Which bus from Philadelphia to St. Louis, MO is the cheapest?

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Compare all timetables for the bus from Philadelphia to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Philadelphia to St. Louis, MO from various bus operators like Greyhound US or FlixBus for the next days.

today
tomorrow
$110
Friday
$117
Saturday
$120
Sunday
$124
Monday
Tuesday
$172

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 22h 50m 5:30 PM Philadelphia Spring Garden St Station 3:20 PM St. Louis, MO Gateway Station  Economy $110
Greyhound US 20h 50m 12:05 PM Philadelphia Spring Garden St Station 7:55 AM St. Louis, MO Gateway Station  Economy $114
FlixBus 24h 25m 8:30 AM Philadelphia Spring Garden St Station 7:55 AM St. Louis, MO Gateway Station  Economy $134
Greyhound US 25h 55m 7:00 AM Philadelphia IRS Building 7:55 AM St. Louis, MO Gateway Station  Economy $135
FlixBus 26h 35m 1:45 PM Philadelphia Spring Garden St Station 3:20 PM St. Louis, MO Gateway Station  Economy $139

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 22h 50m 5:30 PM Philadelphia Spring Garden St Station 3:20 PM St. Louis, MO Gateway Station  Economy $117
Greyhound US 20h 50m 12:05 PM Philadelphia Spring Garden St Station 7:55 AM St. Louis, MO Gateway Station  Economy $128
FlixBus 22h 40m 10:15 AM Philadelphia Spring Garden St Station 7:55 AM St. Louis, MO Gateway Station  Economy $134
Greyhound US 25h 55m 7:00 AM Philadelphia IRS Building 7:55 AM St. Louis, MO Gateway Station  Economy $135
FlixBus 36h 40m 8:15 PM Philadelphia JFK & Broad 7:55 AM St. Louis, MO Gateway Station  Economy $135

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 20h 50m 12:05 PM Philadelphia Convention Center 7:55 AM St. Louis, MO Gateway Station  Economy $120
Greyhound US 22h 50m 5:30 PM Philadelphia Convention Center 3:20 PM St. Louis, MO Gateway Station  Economy $132
FlixBus 22h 40m 10:15 AM Philadelphia Spring Garden St Station 7:55 AM St. Louis, MO Gateway Station  Economy $147
FlixBus 36h 40m 8:15 PM Philadelphia JFK & Broad 7:55 AM St. Louis, MO Gateway Station  Economy $151
Greyhound US 25h 55m 7:00 AM Philadelphia Schuylkill Ave and Walnut Street 7:55 AM St. Louis, MO Gateway Station  Economy $163

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 22h 50m 5:30 PM Philadelphia Spring Garden St Station 3:20 PM St. Louis, MO Gateway Station  Economy $124
Greyhound US 20h 50m 12:05 PM Philadelphia Spring Garden St Station 7:55 AM St. Louis, MO Gateway Station  Economy $132
Greyhound US 20h 30m 3:55 AM Philadelphia Spring Garden St Station 11:25 PM St. Louis, MO Gateway Station  Economy $172
FlixBus 24h 25m 8:30 AM Philadelphia Spring Garden St Station 7:55 AM St. Louis, MO Gateway Station  Economy $176
FlixBus 34h 25m 10:30 PM Philadelphia Spring Garden St Station 7:55 AM St. Louis, MO Gateway Station  Economy $181

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 20h 50m 12:05 PM Philadelphia Spring Garden St Station 7:55 AM St. Louis, MO Gateway Station  Economy $172
Greyhound US 22h 50m 5:30 PM Philadelphia Spring Garden St Station 3:20 PM St. Louis, MO Gateway Station  Economy $177
FlixBus 22h 40m 10:15 AM Philadelphia Spring Garden St Station 7:55 AM St. Louis, MO Gateway Station  Economy $184
Greyhound US 25h 55m 7:00 AM Philadelphia IRS Building 7:55 AM St. Louis, MO Gateway Station  Economy $190
FlixBus 26h 25m 10:00 PM Philadelphia Spring Garden St Station 11:25 PM St. Louis, MO Gateway Station  Economy $199
  • Did you know that if you travel from Philadelphia to St. Louis, MO via Pittsburgh, you can save more than $31? You can find the corresponding connections below.
    • Busbud
      20h 50m
      0
      12:05 PM
      Philadelphia
      Convention Center
      7:00 PM
      Pittsburgh
      Grant Street Transportation Center
      0
      Busbud
      Economy
      $59
      • Waiting Time 1h 0m
    • Busbud
      12h 55m
      0
      8:00 PM
      Pittsburgh
      Grant Street Transportation Center
      7:55 AM
      St. Louis, MO
      Gateway Station
      0
      Busbud
      Economy
      $82
    Travel time is 1h 0m longer, but you will save $31

Best Price Offer: The price for the cheapest bus from Philadelphia to St. Louis, MO is $98 on 1/5/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Philadelphia and St. Louis, MO

See here how frequent the connections between Philadelphia and St. Louis, MO are, during different times and days of the week.
Sunday is the busiest day, with more than 26 daily buses from Philadelphia to St. Louis, MO. Thursday has instead the fewest connections, with only 11 daily coaches between Philadelphia and St. Louis, MO.
The busiest time of the day is the Afternoon, with 37 buses from Philadelphia to St. Louis, MO, while Night sees the fewest connections between Philadelphia and St. Louis, MO, with 8 offers.

Facts about the bus from Philadelphia to St. Louis, MO

Compare all providers like Greyhound US and FlixBus that travel 19 times every day by bus from Philadelphia to St. Louis, MO in one click! Book your bus ticket from Philadelphia to St. Louis, MO starting from $98!

Cheapest Bus $98
Fastest Bus 19h 30m
Earliest Bus 3:55 AM
Latest Bus 10:00 PM
Daily Bus Routes 19 Ø
Distance 807.9 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from Philadelphia to St. Louis, MO

Every day, 19 buses from 2 bus companies leave Philadelphia for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/17/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 12/14
Monday 12/15
Tuesday 12/16
Wednesday 12/17
Thursday 12/18
$110
Friday 12/19
$117
Saturday 12/20
$120
Sunday 12/21
$124
Monday 12/22
Tuesday 12/23
$172
Wednesday 12/24
Thursday 12/25
$122
Friday 12/26
Saturday 12/27
Sunday 12/28
Monday 12/29
$117
Tuesday 12/30
Wednesday 12/31
Thursday 01/01
Friday 01/02
Saturday 01/03
Sunday 01/04
Monday 01/05
$98
Tuesday 01/06
Wednesday 01/07
Thursday 01/08
Friday 01/09
Saturday 01/10

The cheapest time to travel from Philadelphia to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Philadelphia to St. Louis, MO, for the next 30 days.
With a price starting from $110, Thursday is the cheapest day for a bus from Philadelphia to St. Louis, MO. Tuesday instead is the most expensive day with prices starting from $172.
Night is the cheapest day time for bus tickets from Philadelphia to St. Louis, MO, with $69. Evening is the most expensive time of the day with prices starting from $135.

How to save money travelling from Philadelphia to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Philadelphia to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Philadelphia to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Philadelphia to St. Louis, MO are also emptier.

Beloved bus companies from Philadelphia to St. Louis, MO

These are the most booked bus companies between Philadelphia to St. Louis, MO from our users.

FlixBus from Philadelphia to St. Louis, MO

FlixBus

Here you will find the key facts about the FlixBus bus route Philadelphia to St. Louis, MO:

Cheapest Price $134
Fastest Bus 21h 40m
Earliest Bus 8:30 AM
Last Bus 10:00 PM
Daily Connections 7 Ø
Found on 12/15/2025

All bus stations and stops in Philadelphia and St. Louis, MO

In the map below, you can see where to find all bus stations in Philadelphia and St. Louis, MO.

Service and Comfort on the bus from Philadelphia to St. Louis, MO

Want to know which seat classes are available on the buses from Philadelphia to St. Louis, MO? Or which bus companies serve the route Philadelphia to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Philadelphia to St. Louis, MO bus

How much does a Philadelphia St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $98 and takes 21h 50m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Philadelphia to St. Louis, MO?

This route is offered by 2 companies with a range of ticket prices between $98 and $303. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Philadelphia to St. Louis, MO each day?

Every day, the Philadelphia to St. Louis, MO bus route is served by approximately 19 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Philadelphia to St. Louis, MO take?

The fastest bus from Philadelphia to St. Louis, MO is offered by Greyhound US and takes 19h 30m. Bus tickets for this connection cost $136. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Philadelphia to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Philadelphia starts at 3:55 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Philadelphia to St. Louis, MO?

The latest bus trip departing from Philadelphia for St. Louis, MO starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Philadelphia St. Louis, MO route?

When traveling by bus from Philadelphia to St. Louis, MO, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Philadelphia and St. Louis, MO?

You can check all the direct connections between Philadelphia and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Philadelphia to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Philadelphia St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Philadelphia St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Philadelphia to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Philadelphia to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 19 daily trips between Philadelphia and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Philadelphia to St. Louis, MO?

Prices and availability for 19 trips between Philadelphia and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Philadelphia to St. Louis, MO

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Philadelphia and to St. Louis, MO

Here’s an overview of the most popular bus routes to Philadelphia and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!
Buses Richmond, VA - Philadelphia Buses Richmond, VA - Philadelphia
Buses Norfolk, VA to Philadelphia Buses Norfolk, VA to Philadelphia
Bus Columbus, OH to Philadelphia Bus Columbus, OH to Philadelphia
Bus Charlotte - Philadelphia Bus Charlotte - Philadelphia
Bus from Charlotte to St. Louis, MO Bus from Charlotte to St. Louis, MO
From Springfield, IL to St. Louis, MO bus From Springfield, IL to St. Louis, MO bus
Bus to St. Louis, MO from New York Bus to St. Louis, MO from New York
Knoxville, TN to St. Louis, MO bus Knoxville, TN to St. Louis, MO bus
Popular Airport Shuttles to Philadelphia and to St. Louis, MO
CheckMyBus › Buses in USA › Bus to Philadelphia › Bus to St. Louis, MO

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