Which bus from Myrtle Beach, SC to St. Louis, MO is the cheapest?

Compare all bus companies and find the best price: Bus tickets from $104
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Compare all timetables for the bus from Myrtle Beach, SC to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Myrtle Beach, SC to St. Louis, MO from various bus operators like Greyhound US for the next days.

today
$109
tomorrow
Wednesday
$124
Thursday
$110
Friday
$114
Saturday
$120
Sunday

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 26h 50m 1:55 PM Myrtle Beach, SC Bus Stop 3:45 PM St. Louis, MO Gateway Station  Economy $109
  • Did you know that if you travel from Myrtle Beach, SC to St. Louis, MO via Atlanta, GA, you can save more than $15? You can find the corresponding connections below.
    • Greyhound US
      20h 40m
      0
      1:55 PM
      Myrtle Beach, SC
      Bus Stop
      10:50 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $39
      • Waiting Time 1h 9m
    • FlixBus
      10h 36m
      0
      11:59 PM
      Atlanta, GA
      Garnett Transit Station
      9:35 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $55
    Travel Time is 5h 10m shorter, and you will save $15

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 20h 40m 1:55 PM Myrtle Beach, SC Bus Stop 9:35 AM St. Louis, MO Gateway Station  Economy $124
  • Did you know that if you travel from Myrtle Beach, SC to St. Louis, MO via Atlanta, GA, you can save more than $30? You can find the corresponding connections below.
    • Greyhound US
      20h 40m
      0
      1:55 PM
      Myrtle Beach, SC
      Bus Stop
      10:50 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $39
      • Waiting Time 1h 9m
    • FlixBus
      10h 36m
      0
      11:59 PM
      Atlanta, GA
      Garnett Transit Station
      9:35 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $55
    Travel time is 1h 0m longer, but you will save $30

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 20h 40m 1:55 PM Myrtle Beach, SC Bus Stop 9:35 AM St. Louis, MO Gateway Station  Economy $110
  • Did you know that if you travel from Myrtle Beach, SC to St. Louis, MO via Atlanta, GA, you can save more than $16? You can find the corresponding connections below.
    • Greyhound US
      20h 40m
      0
      1:55 PM
      Myrtle Beach, SC
      Bus Stop
      10:50 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $39
      • Waiting Time 1h 9m
    • FlixBus
      10h 36m
      0
      11:59 PM
      Atlanta, GA
      Garnett Transit Station
      9:35 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $55
    Travel time is 1h 0m longer, but you will save $16

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 20h 40m 1:55 PM Myrtle Beach, SC Bus Stop 9:35 AM St. Louis, MO Gateway Station  Economy $114
  • Did you know that if you travel from Myrtle Beach, SC to St. Louis, MO via Atlanta, GA, you can save more than $20? You can find the corresponding connections below.
    • Greyhound US
      20h 40m
      0
      1:55 PM
      Myrtle Beach, SC
      Bus Stop
      10:50 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $39
      • Waiting Time 1h 9m
    • FlixBus
      10h 36m
      0
      11:59 PM
      Atlanta, GA
      Garnett Transit Station
      9:35 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $55
    Travel time is 1h 0m longer, but you will save $20

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 20h 40m 1:55 PM Myrtle Beach, SC Bus Stop 9:35 AM St. Louis, MO Gateway Station  Economy $120
  • Did you know that if you travel from Myrtle Beach, SC to St. Louis, MO via Atlanta, GA, you can save more than $26? You can find the corresponding connections below.
    • Greyhound US
      20h 40m
      0
      1:55 PM
      Myrtle Beach, SC
      Bus Stop
      10:50 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $39
      • Waiting Time 1h 9m
    • FlixBus
      10h 36m
      0
      11:59 PM
      Atlanta, GA
      Garnett Transit Station
      9:35 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $55
    Travel time is 1h 0m longer, but you will save $26

Best Price Offer: The price for the cheapest bus from Myrtle Beach, SC to St. Louis, MO is $104 on 5/13/2026. Flexible travelers save on ticket prices.


Facts about the bus from Myrtle Beach, SC to St. Louis, MO

Compare all providers like Greyhound US that travel 1 times every day by bus from Myrtle Beach, SC to St. Louis, MO in one click! Book your bus ticket from Myrtle Beach, SC to St. Louis, MO starting from $104!

Cheapest Bus $104
Fastest Bus 19h 40m
Earliest Bus 1:55 PM
Latest Bus 1:55 PM
Daily Bus Routes 1 Ø
Distance 717.0 miles
Bus Companies Greyhound US

Cheapest bus connections from Myrtle Beach, SC to St. Louis, MO

Every day, 1 buses from 1 bus companies leave Myrtle Beach, SC for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/20/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 04/19
Monday 04/20
$113
Tuesday 04/21
Wednesday 04/22
$124
Thursday 04/23
$110
Friday 04/24
$114
Saturday 04/25
$120
Sunday 04/26
Monday 04/27
$108
Tuesday 04/28
$112
Wednesday 04/29
$108
Thursday 04/30
Friday 05/01
$107
Saturday 05/02
$114
Sunday 05/03
$107
Monday 05/04
Tuesday 05/05
$107
Wednesday 05/06
Thursday 05/07
Friday 05/08
$113
Saturday 05/09
$116
Sunday 05/10
Monday 05/11
$114
Tuesday 05/12
$110
Wednesday 05/13
$104
Thursday 05/14
$108
Friday 05/15
Saturday 05/16

How to save money travelling from Myrtle Beach, SC to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Myrtle Beach, SC to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Myrtle Beach, SC to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Myrtle Beach, SC to St. Louis, MO are also emptier.

All bus stations and stops in Myrtle Beach, SC and St. Louis, MO

In the map below, you can see where to find all bus stations in Myrtle Beach, SC and St. Louis, MO.

Service and Comfort on the bus from Myrtle Beach, SC to St. Louis, MO

Want to know which seat classes are available on the buses from Myrtle Beach, SC to St. Louis, MO? Or which bus companies serve the route Myrtle Beach, SC to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Myrtle Beach, SC to St. Louis, MO bus

How much does a Myrtle Beach, SC St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $104 and takes 25h 50m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Myrtle Beach, SC to St. Louis, MO?

This route is offered by 1 companies with a range of ticket prices between $104 and $124. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Myrtle Beach, SC to St. Louis, MO each day?

Every day, the Myrtle Beach, SC to St. Louis, MO bus route is served by approximately 1 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Myrtle Beach, SC to St. Louis, MO take?

The fastest bus from Myrtle Beach, SC to St. Louis, MO is offered by Greyhound US and takes 19h 40m. Bus tickets for this connection cost $124. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Myrtle Beach, SC to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Myrtle Beach, SC starts at 1:55 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Myrtle Beach, SC to St. Louis, MO?

The latest bus trip departing from Myrtle Beach, SC for St. Louis, MO starts at 1:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Myrtle Beach, SC St. Louis, MO route?

When traveling by bus from Myrtle Beach, SC to St. Louis, MO, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Myrtle Beach, SC and St. Louis, MO?

You can check all the direct connections between Myrtle Beach, SC and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Myrtle Beach, SC to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Myrtle Beach, SC St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Myrtle Beach, SC St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Myrtle Beach, SC to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Myrtle Beach, SC to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 1 daily trips between Myrtle Beach, SC and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Myrtle Beach, SC to St. Louis, MO?

Prices and availability for 1 trips between Myrtle Beach, SC and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Myrtle Beach, SC to St. Louis, MO

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Myrtle Beach, SC and to St. Louis, MO

Here’s an overview of the most popular bus routes to Myrtle Beach, SC and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus from Windsor, ON to Myrtle Beach, SC Bus from Windsor, ON to Myrtle Beach, SC
Bus Tifton, GA to Myrtle Beach, SC Bus Tifton, GA to Myrtle Beach, SC
Bus to Myrtle Beach, SC from Dalton, GA Bus to Myrtle Beach, SC from Dalton, GA
Bus from Las Vegas to Myrtle Beach, SC Bus from Las Vegas to Myrtle Beach, SC
College Park, MD to St. Louis, MO bus College Park, MD to St. Louis, MO bus
Bus to St. Louis, MO from Toledo, OH Bus to St. Louis, MO from Toledo, OH
Buses from Temple, TX to St. Louis, MO Buses from Temple, TX to St. Louis, MO
From Clarksville, TN to St. Louis, MO bus From Clarksville, TN to St. Louis, MO bus
Popular Airport Shuttles to Myrtle Beach, SC and to St. Louis, MO
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