Bus Orlando, FL to Greenville, SC: Compare prices and save money

Compare all timetables for the bus from Orlando, FL to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Orlando, FL to Greenville, SC from various bus operators like FlixBus or Greyhound US for the next days.

today

$100

tomorrow

$82

Sunday

Monday

$103

Tuesday

$81

Wednesday

$136

Thursday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	17h 5m	2:00 PM	Orlando, FL	Florida Mall	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$100	A Bus from FlixBus goes from Florida Mall, Orlando, FL (USA) at 12/19/2025 2:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/20/2025 7:05:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 17h 5m
FlixBus	11h 45m	10:55 PM	Orlando, FL	Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$109	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 12/19/2025 10:55:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/20/2025 10:40:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 11h 45m
Greyhound US	10h 25m	8:40 PM	Orlando, FL	Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$131	A Bus from Greyhound US goes from Bus Station, Orlando, FL (USA) at 12/19/2025 8:40:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/20/2025 7:05:00 AM. 50 Economy ticket for $131 per person are available. Travel duration is 10h 25m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	11h 55m	10:00 AM	Orlando, FL	Bus Station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$82	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 12/20/2025 10:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/20/2025 9:55:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 11h 55m
FlixBus	11h 45m	10:55 PM	Orlando, FL	Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$82	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 12/20/2025 10:55:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/21/2025 10:40:00 AM. 50 Economy ticket for $82 per person are available. Travel duration is 11h 45m
Greyhound US	10h 25m	8:40 PM	Orlando, FL	Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$82	A Bus from Greyhound US goes from Bus Station, Orlando, FL (USA) at 12/20/2025 8:40:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/21/2025 7:05:00 AM. 50 Economy ticket for $82 per person are available. Travel duration is 10h 25m
FlixBus	14h 55m	4:45 AM	Orlando, FL	Bus Station	7:40 PM	Greenville, SC	Woodruff Rd	Economy	$83	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 12/20/2025 4:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/20/2025 7:40:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 14h 55m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	11h 55m	10:00 AM	Orlando, FL	Bus Station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$103	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 12/22/2025 10:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/22/2025 9:55:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 11h 55m
FlixBus	11h 45m	10:55 PM	Orlando, FL	Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$106	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 12/22/2025 10:55:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/23/2025 10:40:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 11h 45m
FlixBus	14h 55m	4:45 AM	Orlando, FL	Bus Station	7:40 PM	Greenville, SC	Woodruff Rd	Economy	$110	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 12/22/2025 4:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/22/2025 7:40:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 14h 55m
Greyhound US	10h 25m	8:40 PM	Orlando, FL	Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$131	A Bus from Greyhound US goes from Bus Station, Orlando, FL (USA) at 12/22/2025 8:40:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/23/2025 7:05:00 AM. 50 Economy ticket for $131 per person are available. Travel duration is 10h 25m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	11h 55m	10:00 AM	Orlando, FL	Bus Station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$81	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 12/23/2025 10:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/23/2025 9:55:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 11h 55m
FlixBus	11h 45m	10:55 PM	Orlando, FL	Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$81	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 12/23/2025 10:55:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 10:40:00 AM. 50 Economy ticket for $81 per person are available. Travel duration is 11h 45m
FlixBus	14h 55m	4:45 AM	Orlando, FL	Bus Station	7:40 PM	Greenville, SC	Woodruff Rd	Economy	$82	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 12/23/2025 4:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/23/2025 7:40:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 14h 55m
Greyhound US	10h 25m	8:40 PM	Orlando, FL	Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$87	A Bus from Greyhound US goes from Bus Station, Orlando, FL (USA) at 12/23/2025 8:40:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 7:05:00 AM. 50 Economy ticket for $87 per person are available. Travel duration is 10h 25m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	17h 5m	2:00 PM	Orlando, FL	Florida Mall	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$136	A Bus from FlixBus goes from Florida Mall, Orlando, FL (USA) at 12/24/2025 2:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 7:05:00 AM. 50 Economy ticket for $136 per person are available. Travel duration is 17h 5m
FlixBus	14h 55m	4:45 AM	Orlando, FL	Bus Station	7:40 PM	Greenville, SC	Woodruff Rd	Economy	$137	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 12/24/2025 4:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 7:40:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 14h 55m
FlixBus	11h 55m	10:00 AM	Orlando, FL	Bus Station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$137	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 12/24/2025 10:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 9:55:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 11h 55m
Greyhound US	10h 25m	8:40 PM	Orlando, FL	Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$137	A Bus from Greyhound US goes from Bus Station, Orlando, FL (USA) at 12/24/2025 8:40:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 7:05:00 AM. 50 Economy ticket for $137 per person are available. Travel duration is 10h 25m

Best Price Offer: The price for the cheapest bus from Orlando, FL to Greenville, SC is $69 on 1/8/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Orlando, FL and Greenville, SC

See here how frequent the connections between Orlando, FL and Greenville, SC are, during different times and days of the week.

Monday is the busiest day, with more than 10 daily buses from Orlando, FL to Greenville, SC. Wednesday has instead the fewest connections, with only 5 daily coaches between Orlando, FL and Greenville, SC.

The busiest time of the day is the Evening, with 18 buses from Orlando, FL to Greenville, SC, while Morning sees the fewest connections between Orlando, FL and Greenville, SC, with 7 offers.

Facts about the bus from Orlando, FL to Greenville, SC

Compare all providers like FlixBus and Greyhound US that travel 8 times every day by bus from Orlando, FL to Greenville, SC in one click! Book your bus ticket from Orlando, FL to Greenville, SC starting from $69!

Cheapest Bus	$69
Fastest Bus	10h 25m
Earliest Bus	2:00 PM
Latest Bus	10:55 PM
Daily Bus Routes	8 Ø
Distance	440.3 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Orlando, FL to Greenville, SC

Every day, 8 buses from 2 bus companies leave Orlando, FL for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/19/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

$99

Saturday 12/20

$82

Sunday 12/21

Monday 12/22

$103

Tuesday 12/23

$146

Wednesday 12/24

$136

Thursday 12/25

Friday 12/26

$97

Saturday 12/27

Sunday 12/28

$95

Monday 12/29

Tuesday 12/30

$85

Wednesday 12/31

$89

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

$77

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

$69

Friday 01/09

Saturday 01/10

The cheapest time to travel from Orlando, FL to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Orlando, FL to Greenville, SC, for the next 30 days.

With a price starting from $65, Saturday is the cheapest day for a bus from Orlando, FL to Greenville, SC. Friday instead is the most expensive day with prices starting from $97.

Night is the cheapest day time for bus tickets from Orlando, FL to Greenville, SC, with $65. Afternoon is the most expensive time of the day with prices starting from $83.

How to save money travelling from Orlando, FL to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Orlando, FL to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Orlando, FL to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Orlando, FL to Greenville, SC are also emptier.

Beloved bus companies from Orlando, FL to Greenville, SC

These are the most booked bus companies between Orlando, FL to Greenville, SC from our users.

FlixBus from Orlando, FL to Greenville, SC

Here you will find the key facts about the FlixBus bus route Orlando, FL to Greenville, SC:

Cheapest Price	$81
Fastest Bus	11h 45m
Earliest Bus	2:00 PM
Last Bus	10:55 PM
Daily Connections	6 Ø
Found on	12/16/2025

All bus stations and stops in Orlando, FL and Greenville, SC

In the map below, you can see where to find all bus stations in Orlando, FL and Greenville, SC.

Bus Station

N John Young Pkwy 555

Florida Mall

Florida Mall Avenue 1602

RedCoach Station

Belle Isle

Universal Studio Orlando Resort

Universal Blvd 5800

Jet Set Express Orlando Terminal

L B McLeod Rd 3718

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Orlando, FL to Greenville, SC? Compare all modes of transports from Orlando, FL to Greenville, SC.

Service and Comfort on the bus from Orlando, FL to Greenville, SC

Want to know which seat classes are available on the buses from Orlando, FL to Greenville, SC? Or which bus companies serve the route Orlando, FL to Greenville, SC? Below you will find answers to your questions.

FAQs about the Orlando, FL to Greenville, SC bus

How much does a Orlando, FL Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $69 and takes 11h 55m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Orlando, FL to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $69 and $166. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Orlando, FL to Greenville, SC each day?

Every day, the Orlando, FL to Greenville, SC bus route is served by approximately 8 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Orlando, FL to Greenville, SC take?

The fastest bus from Orlando, FL to Greenville, SC is offered by Greyhound US and takes 10h 25m. Bus tickets for this connection cost $131. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Orlando, FL to Greenville, SC?

The earliest bus arriving in Greenville, SC from Orlando, FL starts at 2:00 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Orlando, FL to Greenville, SC?

The latest bus trip departing from Orlando, FL for Greenville, SC starts at 10:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Orlando, FL Greenville, SC route?

When traveling by bus from Orlando, FL to Greenville, SC, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Orlando, FL and Greenville, SC?

You can check all the direct connections between Orlando, FL and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Orlando, FL to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Orlando, FL Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Orlando, FL Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Orlando, FL to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Orlando, FL to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 8 daily trips between Orlando, FL and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Orlando, FL to Greenville, SC?

Prices and availability for 8 trips between Orlando, FL and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Orlando, FL to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Orlando, FL and to Greenville, SC

Here’s an overview of the most popular bus routes to Orlando, FL and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!