Bus St. Louis, MO to Knoxville, TN: Compare prices and save money

Compare all timetables for the bus from St. Louis, MO to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from St. Louis, MO to Knoxville, TN from various bus operators like FlixBus or Greyhound US for the next days.

today

tomorrow

Saturday

Sunday

$134

Monday

Tuesday

Wednesday

$159

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	27h 5m	1:55 PM	St. Louis, MO	Gateway Station	6:00 PM	Knoxville, TN	Greyhound Bus Station	Economy	$134	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/21/2025 1:55:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/22/2025 6:00:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 27h 5m
Greyhound US	15h 55m	2:00 AM	St. Louis, MO	Gateway Station	6:55 PM	Knoxville, TN	Greyhound Bus Station	Economy	$138	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/21/2025 2:00:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/21/2025 6:55:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 15h 55m
FlixBus	21h 20m	11:30 PM	St. Louis, MO	Gateway Station	9:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$151	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/21/2025 11:30:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/22/2025 9:50:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 21h 20m
FlixBus	25h 55m	4:00 PM	St. Louis, MO	Gateway Station	6:55 PM	Knoxville, TN	Greyhound Bus Station	Economy	$154	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/21/2025 4:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/22/2025 6:55:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 25h 55m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 55m	2:00 AM	St. Louis, MO	Gateway Station	6:55 PM	Knoxville, TN	Greyhound Bus Station	Economy	$159	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/24/2025 2:00:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/24/2025 6:55:00 PM. 50 Economy ticket for $159 per person are available. Travel duration is 15h 55m
Greyhound US	27h 5m	1:55 PM	St. Louis, MO	Gateway Station	6:00 PM	Knoxville, TN	Greyhound Bus Station	Economy	$160	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/24/2025 1:55:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/25/2025 6:00:00 PM. 50 Economy ticket for $160 per person are available. Travel duration is 27h 5m
FlixBus	25h 55m	4:00 PM	St. Louis, MO	Gateway Station	6:55 PM	Knoxville, TN	Greyhound Bus Station	Economy	$160	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/24/2025 4:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/25/2025 6:55:00 PM. 50 Economy ticket for $160 per person are available. Travel duration is 25h 55m
FlixBus	21h 20m	11:30 PM	St. Louis, MO	Gateway Station	9:50 PM	Knoxville, TN	Greyhound Bus Station	Economy	$160	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/24/2025 11:30:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/25/2025 9:50:00 PM. 50 Economy ticket for $160 per person are available. Travel duration is 21h 20m

Best Price Offer: The price for the cheapest bus from St. Louis, MO to Knoxville, TN is $108 on 12/16/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between St. Louis, MO and Knoxville, TN

See here how frequent the connections between St. Louis, MO and Knoxville, TN are, during different times and days of the week.

Sunday is the busiest day, with more than 4 daily buses from St. Louis, MO to Knoxville, TN. Sunday has instead the fewest connections, with only 4 daily coaches between St. Louis, MO and Knoxville, TN.

The busiest time of the day is the Afternoon, with 4 buses from St. Louis, MO to Knoxville, TN, while Evening sees the fewest connections between St. Louis, MO and Knoxville, TN, with 2 offers.

Facts about the bus from St. Louis, MO to Knoxville, TN

Compare all providers like FlixBus and Greyhound US that travel 4 times every day by bus from St. Louis, MO to Knoxville, TN in one click! Book your bus ticket from St. Louis, MO to Knoxville, TN starting from $108!

Cheapest Bus	$108
Fastest Bus	16h 55m
Earliest Bus	2:00 AM
Latest Bus	11:30 PM
Daily Bus Routes	4 Ø
Distance	391.5 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from St. Louis, MO to Knoxville, TN

Every day, 4 buses from 2 bus companies leave St. Louis, MO for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/18/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

$134

Monday 12/22

Tuesday 12/23

Wednesday 12/24

$159

Thursday 12/25

Friday 12/26

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

The cheapest time to travel from St. Louis, MO to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from St. Louis, MO to Knoxville, TN, for the next 30 days.

With a price starting from $134, Sunday is the cheapest day for a bus from St. Louis, MO to Knoxville, TN. Wednesday instead is the most expensive day with prices starting from $159.

Night is the cheapest day time for bus tickets from St. Louis, MO to Knoxville, TN, with $94. Evening is the most expensive time of the day with prices starting from $151.

How to save money travelling from St. Louis, MO to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from St. Louis, MO to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from St. Louis, MO to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from St. Louis, MO to Knoxville, TN are also emptier.

All bus stations and stops in St. Louis, MO and Knoxville, TN

In the map below, you can see where to find all bus stations in St. Louis, MO and Knoxville, TN.

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Kingston Pike

Kingston Pike 6927

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Transit Center

E Church Ave 301

Service and Comfort on the bus from St. Louis, MO to Knoxville, TN

Want to know which seat classes are available on the buses from St. Louis, MO to Knoxville, TN? Or which bus companies serve the route St. Louis, MO to Knoxville, TN? Below you will find answers to your questions.

FAQs about the St. Louis, MO to Knoxville, TN bus

How much does a St. Louis, MO Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $108 and takes 28h 5m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from St. Louis, MO to Knoxville, TN?

This route is offered by 2 companies with a range of ticket prices between $108 and $160. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from St. Louis, MO to Knoxville, TN each day?

Every day, the St. Louis, MO to Knoxville, TN bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from St. Louis, MO to Knoxville, TN take?

The fastest bus from St. Louis, MO to Knoxville, TN is offered by Greyhound US and takes 16h 55m. Bus tickets for this connection cost $138. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from St. Louis, MO to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from St. Louis, MO starts at 2:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from St. Louis, MO to Knoxville, TN?

The latest bus trip departing from St. Louis, MO for Knoxville, TN starts at 11:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the St. Louis, MO Knoxville, TN route?

When traveling by bus from St. Louis, MO to Knoxville, TN, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between St. Louis, MO and Knoxville, TN?

You can check all the direct connections between St. Louis, MO and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the St. Louis, MO to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the St. Louis, MO Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the St. Louis, MO Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from St. Louis, MO to Knoxville, TN on your planned travel date.

How does CheckMyBus find the best bus deals from St. Louis, MO to Knoxville, TN?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between St. Louis, MO and Knoxville, TN. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from St. Louis, MO to Knoxville, TN?

Prices and availability for 4 trips between St. Louis, MO and Knoxville, TN change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route St. Louis, MO to Knoxville, TN

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to St. Louis, MO and to Knoxville, TN

Here’s an overview of the most popular bus routes to St. Louis, MO and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!