Bus Denver to St. Louis, MO - Compare all Companies

Compare all timetables for the bus from Denver to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Denver to St. Louis, MO from various bus operators like Greyhound US for the next days.

today

tomorrow

$78

Monday

$79

Tuesday

Wednesday

$75

Thursday

$69

Friday

$71

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	16h 30m	7:25 PM	Denver	Union Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$78	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/21/2026 7:25:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/22/2026 12:55:00 PM. 50 Economy ticket for $78 per person are available. Travel duration is 16h 30m
Greyhound US	17h 40m	1:20 PM	Denver	Union Station	8:00 AM	St. Louis, MO	Gateway Station	Economy	$80	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/21/2026 1:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/22/2026 8:00:00 AM. 50 Economy ticket for $80 per person are available. Travel duration is 17h 40m
Greyhound US	25h 35m	8:10 PM	Denver	Union Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$106	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/21/2026 8:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/22/2026 10:45:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 25h 35m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	16h 30m	7:25 PM	Denver	Union Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$79	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/22/2026 7:25:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/23/2026 12:55:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 16h 30m
Greyhound US	17h 40m	1:20 PM	Denver	Union Station	8:00 AM	St. Louis, MO	Gateway Station	Economy	$84	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/22/2026 1:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/23/2026 8:00:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 17h 40m
Greyhound US	25h 35m	8:10 PM	Denver	Union Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$147	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/22/2026 8:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/23/2026 10:45:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 25h 35m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	16h 30m	7:25 PM	Denver	Union Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$75	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/24/2026 7:25:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/25/2026 12:55:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 16h 30m
Greyhound US	17h 40m	1:20 PM	Denver	Union Station	8:00 AM	St. Louis, MO	Gateway Station	Economy	$79	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/24/2026 1:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/25/2026 8:00:00 AM. 50 Economy ticket for $79 per person are available. Travel duration is 17h 40m
Greyhound US	25h 35m	8:10 PM	Denver	Union Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$138	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/24/2026 8:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/25/2026 10:45:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 25h 35m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	16h 30m	7:25 PM	Denver	Union Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$69	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/25/2026 7:25:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 12:55:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 16h 30m
Greyhound US	17h 40m	1:20 PM	Denver	Union Station	8:00 AM	St. Louis, MO	Gateway Station	Economy	$71	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/25/2026 1:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 8:00:00 AM. 50 Economy ticket for $71 per person are available. Travel duration is 17h 40m
Greyhound US	25h 35m	8:10 PM	Denver	Union Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$104	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/25/2026 8:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 10:45:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 25h 35m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	16h 30m	7:25 PM	Denver	Union Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$71	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/26/2026 7:25:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 12:55:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 16h 30m
Greyhound US	18h 55m	12:05 PM	Denver	Union Station	8:00 AM	St. Louis, MO	Gateway Station	Economy	$73	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/26/2026 12:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 8:00:00 AM. 50 Economy ticket for $73 per person are available. Travel duration is 18h 55m
Greyhound US	17h 40m	1:20 PM	Denver	Union Station	8:00 AM	St. Louis, MO	Gateway Station	Economy	$73	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/26/2026 1:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 8:00:00 AM. 50 Economy ticket for $73 per person are available. Travel duration is 17h 40m
Greyhound US	25h 35m	8:10 PM	Denver	Union Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$106	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/26/2026 8:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 10:45:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 25h 35m

Best Price Offer: The price for the cheapest bus from Denver to St. Louis, MO is $69 on 6/25/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Denver and St. Louis, MO

See here how frequent the connections between Denver and St. Louis, MO are, during different times and days of the week.

Friday is the busiest day, with more than 7 daily buses from Denver to St. Louis, MO. Monday has instead the fewest connections, with only 3 daily coaches between Denver and St. Louis, MO.

The busiest time of the day is the Evening, with 16 buses from Denver to St. Louis, MO, while Afternoon sees the fewest connections between Denver and St. Louis, MO, with 9 offers.

Facts about the bus from Denver to St. Louis, MO

Compare all providers like Greyhound US that travel 5 times every day by bus from Denver to St. Louis, MO in one click! Book your bus ticket from Denver to St. Louis, MO starting from $69!

Cheapest Bus	$69
Fastest Bus	17h 30m
Earliest Bus	1:20 PM
Latest Bus	8:10 PM
Daily Bus Routes	5 Ø
Distance	795.3 miles
Bus Companies	Greyhound US

Cheapest bus connections from Denver to St. Louis, MO

Every day, 5 buses from 1 bus companies leave Denver for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 06/14

Monday 06/15

Tuesday 06/16

Wednesday 06/17

Thursday 06/18

Friday 06/19

Saturday 06/20

Sunday 06/21

$78

Monday 06/22

$79

Tuesday 06/23

Wednesday 06/24

$75

Thursday 06/25

$77

Friday 06/26

$71

Saturday 06/27

$75

Sunday 06/28

$79

Monday 06/29

Tuesday 06/30

Wednesday 07/01

Thursday 07/02

Friday 07/03

Saturday 07/04

$88

Sunday 07/05

$78

Monday 07/06

Tuesday 07/07

Wednesday 07/08

Thursday 07/09

Friday 07/10

Saturday 07/11

The cheapest time to travel from Denver to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Denver to St. Louis, MO, for the next 30 days.

With a price starting from $69, Thursday is the cheapest day for a bus from Denver to St. Louis, MO. Sunday instead is the most expensive day with prices starting from $78.

Evening is the cheapest day time for bus tickets from Denver to St. Louis, MO, with $69. Afternoon is the most expensive time of the day with prices starting from $71.

How to save money travelling from Denver to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Denver to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Denver to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Denver to St. Louis, MO are also emptier.

Beloved bus companies from Denver to St. Louis, MO

These are the most booked bus companies between Denver to St. Louis, MO from our users.

Greyhound US from Denver to St. Louis, MO

Here you will find the key facts about the Greyhound US bus route Denver to St. Louis, MO:

Cheapest Price	$69
Fastest Bus	17h 30m
Earliest Bus	1:20 PM
Last Bus	8:10 PM
Daily Connections	5 Ø
Found on	5/27/2026

All bus stations and stops in Denver and St. Louis, MO

In the map below, you can see where to find all bus stations in Denver and St. Louis, MO.

Federal Blvd & W 19th Ave Bus Stop

Federal Blvd & W 19th Ave Federal Blvd & W 19th Ave

Union Station

Wynkoop St 1701

Bus Stop

Colorado Station

E Evans Ave 4401

19th St. Bus Station

19th St 1055

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from Denver to St. Louis, MO

Want to know which seat classes are available on the buses from Denver to St. Louis, MO? Or which bus companies serve the route Denver to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Denver to St. Louis, MO bus

How much does a Denver St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $69 and takes 17h 30m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Denver to St. Louis, MO?

This route is offered by 1 companies with a range of ticket prices between $69 and $152. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Denver to St. Louis, MO each day?

Every day, the Denver to St. Louis, MO bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Denver to St. Louis, MO take?

The fastest bus from Denver to St. Louis, MO is offered by Greyhound US and takes 17h 30m. Bus tickets for this connection cost $82. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Denver to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Denver starts at 1:20 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Denver to St. Louis, MO?

The latest bus trip departing from Denver for St. Louis, MO starts at 8:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Denver St. Louis, MO route?

When traveling by bus from Denver to St. Louis, MO, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Denver and St. Louis, MO?

You can check all the direct connections between Denver and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Denver to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Denver St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Denver St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Denver to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Denver to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between Denver and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Denver to St. Louis, MO?

Prices and availability for 5 trips between Denver and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Denver to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Denver and to St. Louis, MO

Here’s an overview of the most popular bus routes to Denver and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!