Bus Philadelphia to Knoxville, TN: Compare prices and save money

Compare all timetables for the bus from Philadelphia to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from Philadelphia to Knoxville, TN from various bus operators like FlixBus or Greyhound US for the next days.

today

$119

tomorrow

Saturday

Sunday

$121

Monday

$120

Tuesday

Wednesday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 0m	8:00 PM	Philadelphia	IRS Building	6:00 PM	Knoxville, TN	Greyhound Bus Station	Economy	$119	A Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/25/2025 8:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/26/2025 6:00:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 22h 0m
FlixBus	16h 10m	1:50 AM	Philadelphia	Spring Garden St Station	6:00 PM	Knoxville, TN	Greyhound Bus Station	Economy	$121	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/25/2025 1:50:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/25/2025 6:00:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 16h 10m
FlixBus	20h 0m	10:00 PM	Philadelphia	Spring Garden St Station	6:00 PM	Knoxville, TN	Greyhound Bus Station	Economy	$121	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/25/2025 10:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/26/2025 6:00:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 20h 0m
Greyhound US	21h 30m	8:30 PM	Philadelphia	Spring Garden St Station	6:00 PM	Knoxville, TN	Greyhound Bus Station	Economy	$121	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/25/2025 8:30:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/26/2025 6:00:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 21h 30m
Greyhound US	16h 0m	2:00 AM	Philadelphia	IRS Building	6:00 PM	Knoxville, TN	Greyhound Bus Station	Economy	$121	A Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/25/2025 2:00:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/25/2025 6:00:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 16h 0m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	16h 0m	2:00 AM	Philadelphia	Schuylkill Ave and Walnut Street	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$121	A Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia (USA) at 12/28/2025 2:00:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/28/2025 6:00:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 16h 0m
Greyhound US	21h 30m	8:30 PM	Philadelphia	Convention Center	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$122	A Bus from Greyhound US goes from Convention Center, Philadelphia (USA) at 12/28/2025 8:30:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/29/2025 6:00:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 21h 30m
Greyhound US	22h 0m	8:00 PM	Philadelphia	Schuylkill Ave and Walnut Street	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$122	A Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia (USA) at 12/28/2025 8:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/29/2025 6:00:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 22h 0m
FlixBus	20h 0m	10:00 PM	Philadelphia	Spring Garden St Station	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$123	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/28/2025 10:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/29/2025 6:00:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 20h 0m
FlixBus	28h 0m	2:00 PM	Philadelphia	JFK & Broad	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$124	A Bus from FlixBus goes from JFK & Broad, Philadelphia (USA) at 12/28/2025 2:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/29/2025 6:00:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 28h 0m

Did you know that if you travel from Philadelphia to Knoxville, TN via Baltimore, MD, you can save more than $17? You can find the corresponding connections below.
- OurBus
  
  17h 50m
  
  0
  
  12:10 AM
  
  Philadelphia
  Spring Garden St Station
  
  2:20 AM
  
  Baltimore, MD
  Maryland Ave
  
  0
  
  Basic
  
  $15
  
  A Bus from OurBus goes from Spring Garden St Station, Philadelphia (USA) at 12/28/2025 12:10:00 AM to Maryland Ave, Baltimore, MD (USA) arriving at 12/28/2025 2:20:00 AM. 50 Basic ticket for $15 per person are available. Travel duration is 2h 10m
- FlixBus
  
  13h 25m
  
  0
  
  4:35 AM
  
  Baltimore, MD
  Downtown Bus Station
  
  6:00 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  0
  
  Economy
  
  $89
  
  A Bus from FlixBus goes from Downtown Bus Station, Baltimore, MD (USA) at 12/28/2025 4:35:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/28/2025 6:00:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 13h 25m
Travel time is 1h 50m longer, but you will save $17

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	20h 0m	10:00 PM	Philadelphia	Spring Garden St Station	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$120	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/29/2025 10:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/30/2025 6:00:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 20h 0m
FlixBus	16h 10m	1:50 AM	Philadelphia	Spring Garden St Station	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$121	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/29/2025 1:50:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/29/2025 6:00:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 16h 10m
Greyhound US	21h 30m	8:30 PM	Philadelphia	Convention Center	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$121	A Bus from Greyhound US goes from Convention Center, Philadelphia (USA) at 12/29/2025 8:30:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/30/2025 6:00:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 21h 30m
Greyhound US	22h 0m	8:00 PM	Philadelphia	Schuylkill Ave and Walnut Street	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$121	A Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia (USA) at 12/29/2025 8:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/30/2025 6:00:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 22h 0m
FlixBus	28h 0m	2:00 PM	Philadelphia	JFK & Broad	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$140	A Bus from FlixBus goes from JFK & Broad, Philadelphia (USA) at 12/29/2025 2:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/30/2025 6:00:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 28h 0m

Did you know that if you travel from Philadelphia to Knoxville, TN via Washington, DC, you can save more than $19? You can find the corresponding connections below.
- Distribusion
  
  22h 20m
  
  0
  
  7:40 PM
  
  Philadelphia
  520 N Christopher Columbus Blvd. Bus Stop
  
  11:25 PM
  
  Washington, DC
  Union Station
  
  0
  
  Economy
  
  $25
  
  A Bus from Distribusion goes from 520 N Christopher Columbus Blvd. Bus Stop, Philadelphia (USA) at 12/30/2025 7:40:00 PM to Union Station, Washington, DC (USA) arriving at 12/30/2025 11:25:00 PM. 50 Economy ticket for $25 per person are available. Travel duration is 3h 45m
- Busbud
  
  12h 10m
  
  0
  
  5:50 AM
  
  Washington, DC
  Union Station
  
  6:00 PM
  
  Knoxville, TN
  Knoxville Area Transit Bus Stop
  
  0
  
  Economy
  
  $76
  
  A Bus from Busbud goes from Union Station, Washington, DC (USA) at 12/31/2025 5:50:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/31/2025 6:00:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 12h 10m
Travel time is 6h 10m longer, but you will save $19

Best Price Offer: The price for the cheapest bus from Philadelphia to Knoxville, TN is $119 on 12/25/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Philadelphia and Knoxville, TN

See here how frequent the connections between Philadelphia and Knoxville, TN are, during different times and days of the week.

Sunday is the busiest day, with more than 12 daily buses from Philadelphia to Knoxville, TN. Monday has instead the fewest connections, with only 11 daily coaches between Philadelphia and Knoxville, TN.

The busiest time of the day is the Evening, with 18 buses from Philadelphia to Knoxville, TN, while Afternoon sees the fewest connections between Philadelphia and Knoxville, TN, with 6 offers.

Facts about the bus from Philadelphia to Knoxville, TN

Compare all providers like FlixBus and Greyhound US that travel 11 times every day by bus from Philadelphia to Knoxville, TN in one click! Book your bus ticket from Philadelphia to Knoxville, TN starting from $119!

Cheapest Bus	$119
Fastest Bus	16h 0m
Earliest Bus	1:50 AM
Latest Bus	10:00 PM
Daily Bus Routes	11 Ø
Distance	549.6 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Philadelphia to Knoxville, TN

Every day, 11 buses from 2 bus companies leave Philadelphia for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/25/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

$121

Friday 12/26

Saturday 12/27

Sunday 12/28

$184

Monday 12/29

$164

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

$123

Friday 01/02

Saturday 01/03

$120

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

Sunday 01/11

Monday 01/12

Tuesday 01/13

Wednesday 01/14

Thursday 01/15

Friday 01/16

Saturday 01/17

The cheapest time to travel from Philadelphia to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from Philadelphia to Knoxville, TN, for the next 30 days.

With a price starting from $119, Thursday is the cheapest day for a bus from Philadelphia to Knoxville, TN. Sunday instead is the most expensive day with prices starting from $121.

Night is the cheapest day time for bus tickets from Philadelphia to Knoxville, TN, with $86. Afternoon is the most expensive time of the day with prices starting from $124.

How to save money travelling from Philadelphia to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Philadelphia to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Philadelphia to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Philadelphia to Knoxville, TN are also emptier.

Beloved bus companies from Philadelphia to Knoxville, TN

These are the most booked bus companies between Philadelphia to Knoxville, TN from our users.

Greyhound US from Philadelphia to Knoxville, TN

Here you will find the key facts about the Greyhound US bus route Philadelphia to Knoxville, TN:

Cheapest Price	$119
Fastest Bus	16h 0m
Earliest Bus	2:00 AM
Last Bus	8:30 PM
Daily Connections	5 Ø
Found on	12/21/2025

All bus stations and stops in Philadelphia and Knoxville, TN

In the map below, you can see where to find all bus stations in Philadelphia and Knoxville, TN.

Central Bus Station

Filbert St 1001

Market St

Spring Garden St Station

Spring Garden St & 2nd St

JFK & Broad

John F Kennedy Blvd 1401

30th Street Station

Market St 2955

Kingston Pike

Kingston Pike 6927

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Transit Center

E Church Ave 301

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Philadelphia to Knoxville, TN? Compare all modes of transports from Philadelphia to Knoxville, TN.

Service and Comfort on the bus from Philadelphia to Knoxville, TN

Want to know which seat classes are available on the buses from Philadelphia to Knoxville, TN? Or which bus companies serve the route Philadelphia to Knoxville, TN? Below you will find answers to your questions.

FAQs about the Philadelphia to Knoxville, TN bus

How much does a Philadelphia Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $119 and takes 22h 0m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from Philadelphia to Knoxville, TN?

This route is offered by 2 companies with a range of ticket prices between $119 and $189. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from Philadelphia to Knoxville, TN each day?

Every day, the Philadelphia to Knoxville, TN bus route is served by approximately 11 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Philadelphia to Knoxville, TN take?

The fastest bus from Philadelphia to Knoxville, TN is offered by Greyhound US and takes 16h 0m. Bus tickets for this connection cost $121. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Philadelphia to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from Philadelphia starts at 1:50 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Philadelphia to Knoxville, TN?

The latest bus trip departing from Philadelphia for Knoxville, TN starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Philadelphia Knoxville, TN route?

When traveling by bus from Philadelphia to Knoxville, TN, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Philadelphia and Knoxville, TN?

You can check all the direct connections between Philadelphia and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Philadelphia to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Philadelphia Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Philadelphia Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Philadelphia to Knoxville, TN on your planned travel date.

How does CheckMyBus find the best bus deals from Philadelphia to Knoxville, TN?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 11 daily trips between Philadelphia and Knoxville, TN. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Philadelphia to Knoxville, TN?

Prices and availability for 11 trips between Philadelphia and Knoxville, TN change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Philadelphia to Knoxville, TN

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Philadelphia and to Knoxville, TN

Here’s an overview of the most popular bus routes to Philadelphia and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!