cheapest time to travel from Columbus, OH to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from Columbus, OH to Knoxville, TN, for the next 30 days.

With a price starting from $51, Tuesday is the cheapest day for a bus from Columbus, OH to Knoxville, TN. Thursday instead is the most expensive day with prices starting from $58.

Night is the cheapest day time for bus tickets from Columbus, OH to Knoxville, TN, with $48. Morning is the most expensive time of the day with prices starting from $58.

How to save money travelling from Columbus, OH to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Columbus, OH to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Columbus, OH to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Columbus, OH to Knoxville, TN are also emptier.

All bus stations and stops in Columbus, OH and Knoxville, TN

In the map below, you can see where to find all bus stations in Columbus, OH and Knoxville, TN.

Greyhound Bus Station

E Town St 111

University

N High St 1739

N Wilson

ABM Public Parking

E Rich Street 100

E Main St & S Lazelle St

E Main St 139

Kingston Pike

Kingston Pike 6927

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Transit Center

E Church Ave 301

Service and Comfort on the bus from Columbus, OH to Knoxville, TN

Want to know which seat classes are available on the buses from Columbus, OH to Knoxville, TN? Or which bus companies serve the route Columbus, OH to Knoxville, TN? Below you will find answers to your questions.

FAQs about the Columbus, OH to Knoxville, TN bus

How much does a Columbus, OH Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $48 and takes 14h 30m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from Columbus, OH to Knoxville, TN?

This route is offered by 2 companies with a range of ticket prices between $48 and $72. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from Columbus, OH to Knoxville, TN each day?

Every day, the Columbus, OH to Knoxville, TN bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Columbus, OH to Knoxville, TN take?

The fastest bus from Columbus, OH to Knoxville, TN is offered by FlixBus and takes 10h 5m. Bus tickets for this connection cost $72. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Columbus, OH to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from Columbus, OH starts at 12:50 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Columbus, OH to Knoxville, TN?

The latest bus trip departing from Columbus, OH for Knoxville, TN starts at 9:45 AM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Columbus, OH Knoxville, TN route?

When traveling by bus from Columbus, OH to Knoxville, TN, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Columbus, OH and Knoxville, TN?

You can check all the direct connections between Columbus, OH and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Columbus, OH to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Columbus, OH Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Columbus, OH Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Columbus, OH to Knoxville, TN on your planned travel date.

How does CheckMyBus find the best bus deals from Columbus, OH to Knoxville, TN?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Columbus, OH and Knoxville, TN. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Columbus, OH to Knoxville, TN?

Prices and availability for 3 trips between Columbus, OH and Knoxville, TN change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Columbus, OH to Knoxville, TN

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Columbus, OH and to Knoxville, TN

Here’s an overview of the most popular bus routes to Columbus, OH and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!