Bus St. Louis, MO to Philadelphia: Compare prices and save money

Compare all timetables for the bus from St. Louis, MO to Philadelphia

Here is a selection of the cheapest bus trips from the schedule from St. Louis, MO to Philadelphia from various bus operators like Greyhound US or FlixBus for the next days.

today

$140

tomorrow

Sunday

$136

Monday

Tuesday

$128

Wednesday

$139

Thursday

$131

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 5m	1:55 PM	St. Louis, MO	Gateway Station	1:00 PM	Philadelphia	Spring Garden St Station	Economy	$140	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/19/2025 1:55:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 12/20/2025 1:00:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 22h 5m
FlixBus	32h 15m	11:30 PM	St. Louis, MO	Gateway Station	8:45 AM	Philadelphia	Spring Garden St Station	Economy	$142	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/19/2025 11:30:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 12/21/2025 8:45:00 AM. 50 Economy ticket for $142 per person are available. Travel duration is 32h 15m
FlixBus	30h 15m	11:30 PM	St. Louis, MO	Gateway Station	6:45 AM	Philadelphia	Spring Garden St Station	Economy	$143	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/19/2025 11:30:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 12/21/2025 6:45:00 AM. 50 Economy ticket for $143 per person are available. Travel duration is 30h 15m
Greyhound US	33h 35m	1:45 PM	St. Louis, MO	Gateway Station	12:20 AM	Philadelphia	Spring Garden St Station	Economy	$197	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/19/2025 1:45:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 12/21/2025 12:20:00 AM. 50 Economy ticket for $197 per person are available. Travel duration is 33h 35m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 25m	8:45 AM	St. Louis, MO	Gateway Station	8:10 AM	Philadelphia	Spring Garden St Station	Economy	$136	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/21/2025 8:45:00 AM to Spring Garden St Station, Philadelphia (USA) arriving at 12/22/2025 8:10:00 AM. 50 Economy ticket for $136 per person are available. Travel duration is 22h 25m
Greyhound US	22h 50m	2:00 AM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Spring Garden St Station	Economy	$140	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/21/2025 2:00:00 AM to Spring Garden St Station, Philadelphia (USA) arriving at 12/22/2025 1:50:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 22h 50m
Greyhound US	22h 5m	1:55 PM	St. Louis, MO	Gateway Station	1:00 PM	Philadelphia	Spring Garden St Station	Economy	$144	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/21/2025 1:55:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 12/22/2025 1:00:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 22h 5m
FlixBus	32h 45m	11:30 PM	St. Louis, MO	Gateway Station	9:15 AM	Philadelphia	JFK & Broad	Economy	$159	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/21/2025 11:30:00 PM to JFK & Broad, Philadelphia (USA) arriving at 12/23/2025 9:15:00 AM. 50 Economy ticket for $159 per person are available. Travel duration is 32h 45m
FlixBus	29h 15m	9:30 AM	St. Louis, MO	Gateway Station	3:45 PM	Philadelphia	Spring Garden St Station	Economy	$173	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/21/2025 9:30:00 AM to Spring Garden St Station, Philadelphia (USA) arriving at 12/22/2025 3:45:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 29h 15m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 25m	8:45 AM	St. Louis, MO	Gateway Station	8:10 AM	Philadelphia	Convention Center	Economy	$128	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/23/2025 8:45:00 AM to Convention Center, Philadelphia (USA) arriving at 12/24/2025 8:10:00 AM. 50 Economy ticket for $128 per person are available. Travel duration is 22h 25m
Greyhound US	22h 50m	2:00 AM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Convention Center	Economy	$136	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/23/2025 2:00:00 AM to Convention Center, Philadelphia (USA) arriving at 12/24/2025 1:50:00 AM. 50 Economy ticket for $136 per person are available. Travel duration is 22h 50m
FlixBus	29h 15m	9:30 AM	St. Louis, MO	Gateway Station	3:45 PM	Philadelphia	Spring Garden St Station	Economy	$143	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/23/2025 9:30:00 AM to Spring Garden St Station, Philadelphia (USA) arriving at 12/24/2025 3:45:00 PM. 50 Economy ticket for $143 per person are available. Travel duration is 29h 15m
Greyhound US	33h 35m	1:45 PM	St. Louis, MO	Gateway Station	12:20 AM	Philadelphia	Spring Garden St Station	Economy	$145	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/23/2025 1:45:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 12/25/2025 12:20:00 AM. 50 Economy ticket for $145 per person are available. Travel duration is 33h 35m
FlixBus	30h 15m	11:30 PM	St. Louis, MO	Gateway Station	6:45 AM	Philadelphia	Convention Center	Economy	$161	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/23/2025 11:30:00 PM to Convention Center, Philadelphia (USA) arriving at 12/25/2025 6:45:00 AM. 50 Economy ticket for $161 per person are available. Travel duration is 30h 15m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 50m	2:00 AM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Convention Center	Economy	$139	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/24/2025 2:00:00 AM to Convention Center, Philadelphia (USA) arriving at 12/25/2025 1:50:00 AM. 50 Economy ticket for $139 per person are available. Travel duration is 22h 50m
Greyhound US	22h 25m	8:45 AM	St. Louis, MO	Gateway Station	8:10 AM	Philadelphia	Convention Center	Economy	$139	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/24/2025 8:45:00 AM to Convention Center, Philadelphia (USA) arriving at 12/25/2025 8:10:00 AM. 50 Economy ticket for $139 per person are available. Travel duration is 22h 25m
Greyhound US	22h 5m	1:55 PM	St. Louis, MO	Gateway Station	1:00 PM	Philadelphia	Convention Center	Economy	$139	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/24/2025 1:55:00 PM to Convention Center, Philadelphia (USA) arriving at 12/25/2025 1:00:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 22h 5m
FlixBus	32h 15m	11:30 PM	St. Louis, MO	Gateway Station	8:45 AM	Philadelphia	Spring Garden St Station	Economy	$159	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/24/2025 11:30:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 12/26/2025 8:45:00 AM. 50 Economy ticket for $159 per person are available. Travel duration is 32h 15m
FlixBus	29h 15m	9:30 AM	St. Louis, MO	Gateway Station	3:45 PM	Philadelphia	Spring Garden St Station	Economy	$160	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/24/2025 9:30:00 AM to Spring Garden St Station, Philadelphia (USA) arriving at 12/25/2025 3:45:00 PM. 50 Economy ticket for $160 per person are available. Travel duration is 29h 15m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 50m	2:00 AM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Convention Center	Economy	$131	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/25/2025 2:00:00 AM to Convention Center, Philadelphia (USA) arriving at 12/26/2025 1:50:00 AM. 50 Economy ticket for $131 per person are available. Travel duration is 22h 50m
Greyhound US	33h 35m	1:45 PM	St. Louis, MO	Gateway Station	12:20 AM	Philadelphia	Spring Garden St Station	Economy	$139	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/25/2025 1:45:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 12/27/2025 12:20:00 AM. 50 Economy ticket for $139 per person are available. Travel duration is 33h 35m
FlixBus	29h 15m	9:30 AM	St. Louis, MO	Gateway Station	3:45 PM	Philadelphia	Spring Garden St Station	Economy	$139	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/25/2025 9:30:00 AM to Spring Garden St Station, Philadelphia (USA) arriving at 12/26/2025 3:45:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 29h 15m
Greyhound US	22h 5m	1:55 PM	St. Louis, MO	Gateway Station	1:00 PM	Philadelphia	Convention Center	Economy	$143	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/25/2025 1:55:00 PM to Convention Center, Philadelphia (USA) arriving at 12/26/2025 1:00:00 PM. 50 Economy ticket for $143 per person are available. Travel duration is 22h 5m
FlixBus	30h 15m	11:30 PM	St. Louis, MO	Gateway Station	6:45 AM	Philadelphia	Convention Center	Economy	$152	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/25/2025 11:30:00 PM to Convention Center, Philadelphia (USA) arriving at 12/27/2025 6:45:00 AM. 50 Economy ticket for $152 per person are available. Travel duration is 30h 15m

Best Price Offer: The price for the cheapest bus from St. Louis, MO to Philadelphia is $95 on 12/15/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between St. Louis, MO and Philadelphia

See here how frequent the connections between St. Louis, MO and Philadelphia are, during different times and days of the week.

Tuesday is the busiest day, with more than 14 daily buses from St. Louis, MO to Philadelphia. Friday has instead the fewest connections, with only 4 daily coaches between St. Louis, MO and Philadelphia.

The busiest time of the day is the Evening, with 17 buses from St. Louis, MO to Philadelphia, while Night sees the fewest connections between St. Louis, MO and Philadelphia, with 7 offers.

Facts about the bus from St. Louis, MO to Philadelphia

Compare all providers like Greyhound US and FlixBus that travel 10 times every day by bus from St. Louis, MO to Philadelphia in one click! Book your bus ticket from St. Louis, MO to Philadelphia starting from $95!

Cheapest Bus	$95
Fastest Bus	23h 5m
Earliest Bus	1:45 PM
Latest Bus	11:30 PM
Daily Bus Routes	10 Ø
Distance	807.9 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from St. Louis, MO to Philadelphia

Every day, 10 buses from 2 bus companies leave St. Louis, MO for Philadelphia: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/19/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

$128

Saturday 12/20

Sunday 12/21

$136

Monday 12/22

Tuesday 12/23

$128

Wednesday 12/24

$139

Thursday 12/25

$131

Friday 12/26

$132

Saturday 12/27

Sunday 12/28

$144

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

$118

Friday 01/02

Saturday 01/03

Sunday 01/04

$113

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

The cheapest time to travel from St. Louis, MO to Philadelphia

See here on which day and which time of the day you can find the cheapest bus ticket from St. Louis, MO to Philadelphia, for the next 30 days.

With a price starting from $113, Sunday is the cheapest day for a bus from St. Louis, MO to Philadelphia. Wednesday instead is the most expensive day with prices starting from $139.

Night is the cheapest day time for bus tickets from St. Louis, MO to Philadelphia, with $67. Evening is the most expensive time of the day with prices starting from $142.

How to save money travelling from St. Louis, MO to Philadelphia

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from St. Louis, MO to Philadelphia in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from St. Louis, MO to Philadelphia, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from St. Louis, MO to Philadelphia are also emptier.

All bus stations and stops in St. Louis, MO and Philadelphia

In the map below, you can see where to find all bus stations in St. Louis, MO and Philadelphia.

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Central Bus Station

Filbert St 1001

Market St

Spring Garden St Station

Spring Garden St & 2nd St

JFK & Broad

John F Kennedy Blvd 1401

30th Street Station

Market St 2955

Service and Comfort on the bus from St. Louis, MO to Philadelphia

Want to know which seat classes are available on the buses from St. Louis, MO to Philadelphia? Or which bus companies serve the route St. Louis, MO to Philadelphia? Below you will find answers to your questions.

FAQs about the St. Louis, MO to Philadelphia bus

How much does a St. Louis, MO Philadelphia bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $95 and takes 23h 25m to reach Philadelphia. Compare offers to save money!

How much could I save by comparing buses from St. Louis, MO to Philadelphia?

This route is offered by 2 companies with a range of ticket prices between $95 and $197. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Philadelphia.

On average, how many connections are available from St. Louis, MO to Philadelphia each day?

Every day, the St. Louis, MO to Philadelphia bus route is served by approximately 10 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from St. Louis, MO to Philadelphia take?

The fastest bus from St. Louis, MO to Philadelphia is offered by Greyhound US and takes 23h 5m. Bus tickets for this connection cost $140. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from St. Louis, MO to Philadelphia?

The earliest bus arriving in Philadelphia from St. Louis, MO starts at 1:45 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from St. Louis, MO to Philadelphia?

The latest bus trip departing from St. Louis, MO for Philadelphia starts at 11:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the St. Louis, MO Philadelphia route?

When traveling by bus from St. Louis, MO to Philadelphia, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between St. Louis, MO and Philadelphia?

You can check all the direct connections between St. Louis, MO and Philadelphia by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the St. Louis, MO to Philadelphia bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the St. Louis, MO Philadelphia bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the St. Louis, MO Philadelphia bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from St. Louis, MO to Philadelphia on your planned travel date.

How does CheckMyBus find the best bus deals from St. Louis, MO to Philadelphia?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 10 daily trips between St. Louis, MO and Philadelphia. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from St. Louis, MO to Philadelphia?

Prices and availability for 10 trips between St. Louis, MO and Philadelphia change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route St. Louis, MO to Philadelphia

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to St. Louis, MO and to Philadelphia

Here’s an overview of the most popular bus routes to St. Louis, MO and to Philadelphia. Simply click on the connection of your choice, and you will find all the details about your bus route!