Bus Louisville, KY to Knoxville, TN: Compare prices and save money

Compare all timetables for the bus from Louisville, KY to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from Louisville, KY to Knoxville, TN from various bus operators like Greyhound US for the next days.

today

tomorrow

Sunday

$103

Monday

Tuesday

$116

Wednesday

$97

Thursday

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	16h 5m	2:50 AM	Louisville, KY	Greyhound Bus Station	6:55 PM	Knoxville, TN	Greyhound Bus Station	Economy	$103	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/21/2025 2:50:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/21/2025 6:55:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 16h 5m
Greyhound US	14h 35m	7:15 AM	Louisville, KY	Greyhound Bus Station	9:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$103	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/21/2025 7:15:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/21/2025 9:50:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 14h 35m
Greyhound US	8h 20m	2:20 PM	Louisville, KY	Greyhound Bus Station	10:40 PM	Knoxville, TN	Greyhound Bus Station	Economy	$107	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/21/2025 2:20:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/21/2025 10:40:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 8h 20m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	8h 20m	2:20 PM	Louisville, KY	Greyhound Bus Station	10:40 PM	Knoxville, TN	Greyhound Bus Station	Economy	$116	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/23/2025 2:20:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/23/2025 10:40:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 8h 20m
Greyhound US	16h 5m	2:50 AM	Louisville, KY	Greyhound Bus Station	6:55 PM	Knoxville, TN	Greyhound Bus Station	Economy	$119	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/23/2025 2:50:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/23/2025 6:55:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 16h 5m
Greyhound US	14h 35m	7:15 AM	Louisville, KY	Greyhound Bus Station	9:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$124	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/23/2025 7:15:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/23/2025 9:50:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 14h 35m

Did you know that if you travel from Louisville, KY to Knoxville, TN via Nashville, you can save more than $13? You can find the corresponding connections below.
- FlixBus
  
  8h 20m
  
  0
  
  2:20 PM
  
  Louisville, KY
  Greyhound Bus Station
  
  4:30 PM
  
  Nashville
  5th Ave South Station
  
  0
  
  Economy
  
  $51
  
  A Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/24/2025 2:20:00 PM to 5th Ave South Station, Nashville (USA) arriving at 12/24/2025 4:30:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 3h 10m
- FlixBus
  
  3h 25m
  
  0
  
  6:15 PM
  
  Nashville
  5th Ave South Station
  
  10:40 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  0
  
  Economy
  
  $52
  
  A Bus from FlixBus goes from 5th Ave South Station, Nashville (USA) at 12/24/2025 6:15:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/24/2025 10:40:00 PM. 50 Economy ticket for $52 per person are available. Travel duration is 3h 25m
Travel time is the same as the direct connection, but you will save $13

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 35m	7:15 AM	Louisville, KY	Greyhound Bus Station	9:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$97	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/24/2025 7:15:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/24/2025 9:50:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 14h 35m
Greyhound US	8h 20m	2:20 PM	Louisville, KY	Greyhound Bus Station	10:40 PM	Knoxville, TN	Greyhound Bus Station	Economy	$97	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/24/2025 2:20:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/24/2025 10:40:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 8h 20m
Greyhound US	16h 5m	2:50 AM	Louisville, KY	Greyhound Bus Station	6:55 PM	Knoxville, TN	Greyhound Bus Station	Economy	$99	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/24/2025 2:50:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/24/2025 6:55:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 16h 5m

Best Price Offer: The price for the cheapest bus from Louisville, KY to Knoxville, TN is $66 on 12/16/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Louisville, KY and Knoxville, TN

See here how frequent the connections between Louisville, KY and Knoxville, TN are, during different times and days of the week.

Sunday is the busiest day, with more than 3 daily buses from Louisville, KY to Knoxville, TN. Sunday has instead the fewest connections, with only 3 daily coaches between Louisville, KY and Knoxville, TN.

The busiest time of the day is the Morning, with 3 buses from Louisville, KY to Knoxville, TN, while Morning sees the fewest connections between Louisville, KY and Knoxville, TN, with 3 offers.

Facts about the bus from Louisville, KY to Knoxville, TN

Compare all providers like Greyhound US that travel 3 times every day by bus from Louisville, KY to Knoxville, TN in one click! Book your bus ticket from Louisville, KY to Knoxville, TN starting from $66!

Cheapest Bus	$66
Fastest Bus	8h 20m
Earliest Bus	2:50 AM
Latest Bus	2:20 PM
Daily Bus Routes	3 Ø
Distance	188.3 miles
Bus Companies	Greyhound US

Cheapest bus connections from Louisville, KY to Knoxville, TN

Every day, 3 buses from 1 bus companies leave Louisville, KY for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/19/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

$103

Monday 12/22

Tuesday 12/23

$116

Wednesday 12/24

$97

Thursday 12/25

Friday 12/26

$96

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

The cheapest time to travel from Louisville, KY to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from Louisville, KY to Knoxville, TN, for the next 30 days.

With a price starting from $97, Wednesday is the cheapest day for a bus from Louisville, KY to Knoxville, TN. Tuesday instead is the most expensive day with prices starting from $116.

Night is the cheapest day time for bus tickets from Louisville, KY to Knoxville, TN, with $96. Morning is the most expensive time of the day with prices starting from $97.

How to save money travelling from Louisville, KY to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Louisville, KY to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Louisville, KY to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Louisville, KY to Knoxville, TN are also emptier.

All bus stations and stops in Louisville, KY and Knoxville, TN

In the map below, you can see where to find all bus stations in Louisville, KY and Knoxville, TN.

Convention Center

S 3rd St 300

BP Gas Station

Newburg Rd 3301

W Muhammad Ali Blvd

East Broadway, under the I-65 overpass between S 1st Street and S Brook Street

Greyhound Bus Station

W Muhammad Ali Blvd 720

International Airport

Kingston Pike

Kingston Pike 6927

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Transit Center

E Church Ave 301

Service and Comfort on the bus from Louisville, KY to Knoxville, TN

Want to know which seat classes are available on the buses from Louisville, KY to Knoxville, TN? Or which bus companies serve the route Louisville, KY to Knoxville, TN? Below you will find answers to your questions.

FAQs about the Louisville, KY to Knoxville, TN bus

How much does a Louisville, KY Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $66 and takes 14h 35m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from Louisville, KY to Knoxville, TN?

This route is offered by 1 companies with a range of ticket prices between $66 and $124. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from Louisville, KY to Knoxville, TN each day?

Every day, the Louisville, KY to Knoxville, TN bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Louisville, KY to Knoxville, TN take?

The fastest bus from Louisville, KY to Knoxville, TN is offered by Greyhound US and takes 8h 20m. Bus tickets for this connection cost $107. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Louisville, KY to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from Louisville, KY starts at 2:50 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Louisville, KY to Knoxville, TN?

The latest bus trip departing from Louisville, KY for Knoxville, TN starts at 2:20 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Louisville, KY Knoxville, TN route?

When traveling by bus from Louisville, KY to Knoxville, TN, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Louisville, KY and Knoxville, TN?

You can check all the direct connections between Louisville, KY and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Louisville, KY to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Louisville, KY Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Louisville, KY Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Louisville, KY to Knoxville, TN on your planned travel date.

How does CheckMyBus find the best bus deals from Louisville, KY to Knoxville, TN?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Louisville, KY and Knoxville, TN. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Louisville, KY to Knoxville, TN?

Prices and availability for 3 trips between Louisville, KY and Knoxville, TN change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Louisville, KY to Knoxville, TN

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Louisville, KY and to Knoxville, TN

Here’s an overview of the most popular bus routes to Louisville, KY and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!