Bus from St. Louis, MO to Chicago from $26

Compare all the bus companies and find the best price with CheckMyBus
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from St. Louis, MO to Chicago

Here is a selection of the cheapest bus trips from the schedule from St. Louis, MO to Chicago from various bus operators like FlixBus or Greyhound US for the next days.

today
from $41
tomorrow
Friday
from $40
Saturday
from $37
Sunday
from $40
Monday
from $26
Tuesday

Cheapest bus trips today

Prices are for one way and one person
Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 6h 50m 9:45 AM St. Louis, MO Gateway Station 4:35 PM Chicago Downtown Bus Station  Economy $41
FlixBus 6h 15m 4:00 PM St. Louis, MO Gateway Station 10:15 PM Chicago Downtown Bus Station  Economy $41
FlixBus 6h 15m 11:30 PM St. Louis, MO Gateway Station 5:45 AM Chicago Downtown Bus Station  Economy $41
Greyhound US 11h 45m 2:30 AM St. Louis, MO Gateway Station 2:15 PM Chicago Canal & Van Buren  Economy $50
Greyhound US 12h 5m 2:30 AM St. Louis, MO Gateway Station 2:35 PM Chicago Downtown Bus Station  Economy $50

Cheapest bus trips Friday

Prices are for one way and one person
Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 6h 50m 9:45 AM St. Louis, MO Gateway Station 4:35 PM Chicago Downtown Bus Station  Economy $40
FlixBus 6h 15m 4:00 PM St. Louis, MO Gateway Station 10:15 PM Chicago Downtown Bus Station  Economy $40
FlixBus 6h 15m 11:30 PM St. Louis, MO Gateway Station 5:45 AM Chicago Downtown Bus Station  Economy $40
Greyhound US 11h 45m 2:30 AM St. Louis, MO Gateway Station 2:15 PM Chicago Canal & Van Buren  Economy $98
Greyhound US 12h 5m 2:30 AM St. Louis, MO Gateway Station 2:35 PM Chicago Downtown Bus Station  Economy $98

Cheapest bus trips Saturday

Prices are for one way and one person
Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 6h 50m 9:45 AM St. Louis, MO Gateway Station 4:35 PM Chicago Downtown Bus Station  Economy $37
FlixBus 6h 15m 11:30 PM St. Louis, MO Gateway Station 5:45 AM Chicago Downtown Bus Station  Economy $38
FlixBus 6h 50m 9:45 AM St. Louis, MO Gateway Station 4:35 PM Chicago Downtown Bus Station  Economy $40
Greyhound US 11h 45m 2:30 AM St. Louis, MO Gateway Station 2:15 PM Chicago Canal & Van Buren  Economy $63
Greyhound US 12h 5m 2:30 AM St. Louis, MO Gateway Station 2:35 PM Chicago Downtown Bus Station  Economy $63

Cheapest bus trips Sunday

Prices are for one way and one person
Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 6h 50m 9:45 AM St. Louis, MO Gateway Station 4:35 PM Chicago Downtown Bus Station  Economy $40
FlixBus 6h 50m 9:45 AM St. Louis, MO Gateway Station 4:35 PM Chicago Downtown Bus Station  Economy $44
FlixBus 6h 15m 11:30 PM St. Louis, MO Gateway Station 5:45 AM Chicago Downtown Bus Station  Economy $44
Greyhound US 11h 45m 2:30 AM St. Louis, MO Gateway Station 2:15 PM Chicago Union Station  Economy $91
Greyhound US 12h 5m 2:30 AM St. Louis, MO Gateway Station 2:35 PM Chicago Downtown Bus Station  Economy $91

Cheapest bus trips Monday

Prices are for one way and one person
Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 6h 15m 4:00 PM St. Louis, MO Gateway Station 10:15 PM Chicago Downtown Bus Station  Economy $26
FlixBus 6h 15m 4:00 PM St. Louis, MO Gateway Station 10:15 PM Chicago Downtown Bus Station  Economy $30
FlixBus 6h 50m 9:45 AM St. Louis, MO Gateway Station 4:35 PM Chicago Downtown Bus Station  Economy $40
Greyhound US 11h 45m 2:30 AM St. Louis, MO Gateway Station 2:15 PM Chicago Canal & Van Buren  Economy $49
Greyhound US 12h 5m 2:30 AM St. Louis, MO Gateway Station 2:35 PM Chicago Downtown Bus Station  Economy $49

Frequency of bus connections between St. Louis, MO and Chicago

See here how frequent the connections between St. Louis, MO and Chicago are, during different times and days of the week.
Sunday is the busiest day, with more than 16 daily buses from St. Louis, MO to Chicago. Sunday has instead the fewest connections, with only 16 daily coaches between St. Louis, MO and Chicago.
The busiest time of the day is the Morning, with 20 buses from St. Louis, MO to Chicago, while Morning sees the fewest connections between St. Louis, MO and Chicago, with 20 offers.

Facts about the bus from St. Louis, MO to Chicago

Compare all providers like FlixBus and Greyhound US that travel 16 times every day by bus from St. Louis, MO to Chicago in one click! Book your bus ticket from St. Louis, MO to Chicago starting from $26!

Cheapest Bus $26
Fastest Bus 5h 50m
Earliest Bus 2:30 AM
Latest Bus 11:30 PM
Daily Bus Routes 16 Ø
Distance 262.3 miles
Bus Companies FlixBus and Greyhound US

Cheapest bus connections from St. Louis, MO to Chicago

Every day, 16 buses from 2 bus companies leave St. Louis, MO for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/16/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 07/13
Monday 07/14
Tuesday 07/15
Wednesday 07/16
$41
Thursday 07/17
Friday 07/18
$47
Saturday 07/19
$37
Sunday 07/20
$40
Monday 07/21
$26
Tuesday 07/22
Wednesday 07/23
Thursday 07/24
$44
Friday 07/25
$39
Saturday 07/26
$38
Sunday 07/27
Monday 07/28
Tuesday 07/29
$30
Wednesday 07/30
$42
Thursday 07/31
$40
Friday 08/01
$41
Saturday 08/02
$46
Sunday 08/03
$26
Monday 08/04
$40
Tuesday 08/05
$39
Wednesday 08/06
$26
Thursday 08/07
$42
Friday 08/08
Saturday 08/09

The cheapest time to travel from St. Louis, MO to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from St. Louis, MO to Chicago, for the next 30 days.
With a price starting from $26, Monday is the cheapest day for a bus from St. Louis, MO to Chicago. Wednesday instead is the most expensive day with prices starting from $41.
Afternoon is the cheapest day time for bus tickets from St. Louis, MO to Chicago, with $26. Night is the most expensive time of the day with prices starting from $49.

How to save money travelling from St. Louis, MO to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from St. Louis, MO to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from St. Louis, MO to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from St. Louis, MO to Chicago are also emptier.

Beloved bus companies from St. Louis, MO to Chicago

These are the most booked bus companies between St. Louis, MO to Chicago from our users.

Greyhound US from St. Louis, MO to Chicago

Greyhound US

Here you will find the key facts about the Greyhound US bus route St. Louis, MO to Chicago:

Cheapest Price $49
Fastest Bus 11h 45m
Earliest Bus 2:30 AM
Last Bus 2:30 AM
Daily Connections 4 Ø
Found on 7/16/2025

FlixBus from St. Louis, MO to Chicago

FlixBus

Here you will find the key facts about the FlixBus bus route St. Louis, MO to Chicago:

Cheapest Price $26
Fastest Bus 5h 50m
Earliest Bus 9:45 AM
Last Bus 11:30 PM
Daily Connections 12 Ø
Found on 7/16/2025

All bus stations and stops in St. Louis, MO and Chicago

In the map below, you can see where to find all bus stations in St. Louis, MO and Chicago.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from St. Louis, MO to Chicago? Compare all modes of transports from St. Louis, MO to Chicago.

Service and Comfort on the bus from St. Louis, MO to Chicago

Want to know which seat classes are available on the buses from St. Louis, MO to Chicago? Or which bus companies serve the route St. Louis, MO to Chicago? Below you will find answers to your questions.

FAQs about the St. Louis, MO to Chicago bus

How much does a St. Louis, MO Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $26 and takes 6h 15m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from St. Louis, MO to Chicago?

This route is offered by 2 companies with a range of ticket prices between $26 and $100. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from St. Louis, MO to Chicago each day?

Every day, the St. Louis, MO to Chicago bus route is served by approximately 16 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from St. Louis, MO to Chicago take?

The fastest bus from St. Louis, MO to Chicago is offered by FlixBus and takes 5h 50m. Bus tickets for this connection cost $44. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from St. Louis, MO to Chicago?

The earliest bus arriving in Chicago from St. Louis, MO starts at 2:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from St. Louis, MO to Chicago?

The latest bus trip departing from St. Louis, MO for Chicago starts at 11:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the St. Louis, MO Chicago route?

When traveling by bus from St. Louis, MO to Chicago, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between St. Louis, MO and Chicago?

You can check all the direct connections between St. Louis, MO and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the St. Louis, MO to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the St. Louis, MO Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the St. Louis, MO Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from St. Louis, MO to Chicago on your planned travel date.

Available seat classes which are offered on the bus route St. Louis, MO to Chicago

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to St. Louis, MO and to Chicago

Here’s an overview of the most popular bus routes to St. Louis, MO and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus Houston to St. Louis, MO Bus Houston to St. Louis, MO
From Columbia, MO to St. Louis, MO bus From Columbia, MO to St. Louis, MO bus
Buses from Phoenix, AZ to St. Louis, MO Buses from Phoenix, AZ to St. Louis, MO
Bus Oklahoma City, OK - St. Louis, MO Bus Oklahoma City, OK - St. Louis, MO
From New York to Chicago bus From New York to Chicago bus
Bus to Chicago from Madison, WI Bus to Chicago from Madison, WI
Buses from Milwaukee to Chicago Buses from Milwaukee to Chicago
Bus Detroit to Chicago Bus Detroit to Chicago
Popular Airport Shuttles to St. Louis, MO and to Chicago
CheckMyBus › Buses in USA › Bus to St. Louis, MO › Bus to Chicago

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.