Bus Philadelphia to Greenville, SC: Compare prices and save money

Compare all timetables for the bus from Philadelphia to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Philadelphia to Greenville, SC from various bus operators like FlixBus or Greyhound US for the next days.

today

$116

tomorrow

Friday

$110

Saturday

$112

Sunday

Monday

$113

Tuesday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	17h 0m	5:50 PM	Philadelphia	Convention Center	10:50 AM	Greenville, SC	Woodruff Rd	Economy	$116	A Bus from Greyhound US goes from Convention Center, Philadelphia (USA) at 12/24/2025 5:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 10:50:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 17h 0m
FlixBus	21h 10m	10:30 PM	Philadelphia	Spring Garden St Station	7:40 PM	Greenville, SC	Woodruff Rd	Economy	$135	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/24/2025 10:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 7:40:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 21h 10m
FlixBus	15h 15m	10:00 PM	Philadelphia	Spring Garden St Station	1:15 PM	Greenville, SC	Woodruff Rd	Economy	$138	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/24/2025 10:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 1:15:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 15h 15m
FlixBus	22h 0m	3:15 PM	Philadelphia	Schuylkill Ave and Walnut Street	1:15 PM	Greenville, SC	Woodruff Rd	Economy	$140	A Bus from FlixBus goes from Schuylkill Ave and Walnut Street, Philadelphia (USA) at 12/24/2025 3:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 1:15:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 22h 0m
Greyhound US	17h 5m	3:30 PM	Philadelphia	Convention Center	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$141	A Bus from Greyhound US goes from Convention Center, Philadelphia (USA) at 12/24/2025 3:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 8:35:00 AM. 50 Economy ticket for $141 per person are available. Travel duration is 17h 5m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	17h 0m	5:50 PM	Philadelphia	Spring Garden St Station	10:50 AM	Greenville, SC	Woodruff Rd	Economy	$110	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/26/2025 5:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/27/2025 10:50:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 17h 0m
Greyhound US	17h 40m	2:00 AM	Philadelphia	IRS Building	7:40 PM	Greenville, SC	Woodruff Rd	Economy	$131	A Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/26/2025 2:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/26/2025 7:40:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 17h 40m
Greyhound US	16h 45m	8:30 PM	Philadelphia	Spring Garden St Station	1:15 PM	Greenville, SC	Woodruff Rd	Economy	$132	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/26/2025 8:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/27/2025 1:15:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 16h 45m
FlixBus	14h 40m	5:00 AM	Philadelphia	Spring Garden St Station	7:40 PM	Greenville, SC	Woodruff Rd	Economy	$132	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/26/2025 5:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/26/2025 7:40:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 14h 40m
FlixBus	22h 0m	3:15 PM	Philadelphia	IRS Building	1:15 PM	Greenville, SC	Woodruff Rd	Economy	$134	A Bus from FlixBus goes from IRS Building, Philadelphia (USA) at 12/26/2025 3:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/27/2025 1:15:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 22h 0m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	17h 0m	5:50 PM	Philadelphia	Convention Center	10:50 AM	Greenville, SC	Woodruff Rd	Economy	$112	A Bus from Greyhound US goes from Convention Center, Philadelphia (USA) at 12/27/2025 5:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/28/2025 10:50:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 17h 0m
Greyhound US	17h 5m	3:30 PM	Philadelphia	Spring Garden St Station	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$137	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/27/2025 3:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/28/2025 8:35:00 AM. 50 Economy ticket for $137 per person are available. Travel duration is 17h 5m
FlixBus	20h 20m	12:15 PM	Philadelphia	IRS Building	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$138	A Bus from FlixBus goes from IRS Building, Philadelphia (USA) at 12/27/2025 12:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/28/2025 8:35:00 AM. 50 Economy ticket for $138 per person are available. Travel duration is 20h 20m
FlixBus	14h 5m	6:30 PM	Philadelphia	Spring Garden St Station	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$138	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/27/2025 6:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/28/2025 8:35:00 AM. 50 Economy ticket for $138 per person are available. Travel duration is 14h 5m
FlixBus	18h 35m	2:00 PM	Philadelphia	JFK & Broad	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$139	A Bus from FlixBus goes from JFK & Broad, Philadelphia (USA) at 12/27/2025 2:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/28/2025 8:35:00 AM. 50 Economy ticket for $139 per person are available. Travel duration is 18h 35m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	17h 0m	5:50 PM	Philadelphia	Spring Garden St Station	10:50 AM	Greenville, SC	Woodruff Rd	Economy	$113	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/29/2025 5:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/30/2025 10:50:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 17h 0m
Greyhound US	17h 40m	2:00 AM	Philadelphia	IRS Building	7:40 PM	Greenville, SC	Woodruff Rd	Economy	$123	A Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/29/2025 2:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/29/2025 7:40:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 17h 40m
FlixBus	16h 20m	6:30 PM	Philadelphia	Spring Garden St Station	10:50 AM	Greenville, SC	Woodruff Rd	Economy	$123	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/29/2025 6:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/30/2025 10:50:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 16h 20m
FlixBus	22h 35m	12:15 PM	Philadelphia	IRS Building	10:50 AM	Greenville, SC	Woodruff Rd	Economy	$127	A Bus from FlixBus goes from IRS Building, Philadelphia (USA) at 12/29/2025 12:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/30/2025 10:50:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 22h 35m
Greyhound US	16h 45m	8:30 PM	Philadelphia	Spring Garden St Station	1:15 PM	Greenville, SC	Woodruff Rd	Economy	$131	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/29/2025 8:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/30/2025 1:15:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 16h 45m

Best Price Offer: The price for the cheapest bus from Philadelphia to Greenville, SC is $65 on 1/11/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Philadelphia and Greenville, SC

See here how frequent the connections between Philadelphia and Greenville, SC are, during different times and days of the week.

Saturday is the busiest day, with more than 26 daily buses from Philadelphia to Greenville, SC. Monday has instead the fewest connections, with only 12 daily coaches between Philadelphia and Greenville, SC.

The busiest time of the day is the Evening, with 34 buses from Philadelphia to Greenville, SC, while Morning sees the fewest connections between Philadelphia and Greenville, SC, with 2 offers.

Facts about the bus from Philadelphia to Greenville, SC

Compare all providers like FlixBus and Greyhound US that travel 18 times every day by bus from Philadelphia to Greenville, SC in one click! Book your bus ticket from Philadelphia to Greenville, SC starting from $65!

Cheapest Bus	$65
Fastest Bus	14h 5m
Earliest Bus	2:00 AM
Latest Bus	10:30 PM
Daily Bus Routes	18 Ø
Distance	530.0 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Philadelphia to Greenville, SC

Every day, 18 buses from 2 bus companies leave Philadelphia for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/24/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

$116

Thursday 12/25

Friday 12/26

$110

Saturday 12/27

$112

Sunday 12/28

Monday 12/29

$113

Tuesday 12/30

Wednesday 12/31

$104

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

$98

Monday 01/05

$65

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

Sunday 01/11

$65

Monday 01/12

Tuesday 01/13

Wednesday 01/14

Thursday 01/15

Friday 01/16

Saturday 01/17

The cheapest time to travel from Philadelphia to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Philadelphia to Greenville, SC, for the next 30 days.

With a price starting from $65, Monday is the cheapest day for a bus from Philadelphia to Greenville, SC. Friday instead is the most expensive day with prices starting from $110.

Night is the cheapest day time for bus tickets from Philadelphia to Greenville, SC, with $65. Morning is the most expensive time of the day with prices starting from $148.

How to save money travelling from Philadelphia to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Philadelphia to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Philadelphia to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Philadelphia to Greenville, SC are also emptier.

All bus stations and stops in Philadelphia and Greenville, SC

In the map below, you can see where to find all bus stations in Philadelphia and Greenville, SC.

Central Bus Station

Filbert St 1001

Market St

Spring Garden St Station

Spring Garden St & 2nd St

JFK & Broad

John F Kennedy Blvd 1401

Philadelphia, PA

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

Service and Comfort on the bus from Philadelphia to Greenville, SC

Want to know which seat classes are available on the buses from Philadelphia to Greenville, SC? Or which bus companies serve the route Philadelphia to Greenville, SC? Below you will find answers to your questions.

FAQs about the Philadelphia to Greenville, SC bus

How much does a Philadelphia Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $65 and takes 17h 0m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Philadelphia to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $65 and $239. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Philadelphia to Greenville, SC each day?

Every day, the Philadelphia to Greenville, SC bus route is served by approximately 18 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Philadelphia to Greenville, SC take?

The fastest bus from Philadelphia to Greenville, SC is offered by FlixBus and takes 14h 5m. Bus tickets for this connection cost $173. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Philadelphia to Greenville, SC?

The earliest bus arriving in Greenville, SC from Philadelphia starts at 2:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Philadelphia to Greenville, SC?

The latest bus trip departing from Philadelphia for Greenville, SC starts at 10:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Philadelphia Greenville, SC route?

When traveling by bus from Philadelphia to Greenville, SC, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Philadelphia and Greenville, SC?

You can check all the direct connections between Philadelphia and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Philadelphia to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Philadelphia Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Philadelphia Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Philadelphia to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Philadelphia to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 18 daily trips between Philadelphia and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Philadelphia to Greenville, SC?

Prices and availability for 18 trips between Philadelphia and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Philadelphia to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Philadelphia and to Greenville, SC

Here’s an overview of the most popular bus routes to Philadelphia and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!