Which bus from Pittsburgh to St. Louis, MO is the cheapest?

Compare all bus companies and find the best price: Bus tickets from $45
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Pittsburgh to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Pittsburgh to St. Louis, MO from various bus operators like Greyhound US for the next days.

today
$45
tomorrow
Thursday
Friday
$61
Saturday
Sunday
Monday

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 14h 45m 1:35 AM Pittsburgh Grant Street Transportation Center 3:20 PM St. Louis, MO Gateway Station  Economy $45
Greyhound US 12h 55m 8:00 PM Pittsburgh Grant Street Transportation Center 7:55 AM St. Louis, MO Gateway Station  Economy $45
Greyhound US 13h 35m 10:50 AM Pittsburgh Grant Street Transportation Center 11:25 PM St. Louis, MO Gateway Station  Economy $51

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 14h 50m 1:20 AM Pittsburgh Grant Street Transportation Center 3:10 PM St. Louis, MO Gateway Station  Economy $61
Greyhound US 13h 35m 10:50 AM Pittsburgh Grant Street Transportation Center 11:25 PM St. Louis, MO Gateway Station  Economy $65
Greyhound US 12h 55m 8:00 PM Pittsburgh Grant Street Transportation Center 7:55 AM St. Louis, MO Gateway Station  Economy $65

Best Price Offer: The price for the cheapest bus from Pittsburgh to St. Louis, MO is $45 on 3/24/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Pittsburgh and St. Louis, MO

See here how frequent the connections between Pittsburgh and St. Louis, MO are, during different times and days of the week.
Tuesday is the busiest day, with more than 3 daily buses from Pittsburgh to St. Louis, MO. Tuesday has instead the fewest connections, with only 3 daily coaches between Pittsburgh and St. Louis, MO.
The busiest time of the day is the Morning, with 2 buses from Pittsburgh to St. Louis, MO, while Morning sees the fewest connections between Pittsburgh and St. Louis, MO, with 2 offers.

Facts about the bus from Pittsburgh to St. Louis, MO

Compare all providers like Greyhound US that travel 3 times every day by bus from Pittsburgh to St. Louis, MO in one click! Book your bus ticket from Pittsburgh to St. Louis, MO starting from $45!

Cheapest Bus $45
Fastest Bus 11h 55m
Earliest Bus 1:35 AM
Latest Bus 8:00 PM
Daily Bus Routes 3 Ø
Distance 558.2 miles
Bus Companies Greyhound US

Cheapest bus connections from Pittsburgh to St. Louis, MO

Every day, 3 buses from 1 bus companies leave Pittsburgh for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/24/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 03/22
Monday 03/23
Tuesday 03/24
$45
Wednesday 03/25
Thursday 03/26
Friday 03/27
$61
Saturday 03/28
Sunday 03/29
Monday 03/30
Tuesday 03/31
$59
Wednesday 04/01
$63
Thursday 04/02
Friday 04/03
Saturday 04/04
$59
Sunday 04/05
$57
Monday 04/06
$57
Tuesday 04/07
Wednesday 04/08
$57
Thursday 04/09
$52
Friday 04/10
$61
Saturday 04/11
$56
Sunday 04/12
$57
Monday 04/13
$58
Tuesday 04/14
$56
Wednesday 04/15
$58
Thursday 04/16
$61
Friday 04/17
Saturday 04/18

The cheapest time to travel from Pittsburgh to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Pittsburgh to St. Louis, MO, for the next 30 days.
With a price starting from $45, Tuesday is the cheapest day for a bus from Pittsburgh to St. Louis, MO. Friday instead is the most expensive day with prices starting from $61.
Evening is the cheapest day time for bus tickets from Pittsburgh to St. Louis, MO, with $45. Morning is the most expensive time of the day with prices starting from $51.

How to save money travelling from Pittsburgh to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Pittsburgh to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Pittsburgh to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Pittsburgh to St. Louis, MO are also emptier.

All bus stations and stops in Pittsburgh and St. Louis, MO

In the map below, you can see where to find all bus stations in Pittsburgh and St. Louis, MO.

Service and Comfort on the bus from Pittsburgh to St. Louis, MO

Want to know which seat classes are available on the buses from Pittsburgh to St. Louis, MO? Or which bus companies serve the route Pittsburgh to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Pittsburgh to St. Louis, MO bus

How much does a Pittsburgh St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $45 and takes 13h 45m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Pittsburgh to St. Louis, MO?

This route is offered by 1 companies with a range of ticket prices between $45 and $65. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Pittsburgh to St. Louis, MO each day?

Every day, the Pittsburgh to St. Louis, MO bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Pittsburgh to St. Louis, MO take?

The fastest bus from Pittsburgh to St. Louis, MO is offered by Greyhound US and takes 11h 55m. Bus tickets for this connection cost $45. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Pittsburgh to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Pittsburgh starts at 1:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Pittsburgh to St. Louis, MO?

The latest bus trip departing from Pittsburgh for St. Louis, MO starts at 8:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Pittsburgh St. Louis, MO route?

When traveling by bus from Pittsburgh to St. Louis, MO, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Pittsburgh and St. Louis, MO?

You can check all the direct connections between Pittsburgh and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Pittsburgh to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Pittsburgh St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Pittsburgh St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Pittsburgh to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Pittsburgh to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Pittsburgh and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Pittsburgh to St. Louis, MO?

Prices and availability for 3 trips between Pittsburgh and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Pittsburgh to St. Louis, MO

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Pittsburgh and to St. Louis, MO

Here’s an overview of the most popular bus routes to Pittsburgh and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!
Buses to Pittsburgh from Woodbridge, VA Buses to Pittsburgh from Woodbridge, VA
Buses to Pittsburgh from Ridgewood, NJ Buses to Pittsburgh from Ridgewood, NJ
From Ashland, KY to Pittsburgh bus From Ashland, KY to Pittsburgh bus
Bus Grand Rapids, MI - Pittsburgh Bus Grand Rapids, MI - Pittsburgh
Buses from Fort Worth to St. Louis, MO Buses from Fort Worth to St. Louis, MO
Bus to St. Louis, MO from Washington, MO Bus to St. Louis, MO from Washington, MO
Bus from Conroe, TX to St. Louis, MO Bus from Conroe, TX to St. Louis, MO
San Antonio, TX to St. Louis, MO bus San Antonio, TX to St. Louis, MO bus
Popular Airport Shuttles to Pittsburgh and to St. Louis, MO
CheckMyBus › Buses in USA › Bus to Pittsburgh › Bus to St. Louis, MO

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.