Bus Gainesville, FL to Greenville, SC

Compare all timetables for the bus from Gainesville, FL to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Gainesville, FL to Greenville, SC from various bus operators like FlixBus or Greyhound US for the next days.

today

$69

tomorrow

Thursday

Friday

$68

Saturday

$67

Sunday

Monday

$68

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	10h 25m	11:30 AM	Gainesville, FL	Rosa Parks Transfer station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$69	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 5/5/2026 11:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 5/5/2026 9:55:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 10h 25m
FlixBus	13h 45m	5:15 PM	Gainesville, FL	Rosa Parks Transfer station	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$69	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 5/5/2026 5:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 5/6/2026 7:00:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 13h 45m
FlixBus	16h 35m	6:05 PM	Gainesville, FL	Rosa Parks Transfer station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$69	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 5/5/2026 6:05:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 5/6/2026 10:40:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 16h 35m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	9h 30m	1:10 AM	Gainesville, FL	Rosa Parks Transfer station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$68	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 5/8/2026 1:10:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 5/8/2026 10:40:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 9h 30m
FlixBus	10h 25m	11:30 AM	Gainesville, FL	Rosa Parks Transfer station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$68	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 5/8/2026 11:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 5/8/2026 9:55:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 10h 25m
FlixBus	13h 45m	5:15 PM	Gainesville, FL	Rosa Parks Transfer station	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$68	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 5/8/2026 5:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 5/9/2026 7:00:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 13h 45m
Greyhound US	13h 55m	8:00 AM	Gainesville, FL	North Walmart Supercenter Bus Stop	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$76	A Bus from Greyhound US goes from North Walmart Supercenter Bus Stop, Gainesville, FL (USA) at 5/8/2026 8:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 5/8/2026 9:55:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 13h 55m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	9h 30m	1:10 AM	Gainesville, FL	Rosa Parks Transfer station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$67	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 5/9/2026 1:10:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 5/9/2026 10:40:00 AM. 50 Economy ticket for $67 per person are available. Travel duration is 9h 30m
FlixBus	10h 25m	11:30 AM	Gainesville, FL	Rosa Parks Transfer station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$67	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 5/9/2026 11:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 5/9/2026 9:55:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 10h 25m
FlixBus	13h 45m	5:15 PM	Gainesville, FL	Rosa Parks Transfer station	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$67	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 5/9/2026 5:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 5/10/2026 7:00:00 AM. 50 Economy ticket for $67 per person are available. Travel duration is 13h 45m
Greyhound US	13h 55m	8:00 AM	Gainesville, FL	North Walmart Supercenter Bus Stop	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$67	A Bus from Greyhound US goes from North Walmart Supercenter Bus Stop, Gainesville, FL (USA) at 5/9/2026 8:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 5/9/2026 9:55:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 13h 55m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	10h 25m	11:30 AM	Gainesville, FL	Rosa Parks Transfer station	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$68	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 5/11/2026 11:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 5/11/2026 9:55:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 10h 25m
FlixBus	13h 45m	5:15 PM	Gainesville, FL	Rosa Parks Transfer station	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$68	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 5/11/2026 5:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 5/12/2026 7:00:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 13h 45m
FlixBus	9h 30m	1:10 AM	Gainesville, FL	Rosa Parks Transfer station	10:40 AM	Greenville, SC	Woodruff Rd	Economy	$69	A Bus from FlixBus goes from Rosa Parks Transfer station, Gainesville, FL (USA) at 5/11/2026 1:10:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 5/11/2026 10:40:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 9h 30m
Greyhound US	13h 55m	8:00 AM	Gainesville, FL	North Walmart Supercenter Bus Stop	9:55 PM	Greenville, SC	Woodruff Rd	Economy	$69	A Bus from Greyhound US goes from North Walmart Supercenter Bus Stop, Gainesville, FL (USA) at 5/11/2026 8:00:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 5/11/2026 9:55:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 13h 55m

Best Price Offer: The price for the cheapest bus from Gainesville, FL to Greenville, SC is $63 on 5/3/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Gainesville, FL and Greenville, SC

See here how frequent the connections between Gainesville, FL and Greenville, SC are, during different times and days of the week.

Monday is the busiest day, with more than 10 daily buses from Gainesville, FL to Greenville, SC. Tuesday has instead the fewest connections, with only 3 daily coaches between Gainesville, FL and Greenville, SC.

The busiest time of the day is the Morning, with 11 buses from Gainesville, FL to Greenville, SC, while Night sees the fewest connections between Gainesville, FL and Greenville, SC, with 5 offers.

Facts about the bus from Gainesville, FL to Greenville, SC

Compare all providers like FlixBus and Greyhound US that travel 7 times every day by bus from Gainesville, FL to Greenville, SC in one click! Book your bus ticket from Gainesville, FL to Greenville, SC starting from $63!

Cheapest Bus	$63
Fastest Bus	9h 30m
Earliest Bus	11:30 AM
Latest Bus	6:05 PM
Daily Bus Routes	7 Ø
Distance	359.9 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Gainesville, FL to Greenville, SC

Every day, 7 buses from 2 bus companies leave Gainesville, FL for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/05/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 05/03

Monday 05/04

Tuesday 05/05

$115

Wednesday 05/06

Thursday 05/07

Friday 05/08

$72

Saturday 05/09

$67

Sunday 05/10

Monday 05/11

$68

Tuesday 05/12

$118

Wednesday 05/13

$118

Thursday 05/14

$64

Friday 05/15

$69

Saturday 05/16

$69

Sunday 05/17

$120

Monday 05/18

Tuesday 05/19

$81

Wednesday 05/20

$118

Thursday 05/21

$71

Friday 05/22

$118

Saturday 05/23

$118

Sunday 05/24

$118

Monday 05/25

$79

Tuesday 05/26

$118

Wednesday 05/27

$118

Thursday 05/28

$63

Friday 05/29

$65

Saturday 05/30

The cheapest time to travel from Gainesville, FL to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Gainesville, FL to Greenville, SC, for the next 30 days.

With a price starting from $60, Saturday is the cheapest day for a bus from Gainesville, FL to Greenville, SC. Tuesday instead is the most expensive day with prices starting from $69.

Night is the cheapest day time for bus tickets from Gainesville, FL to Greenville, SC, with $60. Morning is the most expensive time of the day with prices starting from $67.

How to save money travelling from Gainesville, FL to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Gainesville, FL to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Gainesville, FL to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Gainesville, FL to Greenville, SC are also emptier.

All bus stations and stops in Gainesville, FL and Greenville, SC

In the map below, you can see where to find all bus stations in Gainesville, FL and Greenville, SC.

Rosa Parks Transfer station

SE 3rd St 700

Greyhound Bus Station

Northeast 23rd Avenue 101

Central Bus Station

Westgate Plaza Bus Stop

University of Florida (Commuter Lot)

Gale Lemerand Dr

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

N Church St

Greyhound Bus Station

Hendrix Dr 9

Guadalajara Supermarket

White Horse Rd 2803

Service and Comfort on the bus from Gainesville, FL to Greenville, SC

Want to know which seat classes are available on the buses from Gainesville, FL to Greenville, SC? Or which bus companies serve the route Gainesville, FL to Greenville, SC? Below you will find answers to your questions.

FAQs about the Gainesville, FL to Greenville, SC bus

How much does a Gainesville, FL Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $63 and takes 16h 35m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Gainesville, FL to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $63 and $80. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Gainesville, FL to Greenville, SC each day?

Every day, the Gainesville, FL to Greenville, SC bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Gainesville, FL to Greenville, SC take?

The fastest bus from Gainesville, FL to Greenville, SC is offered by FlixBus and takes 9h 30m. Bus tickets for this connection cost $68. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Gainesville, FL to Greenville, SC?

The earliest bus arriving in Greenville, SC from Gainesville, FL starts at 11:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Gainesville, FL to Greenville, SC?

The latest bus trip departing from Gainesville, FL for Greenville, SC starts at 6:05 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Gainesville, FL Greenville, SC route?

When traveling by bus from Gainesville, FL to Greenville, SC, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Gainesville, FL and Greenville, SC?

You can check all the direct connections between Gainesville, FL and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Gainesville, FL to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Gainesville, FL Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Gainesville, FL Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Gainesville, FL to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Gainesville, FL to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between Gainesville, FL and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Gainesville, FL to Greenville, SC?

Prices and availability for 7 trips between Gainesville, FL and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Gainesville, FL to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Gainesville, FL and to Greenville, SC

Here’s an overview of the most popular bus routes to Gainesville, FL and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!