What is the best way to travel from Houston to St. Louis, MO?
Looking for a trip? Compare all the available Flights and Buses for the journey to St. Louis, MO from Houston. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 5 available companies to find your perfect trip!
What is the cheapest way to reach St. Louis, MO from Houston?
You can get to St. Louis, MO with just $69 by taking a Flight from Frontier Airlines, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Frontier Airlines27h 31m07:48 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:19 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/20/2026 7:48:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/21/2026 11:19:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 27h 31m
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American Airlines35h 2m07:48 PMWilliam P. Hobby AirportWilliam P. Hobby Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from William P. Hobby Airport, William P. Hobby Airport (USA) at 4/20/2026 7:48:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/22/2026 6:50:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 35h 2m
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United Airlines2h 8m08:20 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:28 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/20/2026 8:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/20/2026 10:28:00 PM. 50 Economy ticket for $210 per person are available. Travel duration is 2h 8m
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Spirit Airlines9h 21m01:58 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:19 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/20/2026 1:58:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/20/2026 11:19:00 PM. 50 Economy ticket for $215 per person are available. Travel duration is 9h 21m
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Alaska Airlines31h 8m04:51 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/20/2026 4:51:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/21/2026 11:59:00 PM. 50 Economy ticket for $420 per person are available. Travel duration is 31h 8m
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Greyhound US22h 55m08:15 AMHoustonHarrisburg Blvd Station7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/20/2026 8:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/21/2026 7:10:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 22h 55m
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Greyhound US25h 45m02:10 PMHoustonHarrisburg Blvd Station3:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/20/2026 2:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/21/2026 3:55:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 25h 45m
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FlixBus22h 15m08:55 AMHoustonUptown/Upper Kirby7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/20/2026 8:55:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/21/2026 7:10:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 22h 15m
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FlixBus25h 30m011:25 AMHoustonUptown/Upper Kirby12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/20/2026 11:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/21/2026 12:55:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 25h 30m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 4/20/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/21/2026 12:55:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 30h 20m
Cheapest Flights Monday
Cheapest Buses Monday
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Frontier Airlines24h 40m06:10 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/21/2026 6:10:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/22/2026 6:50:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 24h 40m
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Spirit Airlines18h 15m012:35 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/21/2026 12:35:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/22/2026 6:50:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 18h 15m
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United Airlines2h 8m08:20 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:28 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/21/2026 8:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/21/2026 10:28:00 PM. 50 Economy ticket for $185 per person are available. Travel duration is 2h 8m
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Skyscanner2h 5m07:20 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:25 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/21/2026 7:20:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/21/2026 9:25:00 AM. 50 Economy ticket for $185 per person are available. Travel duration is 2h 5m
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Alaska Airlines16h 59m07:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/21/2026 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/21/2026 11:59:00 PM. 50 Economy ticket for $333 per person are available. Travel duration is 16h 59m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/21/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/22/2026 12:55:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 23h 10m
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Greyhound US27h 50m06:55 PMHoustonHarrisburg Blvd Station10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/21/2026 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/22/2026 10:45:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 27h 50m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 4/21/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/22/2026 12:55:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 30h 20m
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FlixBus25h 30m011:25 AMHoustonUptown/Upper Kirby12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/21/2026 11:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/22/2026 12:55:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 25h 30m
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FlixBus26h 55m07:50 PMHoustonUptown/Upper Kirby10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/21/2026 7:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/22/2026 10:45:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 26h 55m
Cheapest Flights Tuesday
Cheapest Buses Tuesday
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Frontier Airlines28h 22m06:57 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:19 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/22/2026 6:57:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/23/2026 11:19:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 28h 22m
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Spirit Airlines21h 55m012:35 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:30 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/22/2026 12:35:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/23/2026 10:30:00 AM. 50 Economy ticket for $160 per person are available. Travel duration is 21h 55m
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United Airlines2h 8m08:20 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:28 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/22/2026 8:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/22/2026 10:28:00 PM. 50 Economy ticket for $185 per person are available. Travel duration is 2h 8m
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Skyscanner2h 5m07:20 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:25 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/22/2026 7:20:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/22/2026 9:25:00 AM. 50 Economy ticket for $185 per person are available. Travel duration is 2h 5m
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Alaska Airlines16h 59m07:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/22/2026 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/22/2026 11:59:00 PM. 50 Economy ticket for $388 per person are available. Travel duration is 16h 59m
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FlixBus25h 30m011:25 AMHoustonUptown/Upper Kirby12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/22/2026 11:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/23/2026 12:55:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 25h 30m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/22/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/23/2026 12:55:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 23h 10m
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Greyhound US27h 50m06:55 PMHoustonHarrisburg Blvd Station10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/22/2026 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/23/2026 10:45:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 27h 50m
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FlixBus25h 45m011:10 AMHoustonDowntown Houston12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 4/22/2026 11:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/23/2026 12:55:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 25h 45m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 4/22/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/23/2026 12:55:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 30h 20m
Cheapest Flights Wednesday
Cheapest Buses Wednesday
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Frontier Airlines8h 46m010:35 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport7:21 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/23/2026 10:35:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/23/2026 7:21:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 8h 46m
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Frontier Airlines12h 36m06:45 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport7:21 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/23/2026 6:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/23/2026 7:21:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 12h 36m
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United Airlines2h 8m08:20 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:28 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/23/2026 8:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/23/2026 10:28:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 2h 8m
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United Airlines2h 5m07:20 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:25 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/23/2026 7:20:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/23/2026 9:25:00 AM. 50 Economy ticket for $169 per person are available. Travel duration is 2h 5m
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Spirit Airlines18h 15m012:35 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/23/2026 12:35:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/24/2026 6:50:00 AM. 50 Economy ticket for $180 per person are available. Travel duration is 18h 15m
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Greyhound US27h 50m06:55 PMHoustonHarrisburg Blvd Station10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/23/2026 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/24/2026 10:45:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 27h 50m
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Greyhound US20h 55m01:50 AMHoustonHarrisburg Blvd Station10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/23/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/23/2026 10:45:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 20h 55m
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Greyhound Lines Mexico37h 15m09:30 AMHoustonSW Agencia Autobuses10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 4/23/2026 9:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/24/2026 10:45:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 37h 15m
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FlixBus22h 15m08:55 AMHoustonUptown/Upper Kirby7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/23/2026 8:55:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/24/2026 7:10:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 22h 15m
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FlixBus20h 35m010:35 AMHoustonDowntown Houston7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 4/23/2026 10:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/24/2026 7:10:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 20h 35m
Cheapest Flights Thursday
Cheapest Buses Thursday
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Frontier Airlines12h 36m06:14 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/24/2026 6:14:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/25/2026 6:50:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 12h 36m
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Frontier Airlines24h 40m06:10 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/24/2026 6:10:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/25/2026 6:50:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 24h 40m
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Spirit Airlines18h 15m012:35 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/24/2026 12:35:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/25/2026 6:50:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 18h 15m
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Spirit Airlines9h 21m01:58 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:19 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/24/2026 1:58:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/24/2026 11:19:00 PM. 50 Economy ticket for $196 per person are available. Travel duration is 9h 21m
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United Airlines2h 7m08:20 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/24/2026 8:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/24/2026 10:27:00 PM. 50 Economy ticket for $212 per person are available. Travel duration is 2h 7m
Cheapest Flights Friday
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Frontier Airlines9h 18m02:01 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:19 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/25/2026 2:01:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/25/2026 11:19:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 9h 18m
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Spirit Airlines16h 19m07:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:19 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/25/2026 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/25/2026 11:19:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 16h 19m
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United Airlines2h 8m08:20 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:28 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/25/2026 8:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/25/2026 10:28:00 PM. 50 Economy ticket for $159 per person are available. Travel duration is 2h 8m
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Skyscanner2h 5m07:20 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:25 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/25/2026 7:20:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/25/2026 9:25:00 AM. 50 Economy ticket for $159 per person are available. Travel duration is 2h 5m
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Alaska Airlines16h 59m07:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/25/2026 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/25/2026 11:59:00 PM. 50 Economy ticket for $481 per person are available. Travel duration is 16h 59m
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Greyhound US22h 55m08:15 AMHoustonHarrisburg Blvd Station7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/25/2026 8:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/26/2026 7:10:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 22h 55m
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Greyhound US20h 55m01:50 AMHoustonHarrisburg Blvd Station10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/25/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/25/2026 10:45:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 20h 55m
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FlixBus20h 35m010:35 AMHoustonDowntown Houston7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 4/25/2026 10:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/26/2026 7:10:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 20h 35m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 4/25/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/26/2026 12:55:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 30h 20m
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FlixBus22h 15m08:55 AMHoustonUptown/Upper Kirby7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/25/2026 8:55:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/26/2026 7:10:00 AM. 50 Economy ticket for $126 per person are available. Travel duration is 22h 15m
Cheapest Flights Saturday
Cheapest Buses Saturday
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FlixBus23h 40m01:15 PMHoustonDowntown Houston12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 4/26/2026 1:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/27/2026 12:55:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 23h 40m
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Greyhound US22h 55m08:15 AMHoustonHarrisburg Blvd Station7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/26/2026 8:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/27/2026 7:10:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 22h 55m
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FlixBus26h 55m07:50 PMHoustonUptown/Upper Kirby10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/26/2026 7:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/27/2026 10:45:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 26h 55m
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Greyhound US20h 55m01:50 AMHoustonHarrisburg Blvd Station10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/26/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/26/2026 10:45:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 20h 55m
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Greyhound Lines Mexico37h 15m09:30 AMHoustonSW Agencia Autobuses10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 4/26/2026 9:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/27/2026 10:45:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 37h 15m
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Frontier Airlines24h 50m06:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/26/2026 6:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/27/2026 6:50:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 24h 50m
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Frontier Airlines12h 36m06:14 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/26/2026 6:14:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/27/2026 6:50:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 12h 36m
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Spirit Airlines18h 15m012:35 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/26/2026 12:35:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/27/2026 6:50:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 18h 15m
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United Airlines2h 5m07:20 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:25 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/26/2026 7:20:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/26/2026 9:25:00 AM. 50 Economy ticket for $212 per person are available. Travel duration is 2h 5m
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United Airlines2h 8m08:20 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:28 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/26/2026 8:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/26/2026 10:28:00 PM. 50 Economy ticket for $212 per person are available. Travel duration is 2h 8m
Cheapest Buses Sunday
Cheapest Flights Sunday
What are the fastest trips from Houston to St. Louis, MO?
You can get to St. Louis, MO from Houston in just 2h 5m with a Flight from Skyscanner. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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United Airlines2h 8m08:20 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:28 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/20/2026 8:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/20/2026 10:28:00 PM. 50 Economy ticket for $210 per person are available. Travel duration is 2h 8m
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Spirit Airlines9h 21m01:58 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:19 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/20/2026 1:58:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/20/2026 11:19:00 PM. 50 Economy ticket for $215 per person are available. Travel duration is 9h 21m
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Frontier Airlines27h 31m07:48 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:19 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/20/2026 7:48:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/21/2026 11:19:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 27h 31m
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Alaska Airlines31h 8m04:51 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/20/2026 4:51:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/21/2026 11:59:00 PM. 50 Economy ticket for $420 per person are available. Travel duration is 31h 8m
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American Airlines35h 2m07:48 PMWilliam P. Hobby AirportWilliam P. Hobby Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from William P. Hobby Airport, William P. Hobby Airport (USA) at 4/20/2026 7:48:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/22/2026 6:50:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 35h 2m
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FlixBus22h 15m08:55 AMHoustonUptown/Upper Kirby7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/20/2026 8:55:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/21/2026 7:10:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 22h 15m
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Greyhound US22h 55m08:15 AMHoustonHarrisburg Blvd Station7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/20/2026 8:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/21/2026 7:10:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 22h 55m
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FlixBus25h 30m011:25 AMHoustonUptown/Upper Kirby12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/20/2026 11:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/21/2026 12:55:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 25h 30m
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Greyhound US25h 45m02:10 PMHoustonHarrisburg Blvd Station3:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/20/2026 2:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/21/2026 3:55:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 25h 45m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 4/20/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/21/2026 12:55:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 30h 20m
Fastest Flights Monday
Fastest Buses Monday
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Skyscanner2h 5m07:20 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:25 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/21/2026 7:20:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/21/2026 9:25:00 AM. 50 Economy ticket for $185 per person are available. Travel duration is 2h 5m
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United Airlines2h 8m08:20 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:28 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/21/2026 8:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/21/2026 10:28:00 PM. 50 Economy ticket for $185 per person are available. Travel duration is 2h 8m
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Alaska Airlines16h 59m07:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/21/2026 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/21/2026 11:59:00 PM. 50 Economy ticket for $333 per person are available. Travel duration is 16h 59m
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Spirit Airlines18h 15m012:35 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/21/2026 12:35:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/22/2026 6:50:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 18h 15m
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Frontier Airlines24h 40m06:10 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/21/2026 6:10:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/22/2026 6:50:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 24h 40m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/21/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/22/2026 12:55:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 23h 10m
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FlixBus25h 30m011:25 AMHoustonUptown/Upper Kirby12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/21/2026 11:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/22/2026 12:55:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 25h 30m
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FlixBus26h 55m07:50 PMHoustonUptown/Upper Kirby10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/21/2026 7:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/22/2026 10:45:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 26h 55m
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Greyhound US27h 50m06:55 PMHoustonHarrisburg Blvd Station10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/21/2026 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/22/2026 10:45:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 27h 50m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 4/21/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/22/2026 12:55:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 30h 20m
Fastest Flights Tuesday
Fastest Buses Tuesday
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Skyscanner2h 5m07:20 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:25 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/22/2026 7:20:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/22/2026 9:25:00 AM. 50 Economy ticket for $185 per person are available. Travel duration is 2h 5m
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United Airlines2h 8m08:20 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:28 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/22/2026 8:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/22/2026 10:28:00 PM. 50 Economy ticket for $185 per person are available. Travel duration is 2h 8m
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Alaska Airlines16h 59m07:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/22/2026 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/22/2026 11:59:00 PM. 50 Economy ticket for $388 per person are available. Travel duration is 16h 59m
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Spirit Airlines21h 55m012:35 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:30 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/22/2026 12:35:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/23/2026 10:30:00 AM. 50 Economy ticket for $160 per person are available. Travel duration is 21h 55m
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Frontier Airlines28h 22m06:57 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:19 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/22/2026 6:57:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/23/2026 11:19:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 28h 22m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/22/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/23/2026 12:55:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 23h 10m
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FlixBus25h 30m011:25 AMHoustonUptown/Upper Kirby12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/22/2026 11:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/23/2026 12:55:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 25h 30m
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FlixBus25h 45m011:10 AMHoustonDowntown Houston12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 4/22/2026 11:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/23/2026 12:55:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 25h 45m
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Greyhound US27h 50m06:55 PMHoustonHarrisburg Blvd Station10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/22/2026 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/23/2026 10:45:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 27h 50m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 4/22/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/23/2026 12:55:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 30h 20m
Fastest Flights Wednesday
Fastest Buses Wednesday
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United Airlines2h 5m07:20 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:25 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/23/2026 7:20:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/23/2026 9:25:00 AM. 50 Economy ticket for $169 per person are available. Travel duration is 2h 5m
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United Airlines2h 8m08:20 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:28 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/23/2026 8:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/23/2026 10:28:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 2h 8m
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Frontier Airlines8h 46m010:35 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport7:21 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/23/2026 10:35:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/23/2026 7:21:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 8h 46m
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Frontier Airlines12h 36m06:45 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport7:21 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/23/2026 6:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/23/2026 7:21:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 12h 36m
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Spirit Airlines18h 15m012:35 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/23/2026 12:35:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/24/2026 6:50:00 AM. 50 Economy ticket for $180 per person are available. Travel duration is 18h 15m
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FlixBus20h 35m010:35 AMHoustonDowntown Houston7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 4/23/2026 10:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/24/2026 7:10:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 20h 35m
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Greyhound US20h 55m01:50 AMHoustonHarrisburg Blvd Station10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/23/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/23/2026 10:45:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 20h 55m
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FlixBus22h 15m08:55 AMHoustonUptown/Upper Kirby7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/23/2026 8:55:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/24/2026 7:10:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 22h 15m
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Greyhound US27h 50m06:55 PMHoustonHarrisburg Blvd Station10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/23/2026 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/24/2026 10:45:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 27h 50m
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Greyhound Lines Mexico37h 15m09:30 AMHoustonSW Agencia Autobuses10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 4/23/2026 9:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/24/2026 10:45:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 37h 15m
Fastest Flights Thursday
Fastest Buses Thursday
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United Airlines2h 7m08:20 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/24/2026 8:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/24/2026 10:27:00 PM. 50 Economy ticket for $212 per person are available. Travel duration is 2h 7m
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Spirit Airlines9h 21m01:58 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:19 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/24/2026 1:58:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/24/2026 11:19:00 PM. 50 Economy ticket for $196 per person are available. Travel duration is 9h 21m
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Frontier Airlines12h 36m06:14 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/24/2026 6:14:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/25/2026 6:50:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 12h 36m
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Spirit Airlines18h 15m012:35 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/24/2026 12:35:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/25/2026 6:50:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 18h 15m
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Frontier Airlines24h 40m06:10 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/24/2026 6:10:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/25/2026 6:50:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 24h 40m
Fastest Flights Friday
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Skyscanner2h 5m07:20 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:25 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/25/2026 7:20:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/25/2026 9:25:00 AM. 50 Economy ticket for $159 per person are available. Travel duration is 2h 5m
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United Airlines2h 8m08:20 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:28 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/25/2026 8:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/25/2026 10:28:00 PM. 50 Economy ticket for $159 per person are available. Travel duration is 2h 8m
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Frontier Airlines9h 18m02:01 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:19 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/25/2026 2:01:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/25/2026 11:19:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 9h 18m
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Spirit Airlines16h 19m07:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:19 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/25/2026 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/25/2026 11:19:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 16h 19m
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Alaska Airlines16h 59m07:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/25/2026 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/25/2026 11:59:00 PM. 50 Economy ticket for $481 per person are available. Travel duration is 16h 59m
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FlixBus20h 35m010:35 AMHoustonDowntown Houston7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 4/25/2026 10:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/26/2026 7:10:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 20h 35m
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Greyhound US20h 55m01:50 AMHoustonHarrisburg Blvd Station10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/25/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/25/2026 10:45:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 20h 55m
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FlixBus22h 15m08:55 AMHoustonUptown/Upper Kirby7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/25/2026 8:55:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/26/2026 7:10:00 AM. 50 Economy ticket for $126 per person are available. Travel duration is 22h 15m
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Greyhound US22h 55m08:15 AMHoustonHarrisburg Blvd Station7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/25/2026 8:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/26/2026 7:10:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 22h 55m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 4/25/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/26/2026 12:55:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 30h 20m
Fastest Flights Saturday
Fastest Buses Saturday
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United Airlines2h 5m07:20 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport9:25 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/26/2026 7:20:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/26/2026 9:25:00 AM. 50 Economy ticket for $212 per person are available. Travel duration is 2h 5m
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United Airlines2h 8m08:20 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:28 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/26/2026 8:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/26/2026 10:28:00 PM. 50 Economy ticket for $212 per person are available. Travel duration is 2h 8m
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Frontier Airlines12h 36m06:14 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/26/2026 6:14:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/27/2026 6:50:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 12h 36m
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Spirit Airlines18h 15m012:35 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/26/2026 12:35:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/27/2026 6:50:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 18h 15m
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Frontier Airlines24h 50m06:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 4/26/2026 6:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 4/27/2026 6:50:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 24h 50m
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Greyhound US20h 55m01:50 AMHoustonHarrisburg Blvd Station10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/26/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/26/2026 10:45:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 20h 55m
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Greyhound US22h 55m08:15 AMHoustonHarrisburg Blvd Station7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 4/26/2026 8:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/27/2026 7:10:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 22h 55m
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FlixBus23h 40m01:15 PMHoustonDowntown Houston12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 4/26/2026 1:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/27/2026 12:55:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 23h 40m
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FlixBus26h 55m07:50 PMHoustonUptown/Upper Kirby10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 4/26/2026 7:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 4/27/2026 10:45:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 26h 55m
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Greyhound Lines Mexico37h 15m09:30 AMHoustonSW Agencia Autobuses10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from SW Agencia Autobuses, Houston (USA) at 4/26/2026 9:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 4/27/2026 10:45:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 37h 15m
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Here you will find all operators and timetables for a
Bus from Houston to St. Louis, MO
What are the most popular stations in Houston and St. Louis, MO?
In Houston, you will usually depart from Hillcroft METRO Park and Ride Bus Station, Lockwood or Main St & Airline Dr, while in St. Louis, MO you will be arriving at Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to St. Louis, MO from Houston? With 9 connections between 5 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Houston and St. Louis, MO, you can pay as low as $69 with a Flight from Frontier Airlines.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Skyscanner: you will get to St. Louis, MO in just 2h 5m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Houston and St. Louis, MO are Greyhound US, FlixBus and Frontier Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Houston and St. Louis, MO is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from West University Place, TX or to Sauget, IL, and look at flights from William P. Hobby Airport, and landing at St. Louis Lambert Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Houston to St. Louis, MO?
The most popular companies between Houston and St. Louis, MO, are Greyhound US, FlixBus and Frontier Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US, FlixBus, Valley Transit and 1 more.
Airlines: Frontier Airlines, United Airlines, Spirit Airlines and 3 more.
All you need to know when you travel from Houston to St. Louis, MO
Check all information on comfort and services on all modes of transports from Houston to St. Louis, MO. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Houston to St. Louis, MO
How can I reach St. Louis, MO from Houston?
Every day, there are on average 9 connections between Flight and Bus, with which you can get to St. Louis, MO from Houston.
How far is St. Louis, MO from Houston?
The distance between Houston and St. Louis, MO is 680.5 miles.
What is the most ecofriendly mode of transport between Houston and St. Louis, MO?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 30 kgs of CO2, a train 38 kgs, a car 186 kgs, and a flight 269 kgs.
What is the cheapest mode of transport from Houston to St. Louis, MO?
You can get to St. Louis, MO with just $69 by taking a Flight from Frontier Airlines.
What is the fastest way to get from Houston to St. Louis, MO?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to St. Louis, MO in just 2h 5m with a Flight from Skyscanner.
More routes to Houston and to St. Louis, MO
Looking for more options? Here you can see the most popular routes to Houston and to St. Louis, MO. Simply click on a connection, and you’ll find all the details about the route!
