Bus Houston to St. Louis, MO - Compare all Companies

Compare all timetables for the bus from Houston to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Houston to St. Louis, MO from various bus operators like FlixBus, Greyhound US or Greyhound Lines Mexico for the next days.

today

$138

tomorrow

Thursday

$104

Friday

$106

Saturday

$99

Sunday

$118

Monday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Valley Transit	30h 20m	6:35 AM	Houston	SW Agencia Autobuses	12:55 PM	St. Louis, MO	Gateway Station	Economy	$138	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 3/24/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/25/2026 12:55:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 30h 20m
FlixBus	23h 40m	1:15 PM	Houston	Downtown Houston	12:55 PM	St. Louis, MO	Gateway Station	Economy	$138	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 3/24/2026 1:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 3/25/2026 12:55:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 23h 40m
Greyhound US	20h 55m	1:50 AM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$139	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 3/24/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/24/2026 10:45:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 20h 55m
Greyhound US	27h 50m	6:55 PM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$139	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 3/24/2026 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 3/25/2026 10:45:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 27h 50m
FlixBus	25h 30m	11:25 AM	Houston	Uptown/Upper Kirby	12:55 PM	St. Louis, MO	Gateway Station	Economy	$139	A Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 3/24/2026 11:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/25/2026 12:55:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 25h 30m

Did you know that if you travel from Houston to St. Louis, MO via Conroe, TX, you can save more than $22? You can find the corresponding connections below.
- Greyhound US
  
  20h 55m
  
  0
  
  1:50 AM
  
  Houston
  Harrisburg Blvd Station
  
  2:45 AM
  
  Conroe, TX
  Bus Stop
  
  0
  
  Economy
  
  $9
  
  A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 3/25/2026 1:50:00 AM to Bus Stop, Conroe, TX (USA) arriving at 3/25/2026 2:45:00 AM. 50 Economy ticket for $9 per person are available. Travel duration is 0h 55m
- Greyhound US
  
  19h 55m
  
  0
  
  2:50 AM
  
  Conroe, TX
  Bus Stop
  
  10:45 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $107
  
  A Bus from Greyhound US goes from Bus Stop, Conroe, TX (USA) at 3/25/2026 2:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/25/2026 10:45:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 19h 55m
Travel time is the same as the direct connection, but you will save $22

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	37h 15m	9:30 AM	Houston	SW Agencia Autobuses	10:45 PM	St. Louis, MO	Gateway Station	Economy	$104	A Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 3/26/2026 9:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/27/2026 10:45:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 37h 15m
Greyhound US	22h 55m	12:05 AM	Houston	Harrisburg Blvd Station	11:00 PM	St. Louis, MO	Gateway Station	Economy	$105	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 3/26/2026 12:05:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/26/2026 11:00:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 22h 55m
Greyhound US	24h 54m	12:01 PM	Houston	Harrisburg Blvd Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$105	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 3/26/2026 12:01:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 3/27/2026 12:55:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 24h 54m
FlixBus	25h 30m	11:25 AM	Houston	Uptown/Upper Kirby	12:55 PM	St. Louis, MO	Gateway Station	Economy	$105	A Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 3/26/2026 11:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/27/2026 12:55:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 25h 30m
Valley Transit	30h 20m	6:35 AM	Houston	SW Agencia Autobuses	12:55 PM	St. Louis, MO	Gateway Station	Economy	$106	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 3/26/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/27/2026 12:55:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 30h 20m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 55m	1:50 AM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$106	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 3/27/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/27/2026 10:45:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 20h 55m
FlixBus	22h 15m	8:55 AM	Houston	Uptown/Upper Kirby	7:10 AM	St. Louis, MO	Gateway Station	Economy	$106	A Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 3/27/2026 8:55:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/28/2026 7:10:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 22h 15m
FlixBus	23h 40m	1:15 PM	Houston	Downtown Houston	12:55 PM	St. Louis, MO	Gateway Station	Economy	$106	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 3/27/2026 1:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 3/28/2026 12:55:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 23h 40m
Greyhound US	23h 10m	1:45 PM	Houston	Harrisburg Blvd Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$107	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 3/27/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 3/28/2026 12:55:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 23h 10m
Valley Transit	30h 20m	6:35 AM	Houston	SW Agencia Autobuses	12:55 PM	St. Louis, MO	Gateway Station	Economy	$107	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 3/27/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/28/2026 12:55:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 30h 20m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 55m	1:50 AM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$99	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 3/28/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/28/2026 10:45:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 20h 55m
FlixBus	23h 40m	1:15 PM	Houston	Downtown Houston	12:55 PM	St. Louis, MO	Gateway Station	Economy	$99	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 3/28/2026 1:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 3/29/2026 12:55:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 23h 40m
Greyhound US	23h 10m	1:45 PM	Houston	Harrisburg Blvd Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$100	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 3/28/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 3/29/2026 12:55:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 23h 10m
Valley Transit	30h 20m	6:35 AM	Houston	SW Agencia Autobuses	12:55 PM	St. Louis, MO	Gateway Station	Economy	$100	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 3/28/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/29/2026 12:55:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 30h 20m
Greyhound Lines Mexico	37h 15m	9:30 AM	Houston	SW Agencia Autobuses	10:45 PM	St. Louis, MO	Gateway Station	Economy	$100	A Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 3/28/2026 9:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/29/2026 10:45:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 37h 15m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	27h 55m	6:55 PM	Houston	Harrisburg Blvd Station	10:50 PM	St. Louis, MO	Gateway Station	Economy	$118	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 3/29/2026 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 3/30/2026 10:50:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 27h 55m
FlixBus	22h 15m	8:55 AM	Houston	Uptown/Upper Kirby	7:10 AM	St. Louis, MO	Gateway Station	Economy	$118	A Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 3/29/2026 8:55:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/30/2026 7:10:00 AM. 50 Economy ticket for $118 per person are available. Travel duration is 22h 15m
FlixBus	23h 40m	1:15 PM	Houston	Downtown Houston	12:55 PM	St. Louis, MO	Gateway Station	Economy	$118	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 3/29/2026 1:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 3/30/2026 12:55:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 23h 40m
Greyhound US	20h 55m	1:50 AM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$119	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 3/29/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/29/2026 10:45:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 20h 55m
Greyhound Lines Mexico	37h 15m	9:30 AM	Houston	SW Agencia Autobuses	10:45 PM	St. Louis, MO	Gateway Station	Economy	$121	A Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 3/29/2026 9:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 3/30/2026 10:45:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 37h 15m

Best Price Offer: The price for the cheapest bus from Houston to St. Louis, MO is $98 on 4/2/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Houston and St. Louis, MO

See here how frequent the connections between Houston and St. Louis, MO are, during different times and days of the week.

Friday is the busiest day, with more than 23 daily buses from Houston to St. Louis, MO. Sunday has instead the fewest connections, with only 10 daily coaches between Houston and St. Louis, MO.

The busiest time of the day is the Morning, with 35 buses from Houston to St. Louis, MO, while Night sees the fewest connections between Houston and St. Louis, MO, with 8 offers.

Facts about the bus from Houston to St. Louis, MO

Compare all providers like FlixBus, Greyhound US and Greyhound Lines Mexico that travel 16 times every day by bus from Houston to St. Louis, MO in one click! Book your bus ticket from Houston to St. Louis, MO starting from $98!

Cheapest Bus	$98
Fastest Bus	20h 35m
Earliest Bus	1:50 AM
Latest Bus	7:50 PM
Daily Bus Routes	16 Ø
Distance	680.5 miles
Bus Companies	FlixBus, Greyhound US, Greyhound Lines Mexico and Valley Transit

Cheapest bus connections from Houston to St. Louis, MO

Every day, 16 buses from 4 bus companies leave Houston for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/24/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 03/22

Monday 03/23

Tuesday 03/24

$138

Wednesday 03/25

Thursday 03/26

$104

Friday 03/27

$114

Saturday 03/28

$99

Sunday 03/29

$117

Monday 03/30

Tuesday 03/31

$119

Wednesday 04/01

Thursday 04/02

$98

Friday 04/03

Saturday 04/04

$106

Sunday 04/05

$115

Monday 04/06

$114

Tuesday 04/07

$128

Wednesday 04/08

$136

Thursday 04/09

$109

Friday 04/10

$114

Saturday 04/11

$129

Sunday 04/12

$127

Monday 04/13

$116

Tuesday 04/14

$127

Wednesday 04/15

$115

Thursday 04/16

$113

Friday 04/17

$113

Saturday 04/18

The cheapest time to travel from Houston to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Houston to St. Louis, MO, for the next 30 days.

With a price starting from $98, Thursday is the cheapest day for a bus from Houston to St. Louis, MO. Tuesday instead is the most expensive day with prices starting from $119.

Night is the cheapest day time for bus tickets from Houston to St. Louis, MO, with $98. Evening is the most expensive time of the day with prices starting from $100.

How to save money travelling from Houston to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Houston to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Houston to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Houston to St. Louis, MO are also emptier.

Beloved bus companies from Houston to St. Louis, MO

These are the most booked bus companies between Houston to St. Louis, MO from our users.

FlixBus from Houston to St. Louis, MO

Here you will find the key facts about the FlixBus bus route Houston to St. Louis, MO:

Cheapest Price	$99
Fastest Bus	20h 35m
Earliest Bus	11:25 AM
Last Bus	7:50 PM
Daily Connections	8 Ø
Found on	3/16/2026

Greyhound Lines Mexico from Houston to St. Louis, MO

Here you will find the key facts about the Greyhound Lines Mexico bus route Houston to St. Louis, MO:

Cheapest Price	$100
Fastest Bus	37h 15m
Earliest Bus	9:30 AM
Last Bus	9:30 AM
Daily Connections	1 Ø
Found on	3/3/2026

All bus stations and stops in Houston and St. Louis, MO

In the map below, you can see where to find all bus stations in Houston and St. Louis, MO.

Downtown Houston

Gray St 605

Harrisburg Blvd Station

Harrisburg Blvd 7000

Main Street

Main St 2121

Chase Bank

Milam Street 212

Uptown/Upper Kirby

Southwest Fwy 2525

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Houston to St. Louis, MO? Compare all modes of transports from Houston to St. Louis, MO.

Service and Comfort on the bus from Houston to St. Louis, MO

Want to know which seat classes are available on the buses from Houston to St. Louis, MO? Or which bus companies serve the route Houston to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Houston to St. Louis, MO bus

How much does a Houston St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $98 and takes 20h 55m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Houston to St. Louis, MO?

This route is offered by 4 companies with a range of ticket prices between $98 and $162. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Houston to St. Louis, MO each day?

Every day, the Houston to St. Louis, MO bus route is served by approximately 16 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Houston to St. Louis, MO take?

The fastest bus from Houston to St. Louis, MO is offered by FlixBus and takes 20h 35m. Bus tickets for this connection cost $106. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Houston to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Houston starts at 1:50 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Houston to St. Louis, MO?

The latest bus trip departing from Houston for St. Louis, MO starts at 7:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Houston St. Louis, MO route?

When traveling by bus from Houston to St. Louis, MO, passengers can travel with FlixBus, Greyhound US and Greyhound Lines Mexico. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Houston and St. Louis, MO?

You can check all the direct connections between Houston and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Greyhound US and Greyhound Lines Mexico.

What can I take with me on the Houston to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Houston St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Houston St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Houston to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Houston to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 16 daily trips between Houston and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Houston to St. Louis, MO?

Prices and availability for 16 trips between Houston and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Houston to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Houston and to St. Louis, MO

Here’s an overview of the most popular bus routes to Houston and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!