Bus San Antonio, TX to Greenville, SC: Compare prices and save money

Compare all timetables for the bus from San Antonio, TX to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from San Antonio, TX to Greenville, SC from various bus operators like FlixBus, Greyhound US or Greyhound Lines Mexico for the next days.

today

tomorrow

$179

Monday

Tuesday

$181

Wednesday

$178

Thursday

Friday

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	37h 10m	7:45 AM	San Antonio, TX	Pearl District	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$179	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 12/21/2025 7:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/22/2025 9:55:00 PM. 50 Economy ticket for $179 per person are available. Travel duration is 37h 10m
Greyhound US	31h 25m	1:30 PM	San Antonio, TX	Bus Station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$181	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 12/21/2025 1:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/22/2025 9:55:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 31h 25m
FlixBus	32h 50m	9:15 PM	San Antonio, TX	Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$188	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 12/21/2025 9:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/23/2025 7:05:00 AM. 50 Economy ticket for $188 per person are available. Travel duration is 32h 50m
Greyhound Lines Mexico	28h 35m	1:30 AM	San Antonio, TX	Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$232	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 12/21/2025 1:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/22/2025 7:05:00 AM. 50 Economy ticket for $232 per person are available. Travel duration is 28h 35m

Did you know that if you travel from San Antonio, TX to Greenville, SC via Atlanta, GA, you can save more than $35? You can find the corresponding connections below.
- Busbud
  
  29h 0m
  
  0
  
  1:05 AM
  
  San Antonio, TX
  Bus Station
  
  11:15 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $115
  
  A Bus from Busbud goes from Bus Station, San Antonio, TX (USA) at 12/23/2025 1:05:00 AM to Garnett Transit Station, Atlanta, GA (USA) arriving at 12/23/2025 11:15:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 21h 10m
- Busbud
  
  2h 25m
  
  0
  
  4:40 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  7:05 AM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $28
  
  A Bus from Busbud goes from Garnett Transit Station, Atlanta, GA (USA) at 12/24/2025 4:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 7:05:00 AM. 50 Economy ticket for $28 per person are available. Travel duration is 2h 25m
Travel Time is 0h 35m shorter, and you will save $35

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	31h 25m	1:30 PM	San Antonio, TX	Bus Station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$181	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 12/23/2025 1:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 9:55:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 31h 25m
Greyhound Lines Mexico	34h 50m	7:15 PM	San Antonio, TX	Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$198	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 12/23/2025 7:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 7:05:00 AM. 50 Economy ticket for $198 per person are available. Travel duration is 34h 50m
Greyhound US	26h 5m	7:35 AM	San Antonio, TX	Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$203	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 12/23/2025 7:35:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 10:40:00 AM. 50 Economy ticket for $203 per person are available. Travel duration is 26h 5m
Greyhound Lines Mexico	28h 35m	1:30 AM	San Antonio, TX	Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$270	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 12/23/2025 1:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 7:05:00 AM. 50 Economy ticket for $270 per person are available. Travel duration is 28h 35m

Did you know that if you travel from San Antonio, TX to Greenville, SC via Atlanta, GA, you can save more than $39? You can find the corresponding connections below.
- Busbud
  
  37h 20m
  
  0
  
  7:35 AM
  
  San Antonio, TX
  Bus Station
  
  7:25 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $113
  
  A Bus from Busbud goes from Bus Station, San Antonio, TX (USA) at 12/23/2025 7:35:00 AM to Garnett Transit Station, Atlanta, GA (USA) arriving at 12/24/2025 7:25:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 22h 50m
- Busbud
  
  2h 40m
  
  0
  
  7:15 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:55 PM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $29
  
  A Bus from Busbud goes from Garnett Transit Station, Atlanta, GA (USA) at 12/24/2025 7:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 9:55:00 PM. 50 Economy ticket for $29 per person are available. Travel duration is 2h 40m
Travel time is 10h 15m longer, but you will save $39

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	26h 5m	7:35 AM	San Antonio, TX	Bus Station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$178	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 12/24/2025 7:35:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 10:40:00 AM. 50 Economy ticket for $178 per person are available. Travel duration is 26h 5m
FlixBus	32h 50m	9:15 PM	San Antonio, TX	Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$178	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 12/24/2025 9:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/26/2025 7:05:00 AM. 50 Economy ticket for $178 per person are available. Travel duration is 32h 50m
Greyhound US	31h 25m	1:30 PM	San Antonio, TX	Bus Station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$181	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 12/24/2025 1:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 9:55:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 31h 25m
FlixBus	46h 20m	7:45 AM	San Antonio, TX	Pearl District	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$184	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 12/24/2025 7:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/26/2025 7:05:00 AM. 50 Economy ticket for $184 per person are available. Travel duration is 46h 20m
Greyhound Lines Mexico	28h 35m	1:30 AM	San Antonio, TX	Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$199	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 12/24/2025 1:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 7:05:00 AM. 50 Economy ticket for $199 per person are available. Travel duration is 28h 35m

Did you know that if you travel from San Antonio, TX to Greenville, SC via Atlanta, GA, you can save more than $36? You can find the corresponding connections below.
- Busbud
  
  37h 20m
  
  0
  
  7:35 AM
  
  San Antonio, TX
  Bus Station
  
  7:25 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $113
  
  A Bus from Busbud goes from Bus Station, San Antonio, TX (USA) at 12/23/2025 7:35:00 AM to Garnett Transit Station, Atlanta, GA (USA) arriving at 12/24/2025 7:25:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 22h 50m
- Busbud
  
  2h 40m
  
  0
  
  7:15 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:55 PM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $29
  
  A Bus from Busbud goes from Garnett Transit Station, Atlanta, GA (USA) at 12/24/2025 7:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 9:55:00 PM. 50 Economy ticket for $29 per person are available. Travel duration is 2h 40m
Travel time is 10h 15m longer, but you will save $36

Best Price Offer: The price for the cheapest bus from San Antonio, TX to Greenville, SC is $158 on 12/16/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between San Antonio, TX and Greenville, SC

See here how frequent the connections between San Antonio, TX and Greenville, SC are, during different times and days of the week.

Sunday is the busiest day, with more than 5 daily buses from San Antonio, TX to Greenville, SC. Tuesday has instead the fewest connections, with only 4 daily coaches between San Antonio, TX and Greenville, SC.

The busiest time of the day is the Morning, with 5 buses from San Antonio, TX to Greenville, SC, while Afternoon sees the fewest connections between San Antonio, TX and Greenville, SC, with 3 offers.

Facts about the bus from San Antonio, TX to Greenville, SC

Compare all providers like FlixBus, Greyhound US and Greyhound Lines Mexico that travel 4 times every day by bus from San Antonio, TX to Greenville, SC in one click! Book your bus ticket from San Antonio, TX to Greenville, SC starting from $158!

Cheapest Bus	$158
Fastest Bus	24h 40m
Earliest Bus	1:30 AM
Latest Bus	9:15 PM
Daily Bus Routes	4 Ø
Distance	1,012.1 miles
Bus Companies	FlixBus, Greyhound US and Greyhound Lines Mexico

Cheapest bus connections from San Antonio, TX to Greenville, SC

Every day, 4 buses from 3 bus companies leave San Antonio, TX for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/20/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

$179

Monday 12/22

Tuesday 12/23

$181

Wednesday 12/24

$178

Thursday 12/25

Friday 12/26

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

The cheapest time to travel from San Antonio, TX to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from San Antonio, TX to Greenville, SC, for the next 30 days.

With a price starting from $178, Wednesday is the cheapest day for a bus from San Antonio, TX to Greenville, SC. Tuesday instead is the most expensive day with prices starting from $181.

Morning is the cheapest day time for bus tickets from San Antonio, TX to Greenville, SC, with $178. Afternoon is the most expensive time of the day with prices starting from $180.

How to save money travelling from San Antonio, TX to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Antonio, TX to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Antonio, TX to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Antonio, TX to Greenville, SC are also emptier.

All bus stations and stops in San Antonio, TX and Greenville, SC

In the map below, you can see where to find all bus stations in San Antonio, TX and Greenville, SC.

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

W. Southcross & Buffalo Bus Stop

Commerce & Bowie Bus Stop

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

Service and Comfort on the bus from San Antonio, TX to Greenville, SC

Want to know which seat classes are available on the buses from San Antonio, TX to Greenville, SC? Or which bus companies serve the route San Antonio, TX to Greenville, SC? Below you will find answers to your questions.

FAQs about the San Antonio, TX to Greenville, SC bus

How much does a San Antonio, TX Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $158 and takes 27h 5m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from San Antonio, TX to Greenville, SC?

This route is offered by 3 companies with a range of ticket prices between $158 and $270. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from San Antonio, TX to Greenville, SC each day?

Every day, the San Antonio, TX to Greenville, SC bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Antonio, TX to Greenville, SC take?

The fastest bus from San Antonio, TX to Greenville, SC is offered by FlixBus and takes 24h 40m. Bus tickets for this connection cost $223. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Antonio, TX to Greenville, SC?

The earliest bus arriving in Greenville, SC from San Antonio, TX starts at 1:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Antonio, TX to Greenville, SC?

The latest bus trip departing from San Antonio, TX for Greenville, SC starts at 9:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Antonio, TX Greenville, SC route?

When traveling by bus from San Antonio, TX to Greenville, SC, passengers can travel with FlixBus, Greyhound US and Greyhound Lines Mexico. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Antonio, TX and Greenville, SC?

You can check all the direct connections between San Antonio, TX and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Greyhound US and Greyhound Lines Mexico.

What can I take with me on the San Antonio, TX to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Antonio, TX Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Antonio, TX Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Antonio, TX to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from San Antonio, TX to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between San Antonio, TX and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Antonio, TX to Greenville, SC?

Prices and availability for 4 trips between San Antonio, TX and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Antonio, TX to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Antonio, TX and to Greenville, SC

Here’s an overview of the most popular bus routes to San Antonio, TX and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!