Bus Detroit to St. Louis, MO - Compare all Companies

Compare all timetables for the bus from Detroit to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Detroit to St. Louis, MO from various bus operators like Greyhound US for the next days.

today

tomorrow

$83

Sunday

$73

Monday

$73

Tuesday

Wednesday

Thursday

$84

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 5m	4:20 PM	Detroit	Central Bus Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$83	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/6/2025 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/7/2025 6:25:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 15h 5m
Greyhound US	16h 55m	11:25 PM	Detroit	Central Bus Station	3:20 PM	St. Louis, MO	Gateway Station	Economy	$84	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/6/2025 11:25:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/7/2025 3:20:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 16h 55m
Greyhound US	15h 50m	8:20 AM	Detroit	Central Bus Station	11:10 PM	St. Louis, MO	Gateway Station	Economy	$87	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/6/2025 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/6/2025 11:10:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 15h 50m

Did you know that if you travel from Detroit to St. Louis, MO via Chicago, you can save more than $10? You can find the corresponding connections below.
- Busbud
  
  15h 50m
  
  0
  
  8:20 AM
  
  Detroit
  Central Bus Station
  
  2:20 PM
  
  Chicago
  Downtown Bus Station
  
  0
  
  Economy
  
  $36
  
  A Bus from Busbud goes from Central Bus Station, Detroit (USA) at 12/8/2025 8:20:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/8/2025 2:20:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 7h 0m
- Busbud
  
  6h 40m
  
  0
  
  4:30 PM
  
  Chicago
  Downtown Bus Station
  
  11:10 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $37
  
  A Bus from Busbud goes from Downtown Bus Station, Chicago (USA) at 12/8/2025 4:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/8/2025 11:10:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 6h 40m
Travel time is 1h 45m longer, but you will save $10

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 50m	8:20 AM	Detroit	Central Bus Station	11:10 PM	St. Louis, MO	Gateway Station	Economy	$73	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/7/2025 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/7/2025 11:10:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 15h 50m
Greyhound US	15h 5m	4:20 PM	Detroit	Central Bus Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$73	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/7/2025 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/8/2025 6:25:00 AM. 50 Economy ticket for $73 per person are available. Travel duration is 15h 5m
Greyhound US	16h 55m	11:25 PM	Detroit	Central Bus Station	3:20 PM	St. Louis, MO	Gateway Station	Economy	$73	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/7/2025 11:25:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/8/2025 3:20:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 16h 55m

Cheapest bus trips Monday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	15h 50m	8:20 AM	Detroit	Central Bus Station	11:10 PM	St. Louis, MO	Gateway Station		Economy	$73	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/8/2025 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/8/2025 11:10:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 15h 50m
	Greyhound US	16h 55m	11:25 PM	Detroit	Central Bus Station	3:20 PM	St. Louis, MO	Gateway Station		Economy	$73	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/8/2025 11:25:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/9/2025 3:20:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 16h 55m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	17h 45m	6:40 AM	Detroit	Central Bus Station	11:25 PM	St. Louis, MO	Gateway Station	Economy	$84	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/11/2025 6:40:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/11/2025 11:25:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 17h 45m
Greyhound US	15h 5m	4:20 PM	Detroit	Central Bus Station	6:25 AM	St. Louis, MO	Gateway Station	Economy	$84	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/11/2025 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/12/2025 6:25:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 15h 5m
Greyhound US	12h 40m	8:15 PM	Detroit	Central Bus Station	7:55 AM	St. Louis, MO	Gateway Station	Economy	$84	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/11/2025 8:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/12/2025 7:55:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 12h 40m
Greyhound US	16h 55m	11:25 PM	Detroit	Central Bus Station	3:20 PM	St. Louis, MO	Gateway Station	Economy	$85	A Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 12/11/2025 11:25:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/12/2025 3:20:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 16h 55m

Did you know that if you travel from Detroit to St. Louis, MO via Chicago, you can save more than $11? You can find the corresponding connections below.
- Busbud
  
  15h 50m
  
  0
  
  8:20 AM
  
  Detroit
  Central Bus Station
  
  2:20 PM
  
  Chicago
  Downtown Bus Station
  
  0
  
  Economy
  
  $36
  
  A Bus from Busbud goes from Central Bus Station, Detroit (USA) at 12/8/2025 8:20:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/8/2025 2:20:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 7h 0m
- Busbud
  
  6h 40m
  
  0
  
  4:30 PM
  
  Chicago
  Downtown Bus Station
  
  11:10 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $37
  
  A Bus from Busbud goes from Downtown Bus Station, Chicago (USA) at 12/8/2025 4:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/8/2025 11:10:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 6h 40m
Travel time is 4h 10m longer, but you will save $11

Best Price Offer: The price for the cheapest bus from Detroit to St. Louis, MO is $73 on 12/12/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Detroit and St. Louis, MO

See here how frequent the connections between Detroit and St. Louis, MO are, during different times and days of the week.

Thursday is the busiest day, with more than 8 daily buses from Detroit to St. Louis, MO. Saturday has instead the fewest connections, with only 3 daily coaches between Detroit and St. Louis, MO.

The busiest time of the day is the Evening, with 9 buses from Detroit to St. Louis, MO, while Afternoon sees the fewest connections between Detroit and St. Louis, MO, with 5 offers.

Facts about the bus from Detroit to St. Louis, MO

Compare all providers like Greyhound US that travel 5 times every day by bus from Detroit to St. Louis, MO in one click! Book your bus ticket from Detroit to St. Louis, MO starting from $73!

Cheapest Bus	$73
Fastest Bus	11h 40m
Earliest Bus	8:20 AM
Latest Bus	11:25 PM
Daily Bus Routes	5 Ø
Distance	454.7 miles
Bus Companies	Greyhound US

Cheapest bus connections from Detroit to St. Louis, MO

Every day, 5 buses from 1 bus companies leave Detroit for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

Saturday 12/06

$83

Sunday 12/07

$73

Monday 12/08

$78

Tuesday 12/09

Wednesday 12/10

Thursday 12/11

$86

Friday 12/12

$73

Saturday 12/13

$84

Sunday 12/14

$86

Monday 12/15

$90

Tuesday 12/16

Wednesday 12/17

$78

Thursday 12/18

$98

Friday 12/19

Saturday 12/20

Sunday 12/21

$114

Monday 12/22

$106

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

The cheapest time to travel from Detroit to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Detroit to St. Louis, MO, for the next 30 days.

With a price starting from $73, Sunday is the cheapest day for a bus from Detroit to St. Louis, MO. Thursday instead is the most expensive day with prices starting from $84.

Evening is the cheapest day time for bus tickets from Detroit to St. Louis, MO, with $73. Morning is the most expensive time of the day with prices starting from $73.

How to save money travelling from Detroit to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Detroit to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Detroit to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Detroit to St. Louis, MO are also emptier.

Beloved bus companies from Detroit to St. Louis, MO

These are the most booked bus companies between Detroit to St. Louis, MO from our users.

Greyhound US from Detroit to St. Louis, MO

Here you will find the key facts about the Greyhound US bus route Detroit to St. Louis, MO:

Cheapest Price	$73
Fastest Bus	11h 40m
Earliest Bus	8:20 AM
Last Bus	11:25 PM
Daily Connections	5 Ø
Found on	12/3/2025

All bus stations and stops in Detroit and St. Louis, MO

In the map below, you can see where to find all bus stations in Detroit and St. Louis, MO.

Central Bus Station

Howard St 1001

Amtrak

W Baltimore Ave 78

VA Medical Center Blue Deck

East Canfield Street (between John R. and Brush St.) 225

Park Avenue

Rosa Parks TC

Cass Ave 1310

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from Detroit to St. Louis, MO

Want to know which seat classes are available on the buses from Detroit to St. Louis, MO? Or which bus companies serve the route Detroit to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Detroit to St. Louis, MO bus

How much does a Detroit St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $73 and takes 15h 55m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Detroit to St. Louis, MO?

This route is offered by 1 companies with a range of ticket prices between $73 and $88. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Detroit to St. Louis, MO each day?

Every day, the Detroit to St. Louis, MO bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Detroit to St. Louis, MO take?

The fastest bus from Detroit to St. Louis, MO is offered by Greyhound US and takes 11h 40m. Bus tickets for this connection cost $84. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Detroit to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Detroit starts at 8:20 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Detroit to St. Louis, MO?

The latest bus trip departing from Detroit for St. Louis, MO starts at 11:25 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Detroit St. Louis, MO route?

When traveling by bus from Detroit to St. Louis, MO, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Detroit and St. Louis, MO?

You can check all the direct connections between Detroit and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Detroit to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Detroit St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Detroit St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Detroit to St. Louis, MO on your planned travel date.

Available seat classes which are offered on the bus route Detroit to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Detroit and to St. Louis, MO

Here’s an overview of the most popular bus routes to Detroit and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!