Bus from St. Louis, MO to Knoxville, TN from $87

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Compare all timetables for the bus from St. Louis, MO to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from St. Louis, MO to Knoxville, TN from various bus operators like FlixBus or Greyhound US for the next days.

today
from $143
tomorrow
from $89
Friday
from $108
Saturday
from $112
Sunday
from $117
Monday
Tuesday
from $87

Cheapest bus trips today

Prices are for one way and one person
  • FlixBus
    22h 20m
    0
    11:30 PM
    St. Louis, MO
    Gateway Station
    9:50 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    FlixBus
    Economy
    $143
  • FlixBus
    14h 10m
    0
    8:30 AM
    St. Louis, MO
    Gateway Station
    10:40 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    FlixBus
    Economy
    $144

Cheapest bus trips tomorrow

Prices are for one way and one person
  • Greyhound US
    16h 45m
    0
    2:30 AM
    St. Louis, MO
    Gateway Station
    7:15 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    Greyhound US
    Economy
    $89
  • FlixBus
    14h 10m
    0
    8:30 AM
    St. Louis, MO
    Gateway Station
    10:40 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    FlixBus
    Economy
    $90
  • FlixBus
    22h 20m
    0
    11:30 PM
    St. Louis, MO
    Gateway Station
    9:50 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    FlixBus
    Economy
    $90

Cheapest bus trips Friday

Prices are for one way and one person
  • FlixBus
    14h 10m
    0
    8:30 AM
    St. Louis, MO
    Gateway Station
    10:40 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    FlixBus
    Economy
    $108
  • Greyhound US
    16h 45m
    0
    2:30 AM
    St. Louis, MO
    Gateway Station
    7:15 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    Greyhound US
    Economy
    $111
  • FlixBus
    22h 20m
    0
    11:30 PM
    St. Louis, MO
    Gateway Station
    9:50 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    FlixBus
    Economy
    $112
  • Did you know that if you travel from St. Louis, MO to Knoxville, TN via Nashville, you can save more than $24? You can find the corresponding connections below.
    • FlixBus
      21h 0m
      0
      1:40 AM
      St. Louis, MO
      Gateway Station
      7:35 AM
      Nashville
      5th Ave South Station
      0
      FlixBus
      Economy
      $43
      • Waiting Time 10h 40m
    • FlixBus
      4h 25m
      0
      6:15 PM
      Nashville
      5th Ave South Station
      10:40 PM
      Knoxville, TN
      Greyhound Bus Station
      0
      FlixBus
      Economy
      $41
    Travel time is 6h 50m longer, but you will save $24

Cheapest bus trips Saturday

Prices are for one way and one person
  • FlixBus
    22h 20m
    0
    11:30 PM
    St. Louis, MO
    Gateway Station
    9:50 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    FlixBus
    Economy
    $112
  • FlixBus
    14h 10m
    0
    8:30 AM
    St. Louis, MO
    Gateway Station
    10:40 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    FlixBus
    Economy
    $116
  • Greyhound US
    16h 45m
    0
    2:30 AM
    St. Louis, MO
    Gateway Station
    7:15 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    Greyhound US
    Economy
    $122
  • Did you know that if you travel from St. Louis, MO to Knoxville, TN via Nashville, you can save more than $28? You can find the corresponding connections below.
    • FlixBus
      21h 0m
      0
      1:40 AM
      St. Louis, MO
      Gateway Station
      7:35 AM
      Nashville
      5th Ave South Station
      0
      FlixBus
      Economy
      $43
      • Waiting Time 10h 40m
    • FlixBus
      4h 25m
      0
      6:15 PM
      Nashville
      5th Ave South Station
      10:40 PM
      Knoxville, TN
      Greyhound Bus Station
      0
      FlixBus
      Economy
      $41
    Travel time is 6h 50m longer, but you will save $28

Cheapest bus trips Sunday

Prices are for one way and one person
  • FlixBus
    14h 10m
    0
    8:30 AM
    St. Louis, MO
    Gateway Station
    10:40 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    FlixBus
    Economy
    $117
  • FlixBus
    22h 20m
    0
    11:30 PM
    St. Louis, MO
    Gateway Station
    9:50 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    FlixBus
    Economy
    $122
  • Greyhound US
    16h 45m
    0
    2:30 AM
    St. Louis, MO
    Gateway Station
    7:15 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    Greyhound US
    Economy
    $123
  • Did you know that if you travel from St. Louis, MO to Knoxville, TN via Nashville, you can save more than $33? You can find the corresponding connections below.
    • FlixBus
      21h 0m
      0
      1:40 AM
      St. Louis, MO
      Gateway Station
      7:35 AM
      Nashville
      5th Ave South Station
      0
      FlixBus
      Economy
      $43
      • Waiting Time 10h 40m
    • FlixBus
      4h 25m
      0
      6:15 PM
      Nashville
      5th Ave South Station
      10:40 PM
      Knoxville, TN
      Greyhound Bus Station
      0
      FlixBus
      Economy
      $41
    Travel time is 6h 50m longer, but you will save $33

Cheapest bus trips Tuesday

Prices are for one way and one person
  • FlixBus
    14h 10m
    0
    8:30 AM
    St. Louis, MO
    Gateway Station
    10:40 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    FlixBus
    Economy
    $87
  • Greyhound US
    16h 45m
    0
    2:30 AM
    St. Louis, MO
    Gateway Station
    7:15 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    Greyhound US
    Economy
    $88
  • FlixBus
    22h 20m
    0
    11:30 PM
    St. Louis, MO
    Gateway Station
    9:50 PM
    Knoxville, TN
    Greyhound Bus Station
    0
    FlixBus
    Economy
    $95

Frequency of bus connections between St. Louis, MO and Knoxville, TN

See here how frequent the connections between St. Louis, MO and Knoxville, TN are, during different times and days of the week.
Sunday is the busiest day, with more than 3 daily buses from St. Louis, MO to Knoxville, TN. Wednesday has instead the fewest connections, with only 2 daily coaches between St. Louis, MO and Knoxville, TN.
The busiest time of the day is the Morning, with 6 buses from St. Louis, MO to Knoxville, TN, while Night sees the fewest connections between St. Louis, MO and Knoxville, TN, with 5 offers.

Facts about the bus from St. Louis, MO to Knoxville, TN

Compare all providers like FlixBus and Greyhound US that travel 2 times every day by bus from St. Louis, MO to Knoxville, TN in one click! Book your bus ticket from St. Louis, MO to Knoxville, TN starting from $87!

Cheapest Bus $87
Fastest Bus 14h 10m
Earliest Bus 8:30 AM
Latest Bus 11:30 PM
Daily Bus Routes 2 Ø
Distance 391.5 miles
Bus Companies FlixBus and Greyhound US

Cheapest bus connections from St. Louis, MO to Knoxville, TN

Every day, 2 buses from 2 bus companies leave St. Louis, MO for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/09/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 07/06
Monday 07/07
Tuesday 07/08
Wednesday 07/09
$130
Thursday 07/10
$89
Friday 07/11
$108
Saturday 07/12
$112
Sunday 07/13
$117
Monday 07/14
Tuesday 07/15
$87
Wednesday 07/16
$83
Thursday 07/17
Friday 07/18
$98
Saturday 07/19
Sunday 07/20
Monday 07/21
Tuesday 07/22
Wednesday 07/23
Thursday 07/24
Friday 07/25
Saturday 07/26
Sunday 07/27
Monday 07/28
Tuesday 07/29
Wednesday 07/30
Thursday 07/31
Friday 08/01
Saturday 08/02

The cheapest time to travel from St. Louis, MO to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from St. Louis, MO to Knoxville, TN, for the next 30 days.
With a price starting from $87, Tuesday is the cheapest day for a bus from St. Louis, MO to Knoxville, TN. Wednesday instead is the most expensive day with prices starting from $143.
Morning is the cheapest day time for bus tickets from St. Louis, MO to Knoxville, TN, with $87. Evening is the most expensive time of the day with prices starting from $90.

How to save money travelling from St. Louis, MO to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from St. Louis, MO to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from St. Louis, MO to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from St. Louis, MO to Knoxville, TN are also emptier.

All bus stations and stops in St. Louis, MO and Knoxville, TN

In the map below, you can see where to find all bus stations in St. Louis, MO and Knoxville, TN.

Service and Comfort on the bus from St. Louis, MO to Knoxville, TN

Want to know which seat classes are available on the buses from St. Louis, MO to Knoxville, TN? Or which bus companies serve the route St. Louis, MO to Knoxville, TN? Below you will find answers to your questions.

FAQs about the St. Louis, MO to Knoxville, TN bus

How much does a St. Louis, MO Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $87 and takes 14h 10m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from St. Louis, MO to Knoxville, TN?

This route is offered by 2 companies with a range of ticket prices between $87 and $144. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from St. Louis, MO to Knoxville, TN each day?

Every day, the St. Louis, MO to Knoxville, TN bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from St. Louis, MO to Knoxville, TN take?

The fastest bus from St. Louis, MO to Knoxville, TN is offered by FlixBus and takes 14h 10m. Bus tickets for this connection cost $144. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from St. Louis, MO to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from St. Louis, MO starts at 8:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from St. Louis, MO to Knoxville, TN?

The latest bus trip departing from St. Louis, MO for Knoxville, TN starts at 11:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the St. Louis, MO Knoxville, TN route?

When traveling by bus from St. Louis, MO to Knoxville, TN, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between St. Louis, MO and Knoxville, TN?

You can check all the direct connections between St. Louis, MO and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the St. Louis, MO to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the St. Louis, MO Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the St. Louis, MO Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from St. Louis, MO to Knoxville, TN on your planned travel date.

Available seat classes which are offered on the bus route St. Louis, MO to Knoxville, TN

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to St. Louis, MO and to Knoxville, TN

Here’s an overview of the most popular bus routes to St. Louis, MO and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Popular Airport Shuttles to St. Louis, MO and to Knoxville, TN
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