Bus from Indianapolis to Greenville, SC from $77

Compare all the bus companies and find the best price with CheckMyBus
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Indianapolis to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Indianapolis to Greenville, SC from various bus operators like Greyhound US or FlixBus for the next days.

today
$104
tomorrow
Tuesday
$130
Wednesday
$127
Thursday
$77
Friday
Saturday
$81

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 17h 25m 4:30 AM Indianapolis Central Bus Station 9:55 PM Greenville, SC Woodruff Rd  Economy $104
Greyhound US 15h 15m 3:50 PM Indianapolis Central Bus Station 7:05 AM Greenville, SC Woodruff Rd  Economy $104
Greyhound US 18h 40m 7:55 PM Indianapolis Central Bus Station 2:35 PM Greenville, SC Woodruff Rd  Economy $104
FlixBus 16h 40m 11:30 PM Indianapolis Washington / Delaware 4:10 PM Greenville, SC Woodruff Rd  Economy $104
FlixBus 16h 15m 6:25 PM Indianapolis Washington / Delaware 10:40 AM Greenville, SC Woodruff Rd  Economy $114

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 15h 15m 3:50 PM Indianapolis Central Bus Station 7:05 AM Greenville, SC Woodruff Rd  Economy $130
Greyhound US 18h 40m 7:55 PM Indianapolis Central Bus Station 2:35 PM Greenville, SC Woodruff Rd  Economy $130
Greyhound US 25h 45m 8:10 PM Indianapolis Central Bus Station 9:55 PM Greenville, SC Woodruff Rd  Economy $130
FlixBus 16h 15m 6:25 PM Indianapolis Washington / Delaware 10:40 AM Greenville, SC Woodruff Rd  Economy $131
  • Did you know that if you travel from Indianapolis to Greenville, SC via Nashville, you can save more than $31? You can find the corresponding connections below.
    • FlixBus
      19h 40m
      0
      11:25 AM
      Indianapolis
      Central Bus Station
      4:30 PM
      Nashville
      5th Ave South Station
      0
      FlixBus
      Economy
      $43
      • Waiting Time 5h 15m
    • Busbud
      8h 20m
      0
      9:45 PM
      Nashville
      5th Ave South Station
      7:05 AM
      Greenville, SC
      Woodruff Rd
      0
      Busbud
      Economy
      $56
    Travel time is 4h 25m longer, but you will save $31

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 17h 25m 4:30 AM Indianapolis Central Bus Station 9:55 PM Greenville, SC Woodruff Rd  Economy $127
Greyhound US 15h 15m 3:50 PM Indianapolis Central Bus Station 7:05 AM Greenville, SC Woodruff Rd  Economy $127
Greyhound US 15h 50m 8:10 PM Indianapolis Central Bus Station 12:00 PM Greenville, SC Woodruff Rd  Economy $127
FlixBus 16h 15m 6:25 PM Indianapolis Washington / Delaware 10:40 AM Greenville, SC Woodruff Rd  Economy $127
  • Did you know that if you travel from Indianapolis to Greenville, SC via Nashville, you can save more than $28? You can find the corresponding connections below.
    • FlixBus
      19h 40m
      0
      11:25 AM
      Indianapolis
      Central Bus Station
      4:30 PM
      Nashville
      5th Ave South Station
      0
      FlixBus
      Economy
      $43
      • Waiting Time 5h 15m
    • Busbud
      8h 20m
      0
      9:45 PM
      Nashville
      5th Ave South Station
      7:05 AM
      Greenville, SC
      Woodruff Rd
      0
      Busbud
      Economy
      $56
    Travel time is 4h 25m longer, but you will save $28

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 15h 50m 8:10 PM Indianapolis Central Bus Station 12:00 PM Greenville, SC Woodruff Rd  Economy $77
FlixBus 16h 15m 6:25 PM Indianapolis Washington / Delaware 10:40 AM Greenville, SC Woodruff Rd  Economy $77
FlixBus 16h 40m 11:30 PM Indianapolis Washington / Delaware 4:10 PM Greenville, SC Woodruff Rd  Economy $77
Greyhound US 17h 25m 4:30 AM Indianapolis Central Bus Station 9:55 PM Greenville, SC Woodruff Rd  Economy $87
Greyhound US 15h 15m 3:50 PM Indianapolis Central Bus Station 7:05 AM Greenville, SC Woodruff Rd  Economy $87

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 16h 15m 6:25 PM Indianapolis Washington / Delaware 10:40 AM Greenville, SC Woodruff Rd  Economy $81
Greyhound US 17h 25m 4:30 AM Indianapolis Central Bus Station 9:55 PM Greenville, SC Woodruff Rd  Economy $82
Greyhound US 15h 15m 3:50 PM Indianapolis Central Bus Station 7:05 AM Greenville, SC Woodruff Rd  Economy $82
Greyhound US 15h 50m 8:10 PM Indianapolis Central Bus Station 12:00 PM Greenville, SC Woodruff Rd  Economy $82
FlixBus 16h 40m 11:30 PM Indianapolis Washington / Delaware 4:10 PM Greenville, SC Woodruff Rd  Economy $82

Best Price Offer: The price for the cheapest bus from Indianapolis to Greenville, SC is $77 on 2/5/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Indianapolis and Greenville, SC

See here how frequent the connections between Indianapolis and Greenville, SC are, during different times and days of the week.
Saturday is the busiest day, with more than 10 daily buses from Indianapolis to Greenville, SC. Tuesday has instead the fewest connections, with only 5 daily coaches between Indianapolis and Greenville, SC.
The busiest time of the day is the Evening, with 20 buses from Indianapolis to Greenville, SC, while Afternoon sees the fewest connections between Indianapolis and Greenville, SC, with 7 offers.

Facts about the bus from Indianapolis to Greenville, SC

Compare all providers like Greyhound US and FlixBus that travel 6 times every day by bus from Indianapolis to Greenville, SC in one click! Book your bus ticket from Indianapolis to Greenville, SC starting from $77!

Cheapest Bus $77
Fastest Bus 15h 15m
Earliest Bus 4:30 AM
Latest Bus 11:30 PM
Daily Bus Routes 6 Ø
Distance 397.5 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from Indianapolis to Greenville, SC

Every day, 6 buses from 2 bus companies leave Indianapolis for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/01/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 02/01
$104
Monday 02/02
Tuesday 02/03
$130
Wednesday 02/04
$128
Thursday 02/05
$77
Friday 02/06
Saturday 02/07
$81
Sunday 02/08
Monday 02/09
Tuesday 02/10
$119
Wednesday 02/11
$80
Thursday 02/12
Friday 02/13
Saturday 02/14
Sunday 02/15
Monday 02/16
Tuesday 02/17
Wednesday 02/18
Thursday 02/19
Friday 02/20
Saturday 02/21
Sunday 02/22
Monday 02/23
Tuesday 02/24
Wednesday 02/25
Thursday 02/26
Friday 02/27
Saturday 02/28

The cheapest time to travel from Indianapolis to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Indianapolis to Greenville, SC, for the next 30 days.
With a price starting from $77, Thursday is the cheapest day for a bus from Indianapolis to Greenville, SC. Tuesday instead is the most expensive day with prices starting from $119.
Evening is the cheapest day time for bus tickets from Indianapolis to Greenville, SC, with $77. Afternoon is the most expensive time of the day with prices starting from $82.

How to save money travelling from Indianapolis to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Indianapolis to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Indianapolis to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Indianapolis to Greenville, SC are also emptier.

Beloved bus companies from Indianapolis to Greenville, SC

These are the most booked bus companies between Indianapolis to Greenville, SC from our users.

Greyhound US from Indianapolis to Greenville, SC

Greyhound US

Here you will find the key facts about the Greyhound US bus route Indianapolis to Greenville, SC:

Cheapest Price $77
Fastest Bus 15h 15m
Earliest Bus 4:30 AM
Last Bus 8:10 PM
Daily Connections 4 Ø
Found on 1/27/2026

FlixBus from Indianapolis to Greenville, SC

FlixBus

Here you will find the key facts about the FlixBus bus route Indianapolis to Greenville, SC:

Cheapest Price $77
Fastest Bus 16h 15m
Earliest Bus 6:25 PM
Last Bus 11:30 PM
Daily Connections 2 Ø
Found on 1/27/2026

All bus stations and stops in Indianapolis and Greenville, SC

In the map below, you can see where to find all bus stations in Indianapolis and Greenville, SC.

Service and Comfort on the bus from Indianapolis to Greenville, SC

Want to know which seat classes are available on the buses from Indianapolis to Greenville, SC? Or which bus companies serve the route Indianapolis to Greenville, SC? Below you will find answers to your questions.

FAQs about the Indianapolis to Greenville, SC bus

How much does a Indianapolis Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $77 and takes 15h 50m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Indianapolis to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $77 and $131. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Indianapolis to Greenville, SC each day?

Every day, the Indianapolis to Greenville, SC bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Indianapolis to Greenville, SC take?

The fastest bus from Indianapolis to Greenville, SC is offered by Greyhound US and takes 15h 15m. Bus tickets for this connection cost $104. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Indianapolis to Greenville, SC?

The earliest bus arriving in Greenville, SC from Indianapolis starts at 4:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Indianapolis to Greenville, SC?

The latest bus trip departing from Indianapolis for Greenville, SC starts at 11:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Indianapolis Greenville, SC route?

When traveling by bus from Indianapolis to Greenville, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Indianapolis and Greenville, SC?

You can check all the direct connections between Indianapolis and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Indianapolis to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Indianapolis Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Indianapolis Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Indianapolis to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Indianapolis to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between Indianapolis and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Indianapolis to Greenville, SC?

Prices and availability for 6 trips between Indianapolis and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Indianapolis to Greenville, SC

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Indianapolis and to Greenville, SC

Here’s an overview of the most popular bus routes to Indianapolis and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
From Gastonia, NC to Indianapolis bus From Gastonia, NC to Indianapolis bus
Buses to Indianapolis from Merced, CA Buses to Indianapolis from Merced, CA
From Palm Coast, FL to Indianapolis bus From Palm Coast, FL to Indianapolis bus
From Birmingham, AL to Indianapolis bus From Birmingham, AL to Indianapolis bus
From Pittsburgh to Greenville, SC bus From Pittsburgh to Greenville, SC bus
From Sacramento to Greenville, SC bus From Sacramento to Greenville, SC bus
From Tucson, AZ to Greenville, SC bus From Tucson, AZ to Greenville, SC bus
Bus Birmingham, AL - Greenville, SC Bus Birmingham, AL - Greenville, SC
Popular Airport Shuttles to Indianapolis and to Greenville, SC
CheckMyBus › Buses in USA › Bus to Indianapolis › Bus to Greenville, SC

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.