Which bus from Columbus, OH to St. Louis, MO is the cheapest?

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Compare all timetables for the bus from Columbus, OH to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Columbus, OH to St. Louis, MO from various bus operators like FlixBus or Greyhound US for the next days.

today
$50
tomorrow
$50
Thursday
$65
Friday
Saturday
Sunday
Monday
$66

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 11h 30m 4:40 AM Columbus, OH E Main St & S Lazelle St 3:10 PM St. Louis, MO Gateway Station  Economy $50
Greyhound US 9h 5m 11:50 PM Columbus, OH E Main St & S Lazelle St 7:55 AM St. Louis, MO Gateway Station  Economy $51
Greyhound US 10h 15m 2:00 PM Columbus, OH E Main St & S Lazelle St 11:15 PM St. Louis, MO Gateway Station  Economy $54
FlixBus 13h 15m 11:00 AM Columbus, OH ABM Public Parking 11:15 PM St. Louis, MO Gateway Station  Economy $69
FlixBus 17h 10m 11:30 PM Columbus, OH ABM Public Parking 3:40 PM St. Louis, MO Gateway Station  Economy $70

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 11h 30m 4:40 AM Columbus, OH E Main St & S Lazelle St 3:10 PM St. Louis, MO Gateway Station  Economy $50
Greyhound US 10h 15m 2:00 PM Columbus, OH E Main St & S Lazelle St 11:15 PM St. Louis, MO Gateway Station  Economy $51
Greyhound US 9h 5m 11:50 PM Columbus, OH E Main St & S Lazelle St 7:55 AM St. Louis, MO Gateway Station  Economy $51
FlixBus 13h 15m 11:00 AM Columbus, OH ABM Public Parking 11:15 PM St. Louis, MO Gateway Station  Economy $67
FlixBus 17h 10m 11:30 PM Columbus, OH ABM Public Parking 3:40 PM St. Louis, MO Gateway Station  Economy $67

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 13h 15m 11:00 AM Columbus, OH ABM Public Parking 11:15 PM St. Louis, MO Gateway Station  Economy $65
FlixBus 17h 10m 11:30 PM Columbus, OH ABM Public Parking 3:40 PM St. Louis, MO Gateway Station  Economy $65

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 17h 10m 11:30 PM Columbus, OH ABM Public Parking 3:40 PM St. Louis, MO Gateway Station  Economy $66
FlixBus 13h 15m 11:00 AM Columbus, OH ABM Public Parking 11:15 PM St. Louis, MO Gateway Station  Economy $71

Best Price Offer: The price for the cheapest bus from Columbus, OH to St. Louis, MO is $46 on 7/21/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Columbus, OH and St. Louis, MO

See here how frequent the connections between Columbus, OH and St. Louis, MO are, during different times and days of the week.
Tuesday is the busiest day, with more than 7 daily buses from Columbus, OH to St. Louis, MO. Monday has instead the fewest connections, with only 2 daily coaches between Columbus, OH and St. Louis, MO.
The busiest time of the day is the Evening, with 8 buses from Columbus, OH to St. Louis, MO, while Afternoon sees the fewest connections between Columbus, OH and St. Louis, MO, with 2 offers.

Facts about the bus from Columbus, OH to St. Louis, MO

Compare all providers like FlixBus and Greyhound US that travel 4 times every day by bus from Columbus, OH to St. Louis, MO in one click! Book your bus ticket from Columbus, OH to St. Louis, MO starting from $46!

Cheapest Bus $46
Fastest Bus 8h 5m
Earliest Bus 4:40 AM
Latest Bus 11:30 PM
Daily Bus Routes 4 Ø
Distance 396.3 miles
Bus Companies FlixBus and Greyhound US

Cheapest bus connections from Columbus, OH to St. Louis, MO

Every day, 4 buses from 2 bus companies leave Columbus, OH for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/21/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 07/19
Monday 07/20
Tuesday 07/21
$46
Wednesday 07/22
$50
Thursday 07/23
$46
Friday 07/24
Saturday 07/25
Sunday 07/26
Monday 07/27
$46
Tuesday 07/28
$46
Wednesday 07/29
$46
Thursday 07/30
$48
Friday 07/31
$49
Saturday 08/01
Sunday 08/02
$50
Monday 08/03
$49
Tuesday 08/04
$47
Wednesday 08/05
$47
Thursday 08/06
Friday 08/07
Saturday 08/08
Sunday 08/09
$50
Monday 08/10
Tuesday 08/11
$46
Wednesday 08/12
$46
Thursday 08/13
Friday 08/14
$49
Saturday 08/15

The cheapest time to travel from Columbus, OH to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Columbus, OH to St. Louis, MO, for the next 30 days.
With a price starting from $46, Monday is the cheapest day for a bus from Columbus, OH to St. Louis, MO. Monday instead is the most expensive day with prices starting from $46.
Night is the cheapest day time for bus tickets from Columbus, OH to St. Louis, MO, with $46. Morning is the most expensive time of the day with prices starting from $65.

How to save money travelling from Columbus, OH to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Columbus, OH to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Columbus, OH to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Columbus, OH to St. Louis, MO are also emptier.

Beloved bus companies from Columbus, OH to St. Louis, MO

These are the most booked bus companies between Columbus, OH to St. Louis, MO from our users.

Greyhound US from Columbus, OH to St. Louis, MO

Greyhound US

Here you will find the key facts about the Greyhound US bus route Columbus, OH to St. Louis, MO:

Cheapest Price $50
Fastest Bus 8h 5m
Earliest Bus 4:40 AM
Last Bus 11:50 PM
Daily Connections 3 Ø
Found on 6/22/2026

All bus stations and stops in Columbus, OH and St. Louis, MO

In the map below, you can see where to find all bus stations in Columbus, OH and St. Louis, MO.

Service and Comfort on the bus from Columbus, OH to St. Louis, MO

Want to know which seat classes are available on the buses from Columbus, OH to St. Louis, MO? Or which bus companies serve the route Columbus, OH to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Columbus, OH to St. Louis, MO bus

How much does a Columbus, OH St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $46 and takes 10h 30m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Columbus, OH to St. Louis, MO?

This route is offered by 2 companies with a range of ticket prices between $46 and $74. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Columbus, OH to St. Louis, MO each day?

Every day, the Columbus, OH to St. Louis, MO bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Columbus, OH to St. Louis, MO take?

The fastest bus from Columbus, OH to St. Louis, MO is offered by Greyhound US and takes 8h 5m. Bus tickets for this connection cost $51. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Columbus, OH to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Columbus, OH starts at 4:40 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Columbus, OH to St. Louis, MO?

The latest bus trip departing from Columbus, OH for St. Louis, MO starts at 11:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Columbus, OH St. Louis, MO route?

When traveling by bus from Columbus, OH to St. Louis, MO, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Columbus, OH and St. Louis, MO?

You can check all the direct connections between Columbus, OH and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Columbus, OH to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Columbus, OH St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Columbus, OH St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Columbus, OH to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Columbus, OH to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Columbus, OH and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Columbus, OH to St. Louis, MO?

Prices and availability for 4 trips between Columbus, OH and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Columbus, OH to St. Louis, MO

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Columbus, OH and to St. Louis, MO

Here’s an overview of the most popular bus routes to Columbus, OH and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!
Buses from Brougham to Columbus, OH Buses from Brougham to Columbus, OH
From Ridgewood, NJ to Columbus, OH bus From Ridgewood, NJ to Columbus, OH bus
Bus Laurel, MD to Columbus, OH Bus Laurel, MD to Columbus, OH
Dallas to Columbus, OH bus Dallas to Columbus, OH bus
Bus from Cheyenne, WY to St. Louis, MO Bus from Cheyenne, WY to St. Louis, MO
Buses Greenville, SC - St. Louis, MO Buses Greenville, SC - St. Louis, MO
Bus Flint, MI to St. Louis, MO Bus Flint, MI to St. Louis, MO
Bus to St. Louis, MO from Los Angeles Bus to St. Louis, MO from Los Angeles
Popular Airport Shuttles to Columbus, OH and to St. Louis, MO
CheckMyBus › Buses in USA › Bus to Columbus, OH › Bus to St. Louis, MO

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