Bus Denver to Knoxville, TN - Compare all Companies

Compare all timetables for the bus from Denver to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from Denver to Knoxville, TN from various bus operators like Greyhound US for the next days.

today

$137

tomorrow

$192

Thursday

Friday

$154

Saturday

Sunday

Monday

$156

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	45h 20m	8:10 PM	Denver	Union Station	7:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$137	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/16/2026 8:10:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/18/2026 7:30:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 45h 20m
Greyhound US	31h 20m	1:20 PM	Denver	Union Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$138	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/16/2026 1:20:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/17/2026 10:40:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 31h 20m
Greyhound US	44h 35m	7:25 PM	Denver	Union Station	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$139	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/16/2026 7:25:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/18/2026 6:00:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 44h 35m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	31h 20m	1:20 PM	Denver	Union Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$192	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/17/2026 1:20:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/18/2026 10:40:00 PM. 50 Economy ticket for $192 per person are available. Travel duration is 31h 20m
Greyhound US	44h 35m	7:25 PM	Denver	Union Station	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$193	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/17/2026 7:25:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/19/2026 6:00:00 PM. 50 Economy ticket for $193 per person are available. Travel duration is 44h 35m
Greyhound US	45h 20m	8:10 PM	Denver	Union Station	7:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$194	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/17/2026 8:10:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/19/2026 7:30:00 PM. 50 Economy ticket for $194 per person are available. Travel duration is 45h 20m

Did you know that if you travel from Denver to Knoxville, TN via St. Louis, MO, you can save more than $25? You can find the corresponding connections below.
- Greyhound US
  
  48h 25m
  
  0
  
  7:25 PM
  
  Denver
  Union Station
  
  12:55 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $77
  
  A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/17/2026 7:25:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/18/2026 12:55:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 16h 30m
- FlixBus
  
  21h 5m
  
  0
  
  11:45 PM
  
  St. Louis, MO
  Gateway Station
  
  9:50 PM
  
  Knoxville, TN
  Knoxville Area Transit Bus Stop
  
  0
  
  Economy
  
  $90
  
  A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 6/18/2026 11:45:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/19/2026 9:50:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 21h 5m
Travel time is 15h 5m longer, but you will save $25

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	31h 20m	1:20 PM	Denver	Union Station	10:40 PM	Knoxville, TN	Greyhound Bus Station	Economy	$154	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/19/2026 1:20:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 6/20/2026 10:40:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 31h 20m
Greyhound US	44h 35m	7:25 PM	Denver	Union Station	6:00 PM	Knoxville, TN	Greyhound Bus Station	Economy	$155	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/19/2026 7:25:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 6/21/2026 6:00:00 PM. 50 Economy ticket for $155 per person are available. Travel duration is 44h 35m
Greyhound US	45h 20m	8:10 PM	Denver	Union Station	7:30 PM	Knoxville, TN	Greyhound Bus Station	Economy	$156	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/19/2026 8:10:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 6/21/2026 7:30:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 45h 20m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	44h 35m	7:25 PM	Denver	Union Station	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$156	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/22/2026 7:25:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/24/2026 6:00:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 44h 35m
Greyhound US	45h 20m	8:10 PM	Denver	Union Station	7:30 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$157	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/22/2026 8:10:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/24/2026 7:30:00 PM. 50 Economy ticket for $157 per person are available. Travel duration is 45h 20m
Greyhound US	31h 20m	1:20 PM	Denver	Union Station	10:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	Economy	$158	A Bus from Greyhound US goes from Union Station, Denver (USA) at 6/22/2026 1:20:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 6/23/2026 10:40:00 PM. 50 Economy ticket for $158 per person are available. Travel duration is 31h 20m

Best Price Offer: The price for the cheapest bus from Denver to Knoxville, TN is $133 on 7/10/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Denver and Knoxville, TN

See here how frequent the connections between Denver and Knoxville, TN are, during different times and days of the week.

Monday is the busiest day, with more than 6 daily buses from Denver to Knoxville, TN. Tuesday has instead the fewest connections, with only 3 daily coaches between Denver and Knoxville, TN.

The busiest time of the day is the Evening, with 10 buses from Denver to Knoxville, TN, while Afternoon sees the fewest connections between Denver and Knoxville, TN, with 5 offers.

Facts about the bus from Denver to Knoxville, TN

Compare all providers like Greyhound US that travel 3 times every day by bus from Denver to Knoxville, TN in one click! Book your bus ticket from Denver to Knoxville, TN starting from $133!

Cheapest Bus	$133
Fastest Bus	33h 20m
Earliest Bus	1:20 PM
Latest Bus	8:10 PM
Daily Bus Routes	3 Ø
Distance	1,176.8 miles
Bus Companies	Greyhound US

Cheapest bus connections from Denver to Knoxville, TN

Every day, 3 buses from 1 bus companies leave Denver for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/16/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 06/14

Monday 06/15

Tuesday 06/16

$137

Wednesday 06/17

$192

Thursday 06/18

Friday 06/19

$154

Saturday 06/20

Sunday 06/21

Monday 06/22

$156

Tuesday 06/23

$170

Wednesday 06/24

Thursday 06/25

$140

Friday 06/26

Saturday 06/27

$165

Sunday 06/28

$133

Monday 06/29

Tuesday 06/30

Wednesday 07/01

Thursday 07/02

Friday 07/03

Saturday 07/04

Sunday 07/05

Monday 07/06

Tuesday 07/07

Wednesday 07/08

Thursday 07/09

Friday 07/10

$133

Saturday 07/11

The cheapest time to travel from Denver to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from Denver to Knoxville, TN, for the next 30 days.

With a price starting from $133, Friday is the cheapest day for a bus from Denver to Knoxville, TN. Wednesday instead is the most expensive day with prices starting from $192.

Evening is the cheapest day time for bus tickets from Denver to Knoxville, TN, with $137. Afternoon is the most expensive time of the day with prices starting from $138.

How to save money travelling from Denver to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Denver to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Denver to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Denver to Knoxville, TN are also emptier.

All bus stations and stops in Denver and Knoxville, TN

In the map below, you can see where to find all bus stations in Denver and Knoxville, TN.

Federal Blvd & W 19th Ave Bus Stop

Federal Blvd & W 19th Ave Federal Blvd & W 19th Ave

Union Station

Wynkoop St 1701

Bus Stop

Colorado Station

E Evans Ave 4401

19th St. Bus Station

19th St 1055

Kingston Pike

Kingston Pike 6927

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Transit Center

E Church Ave 301

Service and Comfort on the bus from Denver to Knoxville, TN

Want to know which seat classes are available on the buses from Denver to Knoxville, TN? Or which bus companies serve the route Denver to Knoxville, TN? Below you will find answers to your questions.

FAQs about the Denver to Knoxville, TN bus

How much does a Denver Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $133 and takes 47h 20m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from Denver to Knoxville, TN?

This route is offered by 1 companies with a range of ticket prices between $133 and $194. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from Denver to Knoxville, TN each day?

Every day, the Denver to Knoxville, TN bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Denver to Knoxville, TN take?

The fastest bus from Denver to Knoxville, TN is offered by Greyhound US and takes 33h 20m. Bus tickets for this connection cost $138. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Denver to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from Denver starts at 1:20 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Denver to Knoxville, TN?

The latest bus trip departing from Denver for Knoxville, TN starts at 8:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Denver Knoxville, TN route?

When traveling by bus from Denver to Knoxville, TN, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Denver and Knoxville, TN?

You can check all the direct connections between Denver and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Denver to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Denver Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Denver Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Denver to Knoxville, TN on your planned travel date.

How does CheckMyBus find the best bus deals from Denver to Knoxville, TN?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Denver and Knoxville, TN. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Denver to Knoxville, TN?

Prices and availability for 3 trips between Denver and Knoxville, TN change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Denver to Knoxville, TN

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Denver and to Knoxville, TN

Here’s an overview of the most popular bus routes to Denver and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!