What is the best way to travel from Houston to St. Louis, MO?
Looking for a trip? Compare all the available Buses and Flights for the journey to St. Louis, MO from Houston. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 5 available companies to find your perfect trip!
What is the cheapest way to reach St. Louis, MO from Houston?
You can get to St. Louis, MO with just $150 by taking a Bus from Greyhound US, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus22h 40m05:05 PMHoustonDowntown Houston3:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 12/26/2025 5:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/27/2025 3:45:00 PM. 50 Economy ticket for $174 per person are available. Travel duration is 22h 40m
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Greyhound US25h 0m010:00 PMHoustonHarrisburg Blvd Station11:00 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/26/2025 10:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/27/2025 11:00:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 25h 0m
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FlixBus25h 55m01:50 PMHoustonUptown/Upper Kirby3:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 12/26/2025 1:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/27/2025 3:45:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 25h 55m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 12/26/2025 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/27/2025 12:55:00 PM. 50 Economy ticket for $237 per person are available. Travel duration is 30h 20m
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Frontier Airlines12h 7m09:55 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:02 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/26/2025 9:55:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/27/2025 10:02:00 AM. 50 Economy ticket for $237 per person are available. Travel duration is 12h 7m
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United Airlines2h 5m07:50 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:55 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/26/2025 7:50:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/26/2025 9:55:00 PM. 50 Economy ticket for $443 per person are available. Travel duration is 2h 5m
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Skyscanner2h 4m07:45 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:49 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/26/2025 7:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/26/2025 9:49:00 AM. 50 Economy ticket for $443 per person are available. Travel duration is 2h 4m
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Skyscanner2h 8m02:28 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport4:36 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/26/2025 2:28:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/26/2025 4:36:00 PM. 50 Economy ticket for $443 per person are available. Travel duration is 2h 8m
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United Airlines5h 57m06:30 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport12:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/26/2025 6:30:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/26/2025 12:27:00 PM. 50 Economy ticket for $453 per person are available. Travel duration is 5h 57m
Cheapest Buses Friday
Cheapest Flights Friday
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/27/2025 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/28/2025 12:55:00 PM. 50 Economy ticket for $150 per person are available. Travel duration is 23h 10m
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FlixBus28h 50m06:00 PMHoustonDowntown Houston10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 12/27/2025 6:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/28/2025 10:50:00 PM. 50 Economy ticket for $150 per person are available. Travel duration is 28h 50m
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Greyhound Lines Mexico37h 20m09:30 AMHoustonSW Agencia Autobuses10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 12/27/2025 9:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/28/2025 10:50:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 37h 20m
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FlixBus25h 30m011:25 AMHoustonUptown/Upper Kirby12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 12/27/2025 11:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/28/2025 12:55:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 25h 30m
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Greyhound US27h 50m07:00 PMHoustonHarrisburg Blvd Station10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/27/2025 7:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/28/2025 10:50:00 PM. 50 Economy ticket for $152 per person are available. Travel duration is 27h 50m
Cheapest Buses Saturday
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FlixBus22h 40m05:05 PMHoustonDowntown Houston3:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 12/28/2025 5:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/29/2025 3:45:00 PM. 50 Economy ticket for $172 per person are available. Travel duration is 22h 40m
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Greyhound US27h 55m06:55 PMHoustonHarrisburg Blvd Station10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/28/2025 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/29/2025 10:50:00 PM. 50 Economy ticket for $177 per person are available. Travel duration is 27h 55m
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FlixBus30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 12/28/2025 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/29/2025 12:55:00 PM. 50 Economy ticket for $177 per person are available. Travel duration is 30h 20m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/28/2025 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/29/2025 12:55:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 23h 10m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 12/28/2025 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/29/2025 12:55:00 PM. 50 Economy ticket for $182 per person are available. Travel duration is 30h 20m
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Frontier Airlines12h 11m09:34 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:45 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/28/2025 9:34:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/29/2025 9:45:00 AM. 50 Economy ticket for $207 per person are available. Travel duration is 12h 11m
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Frontier Airlines30h 53m02:32 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:25 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/28/2025 2:32:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/29/2025 9:25:00 PM. 50 Economy ticket for $325 per person are available. Travel duration is 30h 53m
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United Airlines2h 5m07:50 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:55 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/28/2025 7:50:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/28/2025 9:55:00 PM. 50 Economy ticket for $343 per person are available. Travel duration is 2h 5m
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Skyscanner2h 4m07:45 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:49 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/28/2025 7:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/28/2025 9:49:00 AM. 50 Economy ticket for $344 per person are available. Travel duration is 2h 4m
Cheapest Buses Sunday
Cheapest Flights Sunday
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/29/2025 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/30/2025 12:55:00 PM. 50 Economy ticket for $160 per person are available. Travel duration is 23h 10m
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FlixBus22h 40m05:05 PMHoustonDowntown Houston3:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 12/29/2025 5:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/30/2025 3:45:00 PM. 50 Economy ticket for $160 per person are available. Travel duration is 22h 40m
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Greyhound US22h 55m08:15 AMHoustonHarrisburg Blvd Station7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/29/2025 8:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/30/2025 7:10:00 AM. 50 Economy ticket for $161 per person are available. Travel duration is 22h 55m
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FlixBus25h 30m011:25 AMHoustonUptown/Upper Kirby12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 12/29/2025 11:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/30/2025 12:55:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 25h 30m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 12/29/2025 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/30/2025 12:55:00 PM. 50 Economy ticket for $162 per person are available. Travel duration is 30h 20m
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Frontier Airlines15h 35m06:05 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:40 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/29/2025 6:05:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/30/2025 9:40:00 AM. 50 Economy ticket for $296 per person are available. Travel duration is 15h 35m
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Frontier Airlines27h 40m06:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:40 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/29/2025 6:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/30/2025 9:40:00 AM. 50 Economy ticket for $301 per person are available. Travel duration is 27h 40m
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Spirit Airlines18h 31m03:09 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:40 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/29/2025 3:09:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/30/2025 9:40:00 AM. 50 Economy ticket for $321 per person are available. Travel duration is 18h 31m
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Spirit Airlines16h 47m05:46 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/29/2025 5:46:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/29/2025 10:33:00 PM. 50 Economy ticket for $333 per person are available. Travel duration is 16h 47m
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United Airlines7h 27m05:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport12:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/29/2025 5:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/29/2025 12:27:00 PM. 50 Economy ticket for $352 per person are available. Travel duration is 7h 27m
Cheapest Buses Monday
Cheapest Flights Monday
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/30/2025 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/31/2025 12:55:00 PM. 50 Economy ticket for $171 per person are available. Travel duration is 23h 10m
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FlixBus27h 0m07:50 PMHoustonUptown/Upper Kirby10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 12/30/2025 7:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/31/2025 10:50:00 PM. 50 Economy ticket for $171 per person are available. Travel duration is 27h 0m
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Greyhound US27h 55m06:55 PMHoustonHarrisburg Blvd Station10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/30/2025 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/31/2025 10:50:00 PM. 50 Economy ticket for $172 per person are available. Travel duration is 27h 55m
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FlixBus27h 15m07:35 PMHoustonDowntown Houston10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 12/30/2025 7:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/31/2025 10:50:00 PM. 50 Economy ticket for $172 per person are available. Travel duration is 27h 15m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 12/30/2025 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/31/2025 12:55:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 30h 20m
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United Airlines2h 5m07:50 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:55 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/30/2025 7:50:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/30/2025 9:55:00 PM. 50 Economy ticket for $344 per person are available. Travel duration is 2h 5m
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Skyscanner2h 4m07:45 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:49 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/30/2025 7:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/30/2025 9:49:00 AM. 50 Economy ticket for $344 per person are available. Travel duration is 2h 4m
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Skyscanner2h 8m02:28 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport4:36 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/30/2025 2:28:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/30/2025 4:36:00 PM. 50 Economy ticket for $344 per person are available. Travel duration is 2h 8m
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United Airlines5h 57m06:30 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport12:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/30/2025 6:30:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/30/2025 12:27:00 PM. 50 Economy ticket for $354 per person are available. Travel duration is 5h 57m
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Frontier Airlines27h 17m06:45 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:02 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/30/2025 6:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/31/2025 10:02:00 AM. 50 Economy ticket for $360 per person are available. Travel duration is 27h 17m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
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Spirit Airlines24h 48m010:08 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:56 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/31/2025 10:08:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/1/2026 10:56:00 AM. 50 Economy ticket for $240 per person are available. Travel duration is 24h 48m
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Spirit Airlines16h 1m06:55 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:56 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/31/2025 6:55:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/1/2026 10:56:00 AM. 50 Economy ticket for $240 per person are available. Travel duration is 16h 1m
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United Airlines19h 46m06:40 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport2:26 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/31/2025 6:40:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/1/2026 2:26:00 PM. 50 Economy ticket for $252 per person are available. Travel duration is 19h 46m
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United Airlines18h 31m07:55 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport2:26 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/31/2025 7:55:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/1/2026 2:26:00 PM. 50 Economy ticket for $252 per person are available. Travel duration is 18h 31m
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Frontier Airlines15h 35m06:05 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:40 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/31/2025 6:05:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/1/2026 9:40:00 AM. 50 Economy ticket for $304 per person are available. Travel duration is 15h 35m
Cheapest Flights Wednesday
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Greyhound Lines Mexico37h 20m09:30 AMHoustonSW Agencia Autobuses10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 1/1/2026 9:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 1/2/2026 10:50:00 PM. 50 Economy ticket for $158 per person are available. Travel duration is 37h 20m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 1/1/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 1/2/2026 12:55:00 PM. 50 Economy ticket for $159 per person are available. Travel duration is 23h 10m
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Greyhound US27h 55m06:55 PMHoustonHarrisburg Blvd Station10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 1/1/2026 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 1/2/2026 10:50:00 PM. 50 Economy ticket for $159 per person are available. Travel duration is 27h 55m
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FlixBus22h 40m05:05 PMHoustonDowntown Houston3:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 1/1/2026 5:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 1/2/2026 3:45:00 PM. 50 Economy ticket for $159 per person are available. Travel duration is 22h 40m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 1/1/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 1/2/2026 12:55:00 PM. 50 Economy ticket for $160 per person are available. Travel duration is 30h 20m
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Frontier Airlines12h 11m09:34 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:45 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 1/1/2026 9:34:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/2/2026 9:45:00 AM. 50 Economy ticket for $310 per person are available. Travel duration is 12h 11m
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Frontier Airlines27h 17m06:45 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:02 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 1/1/2026 6:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/2/2026 10:02:00 AM. 50 Economy ticket for $316 per person are available. Travel duration is 27h 17m
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Spirit Airlines14h 0m07:45 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:45 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 1/1/2026 7:45:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/2/2026 9:45:00 AM. 50 Economy ticket for $326 per person are available. Travel duration is 14h 0m
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United Airlines6h 11m08:15 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport2:26 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 1/1/2026 8:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/1/2026 2:26:00 PM. 50 Economy ticket for $439 per person are available. Travel duration is 6h 11m
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United Airlines4h 56m09:30 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport2:26 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 1/1/2026 9:30:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/1/2026 2:26:00 PM. 50 Economy ticket for $439 per person are available. Travel duration is 4h 56m
Cheapest Buses Thursday
Cheapest Flights Thursday
What are the fastest trips from Houston to St. Louis, MO?
You can get to St. Louis, MO from Houston in just 2h 4m with a Flight from Skyscanner. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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Skyscanner2h 4m07:45 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:49 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/26/2025 7:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/26/2025 9:49:00 AM. 50 Economy ticket for $443 per person are available. Travel duration is 2h 4m
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United Airlines2h 5m07:50 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:55 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/26/2025 7:50:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/26/2025 9:55:00 PM. 50 Economy ticket for $443 per person are available. Travel duration is 2h 5m
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Skyscanner2h 8m02:28 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport4:36 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/26/2025 2:28:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/26/2025 4:36:00 PM. 50 Economy ticket for $443 per person are available. Travel duration is 2h 8m
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United Airlines5h 57m06:30 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport12:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/26/2025 6:30:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/26/2025 12:27:00 PM. 50 Economy ticket for $453 per person are available. Travel duration is 5h 57m
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Frontier Airlines12h 7m09:55 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:02 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/26/2025 9:55:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/27/2025 10:02:00 AM. 50 Economy ticket for $237 per person are available. Travel duration is 12h 7m
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FlixBus22h 40m05:05 PMHoustonDowntown Houston3:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 12/26/2025 5:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/27/2025 3:45:00 PM. 50 Economy ticket for $174 per person are available. Travel duration is 22h 40m
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Greyhound US25h 0m010:00 PMHoustonHarrisburg Blvd Station11:00 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/26/2025 10:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/27/2025 11:00:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 25h 0m
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FlixBus25h 55m01:50 PMHoustonUptown/Upper Kirby3:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 12/26/2025 1:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/27/2025 3:45:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 25h 55m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 12/26/2025 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/27/2025 12:55:00 PM. 50 Economy ticket for $237 per person are available. Travel duration is 30h 20m
Fastest Flights Friday
Fastest Buses Friday
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/27/2025 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/28/2025 12:55:00 PM. 50 Economy ticket for $150 per person are available. Travel duration is 23h 10m
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FlixBus25h 30m011:25 AMHoustonUptown/Upper Kirby12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 12/27/2025 11:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/28/2025 12:55:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 25h 30m
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Greyhound US27h 50m07:00 PMHoustonHarrisburg Blvd Station10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/27/2025 7:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/28/2025 10:50:00 PM. 50 Economy ticket for $152 per person are available. Travel duration is 27h 50m
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FlixBus28h 50m06:00 PMHoustonDowntown Houston10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 12/27/2025 6:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/28/2025 10:50:00 PM. 50 Economy ticket for $150 per person are available. Travel duration is 28h 50m
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Greyhound Lines Mexico37h 20m09:30 AMHoustonSW Agencia Autobuses10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 12/27/2025 9:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/28/2025 10:50:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 37h 20m
Fastest Buses Saturday
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Skyscanner2h 4m07:45 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:49 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/28/2025 7:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/28/2025 9:49:00 AM. 50 Economy ticket for $344 per person are available. Travel duration is 2h 4m
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United Airlines2h 5m07:50 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:55 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/28/2025 7:50:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/28/2025 9:55:00 PM. 50 Economy ticket for $343 per person are available. Travel duration is 2h 5m
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Frontier Airlines12h 11m09:34 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:45 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/28/2025 9:34:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/29/2025 9:45:00 AM. 50 Economy ticket for $207 per person are available. Travel duration is 12h 11m
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Frontier Airlines30h 53m02:32 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:25 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/28/2025 2:32:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/29/2025 9:25:00 PM. 50 Economy ticket for $325 per person are available. Travel duration is 30h 53m
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FlixBus22h 40m05:05 PMHoustonDowntown Houston3:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 12/28/2025 5:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/29/2025 3:45:00 PM. 50 Economy ticket for $172 per person are available. Travel duration is 22h 40m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/28/2025 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/29/2025 12:55:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 23h 10m
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Greyhound US27h 55m06:55 PMHoustonHarrisburg Blvd Station10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/28/2025 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/29/2025 10:50:00 PM. 50 Economy ticket for $177 per person are available. Travel duration is 27h 55m
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FlixBus30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 12/28/2025 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/29/2025 12:55:00 PM. 50 Economy ticket for $177 per person are available. Travel duration is 30h 20m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 12/28/2025 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/29/2025 12:55:00 PM. 50 Economy ticket for $182 per person are available. Travel duration is 30h 20m
Fastest Flights Sunday
Fastest Buses Sunday
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United Airlines7h 27m05:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport12:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/29/2025 5:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/29/2025 12:27:00 PM. 50 Economy ticket for $352 per person are available. Travel duration is 7h 27m
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Frontier Airlines15h 35m06:05 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:40 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/29/2025 6:05:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/30/2025 9:40:00 AM. 50 Economy ticket for $296 per person are available. Travel duration is 15h 35m
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Spirit Airlines16h 47m05:46 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/29/2025 5:46:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/29/2025 10:33:00 PM. 50 Economy ticket for $333 per person are available. Travel duration is 16h 47m
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Spirit Airlines18h 31m03:09 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:40 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/29/2025 3:09:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/30/2025 9:40:00 AM. 50 Economy ticket for $321 per person are available. Travel duration is 18h 31m
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Frontier Airlines27h 40m06:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:40 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/29/2025 6:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/30/2025 9:40:00 AM. 50 Economy ticket for $301 per person are available. Travel duration is 27h 40m
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FlixBus22h 40m05:05 PMHoustonDowntown Houston3:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 12/29/2025 5:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/30/2025 3:45:00 PM. 50 Economy ticket for $160 per person are available. Travel duration is 22h 40m
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Greyhound US22h 55m08:15 AMHoustonHarrisburg Blvd Station7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/29/2025 8:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/30/2025 7:10:00 AM. 50 Economy ticket for $161 per person are available. Travel duration is 22h 55m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/29/2025 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/30/2025 12:55:00 PM. 50 Economy ticket for $160 per person are available. Travel duration is 23h 10m
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FlixBus25h 30m011:25 AMHoustonUptown/Upper Kirby12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 12/29/2025 11:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/30/2025 12:55:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 25h 30m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 12/29/2025 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/30/2025 12:55:00 PM. 50 Economy ticket for $162 per person are available. Travel duration is 30h 20m
Fastest Flights Monday
Fastest Buses Monday
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Skyscanner2h 4m07:45 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:49 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/30/2025 7:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/30/2025 9:49:00 AM. 50 Economy ticket for $344 per person are available. Travel duration is 2h 4m
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United Airlines2h 5m07:50 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:55 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/30/2025 7:50:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/30/2025 9:55:00 PM. 50 Economy ticket for $344 per person are available. Travel duration is 2h 5m
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Skyscanner2h 8m02:28 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport4:36 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/30/2025 2:28:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/30/2025 4:36:00 PM. 50 Economy ticket for $344 per person are available. Travel duration is 2h 8m
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United Airlines5h 57m06:30 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport12:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/30/2025 6:30:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/30/2025 12:27:00 PM. 50 Economy ticket for $354 per person are available. Travel duration is 5h 57m
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Frontier Airlines27h 17m06:45 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:02 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/30/2025 6:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/31/2025 10:02:00 AM. 50 Economy ticket for $360 per person are available. Travel duration is 27h 17m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/30/2025 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/31/2025 12:55:00 PM. 50 Economy ticket for $171 per person are available. Travel duration is 23h 10m
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FlixBus27h 0m07:50 PMHoustonUptown/Upper Kirby10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 12/30/2025 7:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/31/2025 10:50:00 PM. 50 Economy ticket for $171 per person are available. Travel duration is 27h 0m
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FlixBus27h 15m07:35 PMHoustonDowntown Houston10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 12/30/2025 7:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/31/2025 10:50:00 PM. 50 Economy ticket for $172 per person are available. Travel duration is 27h 15m
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Greyhound US27h 55m06:55 PMHoustonHarrisburg Blvd Station10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 12/30/2025 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/31/2025 10:50:00 PM. 50 Economy ticket for $172 per person are available. Travel duration is 27h 55m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 12/30/2025 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/31/2025 12:55:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 30h 20m
Fastest Flights Tuesday
Fastest Buses Tuesday
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Frontier Airlines15h 35m06:05 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:40 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/31/2025 6:05:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/1/2026 9:40:00 AM. 50 Economy ticket for $304 per person are available. Travel duration is 15h 35m
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Spirit Airlines16h 1m06:55 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:56 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/31/2025 6:55:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/1/2026 10:56:00 AM. 50 Economy ticket for $240 per person are available. Travel duration is 16h 1m
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United Airlines18h 31m07:55 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport2:26 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/31/2025 7:55:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/1/2026 2:26:00 PM. 50 Economy ticket for $252 per person are available. Travel duration is 18h 31m
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United Airlines19h 46m06:40 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport2:26 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/31/2025 6:40:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/1/2026 2:26:00 PM. 50 Economy ticket for $252 per person are available. Travel duration is 19h 46m
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Spirit Airlines24h 48m010:08 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:56 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 12/31/2025 10:08:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/1/2026 10:56:00 AM. 50 Economy ticket for $240 per person are available. Travel duration is 24h 48m
Fastest Flights Wednesday
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United Airlines4h 56m09:30 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport2:26 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 1/1/2026 9:30:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/1/2026 2:26:00 PM. 50 Economy ticket for $439 per person are available. Travel duration is 4h 56m
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United Airlines6h 11m08:15 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport2:26 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 1/1/2026 8:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/1/2026 2:26:00 PM. 50 Economy ticket for $439 per person are available. Travel duration is 6h 11m
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Frontier Airlines12h 11m09:34 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:45 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 1/1/2026 9:34:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/2/2026 9:45:00 AM. 50 Economy ticket for $310 per person are available. Travel duration is 12h 11m
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Spirit Airlines14h 0m07:45 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:45 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 1/1/2026 7:45:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/2/2026 9:45:00 AM. 50 Economy ticket for $326 per person are available. Travel duration is 14h 0m
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Frontier Airlines27h 17m06:45 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:02 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 1/1/2026 6:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 1/2/2026 10:02:00 AM. 50 Economy ticket for $316 per person are available. Travel duration is 27h 17m
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FlixBus22h 40m05:05 PMHoustonDowntown Houston3:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 1/1/2026 5:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 1/2/2026 3:45:00 PM. 50 Economy ticket for $159 per person are available. Travel duration is 22h 40m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 1/1/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 1/2/2026 12:55:00 PM. 50 Economy ticket for $159 per person are available. Travel duration is 23h 10m
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Greyhound US27h 55m06:55 PMHoustonHarrisburg Blvd Station10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 1/1/2026 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 1/2/2026 10:50:00 PM. 50 Economy ticket for $159 per person are available. Travel duration is 27h 55m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 1/1/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 1/2/2026 12:55:00 PM. 50 Economy ticket for $160 per person are available. Travel duration is 30h 20m
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Greyhound Lines Mexico37h 20m09:30 AMHoustonSW Agencia Autobuses10:50 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 1/1/2026 9:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 1/2/2026 10:50:00 PM. 50 Economy ticket for $158 per person are available. Travel duration is 37h 20m
Fastest Flights Thursday
Fastest Buses Thursday
Here you will find all operators and timetables for a
Bus from Houston to St. Louis, MO
What are the most popular stations in Houston and St. Louis, MO?
In Houston, you will usually depart from Hillcroft METRO Park and Ride Bus Station, Lockwood or Main St & Airline Dr, while in St. Louis, MO you will be arriving at Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to St. Louis, MO from Houston? With 8 connections between 5 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Houston and St. Louis, MO, you can pay as low as $150 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Skyscanner: you will get to St. Louis, MO in just 2h 4m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Houston and St. Louis, MO are Greyhound US, FlixBus and United Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Houston and St. Louis, MO is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from West University Place, TX or to Sauget, IL, and look at flights from William P. Hobby Airport, and landing at St. Louis Lambert Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Houston to St. Louis, MO?
The most popular companies between Houston and St. Louis, MO, are Greyhound US, FlixBus and United Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US, FlixBus, Valley Transit and 1 more.
Airlines: United Airlines, Frontier Airlines, Skyscanner and 1 more.
All you need to know when you travel from Houston to St. Louis, MO
Check all information on comfort and services on all modes of transports from Houston to St. Louis, MO. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Houston to St. Louis, MO
How can I reach St. Louis, MO from Houston?
Every day, there are on average 8 connections between Bus and Flight, with which you can get to St. Louis, MO from Houston.
How far is St. Louis, MO from Houston?
The distance between Houston and St. Louis, MO is 680.5 miles.
What is the most ecofriendly mode of transport between Houston and St. Louis, MO?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 30 kgs of CO2, a train 38 kgs, a car 186 kgs, and a flight 269 kgs.
What is the cheapest mode of transport from Houston to St. Louis, MO?
You can get to St. Louis, MO with just $150 by taking a Bus from Greyhound US.
What is the fastest way to get from Houston to St. Louis, MO?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to St. Louis, MO in just 2h 4m with a Flight from Skyscanner.
More routes to Houston and to St. Louis, MO
Looking for more options? Here you can see the most popular routes to Houston and to St. Louis, MO. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Houston
- Aguascalientes to Houston
- Atlanta, GA to Houston
- Brownsville, TX to Houston
- Chicago to Houston
- Dallas to Houston
- Durango, DG to Houston
- El Paso, TX to Houston
- Fort Worth to Houston
- Guadalajara, JC to Houston
- Indianapolis to Houston
- Laredo, TX to Houston
- Los Angeles to Houston
- Matamoros to Houston
- McAllen, TX to Houston
- Mexico City to Houston
- Monterrey, NL to Houston
- Morelia to Houston
- New Orleans, LA to Houston
- New York to Houston
- Oklahoma City, OK to Houston
- Reynosa to Houston
- San Antonio, TX to Houston
- Santiago de Queretaro to Houston
- Tulsa to Houston
