Bus from Indianapolis to Greenville, SC from $82

Compare all the bus companies and find the best price with CheckMyBus
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Indianapolis to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Indianapolis to Greenville, SC from various bus operators like Greyhound US or FlixBus for the next days.

today
tomorrow
Saturday
Sunday
Monday
Tuesday
$102
Wednesday

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 17h 15m 4:40 AM Indianapolis Central Bus Station 9:55 PM Greenville, SC Woodruff Rd  Economy $102
Greyhound US 15h 10m 3:50 PM Indianapolis Central Bus Station 7:00 AM Greenville, SC Woodruff Rd  Economy $102
Greyhound US 20h 0m 8:10 PM Indianapolis Central Bus Station 4:10 PM Greenville, SC Woodruff Rd  Economy $102
FlixBus 16h 15m 6:25 PM Indianapolis Downtown Transit Center 10:40 AM Greenville, SC Woodruff Rd  Economy $102
FlixBus 16h 40m 11:30 PM Indianapolis Downtown Transit Center 4:10 PM Greenville, SC Woodruff Rd  Economy $102
  • Did you know that if you travel from Indianapolis to Greenville, SC via Nashville, you can save more than $15? You can find the corresponding connections below.
    • Greyhound US
      15h 50m
      0
      8:10 PM
      Indianapolis
      Central Bus Station
      1:25 AM
      Nashville
      5th Ave South Station
      0
      Greyhound US
      Economy
      $31
      • Waiting Time 1h 25m
    • Greyhound US
      8h 10m
      0
      2:50 AM
      Nashville
      5th Ave South Station
      12:00 PM
      Greenville, SC
      Woodruff Rd
      0
      Greyhound US
      Economy
      $56
    Travel time is 0h 40m longer, but you will save $15

Best Price Offer: The price for the cheapest bus from Indianapolis to Greenville, SC is $82 on 4/9/2026. Flexible travelers save on ticket prices.


Facts about the bus from Indianapolis to Greenville, SC

Compare all providers like Greyhound US and FlixBus that travel 6 times every day by bus from Indianapolis to Greenville, SC in one click! Book your bus ticket from Indianapolis to Greenville, SC starting from $82!

Cheapest Bus $82
Fastest Bus 15h 10m
Earliest Bus 4:40 AM
Latest Bus 11:30 PM
Daily Bus Routes 6 Ø
Distance 397.5 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from Indianapolis to Greenville, SC

Every day, 6 buses from 2 bus companies leave Indianapolis for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/19/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 03/15
Monday 03/16
Tuesday 03/17
Wednesday 03/18
Thursday 03/19
Friday 03/20
Saturday 03/21
Sunday 03/22
Monday 03/23
Tuesday 03/24
$102
Wednesday 03/25
Thursday 03/26
Friday 03/27
Saturday 03/28
Sunday 03/29
$97
Monday 03/30
Tuesday 03/31
$105
Wednesday 04/01
Thursday 04/02
$85
Friday 04/03
Saturday 04/04
$106
Sunday 04/05
$101
Monday 04/06
$92
Tuesday 04/07
$92
Wednesday 04/08
$93
Thursday 04/09
$82
Friday 04/10
$86
Saturday 04/11

How to save money travelling from Indianapolis to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Indianapolis to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Indianapolis to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Indianapolis to Greenville, SC are also emptier.

Beloved bus companies from Indianapolis to Greenville, SC

These are the most booked bus companies between Indianapolis to Greenville, SC from our users.

Greyhound US from Indianapolis to Greenville, SC

Greyhound US

Here you will find the key facts about the Greyhound US bus route Indianapolis to Greenville, SC:

Cheapest Price $102
Fastest Bus 15h 10m
Earliest Bus 4:40 AM
Last Bus 8:10 PM
Daily Connections 4 Ø
Found on 2/21/2026

FlixBus from Indianapolis to Greenville, SC

FlixBus

Here you will find the key facts about the FlixBus bus route Indianapolis to Greenville, SC:

Cheapest Price $102
Fastest Bus 16h 15m
Earliest Bus 6:25 PM
Last Bus 11:30 PM
Daily Connections 2 Ø
Found on 2/21/2026

All bus stations and stops in Indianapolis and Greenville, SC

In the map below, you can see where to find all bus stations in Indianapolis and Greenville, SC.

Service and Comfort on the bus from Indianapolis to Greenville, SC

Want to know which seat classes are available on the buses from Indianapolis to Greenville, SC? Or which bus companies serve the route Indianapolis to Greenville, SC? Below you will find answers to your questions.

FAQs about the Indianapolis to Greenville, SC bus

How much does a Indianapolis Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $82 and takes 17h 15m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Indianapolis to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $82 and $103. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Indianapolis to Greenville, SC each day?

Every day, the Indianapolis to Greenville, SC bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Indianapolis to Greenville, SC take?

The fastest bus from Indianapolis to Greenville, SC is offered by Greyhound US and takes 15h 10m. Bus tickets for this connection cost $102. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Indianapolis to Greenville, SC?

The earliest bus arriving in Greenville, SC from Indianapolis starts at 4:40 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Indianapolis to Greenville, SC?

The latest bus trip departing from Indianapolis for Greenville, SC starts at 11:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Indianapolis Greenville, SC route?

When traveling by bus from Indianapolis to Greenville, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Indianapolis and Greenville, SC?

You can check all the direct connections between Indianapolis and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Indianapolis to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Indianapolis Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Indianapolis Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Indianapolis to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Indianapolis to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between Indianapolis and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Indianapolis to Greenville, SC?

Prices and availability for 6 trips between Indianapolis and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Indianapolis to Greenville, SC

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Indianapolis and to Greenville, SC

Here’s an overview of the most popular bus routes to Indianapolis and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus Syracuse, NY to Indianapolis Bus Syracuse, NY to Indianapolis
Buses Rockford, IL - Indianapolis Buses Rockford, IL - Indianapolis
From Chattanooga, TN to Indianapolis bus From Chattanooga, TN to Indianapolis bus
New Orleans, LA to Indianapolis bus New Orleans, LA to Indianapolis bus
From Tucson, AZ to Greenville, SC bus From Tucson, AZ to Greenville, SC bus
Bus Guadalajara, JC to Greenville, SC Bus Guadalajara, JC to Greenville, SC
Bus from Cincinnati to Greenville, SC Bus from Cincinnati to Greenville, SC
Buses Norcross, GA to Greenville, SC Buses Norcross, GA to Greenville, SC
Popular Airport Shuttles to Indianapolis and to Greenville, SC
CheckMyBus › Buses in USA › Bus to Indianapolis › Bus to Greenville, SC

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.