Bus Gainesville, FL to Greenville, SC

Compare all timetables for the bus from Gainesville, FL to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Gainesville, FL to Greenville, SC from various bus operators like FlixBus or Greyhound US for the next days.

today

$94

tomorrow

Sunday

Monday

Tuesday

$105

Wednesday

$113

Thursday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	9h 35m	12:20 PM	Gainesville, FL	Rosa Parks Transfer station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$94	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 12/19/2025 12:20:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/19/2025 9:55:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 9h 35m
FlixBus	14h 5m	5:00 PM	Gainesville, FL	Rosa Parks Transfer station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$111	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 12/19/2025 5:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/20/2025 7:05:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 14h 5m
Greyhound US	17h 35m	1:30 PM	Gainesville, FL	Greyhound Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$112	A Bus from Greyhound US goes from Greyhound Bus Station, Gainesville, FL (USA) at 12/19/2025 1:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/20/2025 7:05:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 17h 35m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	9h 35m	12:20 PM	Gainesville, FL	Rosa Parks Transfer station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$105	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 12/23/2025 12:20:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/23/2025 9:55:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 9h 35m
FlixBus	14h 5m	5:00 PM	Gainesville, FL	Rosa Parks Transfer station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$105	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 12/23/2025 5:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 7:05:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 14h 5m
FlixBus	9h 30m	1:10 AM	Gainesville, FL	Rosa Parks Transfer station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$107	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 12/23/2025 1:10:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/23/2025 10:40:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 9h 30m
Greyhound US	13h 55m	8:00 AM	Gainesville, FL	Greyhound Bus Station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$120	A Bus from Greyhound US goes from Greyhound Bus Station, Gainesville, FL (USA) at 12/23/2025 8:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/23/2025 9:55:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 13h 55m
Greyhound US	17h 35m	1:30 PM	Gainesville, FL	Greyhound Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$120	A Bus from Greyhound US goes from Greyhound Bus Station, Gainesville, FL (USA) at 12/23/2025 1:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 7:05:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 17h 35m

Did you know that if you travel from Gainesville, FL to Greenville, SC via Atlanta, GA, you can save more than $15? You can find the corresponding connections below.
- Busbud
  
  10h 25m
  
  0
  
  11:30 AM
  
  Gainesville, FL
  Rosa Parks Transfer station
  
  6:05 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $60
  
  A Bus from Busbud goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 12/21/2025 11:30:00 AM to Garnett Transit Station, Atlanta, GA (USA) arriving at 12/21/2025 6:05:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 6h 35m
- Busbud
  
  2h 40m
  
  0
  
  7:15 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:55 PM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $29
  
  A Bus from Busbud goes from Garnett Transit Station, Atlanta, GA (USA) at 12/21/2025 7:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/21/2025 9:55:00 PM. 50 Economy ticket for $29 per person are available. Travel duration is 2h 40m
Travel time is 0h 55m longer, but you will save $15

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	9h 35m	12:20 PM	Gainesville, FL	Rosa Parks Transfer station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$113	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 12/24/2025 12:20:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 9:55:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 9h 35m
FlixBus	14h 5m	5:00 PM	Gainesville, FL	Rosa Parks Transfer station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$113	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 12/24/2025 5:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 7:05:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 14h 5m
FlixBus	9h 30m	1:10 AM	Gainesville, FL	Rosa Parks Transfer station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$114	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 12/24/2025 1:10:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 10:40:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 9h 30m
Greyhound US	17h 35m	1:30 PM	Gainesville, FL	Greyhound Bus Station	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$114	A Bus from Greyhound US goes from Greyhound Bus Station, Gainesville, FL (USA) at 12/24/2025 1:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/25/2025 7:05:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 17h 35m
Greyhound US	13h 55m	8:00 AM	Gainesville, FL	Greyhound Bus Station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$123	A Bus from Greyhound US goes from Greyhound Bus Station, Gainesville, FL (USA) at 12/24/2025 8:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/24/2025 9:55:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 13h 55m

Did you know that if you travel from Gainesville, FL to Greenville, SC via Atlanta, GA, you can save more than $23? You can find the corresponding connections below.
- Busbud
  
  10h 25m
  
  0
  
  11:30 AM
  
  Gainesville, FL
  Rosa Parks Transfer station
  
  6:05 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $60
  
  A Bus from Busbud goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 12/21/2025 11:30:00 AM to Garnett Transit Station, Atlanta, GA (USA) arriving at 12/21/2025 6:05:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 6h 35m
- Busbud
  
  2h 40m
  
  0
  
  7:15 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:55 PM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $29
  
  A Bus from Busbud goes from Garnett Transit Station, Atlanta, GA (USA) at 12/21/2025 7:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/21/2025 9:55:00 PM. 50 Economy ticket for $29 per person are available. Travel duration is 2h 40m
Travel time is 0h 55m longer, but you will save $23

Best Price Offer: The price for the cheapest bus from Gainesville, FL to Greenville, SC is $88 on 12/18/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Gainesville, FL and Greenville, SC

See here how frequent the connections between Gainesville, FL and Greenville, SC are, during different times and days of the week.

Tuesday is the busiest day, with more than 5 daily buses from Gainesville, FL to Greenville, SC. Friday has instead the fewest connections, with only 3 daily coaches between Gainesville, FL and Greenville, SC.

The busiest time of the day is the Afternoon, with 9 buses from Gainesville, FL to Greenville, SC, while Morning sees the fewest connections between Gainesville, FL and Greenville, SC, with 2 offers.

Facts about the bus from Gainesville, FL to Greenville, SC

Compare all providers like FlixBus and Greyhound US that travel 4 times every day by bus from Gainesville, FL to Greenville, SC in one click! Book your bus ticket from Gainesville, FL to Greenville, SC starting from $88!

Cheapest Bus	$88
Fastest Bus	9h 30m
Earliest Bus	12:20 PM
Latest Bus	5:00 PM
Daily Bus Routes	4 Ø
Distance	359.9 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Gainesville, FL to Greenville, SC

Every day, 4 buses from 2 bus companies leave Gainesville, FL for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/19/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

$92

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

$105

Wednesday 12/24

$113

Thursday 12/25

Friday 12/26

$100

Saturday 12/27

Sunday 12/28

$128

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

The cheapest time to travel from Gainesville, FL to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Gainesville, FL to Greenville, SC, for the next 30 days.

With a price starting from $92, Friday is the cheapest day for a bus from Gainesville, FL to Greenville, SC. Wednesday instead is the most expensive day with prices starting from $113.

Night is the cheapest day time for bus tickets from Gainesville, FL to Greenville, SC, with $92. Morning is the most expensive time of the day with prices starting from $120.

How to save money travelling from Gainesville, FL to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Gainesville, FL to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Gainesville, FL to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Gainesville, FL to Greenville, SC are also emptier.

All bus stations and stops in Gainesville, FL and Greenville, SC

In the map below, you can see where to find all bus stations in Gainesville, FL and Greenville, SC.

Rosa Parks Transfer station

SE 3rd St 700

North Walmart Supercenter Bus Stop

Westgate Plaza Bus Stop

Central Bus Station

University of Florida (Commuter Lot)

Gale Lemerand Dr

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

Service and Comfort on the bus from Gainesville, FL to Greenville, SC

Want to know which seat classes are available on the buses from Gainesville, FL to Greenville, SC? Or which bus companies serve the route Gainesville, FL to Greenville, SC? Below you will find answers to your questions.

FAQs about the Gainesville, FL to Greenville, SC bus

How much does a Gainesville, FL Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $88 and takes 9h 35m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Gainesville, FL to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $88 and $123. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Gainesville, FL to Greenville, SC each day?

Every day, the Gainesville, FL to Greenville, SC bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Gainesville, FL to Greenville, SC take?

The fastest bus from Gainesville, FL to Greenville, SC is offered by FlixBus and takes 9h 30m. Bus tickets for this connection cost $107. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Gainesville, FL to Greenville, SC?

The earliest bus arriving in Greenville, SC from Gainesville, FL starts at 12:20 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Gainesville, FL to Greenville, SC?

The latest bus trip departing from Gainesville, FL for Greenville, SC starts at 5:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Gainesville, FL Greenville, SC route?

When traveling by bus from Gainesville, FL to Greenville, SC, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Gainesville, FL and Greenville, SC?

You can check all the direct connections between Gainesville, FL and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Gainesville, FL to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Gainesville, FL Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Gainesville, FL Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Gainesville, FL to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Gainesville, FL to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Gainesville, FL and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Gainesville, FL to Greenville, SC?

Prices and availability for 4 trips between Gainesville, FL and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Gainesville, FL to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Gainesville, FL and to Greenville, SC

Here’s an overview of the most popular bus routes to Gainesville, FL and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!