Which bus from Detroit to St. Louis, MO is the cheapest?

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Compare all timetables for the bus from Detroit to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Detroit to St. Louis, MO from various bus operators like Greyhound US for the next days.

today
tomorrow
$79
Tuesday
$93
Wednesday
$90
Thursday
Friday
$71
Saturday
$90

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 15h 5m 4:20 PM Detroit Central Bus Station 6:25 AM St. Louis, MO Gateway Station  Economy $79
Greyhound US 12h 40m 8:15 PM Detroit Central Bus Station 7:55 AM St. Louis, MO Gateway Station  Economy $79
Greyhound US 16h 55m 11:15 PM Detroit Central Bus Station 3:10 PM St. Louis, MO Gateway Station  Economy $79
Greyhound US 15h 50m 8:20 AM Detroit Central Bus Station 11:10 PM St. Louis, MO Gateway Station  Economy $80
Greyhound US 17h 5m 11:15 PM Detroit Central Bus Station 3:20 PM St. Louis, MO Gateway Station  Economy $81
  • Did you know that if you travel from Detroit to St. Louis, MO via Chicago, you can save more than $16? You can find the corresponding connections below.
    • Greyhound US
      15h 5m
      0
      4:20 PM
      Detroit
      Central Bus Station
      9:25 PM
      Chicago
      Downtown Bus Station
      0
      Greyhound US
      Economy
      $32
      • Waiting Time 2h 50m
    • FlixBus
      6h 10m
      0
      12:15 AM
      Chicago
      Downtown Bus Station
      6:25 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $31
    Travel time is 3h 25m longer, but you will save $16

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 12h 40m 8:15 PM Detroit Central Bus Station 7:55 AM St. Louis, MO Gateway Station  Economy $93
Greyhound US 17h 5m 11:15 PM Detroit Central Bus Station 3:20 PM St. Louis, MO Gateway Station  Economy $93
Greyhound US 15h 50m 8:20 AM Detroit Central Bus Station 11:10 PM St. Louis, MO Gateway Station  Economy $94
Greyhound US 15h 5m 4:20 PM Detroit Central Bus Station 6:25 AM St. Louis, MO Gateway Station  Economy $95
  • Did you know that if you travel from Detroit to St. Louis, MO via Chicago, you can save more than $30? You can find the corresponding connections below.
    • Greyhound US
      15h 5m
      0
      4:20 PM
      Detroit
      Central Bus Station
      9:25 PM
      Chicago
      Downtown Bus Station
      0
      Greyhound US
      Economy
      $32
      • Waiting Time 2h 50m
    • FlixBus
      6h 10m
      0
      12:15 AM
      Chicago
      Downtown Bus Station
      6:25 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $31
    Travel time is 3h 25m longer, but you will save $30

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 12h 40m 8:15 PM Detroit Central Bus Station 7:55 AM St. Louis, MO Gateway Station  Economy $90
Greyhound US 17h 5m 11:15 PM Detroit Central Bus Station 3:20 PM St. Louis, MO Gateway Station  Economy $90
Greyhound US 15h 5m 4:20 PM Detroit Central Bus Station 6:25 AM St. Louis, MO Gateway Station  Economy $91
Greyhound US 17h 10m 7:15 AM Detroit Central Bus Station 11:25 PM St. Louis, MO Gateway Station  Economy $92
  • Did you know that if you travel from Detroit to St. Louis, MO via Chicago, you can save more than $27? You can find the corresponding connections below.
    • Greyhound US
      15h 5m
      0
      4:20 PM
      Detroit
      Central Bus Station
      9:25 PM
      Chicago
      Downtown Bus Station
      0
      Greyhound US
      Economy
      $32
      • Waiting Time 2h 50m
    • FlixBus
      6h 10m
      0
      12:15 AM
      Chicago
      Downtown Bus Station
      6:25 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $31
    Travel time is 3h 25m longer, but you will save $27

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 15h 50m 8:20 AM Detroit Central Bus Station 11:10 PM St. Louis, MO Gateway Station  Economy $71
Greyhound US 15h 5m 4:20 PM Detroit Central Bus Station 6:25 AM St. Louis, MO Gateway Station  Economy $71
Greyhound US 12h 40m 8:15 PM Detroit Central Bus Station 7:55 AM St. Louis, MO Gateway Station  Economy $71
Greyhound US 17h 5m 11:15 PM Detroit Central Bus Station 3:20 PM St. Louis, MO Gateway Station  Economy $71
Greyhound US 16h 55m 11:15 PM Detroit Central Bus Station 3:10 PM St. Louis, MO Gateway Station  Economy $91
  • Did you know that if you travel from Detroit to St. Louis, MO via Chicago, you can save more than $8? You can find the corresponding connections below.
    • Greyhound US
      15h 5m
      0
      4:20 PM
      Detroit
      Central Bus Station
      9:25 PM
      Chicago
      Downtown Bus Station
      0
      Greyhound US
      Economy
      $32
      • Waiting Time 2h 50m
    • FlixBus
      6h 10m
      0
      12:15 AM
      Chicago
      Downtown Bus Station
      6:25 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $31
    Travel time is 3h 25m longer, but you will save $8

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 15h 50m 8:20 AM Detroit Central Bus Station 11:10 PM St. Louis, MO Gateway Station  Economy $90
Greyhound US 12h 40m 8:15 PM Detroit Central Bus Station 7:55 AM St. Louis, MO Gateway Station  Economy $90
Greyhound US 17h 5m 11:15 PM Detroit Central Bus Station 3:20 PM St. Louis, MO Gateway Station  Economy $90
Greyhound US 15h 5m 4:20 PM Detroit Central Bus Station 6:25 AM St. Louis, MO Gateway Station  Economy $91
  • Did you know that if you travel from Detroit to St. Louis, MO via Chicago, you can save more than $27? You can find the corresponding connections below.
    • Greyhound US
      15h 5m
      0
      4:20 PM
      Detroit
      Central Bus Station
      9:25 PM
      Chicago
      Downtown Bus Station
      0
      Greyhound US
      Economy
      $32
      • Waiting Time 2h 50m
    • FlixBus
      6h 10m
      0
      12:15 AM
      Chicago
      Downtown Bus Station
      6:25 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $31
    Travel time is 3h 25m longer, but you will save $27

Best Price Offer: The price for the cheapest bus from Detroit to St. Louis, MO is $68 on 4/16/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Detroit and St. Louis, MO

See here how frequent the connections between Detroit and St. Louis, MO are, during different times and days of the week.
Monday is the busiest day, with more than 8 daily buses from Detroit to St. Louis, MO. Tuesday has instead the fewest connections, with only 4 daily coaches between Detroit and St. Louis, MO.
The busiest time of the day is the Evening, with 14 buses from Detroit to St. Louis, MO, while Morning sees the fewest connections between Detroit and St. Louis, MO, with 7 offers.

Facts about the bus from Detroit to St. Louis, MO

Compare all providers like Greyhound US that travel 5 times every day by bus from Detroit to St. Louis, MO in one click! Book your bus ticket from Detroit to St. Louis, MO starting from $68!

Cheapest Bus $68
Fastest Bus 11h 40m
Earliest Bus 8:20 AM
Latest Bus 11:15 PM
Daily Bus Routes 5 Ø
Distance 454.7 miles
Bus Companies Greyhound US

Cheapest bus connections from Detroit to St. Louis, MO

Every day, 5 buses from 1 bus companies leave Detroit for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/22/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 03/22
Monday 03/23
$79
Tuesday 03/24
$93
Wednesday 03/25
$90
Thursday 03/26
Friday 03/27
$91
Saturday 03/28
$90
Sunday 03/29
$90
Monday 03/30
$85
Tuesday 03/31
$83
Wednesday 04/01
Thursday 04/02
$75
Friday 04/03
Saturday 04/04
$87
Sunday 04/05
$75
Monday 04/06
$69
Tuesday 04/07
$69
Wednesday 04/08
$76
Thursday 04/09
$68
Friday 04/10
$82
Saturday 04/11
$87
Sunday 04/12
$83
Monday 04/13
$75
Tuesday 04/14
$78
Wednesday 04/15
$78
Thursday 04/16
$68
Friday 04/17
$75
Saturday 04/18

The cheapest time to travel from Detroit to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Detroit to St. Louis, MO, for the next 30 days.
With a price starting from $69, Tuesday is the cheapest day for a bus from Detroit to St. Louis, MO. Saturday instead is the most expensive day with prices starting from $87.
Evening is the cheapest day time for bus tickets from Detroit to St. Louis, MO, with $71. Morning is the most expensive time of the day with prices starting from $71.

How to save money travelling from Detroit to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Detroit to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Detroit to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Detroit to St. Louis, MO are also emptier.

Beloved bus companies from Detroit to St. Louis, MO

These are the most booked bus companies between Detroit to St. Louis, MO from our users.

Greyhound US from Detroit to St. Louis, MO

Greyhound US

Here you will find the key facts about the Greyhound US bus route Detroit to St. Louis, MO:

Cheapest Price $71
Fastest Bus 11h 40m
Earliest Bus 8:20 AM
Last Bus 11:15 PM
Daily Connections 5 Ø
Found on 2/25/2026

All bus stations and stops in Detroit and St. Louis, MO

In the map below, you can see where to find all bus stations in Detroit and St. Louis, MO.

Service and Comfort on the bus from Detroit to St. Louis, MO

Want to know which seat classes are available on the buses from Detroit to St. Louis, MO? Or which bus companies serve the route Detroit to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Detroit to St. Louis, MO bus

How much does a Detroit St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $68 and takes 16h 5m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Detroit to St. Louis, MO?

This route is offered by 1 companies with a range of ticket prices between $68 and $95. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Detroit to St. Louis, MO each day?

Every day, the Detroit to St. Louis, MO bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Detroit to St. Louis, MO take?

The fastest bus from Detroit to St. Louis, MO is offered by Greyhound US and takes 11h 40m. Bus tickets for this connection cost $79. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Detroit to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Detroit starts at 8:20 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Detroit to St. Louis, MO?

The latest bus trip departing from Detroit for St. Louis, MO starts at 11:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Detroit St. Louis, MO route?

When traveling by bus from Detroit to St. Louis, MO, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Detroit and St. Louis, MO?

You can check all the direct connections between Detroit and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Detroit to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Detroit St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Detroit St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Detroit to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Detroit to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between Detroit and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Detroit to St. Louis, MO?

Prices and availability for 5 trips between Detroit and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Detroit to St. Louis, MO

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Detroit and to St. Louis, MO

Here’s an overview of the most popular bus routes to Detroit and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Bus Washington, MO to St. Louis, MO Bus Washington, MO to St. Louis, MO
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Bus Mansfield, OH - St. Louis, MO Bus Mansfield, OH - St. Louis, MO
Popular Airport Shuttles to Detroit and to St. Louis, MO
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