Bus San Antonio, TX to St. Louis, MO

Compare all timetables for the bus from San Antonio, TX to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from San Antonio, TX to St. Louis, MO from various bus operators like FlixBus, Greyhound US or Greyhound Lines Mexico for the next days.

today

$121

tomorrow

$104

Wednesday

$93

Thursday

Friday

$97

Saturday

$101

Sunday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	24h 20m	12:35 PM	San Antonio, TX	Bus Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$121	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 9/21/2026 12:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 9/22/2026 12:55:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 24h 20m
FlixBus	24h 50m	9:55 PM	San Antonio, TX	Bus Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$122	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 9/21/2026 9:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 9/22/2026 10:45:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 24h 50m
FlixBus	23h 40m	7:30 AM	San Antonio, TX	Bus Station	7:10 AM	St. Louis, MO	Gateway Station	Economy	$123	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 9/21/2026 7:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 9/22/2026 7:10:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 23h 40m
FlixBus	23h 25m	7:45 AM	San Antonio, TX	Pearl District	7:10 AM	St. Louis, MO	Gateway Station	Economy	$123	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 9/21/2026 7:45:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 9/22/2026 7:10:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 23h 25m

Did you know that if you travel from San Antonio, TX to St. Louis, MO via Austin, you can save more than $23? You can find the corresponding connections below.
- FlixBus
  
  28h 50m
  
  0
  
  5:55 PM
  
  San Antonio, TX
  Pearl District
  
  7:50 PM
  
  Austin
  Austin South Congress Bus Stop
  
  0
  
  Economy
  
  $10
  
  A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 9/22/2026 5:55:00 PM to Austin South Congress Bus Stop, Austin (USA) arriving at 9/22/2026 7:50:00 PM. 50 Economy ticket for $10 per person are available. Travel duration is 1h 55m
- Greyhound Lines Mexico
  
  19h 45m
  
  0
  
  3:00 AM
  
  Austin
  5119 Eastside Bus Plaza
  
  10:45 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $88
  
  A Bus from Greyhound Lines Mexico goes from 5119 Eastside Bus Plaza, Austin (USA) at 9/23/2026 3:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 9/23/2026 10:45:00 PM. 50 Economy ticket for $88 per person are available. Travel duration is 19h 45m
Travel time is 5h 25m longer, but you will save $23

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 15m	1:30 AM	San Antonio, TX	Bus Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$104	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 9/22/2026 1:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 9/22/2026 10:45:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 21h 15m
FlixBus	24h 50m	9:55 PM	San Antonio, TX	Bus Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$104	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 9/22/2026 9:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 9/23/2026 10:45:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 24h 50m
Greyhound US	24h 20m	12:35 PM	San Antonio, TX	Bus Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$105	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 9/22/2026 12:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 9/23/2026 12:55:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 24h 20m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	21h 15m	1:30 AM	San Antonio, TX	Bus Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$93	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 9/23/2026 1:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 9/23/2026 10:45:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 21h 15m
Greyhound US	24h 20m	12:35 PM	San Antonio, TX	Bus Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$94	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 9/23/2026 12:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 9/24/2026 12:55:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 24h 20m
Valley Transit	25h 45m	9:00 PM	San Antonio, TX	Bus Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$102	A Bus from Valley Transit goes from Bus Station, San Antonio, TX (USA) at 9/23/2026 9:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 9/24/2026 10:45:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 25h 45m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 15m	1:30 AM	San Antonio, TX	Bus Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$97	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 9/25/2026 1:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 9/25/2026 10:45:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 21h 15m
Greyhound US	24h 20m	12:35 PM	San Antonio, TX	Bus Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$97	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 9/25/2026 12:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 9/26/2026 12:55:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 24h 20m
FlixBus	24h 50m	9:55 PM	San Antonio, TX	Bus Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$98	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 9/25/2026 9:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 9/26/2026 10:45:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 24h 50m
FlixBus	23h 40m	7:30 AM	San Antonio, TX	Bus Station	7:10 AM	St. Louis, MO	Gateway Station	Economy	$109	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 9/25/2026 7:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 9/26/2026 7:10:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 23h 40m
FlixBus	23h 25m	7:45 AM	San Antonio, TX	Pearl District	7:10 AM	St. Louis, MO	Gateway Station	Economy	$109	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 9/25/2026 7:45:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 9/26/2026 7:10:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 23h 25m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 15m	1:30 AM	San Antonio, TX	Bus Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$101	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 9/26/2026 1:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 9/26/2026 10:45:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 21h 15m
Greyhound US	24h 20m	12:35 PM	San Antonio, TX	Bus Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$102	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 9/26/2026 12:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 9/27/2026 12:55:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 24h 20m
FlixBus	24h 50m	9:55 PM	San Antonio, TX	Bus Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$105	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 9/26/2026 9:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 9/27/2026 10:45:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 24h 50m
FlixBus	23h 40m	7:30 AM	San Antonio, TX	Bus Station	7:10 AM	St. Louis, MO	Gateway Station	Economy	$108	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 9/26/2026 7:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 9/27/2026 7:10:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 23h 40m
FlixBus	23h 25m	7:45 AM	San Antonio, TX	Pearl District	7:10 AM	St. Louis, MO	Gateway Station	Economy	$108	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 9/26/2026 7:45:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 9/27/2026 7:10:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 23h 25m

Best Price Offer: The price for the cheapest bus from San Antonio, TX to St. Louis, MO is $93 on 9/23/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Antonio, TX and St. Louis, MO

See here how frequent the connections between San Antonio, TX and St. Louis, MO are, during different times and days of the week.

Friday is the busiest day, with more than 10 daily buses from San Antonio, TX to St. Louis, MO. Tuesday has instead the fewest connections, with only 3 daily coaches between San Antonio, TX and St. Louis, MO.

The busiest time of the day is the Morning, with 10 buses from San Antonio, TX to St. Louis, MO, while Night sees the fewest connections between San Antonio, TX and St. Louis, MO, with 6 offers.

Facts about the bus from San Antonio, TX to St. Louis, MO

Compare all providers like FlixBus, Greyhound US and Greyhound Lines Mexico that travel 6 times every day by bus from San Antonio, TX to St. Louis, MO in one click! Book your bus ticket from San Antonio, TX to St. Louis, MO starting from $93!

Cheapest Bus	$93
Fastest Bus	21h 15m
Earliest Bus	7:30 AM
Latest Bus	9:55 PM
Daily Bus Routes	6 Ø
Distance	792.3 miles
Bus Companies	FlixBus, Greyhound US, Greyhound Lines Mexico and Valley Transit

Cheapest bus connections from San Antonio, TX to St. Louis, MO

Every day, 6 buses from 4 bus companies leave San Antonio, TX for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/21/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 09/20

Monday 09/21

$121

Tuesday 09/22

$104

Wednesday 09/23

$93

Thursday 09/24

Friday 09/25

$101

Saturday 09/26

$101

Sunday 09/27

Monday 09/28

$122

Tuesday 09/29

$110

Wednesday 09/30

$108

Thursday 10/01

Friday 10/02

Saturday 10/03

$104

Sunday 10/04

$112

Monday 10/05

$108

Tuesday 10/06

Wednesday 10/07

$120

Thursday 10/08

$115

Friday 10/09

$108

Saturday 10/10

$108

Sunday 10/11

$124

Monday 10/12

Tuesday 10/13

$127

Wednesday 10/14

$127

Thursday 10/15

$110

Friday 10/16

$109

Saturday 10/17

The cheapest time to travel from San Antonio, TX to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from San Antonio, TX to St. Louis, MO, for the next 30 days.

With a price starting from $93, Wednesday is the cheapest day for a bus from San Antonio, TX to St. Louis, MO. Monday instead is the most expensive day with prices starting from $108.

Night is the cheapest day time for bus tickets from San Antonio, TX to St. Louis, MO, with $93. Morning is the most expensive time of the day with prices starting from $108.

How to save money travelling from San Antonio, TX to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Antonio, TX to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Antonio, TX to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Antonio, TX to St. Louis, MO are also emptier.

All bus stations and stops in San Antonio, TX and St. Louis, MO

In the map below, you can see where to find all bus stations in San Antonio, TX and St. Louis, MO.

Bus Station

N St Mary's St 500

Pearl District

Avenue A 699-599

Commerce & Bowie Bus Stop

W. Southcross & Buffalo Bus Stop

La Cantera

La Cantera Pkwy 15900

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from San Antonio, TX to St. Louis, MO

Want to know which seat classes are available on the buses from San Antonio, TX to St. Louis, MO? Or which bus companies serve the route San Antonio, TX to St. Louis, MO? Below you will find answers to your questions.

FAQs about the San Antonio, TX to St. Louis, MO bus

How much does a San Antonio, TX St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $93 and takes 21h 15m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from San Antonio, TX to St. Louis, MO?

This route is offered by 4 companies with a range of ticket prices between $93 and $126. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from San Antonio, TX to St. Louis, MO each day?

Every day, the San Antonio, TX to St. Louis, MO bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Antonio, TX to St. Louis, MO take?

The fastest bus from San Antonio, TX to St. Louis, MO is offered by Greyhound US and takes 21h 15m. Bus tickets for this connection cost $104. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Antonio, TX to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from San Antonio, TX starts at 7:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Antonio, TX to St. Louis, MO?

The latest bus trip departing from San Antonio, TX for St. Louis, MO starts at 9:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Antonio, TX St. Louis, MO route?

When traveling by bus from San Antonio, TX to St. Louis, MO, passengers can travel with FlixBus, Greyhound US and Greyhound Lines Mexico. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Antonio, TX and St. Louis, MO?

You can check all the direct connections between San Antonio, TX and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Greyhound US and Greyhound Lines Mexico.

What can I take with me on the San Antonio, TX to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Antonio, TX St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Antonio, TX St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Antonio, TX to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from San Antonio, TX to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between San Antonio, TX and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Antonio, TX to St. Louis, MO?

Prices and availability for 6 trips between San Antonio, TX and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Antonio, TX to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Antonio, TX and to St. Louis, MO

Here’s an overview of the most popular bus routes to San Antonio, TX and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!