Bus Philadelphia to St. Louis, MO - Compare all Companies

Compare all timetables for the bus from Philadelphia to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Philadelphia to St. Louis, MO from various bus operators like Greyhound US or FlixBus for the next days.

today

$101

tomorrow

$95

Wednesday

$95

Thursday

$95

Friday

Saturday

$94

Sunday

$98

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 50m	12:05 PM	Philadelphia	Spring Garden St Station	7:55 AM	St. Louis, MO	Gateway Station	Economy	$101	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 6/22/2026 12:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/23/2026 7:55:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 20h 50m
FlixBus	24h 20m	11:55 PM	Philadelphia	Spring Garden St Station	11:15 PM	St. Louis, MO	Gateway Station	Economy	$112	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 6/22/2026 11:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/23/2026 11:15:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 24h 20m
Greyhound US	20h 50m	3:25 AM	Philadelphia	Spring Garden St Station	11:15 PM	St. Louis, MO	Gateway Station	Economy	$114	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 6/22/2026 3:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/22/2026 11:15:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 20h 50m
Greyhound US	22h 35m	5:35 PM	Philadelphia	Spring Garden St Station	3:10 PM	St. Louis, MO	Gateway Station	Economy	$200	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 6/22/2026 5:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/23/2026 3:10:00 PM. 50 Economy ticket for $200 per person are available. Travel duration is 22h 35m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	28h 25m	11:45 AM	Philadelphia	Schuylkill Ave and Walnut Street	3:10 PM	St. Louis, MO	Gateway Station	Economy	$95	A Bus from FlixBus goes from Schuylkill Ave and Walnut Street, Philadelphia (USA) at 6/23/2026 11:45:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/24/2026 3:10:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 28h 25m
FlixBus	38h 10m	6:45 PM	Philadelphia	Schuylkill Ave and Walnut Street	7:55 AM	St. Louis, MO	Gateway Station	Economy	$96	A Bus from FlixBus goes from Schuylkill Ave and Walnut Street, Philadelphia (USA) at 6/23/2026 6:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/25/2026 7:55:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 38h 10m
FlixBus	34h 0m	2:15 PM	Philadelphia	Schuylkill Ave and Walnut Street	11:15 PM	St. Louis, MO	Gateway Station	Economy	$99	A Bus from FlixBus goes from Schuylkill Ave and Walnut Street, Philadelphia (USA) at 6/23/2026 2:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/24/2026 11:15:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 34h 0m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 35m	5:35 PM	Philadelphia	Spring Garden St Station	3:10 PM	St. Louis, MO	Gateway Station	Economy	$95	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 6/24/2026 5:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/25/2026 3:10:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 22h 35m
Greyhound US	20h 50m	12:05 PM	Philadelphia	Central Bus Station	7:55 AM	St. Louis, MO	Gateway Station	Economy	$98	A Bus from Greyhound US goes from Central Bus Station, Philadelphia (USA) at 6/24/2026 12:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/25/2026 7:55:00 AM. 50 Economy ticket for $98 per person are available. Travel duration is 20h 50m
Greyhound US	20h 50m	3:25 AM	Philadelphia	Central Bus Station	11:15 PM	St. Louis, MO	Gateway Station	Economy	$104	A Bus from Greyhound US goes from Central Bus Station, Philadelphia (USA) at 6/24/2026 3:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/24/2026 11:15:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 20h 50m
Greyhound US	28h 55m	7:20 PM	Philadelphia	Central Bus Station	11:15 PM	St. Louis, MO	Gateway Station	Economy	$108	A Bus from Greyhound US goes from Central Bus Station, Philadelphia (USA) at 6/24/2026 7:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/25/2026 11:15:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 28h 55m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 50m	12:05 PM	Philadelphia	Spring Garden St Station	7:55 AM	St. Louis, MO	Gateway Station	Economy	$95	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 6/25/2026 12:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 7:55:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 20h 50m
Greyhound US	26h 55m	6:00 AM	Philadelphia	Schuylkill Ave and Walnut Street	7:55 AM	St. Louis, MO	Gateway Station	Economy	$101	A Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia (USA) at 6/25/2026 6:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 7:55:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 26h 55m
Greyhound US	28h 35m	8:10 PM	Philadelphia	Schuylkill Ave and Walnut Street	11:45 PM	St. Louis, MO	Gateway Station	Economy	$101	A Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia (USA) at 6/25/2026 8:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 11:45:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 28h 35m
FlixBus	27h 30m	8:45 PM	Philadelphia	Spring Garden St Station	11:15 PM	St. Louis, MO	Gateway Station	Economy	$103	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 6/25/2026 8:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 11:15:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 27h 30m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	24h 20m	11:55 PM	Philadelphia	Spring Garden St Station	11:15 PM	St. Louis, MO	Gateway Station	Economy	$94	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 6/27/2026 11:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/28/2026 11:15:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 24h 20m
Greyhound US	22h 35m	5:35 PM	Philadelphia	Spring Garden St Station	3:10 PM	St. Louis, MO	Gateway Station	Economy	$101	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 6/27/2026 5:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/28/2026 3:10:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 22h 35m
Greyhound US	20h 50m	12:05 PM	Philadelphia	Spring Garden St Station	7:55 AM	St. Louis, MO	Gateway Station	Economy	$110	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 6/27/2026 12:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/28/2026 7:55:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 20h 50m
Greyhound US	20h 50m	3:25 AM	Philadelphia	Spring Garden St Station	11:15 PM	St. Louis, MO	Gateway Station	Economy	$124	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 6/27/2026 3:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 11:15:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 20h 50m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	24h 20m	11:55 PM	Philadelphia	Spring Garden St Station	11:15 PM	St. Louis, MO	Gateway Station	Economy	$98	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 6/28/2026 11:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2026 11:15:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 24h 20m
Greyhound US	20h 50m	12:05 PM	Philadelphia	Spring Garden St Station	7:55 AM	St. Louis, MO	Gateway Station	Economy	$136	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 6/28/2026 12:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2026 7:55:00 AM. 50 Economy ticket for $136 per person are available. Travel duration is 20h 50m
Greyhound US	22h 35m	5:35 PM	Philadelphia	Spring Garden St Station	3:10 PM	St. Louis, MO	Gateway Station	Economy	$136	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 6/28/2026 5:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2026 3:10:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 22h 35m
Greyhound US	20h 50m	3:25 AM	Philadelphia	Spring Garden St Station	11:15 PM	St. Louis, MO	Gateway Station	Economy	$144	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 6/28/2026 3:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/28/2026 11:15:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 20h 50m

Best Price Offer: The price for the cheapest bus from Philadelphia to St. Louis, MO is $89 on 7/11/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Philadelphia and St. Louis, MO

See here how frequent the connections between Philadelphia and St. Louis, MO are, during different times and days of the week.

Wednesday is the busiest day, with more than 8 daily buses from Philadelphia to St. Louis, MO. Tuesday has instead the fewest connections, with only 3 daily coaches between Philadelphia and St. Louis, MO.

The busiest time of the day is the Afternoon, with 14 buses from Philadelphia to St. Louis, MO, while Morning sees the fewest connections between Philadelphia and St. Louis, MO, with 2 offers.

Facts about the bus from Philadelphia to St. Louis, MO

Compare all providers like Greyhound US and FlixBus that travel 5 times every day by bus from Philadelphia to St. Louis, MO in one click! Book your bus ticket from Philadelphia to St. Louis, MO starting from $89!

Cheapest Bus	$89
Fastest Bus	19h 50m
Earliest Bus	3:25 AM
Latest Bus	11:55 PM
Daily Bus Routes	5 Ø
Distance	807.9 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Philadelphia to St. Louis, MO

Every day, 5 buses from 2 bus companies leave Philadelphia for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/22/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 06/21

Monday 06/22

$101

Tuesday 06/23

$95

Wednesday 06/24

$95

Thursday 06/25

$93

Friday 06/26

Saturday 06/27

$93

Sunday 06/28

$98

Monday 06/29

$97

Tuesday 06/30

Wednesday 07/01

Thursday 07/02

$107

Friday 07/03

$101

Saturday 07/04

Sunday 07/05

$103

Monday 07/06

$99

Tuesday 07/07

Wednesday 07/08

Thursday 07/09

Friday 07/10

Saturday 07/11

$89

Sunday 07/12

$91

Monday 07/13

Tuesday 07/14

$89

Wednesday 07/15

Thursday 07/16

Friday 07/17

$90

Saturday 07/18

The cheapest time to travel from Philadelphia to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Philadelphia to St. Louis, MO, for the next 30 days.

With a price starting from $89, Tuesday is the cheapest day for a bus from Philadelphia to St. Louis, MO. Monday instead is the most expensive day with prices starting from $97.

Night is the cheapest day time for bus tickets from Philadelphia to St. Louis, MO, with $89. Morning is the most expensive time of the day with prices starting from $95.

How to save money travelling from Philadelphia to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Philadelphia to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Philadelphia to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Philadelphia to St. Louis, MO are also emptier.

All bus stations and stops in Philadelphia and St. Louis, MO

In the map below, you can see where to find all bus stations in Philadelphia and St. Louis, MO.

Central Bus Station

Filbert St 1001

Market St

Spring Garden St Station

Spring Garden St & 2nd St

30th Street Station

Market St 2955

Philadelphia, PA

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from Philadelphia to St. Louis, MO

Want to know which seat classes are available on the buses from Philadelphia to St. Louis, MO? Or which bus companies serve the route Philadelphia to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Philadelphia to St. Louis, MO bus

How much does a Philadelphia St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $89 and takes 23h 20m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Philadelphia to St. Louis, MO?

This route is offered by 2 companies with a range of ticket prices between $89 and $212. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Philadelphia to St. Louis, MO each day?

Every day, the Philadelphia to St. Louis, MO bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Philadelphia to St. Louis, MO take?

The fastest bus from Philadelphia to St. Louis, MO is offered by Greyhound US and takes 19h 50m. Bus tickets for this connection cost $114. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Philadelphia to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Philadelphia starts at 3:25 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Philadelphia to St. Louis, MO?

The latest bus trip departing from Philadelphia for St. Louis, MO starts at 11:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Philadelphia St. Louis, MO route?

When traveling by bus from Philadelphia to St. Louis, MO, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Philadelphia and St. Louis, MO?

You can check all the direct connections between Philadelphia and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Philadelphia to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Philadelphia St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Philadelphia St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Philadelphia to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Philadelphia to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between Philadelphia and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Philadelphia to St. Louis, MO?

Prices and availability for 5 trips between Philadelphia and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Philadelphia to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Philadelphia and to St. Louis, MO

Here’s an overview of the most popular bus routes to Philadelphia and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!