What is the best way to travel from Houston to St. Louis, MO?
Looking for a trip? Compare all the available Flights and Buses for the journey to St. Louis, MO from Houston. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 4 available companies to find your perfect trip!
What is the cheapest way to reach St. Louis, MO from Houston?
You can get to St. Louis, MO with just $92 by taking a Bus from FlixBus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus25h 45m011:10 AMHoustonDowntown Houston12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/25/2026 11:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 12:55:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 25h 45m
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FlixBus21h 10m010:00 AMHoustonDowntown Houston7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/25/2026 10:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 7:10:00 AM. 50 Economy ticket for $93 per person are available. Travel duration is 21h 10m
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Greyhound US22h 55m08:15 AMHoustonHarrisburg Blvd Station7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/25/2026 8:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 7:10:00 AM. 50 Economy ticket for $93 per person are available. Travel duration is 22h 55m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/25/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 12:55:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 23h 10m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/25/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 12:55:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 30h 20m
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Frontier Airlines11h 0m06:30 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport5:30 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/25/2026 6:30:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/25/2026 5:30:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 11h 0m
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Frontier Airlines26h 22m06:30 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport8:52 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/25/2026 6:30:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/26/2026 8:52:00 AM. 50 Economy ticket for $165 per person are available. Travel duration is 26h 22m
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Frontier Airlines6h 18m011:12 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport5:30 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/25/2026 11:12:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/25/2026 5:30:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 6h 18m
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United Airlines2h 7m08:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:07 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/25/2026 8:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/25/2026 10:07:00 AM. 50 Economy ticket for $208 per person are available. Travel duration is 2h 7m
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United Airlines2h 11m03:31 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport5:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/25/2026 3:31:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/25/2026 5:42:00 PM. 50 Economy ticket for $215 per person are available. Travel duration is 2h 11m
Cheapest Buses Thursday
Cheapest Flights Thursday
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FlixBus22h 15m08:55 AMHoustonUptown/Upper Kirby7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 6/26/2026 8:55:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 7:10:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 22h 15m
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FlixBus32h 5m01:15 PMHoustonUptown/Upper Kirby9:20 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 6/26/2026 1:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 9:20:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 32h 5m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/26/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 12:55:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 23h 10m
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Greyhound US25h 0m010:00 PMHoustonHarrisburg Blvd Station11:00 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/26/2026 10:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 11:00:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 25h 0m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/26/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 12:55:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 30h 20m
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Frontier Airlines27h 7m05:45 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport8:52 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/26/2026 5:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/27/2026 8:52:00 AM. 50 Economy ticket for $154 per person are available. Travel duration is 27h 7m
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Frontier Airlines11h 57m08:55 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport8:52 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/26/2026 8:55:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/27/2026 8:52:00 AM. 50 Economy ticket for $154 per person are available. Travel duration is 11h 57m
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United Airlines2h 7m08:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:07 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/26/2026 8:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/26/2026 10:07:00 AM. 50 Economy ticket for $248 per person are available. Travel duration is 2h 7m
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United Airlines2h 16m012:00 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport2:16 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/26/2026 12:00:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/26/2026 2:16:00 PM. 50 Economy ticket for $248 per person are available. Travel duration is 2h 16m
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Alaska Airlines22h 18m06:19 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport4:37 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/26/2026 6:19:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/27/2026 4:37:00 PM. 50 Economy ticket for $632 per person are available. Travel duration is 22h 18m
Cheapest Buses Friday
Cheapest Flights Friday
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Greyhound US20h 55m01:50 AMHoustonHarrisburg Blvd Station10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/27/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 10:45:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 20h 55m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/27/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/28/2026 12:55:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 23h 10m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/27/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/28/2026 12:55:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 30h 20m
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FlixBus23h 40m01:15 PMHoustonDowntown Houston12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/27/2026 1:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/28/2026 12:55:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 23h 40m
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FlixBus21h 10m010:00 AMHoustonDowntown Houston7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/27/2026 10:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/28/2026 7:10:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 21h 10m
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Frontier Airlines12h 23m06:30 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:53 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/27/2026 6:30:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/27/2026 6:53:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 12h 23m
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Frontier Airlines28h 25m07:24 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:49 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/27/2026 7:24:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/28/2026 11:49:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 28h 25m
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United Airlines2h 7m08:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:07 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/27/2026 8:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/27/2026 10:07:00 AM. 50 Economy ticket for $208 per person are available. Travel duration is 2h 7m
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United Airlines2h 14m06:28 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport8:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/27/2026 6:28:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/27/2026 8:42:00 PM. 50 Economy ticket for $208 per person are available. Travel duration is 2h 14m
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Skyscanner2h 7m08:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:07 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/27/2026 8:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/27/2026 10:07:00 AM. 50 Economy ticket for $208 per person are available. Travel duration is 2h 7m
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Frontier Airlines34h 55m09:58 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport8:53 AMMidAmerica St. Louis AirportMidAmerica St. Louis Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/27/2026 9:58:00 PM to MidAmerica St. Louis Airport, MidAmerica St. Louis Airport (USA) arriving at 6/29/2026 8:53:00 AM. 50 Economy ticket for $222 per person are available. Travel duration is 34h 55m
Cheapest Buses Saturday
Cheapest Flights Saturday
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/28/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2026 12:55:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 23h 10m
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FlixBus23h 40m01:15 PMHoustonDowntown Houston12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/28/2026 1:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2026 12:55:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 23h 40m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/28/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2026 12:55:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 30h 20m
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FlixBus21h 10m010:00 AMHoustonDowntown Houston7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/28/2026 10:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2026 7:10:00 AM. 50 Economy ticket for $151 per person are available. Travel duration is 21h 10m
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Greyhound US22h 55m08:15 AMHoustonHarrisburg Blvd Station7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/28/2026 8:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2026 7:10:00 AM. 50 Economy ticket for $153 per person are available. Travel duration is 22h 55m
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Frontier Airlines11h 0m06:30 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport5:30 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/28/2026 6:30:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/28/2026 5:30:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 11h 0m
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United Airlines2h 7m08:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:07 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/28/2026 8:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/28/2026 10:07:00 AM. 50 Economy ticket for $208 per person are available. Travel duration is 2h 7m
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United Airlines2h 14m06:28 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport8:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/28/2026 6:28:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/28/2026 8:42:00 PM. 50 Economy ticket for $208 per person are available. Travel duration is 2h 14m
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Skyscanner2h 7m08:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:07 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/28/2026 8:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/28/2026 10:07:00 AM. 50 Economy ticket for $208 per person are available. Travel duration is 2h 7m
Cheapest Buses Sunday
Cheapest Flights Sunday
What are the fastest trips from Houston to St. Louis, MO?
You can get to St. Louis, MO from Houston in just 2h 7m with a Flight from United Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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United Airlines2h 7m08:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:07 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/25/2026 8:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/25/2026 10:07:00 AM. 50 Economy ticket for $208 per person are available. Travel duration is 2h 7m
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United Airlines2h 11m03:31 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport5:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/25/2026 3:31:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/25/2026 5:42:00 PM. 50 Economy ticket for $215 per person are available. Travel duration is 2h 11m
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Frontier Airlines6h 18m011:12 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport5:30 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/25/2026 11:12:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/25/2026 5:30:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 6h 18m
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Frontier Airlines11h 0m06:30 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport5:30 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/25/2026 6:30:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/25/2026 5:30:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 11h 0m
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Frontier Airlines26h 22m06:30 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport8:52 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/25/2026 6:30:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/26/2026 8:52:00 AM. 50 Economy ticket for $165 per person are available. Travel duration is 26h 22m
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FlixBus21h 10m010:00 AMHoustonDowntown Houston7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/25/2026 10:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 7:10:00 AM. 50 Economy ticket for $93 per person are available. Travel duration is 21h 10m
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Greyhound US22h 55m08:15 AMHoustonHarrisburg Blvd Station7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/25/2026 8:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 7:10:00 AM. 50 Economy ticket for $93 per person are available. Travel duration is 22h 55m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/25/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 12:55:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 23h 10m
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FlixBus25h 45m011:10 AMHoustonDowntown Houston12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/25/2026 11:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 12:55:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 25h 45m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/25/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 12:55:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 30h 20m
Fastest Flights Thursday
Fastest Buses Thursday
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United Airlines2h 7m08:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:07 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/26/2026 8:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/26/2026 10:07:00 AM. 50 Economy ticket for $248 per person are available. Travel duration is 2h 7m
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United Airlines2h 16m012:00 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport2:16 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/26/2026 12:00:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/26/2026 2:16:00 PM. 50 Economy ticket for $248 per person are available. Travel duration is 2h 16m
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Frontier Airlines11h 57m08:55 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport8:52 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/26/2026 8:55:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/27/2026 8:52:00 AM. 50 Economy ticket for $154 per person are available. Travel duration is 11h 57m
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Alaska Airlines22h 18m06:19 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport4:37 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/26/2026 6:19:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/27/2026 4:37:00 PM. 50 Economy ticket for $632 per person are available. Travel duration is 22h 18m
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Frontier Airlines27h 7m05:45 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport8:52 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/26/2026 5:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/27/2026 8:52:00 AM. 50 Economy ticket for $154 per person are available. Travel duration is 27h 7m
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FlixBus22h 15m08:55 AMHoustonUptown/Upper Kirby7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 6/26/2026 8:55:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 7:10:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 22h 15m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/26/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 12:55:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 23h 10m
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Greyhound US25h 0m010:00 PMHoustonHarrisburg Blvd Station11:00 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/26/2026 10:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 11:00:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 25h 0m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/26/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 12:55:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 30h 20m
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FlixBus32h 5m01:15 PMHoustonUptown/Upper Kirby9:20 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 6/26/2026 1:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 9:20:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 32h 5m
Fastest Flights Friday
Fastest Buses Friday
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United Airlines2h 7m08:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:07 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/27/2026 8:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/27/2026 10:07:00 AM. 50 Economy ticket for $208 per person are available. Travel duration is 2h 7m
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Skyscanner2h 7m08:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:07 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/27/2026 8:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/27/2026 10:07:00 AM. 50 Economy ticket for $208 per person are available. Travel duration is 2h 7m
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United Airlines2h 14m06:28 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport8:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/27/2026 6:28:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/27/2026 8:42:00 PM. 50 Economy ticket for $208 per person are available. Travel duration is 2h 14m
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Frontier Airlines12h 23m06:30 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport6:53 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/27/2026 6:30:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/27/2026 6:53:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 12h 23m
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JetBlue Airways26h 8m06:20 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport8:28 PMMidAmerica St. Louis AirportMidAmerica St. Louis Airport0EconomyA Flight from JetBlue Airways goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/27/2026 6:20:00 PM to MidAmerica St. Louis Airport, MidAmerica St. Louis Airport (USA) arriving at 6/28/2026 8:28:00 PM. 50 Economy ticket for $453 per person are available. Travel duration is 26h 8m
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Frontier Airlines28h 25m07:24 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport11:49 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/27/2026 7:24:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/28/2026 11:49:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 28h 25m
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Greyhound US20h 55m01:50 AMHoustonHarrisburg Blvd Station10:45 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/27/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 10:45:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 20h 55m
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FlixBus21h 10m010:00 AMHoustonDowntown Houston7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/27/2026 10:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/28/2026 7:10:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 21h 10m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/27/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/28/2026 12:55:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 23h 10m
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FlixBus23h 40m01:15 PMHoustonDowntown Houston12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/27/2026 1:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/28/2026 12:55:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 23h 40m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/27/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/28/2026 12:55:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 30h 20m
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United Airlines2h 7m08:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:07 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/28/2026 8:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/28/2026 10:07:00 AM. 50 Economy ticket for $208 per person are available. Travel duration is 2h 7m
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Skyscanner2h 7m08:00 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport10:07 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/28/2026 8:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/28/2026 10:07:00 AM. 50 Economy ticket for $208 per person are available. Travel duration is 2h 7m
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United Airlines2h 14m06:28 PMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport8:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/28/2026 6:28:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/28/2026 8:42:00 PM. 50 Economy ticket for $208 per person are available. Travel duration is 2h 14m
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Frontier Airlines11h 0m06:30 AMGeorge Bush Intercontinental Houston AirportGeorge Bush Intercontinental Houston Airport5:30 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from George Bush Intercontinental Houston Airport, George Bush Intercontinental Houston Airport (USA) at 6/28/2026 6:30:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/28/2026 5:30:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 11h 0m
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FlixBus21h 10m010:00 AMHoustonDowntown Houston7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/28/2026 10:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2026 7:10:00 AM. 50 Economy ticket for $151 per person are available. Travel duration is 21h 10m
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Greyhound US22h 55m08:15 AMHoustonHarrisburg Blvd Station7:10 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/28/2026 8:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2026 7:10:00 AM. 50 Economy ticket for $153 per person are available. Travel duration is 22h 55m
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Greyhound US23h 10m01:45 PMHoustonHarrisburg Blvd Station12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/28/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2026 12:55:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 23h 10m
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FlixBus23h 40m01:15 PMHoustonDowntown Houston12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/28/2026 1:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2026 12:55:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 23h 40m
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Valley Transit30h 20m06:35 AMHoustonSW Agencia Autobuses12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/28/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2026 12:55:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 30h 20m
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Here you will find all operators and timetables for a
Bus from Houston to St. Louis, MO
What are the most popular stations in Houston and St. Louis, MO?
In Houston, you will usually depart from Hillcroft METRO Park and Ride Bus Station, Lockwood or Main St & Airline Dr, while in St. Louis, MO you will be arriving at Gateway Station, Skinker Boulevard or Lindbergh @ Hackberry NB Bus Stop, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to St. Louis, MO from Houston? With 11 connections between 4 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Houston and St. Louis, MO, you can pay as low as $92 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to St. Louis, MO in just 2h 7m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Houston and St. Louis, MO are Frontier Airlines, FlixBus and Greyhound US, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Houston and St. Louis, MO is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from West University Place, TX or to Sauget, IL, and look at flights from William P. Hobby Airport, and landing at St. Louis Lambert Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Houston to St. Louis, MO?
The most popular companies between Houston and St. Louis, MO, are Frontier Airlines, FlixBus and Greyhound US. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus, Greyhound US and Valley Transit
Airlines: Frontier Airlines, United Airlines, Skyscanner and 2 more.
All you need to know when you travel from Houston to St. Louis, MO
Check all information on comfort and services on all modes of transports from Houston to St. Louis, MO. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Houston to St. Louis, MO
How can I reach St. Louis, MO from Houston?
Every day, there are on average 11 connections between Flight and Bus, with which you can get to St. Louis, MO from Houston.
How far is St. Louis, MO from Houston?
The distance between Houston and St. Louis, MO is 680.5 miles.
What is the most ecofriendly mode of transport between Houston and St. Louis, MO?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 30 kgs of CO2, a train 38 kgs, a car 186 kgs, and a flight 269 kgs.
What is the cheapest mode of transport from Houston to St. Louis, MO?
You can get to St. Louis, MO with just $92 by taking a Bus from FlixBus.
What is the fastest way to get from Houston to St. Louis, MO?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to St. Louis, MO in just 2h 7m with a Flight from United Airlines.
More routes to Houston and to St. Louis, MO
Looking for more options? Here you can see the most popular routes to Houston and to St. Louis, MO. Simply click on a connection, and you’ll find all the details about the route!
