Bus San Antonio, TX to St. Louis, MO

Compare all timetables for the bus from San Antonio, TX to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from San Antonio, TX to St. Louis, MO from various bus operators like FlixBus, Greyhound Lines Mexico or Greyhound US for the next days.

today

$152

tomorrow

Thursday

Friday

Saturday

$171

Sunday

$154

Monday

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	24h 20m	12:35 PM	San Antonio, TX	Bus Station	12:55 PM	St. Louis, MO	Gateway Station		Economy	$152	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 12/16/2025 12:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/17/2025 12:55:00 PM. 50 Economy ticket for $152 per person are available. Travel duration is 24h 20m
	Greyhound Lines Mexico	27h 35m	7:15 PM	San Antonio, TX	Bus Station	10:50 PM	St. Louis, MO	Gateway Station		Economy	$153	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 12/16/2025 7:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/17/2025 10:50:00 PM. 50 Economy ticket for $153 per person are available. Travel duration is 27h 35m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	21h 15m	1:30 AM	San Antonio, TX	Bus Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$171	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 12/20/2025 1:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/20/2025 10:45:00 PM. 50 Economy ticket for $171 per person are available. Travel duration is 21h 15m
Greyhound Lines Mexico	25h 5m	6:05 AM	San Antonio, TX	Bus Station	7:10 AM	St. Louis, MO	Gateway Station	Economy	$171	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 12/20/2025 6:05:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/21/2025 7:10:00 AM. 50 Economy ticket for $171 per person are available. Travel duration is 25h 5m
Valley Transit	25h 30m	9:15 PM	San Antonio, TX	Bus Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$171	A Bus from Valley Transit goes from Bus Station, San Antonio, TX (USA) at 12/20/2025 9:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/21/2025 10:45:00 PM. 50 Economy ticket for $171 per person are available. Travel duration is 25h 30m
Greyhound US	24h 15m	12:40 PM	San Antonio, TX	Bus Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$172	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 12/20/2025 12:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/21/2025 12:55:00 PM. 50 Economy ticket for $172 per person are available. Travel duration is 24h 15m
FlixBus	23h 40m	7:30 AM	San Antonio, TX	Bus Station	7:10 AM	St. Louis, MO	Gateway Station	Economy	$173	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 12/20/2025 7:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/21/2025 7:10:00 AM. 50 Economy ticket for $173 per person are available. Travel duration is 23h 40m

Did you know that if you travel from San Antonio, TX to St. Louis, MO via Dallas, you can save more than $31? You can find the corresponding connections below.
- FlixBus
  
  28h 40m
  
  0
  
  6:10 PM
  
  San Antonio, TX
  Bus Station
  
  11:20 PM
  
  Dallas
  Bus Station
  
  0
  
  Economy
  
  $42
  
  A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 12/17/2025 6:10:00 PM to Bus Station, Dallas (USA) arriving at 12/17/2025 11:20:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 5h 10m
- FlixBus
  
  15h 50m
  
  0
  
  7:00 AM
  
  Dallas
  Bus Station
  
  10:50 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $98
  
  A Bus from FlixBus goes from Bus Station, Dallas (USA) at 12/18/2025 7:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/18/2025 10:50:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 15h 50m
Travel time is 7h 25m longer, but you will save $31

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	23h 40m	7:30 AM	San Antonio, TX	Bus Station	7:10 AM	St. Louis, MO	Gateway Station	Economy	$154	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 12/21/2025 7:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/22/2025 7:10:00 AM. 50 Economy ticket for $154 per person are available. Travel duration is 23h 40m
Valley Transit	25h 35m	9:15 PM	San Antonio, TX	Bus Station	10:50 PM	St. Louis, MO	Gateway Station	Economy	$155	A Bus from Valley Transit goes from Bus Station, San Antonio, TX (USA) at 12/21/2025 9:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/22/2025 10:50:00 PM. 50 Economy ticket for $155 per person are available. Travel duration is 25h 35m
Greyhound Lines Mexico	21h 20m	1:30 AM	San Antonio, TX	Bus Station	10:50 PM	St. Louis, MO	Gateway Station	Economy	$156	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 12/21/2025 1:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/21/2025 10:50:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 21h 20m
FlixBus	23h 25m	7:45 AM	San Antonio, TX	Pearl District	7:10 AM	St. Louis, MO	Gateway Station	Economy	$156	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 12/21/2025 7:45:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/22/2025 7:10:00 AM. 50 Economy ticket for $156 per person are available. Travel duration is 23h 25m
Greyhound US	24h 15m	12:40 PM	San Antonio, TX	Bus Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$158	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 12/21/2025 12:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/22/2025 12:55:00 PM. 50 Economy ticket for $158 per person are available. Travel duration is 24h 15m

Best Price Offer: The price for the cheapest bus from San Antonio, TX to St. Louis, MO is $125 on 1/9/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Antonio, TX and St. Louis, MO

See here how frequent the connections between San Antonio, TX and St. Louis, MO are, during different times and days of the week.

Sunday is the busiest day, with more than 10 daily buses from San Antonio, TX to St. Louis, MO. Tuesday has instead the fewest connections, with only 2 daily coaches between San Antonio, TX and St. Louis, MO.

The busiest time of the day is the Morning, with 7 buses from San Antonio, TX to St. Louis, MO, while Night sees the fewest connections between San Antonio, TX and St. Louis, MO, with 4 offers.

Facts about the bus from San Antonio, TX to St. Louis, MO

Compare all providers like FlixBus, Greyhound Lines Mexico and Greyhound US that travel 7 times every day by bus from San Antonio, TX to St. Louis, MO in one click! Book your bus ticket from San Antonio, TX to St. Louis, MO starting from $125!

Cheapest Bus	$125
Fastest Bus	21h 15m
Earliest Bus	12:35 PM
Latest Bus	9:15 PM
Daily Bus Routes	7 Ø
Distance	792.3 miles
Bus Companies	FlixBus, Greyhound Lines Mexico, Greyhound US and Valley Transit

Cheapest bus connections from San Antonio, TX to St. Louis, MO

Every day, 7 buses from 4 bus companies leave San Antonio, TX for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/16/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

$152

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

$171

Sunday 12/21

$180

Monday 12/22

Tuesday 12/23

$145

Wednesday 12/24

$197

Thursday 12/25

$145

Friday 12/26

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

$145

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

$134

Friday 01/09

$125

Saturday 01/10

The cheapest time to travel from San Antonio, TX to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from San Antonio, TX to St. Louis, MO, for the next 30 days.

With a price starting from $145, Tuesday is the cheapest day for a bus from San Antonio, TX to St. Louis, MO. Saturday instead is the most expensive day with prices starting from $171.

Night is the cheapest day time for bus tickets from San Antonio, TX to St. Louis, MO, with $125. Morning is the most expensive time of the day with prices starting from $154.

How to save money travelling from San Antonio, TX to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Antonio, TX to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Antonio, TX to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Antonio, TX to St. Louis, MO are also emptier.

Beloved bus companies from San Antonio, TX to St. Louis, MO

These are the most booked bus companies between San Antonio, TX to St. Louis, MO from our users.

Greyhound US from San Antonio, TX to St. Louis, MO

Here you will find the key facts about the Greyhound US bus route San Antonio, TX to St. Louis, MO:

Cheapest Price	$152
Fastest Bus	24h 15m
Earliest Bus	12:35 PM
Last Bus	12:40 PM
Daily Connections	1 Ø
Found on	12/13/2025

All bus stations and stops in San Antonio, TX and St. Louis, MO

In the map below, you can see where to find all bus stations in San Antonio, TX and St. Louis, MO.

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

W. Southcross & Buffalo Bus Stop

Commerce & Bowie Bus Stop

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from San Antonio, TX to St. Louis, MO

Want to know which seat classes are available on the buses from San Antonio, TX to St. Louis, MO? Or which bus companies serve the route San Antonio, TX to St. Louis, MO? Below you will find answers to your questions.

FAQs about the San Antonio, TX to St. Louis, MO bus

How much does a San Antonio, TX St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $125 and takes 24h 20m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from San Antonio, TX to St. Louis, MO?

This route is offered by 4 companies with a range of ticket prices between $125 and $240. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from San Antonio, TX to St. Louis, MO each day?

Every day, the San Antonio, TX to St. Louis, MO bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Antonio, TX to St. Louis, MO take?

The fastest bus from San Antonio, TX to St. Louis, MO is offered by Greyhound Lines Mexico and takes 21h 15m. Bus tickets for this connection cost $171. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Antonio, TX to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from San Antonio, TX starts at 12:35 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Antonio, TX to St. Louis, MO?

The latest bus trip departing from San Antonio, TX for St. Louis, MO starts at 9:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Antonio, TX St. Louis, MO route?

When traveling by bus from San Antonio, TX to St. Louis, MO, passengers can travel with FlixBus, Greyhound Lines Mexico and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Antonio, TX and St. Louis, MO?

You can check all the direct connections between San Antonio, TX and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Greyhound Lines Mexico and Greyhound US.

What can I take with me on the San Antonio, TX to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Antonio, TX St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Antonio, TX St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Antonio, TX to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from San Antonio, TX to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between San Antonio, TX and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Antonio, TX to St. Louis, MO?

Prices and availability for 7 trips between San Antonio, TX and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Antonio, TX to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Antonio, TX and to St. Louis, MO

Here’s an overview of the most popular bus routes to San Antonio, TX and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!