Bus Indianapolis to Greenville, SC: Compare prices and save money

Compare all timetables for the bus from Indianapolis to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Indianapolis to Greenville, SC from various bus operators like FlixBus or Greyhound US for the next days.

today

$140

tomorrow

Friday

Saturday

Sunday

Monday

Tuesday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	16h 15m	6:25 PM	Indianapolis	Downtown Transit Center	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$140	A Bus from FlixBus goes from Downtown Transit Center, Indianapolis (USA) at 12/17/2025 6:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/18/2025 10:40:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 16h 15m
Greyhound US	15h 50m	8:10 PM	Indianapolis	Central Bus Station	12:00 PM	Greenville, SC	Woodruff Rd	Economy	$143	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/17/2025 8:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/18/2025 12:00:00 PM. 50 Economy ticket for $143 per person are available. Travel duration is 15h 50m
FlixBus	16h 40m	11:30 PM	Indianapolis	Downtown Transit Center	4:10 PM	Greenville, SC	Woodruff Rd	Economy	$143	A Bus from FlixBus goes from Downtown Transit Center, Indianapolis (USA) at 12/17/2025 11:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/18/2025 4:10:00 PM. 50 Economy ticket for $143 per person are available. Travel duration is 16h 40m
Greyhound US	15h 15m	3:50 PM	Indianapolis	Central Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$169	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/17/2025 3:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/18/2025 7:05:00 AM. 50 Economy ticket for $169 per person are available. Travel duration is 15h 15m

Best Price Offer: The price for the cheapest bus from Indianapolis to Greenville, SC is $140 on 12/17/2025. Flexible travelers save on ticket prices.

Facts about the bus from Indianapolis to Greenville, SC

Compare all providers like FlixBus and Greyhound US that travel 8 times every day by bus from Indianapolis to Greenville, SC in one click! Book your bus ticket from Indianapolis to Greenville, SC starting from $140!

Cheapest Bus	$140
Fastest Bus	15h 15m
Earliest Bus	3:50 PM
Latest Bus	11:30 PM
Daily Bus Routes	8 Ø
Distance	397.5 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Indianapolis to Greenville, SC

Every day, 8 buses from 2 bus companies leave Indianapolis for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/17/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

$140

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

How to save money travelling from Indianapolis to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Indianapolis to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Indianapolis to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Indianapolis to Greenville, SC are also emptier.

All bus stations and stops in Indianapolis and Greenville, SC

In the map below, you can see where to find all bus stations in Indianapolis and Greenville, SC.

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

McDonald's

Woodruff Rd 1111

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

Woodruff Rd

Woodruff Rd 1116

Service and Comfort on the bus from Indianapolis to Greenville, SC

Want to know which seat classes are available on the buses from Indianapolis to Greenville, SC? Or which bus companies serve the route Indianapolis to Greenville, SC? Below you will find answers to your questions.

FAQs about the Indianapolis to Greenville, SC bus

How much does a Indianapolis Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $140 and takes 16h 15m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Indianapolis to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $140 and $173. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Indianapolis to Greenville, SC each day?

Every day, the Indianapolis to Greenville, SC bus route is served by approximately 8 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Indianapolis to Greenville, SC take?

The fastest bus from Indianapolis to Greenville, SC is offered by Greyhound US and takes 15h 15m. Bus tickets for this connection cost $173. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Indianapolis to Greenville, SC?

The earliest bus arriving in Greenville, SC from Indianapolis starts at 3:50 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Indianapolis to Greenville, SC?

The latest bus trip departing from Indianapolis for Greenville, SC starts at 11:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Indianapolis Greenville, SC route?

When traveling by bus from Indianapolis to Greenville, SC, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Indianapolis and Greenville, SC?

You can check all the direct connections between Indianapolis and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Indianapolis to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Indianapolis Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Indianapolis Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Indianapolis to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Indianapolis to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 8 daily trips between Indianapolis and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Indianapolis to Greenville, SC?

Prices and availability for 8 trips between Indianapolis and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Indianapolis to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Indianapolis and to Greenville, SC

Here’s an overview of the most popular bus routes to Indianapolis and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!