Bus Pittsburgh to St. Louis, MO - Compare all Companies

Compare all timetables for the bus from Pittsburgh to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Pittsburgh to St. Louis, MO from various bus operators like Greyhound US for the next days.

today

$56

tomorrow

$59

Wednesday

$59

Thursday

$58

Friday

$63

Saturday

$61

Sunday

$67

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	12h 55m	8:00 PM	Pittsburgh	Grant Street Transportation Center	7:55 AM	St. Louis, MO	Gateway Station	Economy	$56	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/22/2026 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/23/2026 7:55:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 12h 55m
Greyhound US	13h 55m	10:20 AM	Pittsburgh	Grant Street Transportation Center	11:15 PM	St. Louis, MO	Gateway Station	Economy	$56	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/22/2026 10:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/22/2026 11:15:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 13h 55m
Greyhound US	14h 45m	1:25 AM	Pittsburgh	Grant Street Transportation Center	3:10 PM	St. Louis, MO	Gateway Station	Economy	$58	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/22/2026 1:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/22/2026 3:10:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 14h 45m
Greyhound US	14h 50m	1:20 AM	Pittsburgh	Grant Street Transportation Center	3:10 PM	St. Louis, MO	Gateway Station	Economy	$63	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/22/2026 1:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/22/2026 3:10:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 14h 50m
Greyhound US	13h 55m	10:50 AM	Pittsburgh	Grant Street Transportation Center	11:45 PM	St. Louis, MO	Gateway Station	Economy	$63	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/22/2026 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/22/2026 11:45:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 13h 55m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 45m	1:25 AM	Pittsburgh	Grant Street Transportation Center	3:10 PM	St. Louis, MO	Gateway Station	Economy	$59	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/23/2026 1:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/23/2026 3:10:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 14h 45m
Greyhound US	13h 55m	10:50 AM	Pittsburgh	Grant Street Transportation Center	11:45 PM	St. Louis, MO	Gateway Station	Economy	$59	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/23/2026 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/23/2026 11:45:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 13h 55m
Greyhound US	12h 55m	8:00 PM	Pittsburgh	Grant Street Transportation Center	7:55 AM	St. Louis, MO	Gateway Station	Economy	$59	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/23/2026 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/24/2026 7:55:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 12h 55m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 45m	1:25 AM	Pittsburgh	Grant Street Transportation Center	3:10 PM	St. Louis, MO	Gateway Station	Economy	$59	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/24/2026 1:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/24/2026 3:10:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 14h 45m
Greyhound US	13h 55m	10:50 AM	Pittsburgh	Grant Street Transportation Center	11:45 PM	St. Louis, MO	Gateway Station	Economy	$59	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/24/2026 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/24/2026 11:45:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 13h 55m
Greyhound US	12h 55m	8:00 PM	Pittsburgh	Grant Street Transportation Center	7:55 AM	St. Louis, MO	Gateway Station	Economy	$59	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/24/2026 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/25/2026 7:55:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 12h 55m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 45m	1:25 AM	Pittsburgh	Grant Street Transportation Center	3:10 PM	St. Louis, MO	Gateway Station	Economy	$58	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/25/2026 1:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/25/2026 3:10:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 14h 45m
Greyhound US	12h 55m	8:00 PM	Pittsburgh	Grant Street Transportation Center	7:55 AM	St. Louis, MO	Gateway Station	Economy	$58	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/25/2026 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 7:55:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 12h 55m
Greyhound US	13h 55m	10:20 AM	Pittsburgh	Grant Street Transportation Center	11:15 PM	St. Louis, MO	Gateway Station	Economy	$67	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/25/2026 10:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/25/2026 11:15:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 13h 55m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	12h 55m	8:00 PM	Pittsburgh	Grant Street Transportation Center	7:55 AM	St. Louis, MO	Gateway Station	Economy	$63	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/26/2026 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 7:55:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 12h 55m
Greyhound US	13h 55m	10:50 AM	Pittsburgh	Grant Street Transportation Center	11:45 PM	St. Louis, MO	Gateway Station	Economy	$63	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/26/2026 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 11:45:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 13h 55m
Greyhound US	13h 55m	10:20 AM	Pittsburgh	Grant Street Transportation Center	11:15 PM	St. Louis, MO	Gateway Station	Economy	$65	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/26/2026 10:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 11:15:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 13h 55m
Greyhound US	14h 45m	1:25 AM	Pittsburgh	Grant Street Transportation Center	3:10 PM	St. Louis, MO	Gateway Station	Economy	$67	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/26/2026 1:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/26/2026 3:10:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 14h 45m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 45m	1:25 AM	Pittsburgh	Grant Street Transportation Center	3:10 PM	St. Louis, MO	Gateway Station	Economy	$61	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/27/2026 1:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 3:10:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 14h 45m
Greyhound US	13h 55m	10:50 AM	Pittsburgh	Grant Street Transportation Center	11:45 PM	St. Louis, MO	Gateway Station	Economy	$61	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/27/2026 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/27/2026 11:45:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 13h 55m
Greyhound US	12h 55m	8:00 PM	Pittsburgh	Grant Street Transportation Center	7:55 AM	St. Louis, MO	Gateway Station	Economy	$63	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/27/2026 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/28/2026 7:55:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 12h 55m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 45m	1:25 AM	Pittsburgh	Grant Street Transportation Center	3:10 PM	St. Louis, MO	Gateway Station	Economy	$67	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/28/2026 1:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/28/2026 3:10:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 14h 45m
Greyhound US	13h 55m	10:50 AM	Pittsburgh	Grant Street Transportation Center	11:45 PM	St. Louis, MO	Gateway Station	Economy	$67	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/28/2026 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/28/2026 11:45:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 13h 55m
Greyhound US	12h 55m	8:00 PM	Pittsburgh	Grant Street Transportation Center	7:55 AM	St. Louis, MO	Gateway Station	Economy	$67	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/28/2026 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2026 7:55:00 AM. 50 Economy ticket for $67 per person are available. Travel duration is 12h 55m

Best Price Offer: The price for the cheapest bus from Pittsburgh to St. Louis, MO is $54 on 7/11/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Pittsburgh and St. Louis, MO

See here how frequent the connections between Pittsburgh and St. Louis, MO are, during different times and days of the week.

Monday is the busiest day, with more than 7 daily buses from Pittsburgh to St. Louis, MO. Sunday has instead the fewest connections, with only 3 daily coaches between Pittsburgh and St. Louis, MO.

The busiest time of the day is the Night, with 10 buses from Pittsburgh to St. Louis, MO, while Morning sees the fewest connections between Pittsburgh and St. Louis, MO, with 9 offers.

Facts about the bus from Pittsburgh to St. Louis, MO

Compare all providers like Greyhound US that travel 4 times every day by bus from Pittsburgh to St. Louis, MO in one click! Book your bus ticket from Pittsburgh to St. Louis, MO starting from $54!

Cheapest Bus	$54
Fastest Bus	11h 55m
Earliest Bus	1:20 AM
Latest Bus	8:00 PM
Daily Bus Routes	4 Ø
Distance	558.2 miles
Bus Companies	Greyhound US

Cheapest bus connections from Pittsburgh to St. Louis, MO

Every day, 4 buses from 1 bus companies leave Pittsburgh for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/22/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 06/21

Monday 06/22

$63

Tuesday 06/23

$59

Wednesday 06/24

$59

Thursday 06/25

$58

Friday 06/26

$63

Saturday 06/27

$61

Sunday 06/28

$67

Monday 06/29

Tuesday 06/30

Wednesday 07/01

Thursday 07/02

$61

Friday 07/03

Saturday 07/04

$65

Sunday 07/05

Monday 07/06

Tuesday 07/07

Wednesday 07/08

Thursday 07/09

Friday 07/10

Saturday 07/11

$54

Sunday 07/12

$71

Monday 07/13

$54

Tuesday 07/14

$59

Wednesday 07/15

$58

Thursday 07/16

$58

Friday 07/17

$61

Saturday 07/18

The cheapest time to travel from Pittsburgh to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Pittsburgh to St. Louis, MO, for the next 30 days.

With a price starting from $54, Monday is the cheapest day for a bus from Pittsburgh to St. Louis, MO. Sunday instead is the most expensive day with prices starting from $66.

Night is the cheapest day time for bus tickets from Pittsburgh to St. Louis, MO, with $54. Morning is the most expensive time of the day with prices starting from $56.

How to save money travelling from Pittsburgh to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Pittsburgh to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Pittsburgh to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Pittsburgh to St. Louis, MO are also emptier.

All bus stations and stops in Pittsburgh and St. Louis, MO

In the map below, you can see where to find all bus stations in Pittsburgh and St. Louis, MO.

Grant Street Transportation Center

11th St 55

David L. Lawrence Convention Center

10th St Pittsburgh 131-199

Carnegie Mellon

Forbes Ave

University of

Bus Stop

Forbes Ave 3501

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from Pittsburgh to St. Louis, MO

Want to know which seat classes are available on the buses from Pittsburgh to St. Louis, MO? Or which bus companies serve the route Pittsburgh to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Pittsburgh to St. Louis, MO bus

How much does a Pittsburgh St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $54 and takes 12h 55m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Pittsburgh to St. Louis, MO?

This route is offered by 1 companies with a range of ticket prices between $54 and $106. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Pittsburgh to St. Louis, MO each day?

Every day, the Pittsburgh to St. Louis, MO bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Pittsburgh to St. Louis, MO take?

The fastest bus from Pittsburgh to St. Louis, MO is offered by Greyhound US and takes 11h 55m. Bus tickets for this connection cost $65. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Pittsburgh to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Pittsburgh starts at 1:20 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Pittsburgh to St. Louis, MO?

The latest bus trip departing from Pittsburgh for St. Louis, MO starts at 8:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Pittsburgh St. Louis, MO route?

When traveling by bus from Pittsburgh to St. Louis, MO, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Pittsburgh and St. Louis, MO?

You can check all the direct connections between Pittsburgh and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Pittsburgh to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Pittsburgh St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Pittsburgh St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Pittsburgh to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Pittsburgh to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Pittsburgh and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Pittsburgh to St. Louis, MO?

Prices and availability for 4 trips between Pittsburgh and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Pittsburgh to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Pittsburgh and to St. Louis, MO

Here’s an overview of the most popular bus routes to Pittsburgh and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!