Bus Tampa to Greenville, SC: Compare prices and save money

Compare all timetables for the bus from Tampa to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Tampa to Greenville, SC from various bus operators like FlixBus for the next days.

today

$108

tomorrow

$85

Sunday

Monday

$99

Tuesday

Wednesday

$119

Thursday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	15h 35m	6:20 AM	Tampa	Marion Street	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$108	A Bus from FlixBus goes from Marion Street, Tampa (USA) at 12/5/2025 6:20:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/5/2025 9:55:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 15h 35m
FlixBus	14h 40m	8:00 PM	Tampa	Marion Street	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$108	A Bus from FlixBus goes from Marion Street, Tampa (USA) at 12/5/2025 8:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/6/2025 10:40:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 14h 40m
FlixBus	13h 40m	5:25 PM	Tampa	Marion Street	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$109	A Bus from FlixBus goes from Marion Street, Tampa (USA) at 12/5/2025 5:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/6/2025 7:05:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 13h 40m
FlixBus	21h 5m	10:35 PM	Tampa	Marion Street	7:40 PM	Greenville, SC	Woodruff Rd	Economy	$110	A Bus from FlixBus goes from Marion Street, Tampa (USA) at 12/5/2025 10:35:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/6/2025 7:40:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 21h 5m
FlixBus	13h 10m	5:55 PM	Tampa	USF	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$110	A Bus from FlixBus goes from USF, Tampa (USA) at 12/5/2025 5:55:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/6/2025 7:05:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 13h 10m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	13h 10m	5:55 PM	Tampa	USF	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$85	A Bus from FlixBus goes from USF, Tampa (USA) at 12/6/2025 5:55:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/7/2025 7:05:00 AM. 50 Economy ticket for $85 per person are available. Travel duration is 13h 10m
FlixBus	13h 40m	5:25 PM	Tampa	Marion Street	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$86	A Bus from FlixBus goes from Marion Street, Tampa (USA) at 12/6/2025 5:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/7/2025 7:05:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 13h 40m
FlixBus	21h 5m	10:35 PM	Tampa	Marion Street	7:40 PM	Greenville, SC	Woodruff Rd	Economy	$86	A Bus from FlixBus goes from Marion Street, Tampa (USA) at 12/6/2025 10:35:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/7/2025 7:40:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 21h 5m
FlixBus	21h 50m	9:50 PM	Tampa	USF	7:40 PM	Greenville, SC	Woodruff Rd	Economy	$86	A Bus from FlixBus goes from USF, Tampa (USA) at 12/6/2025 9:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/7/2025 7:40:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 21h 50m
FlixBus	15h 35m	6:20 AM	Tampa	Marion Street	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$87	A Bus from FlixBus goes from Marion Street, Tampa (USA) at 12/6/2025 6:20:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/6/2025 9:55:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 15h 35m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	15h 35m	6:20 AM	Tampa	Marion Street	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$99	A Bus from FlixBus goes from Marion Street, Tampa (USA) at 12/8/2025 6:20:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/8/2025 9:55:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 15h 35m
FlixBus	23h 20m	10:35 PM	Tampa	Marion Street	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$99	A Bus from FlixBus goes from Marion Street, Tampa (USA) at 12/8/2025 10:35:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/9/2025 9:55:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 23h 20m
FlixBus	24h 5m	9:50 PM	Tampa	USF	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$99	A Bus from FlixBus goes from USF, Tampa (USA) at 12/8/2025 9:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/9/2025 9:55:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 24h 5m
FlixBus	13h 40m	5:25 PM	Tampa	Marion Street	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$101	A Bus from FlixBus goes from Marion Street, Tampa (USA) at 12/8/2025 5:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/9/2025 7:05:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 13h 40m
FlixBus	13h 10m	5:55 PM	Tampa	USF	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$101	A Bus from FlixBus goes from USF, Tampa (USA) at 12/8/2025 5:55:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/9/2025 7:05:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 13h 10m

Did you know that if you travel from Tampa to Greenville, SC via Orlando, FL, you can save more than $14? You can find the corresponding connections below.
- Busbud
  
  15h 35m
  
  0
  
  6:20 AM
  
  Tampa
  Marion Street
  
  8:20 AM
  
  Orlando, FL
  Bus Station
  
  0
  
  Economy
  
  $10
  
  A Bus from Busbud goes from Marion Street, Tampa (USA) at 12/8/2025 6:20:00 AM to Bus Station, Orlando, FL (USA) arriving at 12/8/2025 8:20:00 AM. 50 Economy ticket for $10 per person are available. Travel duration is 2h 0m
- Busbud
  
  11h 55m
  
  0
  
  10:00 AM
  
  Orlando, FL
  Bus Station
  
  9:55 PM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $75
  
  A Bus from Busbud goes from Bus Station, Orlando, FL (USA) at 12/8/2025 10:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/8/2025 9:55:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 11h 55m
Travel time is 2h 25m longer, but you will save $14

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	15h 35m	6:20 AM	Tampa	Marion Street	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$119	A Bus from FlixBus goes from Marion Street, Tampa (USA) at 12/10/2025 6:20:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/10/2025 9:55:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 15h 35m
FlixBus	13h 40m	5:25 PM	Tampa	Marion Street	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$120	A Bus from FlixBus goes from Marion Street, Tampa (USA) at 12/10/2025 5:25:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/11/2025 7:05:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 13h 40m
FlixBus	23h 20m	10:35 PM	Tampa	Marion Street	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$121	A Bus from FlixBus goes from Marion Street, Tampa (USA) at 12/10/2025 10:35:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/11/2025 9:55:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 23h 20m
FlixBus	13h 10m	5:55 PM	Tampa	USF	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$121	A Bus from FlixBus goes from USF, Tampa (USA) at 12/10/2025 5:55:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/11/2025 7:05:00 AM. 50 Economy ticket for $121 per person are available. Travel duration is 13h 10m
FlixBus	24h 5m	9:50 PM	Tampa	USF	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$121	A Bus from FlixBus goes from USF, Tampa (USA) at 12/10/2025 9:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/11/2025 9:55:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 24h 5m

Did you know that if you travel from Tampa to Greenville, SC via Orlando, FL, you can save more than $34? You can find the corresponding connections below.
- Busbud
  
  15h 35m
  
  0
  
  6:20 AM
  
  Tampa
  Marion Street
  
  8:20 AM
  
  Orlando, FL
  Bus Station
  
  0
  
  Economy
  
  $10
  
  A Bus from Busbud goes from Marion Street, Tampa (USA) at 12/8/2025 6:20:00 AM to Bus Station, Orlando, FL (USA) arriving at 12/8/2025 8:20:00 AM. 50 Economy ticket for $10 per person are available. Travel duration is 2h 0m
- Busbud
  
  11h 55m
  
  0
  
  10:00 AM
  
  Orlando, FL
  Bus Station
  
  9:55 PM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $75
  
  A Bus from Busbud goes from Bus Station, Orlando, FL (USA) at 12/8/2025 10:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/8/2025 9:55:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 11h 55m
Travel time is 2h 25m longer, but you will save $34

Best Price Offer: The price for the cheapest bus from Tampa to Greenville, SC is $85 on 12/6/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Tampa and Greenville, SC

See here how frequent the connections between Tampa and Greenville, SC are, during different times and days of the week.

Friday is the busiest day, with more than 12 daily buses from Tampa to Greenville, SC. Wednesday has instead the fewest connections, with only 5 daily coaches between Tampa and Greenville, SC.

The busiest time of the day is the Evening, with 18 buses from Tampa to Greenville, SC, while Morning sees the fewest connections between Tampa and Greenville, SC, with 7 offers.

Facts about the bus from Tampa to Greenville, SC

Compare all providers like FlixBus that travel 9 times every day by bus from Tampa to Greenville, SC in one click! Book your bus ticket from Tampa to Greenville, SC starting from $85!

Cheapest Bus	$85
Fastest Bus	13h 10m
Earliest Bus	6:20 AM
Latest Bus	10:35 PM
Daily Bus Routes	9 Ø
Distance	476.7 miles
Bus Companies	FlixBus

Cheapest bus connections from Tampa to Greenville, SC

Every day, 9 buses from 1 bus companies leave Tampa for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

$108

Saturday 12/06

$85

Sunday 12/07

Monday 12/08

$99

Tuesday 12/09

Wednesday 12/10

$119

Thursday 12/11

Friday 12/12

Saturday 12/13

$114

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

$99

Friday 12/19

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

$119

Thursday 12/25

Friday 12/26

Saturday 12/27

The cheapest time to travel from Tampa to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Tampa to Greenville, SC, for the next 30 days.

With a price starting from $85, Saturday is the cheapest day for a bus from Tampa to Greenville, SC. Wednesday instead is the most expensive day with prices starting from $119.

Afternoon is the cheapest day time for bus tickets from Tampa to Greenville, SC, with $85. Morning is the most expensive time of the day with prices starting from $87.

How to save money travelling from Tampa to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Tampa to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Tampa to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Tampa to Greenville, SC are also emptier.

All bus stations and stops in Tampa and Greenville, SC

In the map below, you can see where to find all bus stations in Tampa and Greenville, SC.

Marion Street

N Marion St 1211

USF

USF Holly Drive 3755

Greyhound Bus Station

East Polk Street 602

Western Union

Tampa Gateway Blvd, I 4 Exit 10 11706

Port of Tampa Cruise Terminals

Channelside Dr. 1101

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

Service and Comfort on the bus from Tampa to Greenville, SC

Want to know which seat classes are available on the buses from Tampa to Greenville, SC? Or which bus companies serve the route Tampa to Greenville, SC? Below you will find answers to your questions.

FAQs about the Tampa to Greenville, SC bus

How much does a Tampa Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $85 and takes 13h 10m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Tampa to Greenville, SC?

This route is offered by 1 companies with a range of ticket prices between $85 and $121. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Tampa to Greenville, SC each day?

Every day, the Tampa to Greenville, SC bus route is served by approximately 9 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Tampa to Greenville, SC take?

The fastest bus from Tampa to Greenville, SC is offered by FlixBus and takes 13h 10m. Bus tickets for this connection cost $110. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Tampa to Greenville, SC?

The earliest bus arriving in Greenville, SC from Tampa starts at 6:20 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Tampa to Greenville, SC?

The latest bus trip departing from Tampa for Greenville, SC starts at 10:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Tampa Greenville, SC route?

When traveling by bus from Tampa to Greenville, SC, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Tampa and Greenville, SC?

You can check all the direct connections between Tampa and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Tampa to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Tampa Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Tampa Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Tampa to Greenville, SC on your planned travel date.

Available seat classes which are offered on the bus route Tampa to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Tampa and to Greenville, SC

Here’s an overview of the most popular bus routes to Tampa and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!