Bus from Knoxville, TN to Gainesville, FL from $125

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Compare all timetables for the bus from Knoxville, TN to Gainesville, FL

Here is a selection of the cheapest bus trips from the schedule from Knoxville, TN to Gainesville, FL from various bus operators like Greyhound US for the next days.
today
from $125
tomorrow
Tuesday
from $170
Wednesday
from $127
Thursday
Friday
from $141
Saturday

Cheapest bus trips today

Prices are for one way and one person
  • Greyhound US
    11h 0m
    0
    7:25 PM
    Knoxville, TN
    Greyhound Bus Station
    6:25 AM
    Gainesville, FL
    Greyhound Bus Station
    0
    Greyhound US
    Economy
    $125
  • Greyhound US
    18h 25m
    0
    7:25 PM
    Knoxville, TN
    Greyhound Bus Station
    1:50 PM
    Gainesville, FL
    Rosa Parks Transfer station
    0
    Greyhound US
    Economy
    $151
  • Did you know that if you travel from Knoxville, TN to Gainesville, FL via Atlanta, GA, you can save more than $36? You can find the corresponding connections below.
    • FlixBus
      11h 0m
      0
      7:25 PM
      Knoxville, TN
      Greyhound Bus Station
      11:20 PM
      Atlanta, GA
      Garnett Transit Station
      0
      FlixBus
      Economy
      $46
      • Waiting Time 1h 30m
    • FlixBus
      5h 35m
      0
      12:50 AM
      Atlanta, GA
      Garnett Transit Station
      6:25 AM
      Gainesville, FL
      Greyhound Bus Station
      0
      FlixBus
      Economy
      $43
    Travel time is the same as the direct connection, but you will save $36

Cheapest bus trips Tuesday

Prices are for one way and one person
  • Greyhound US
    11h 0m
    0
    7:25 PM
    Knoxville, TN
    Greyhound Bus Station
    6:25 AM
    Gainesville, FL
    Greyhound Bus Station
    0
    Greyhound US
    Economy
    $170
  • Greyhound US
    16h 50m
    0
    7:25 PM
    Knoxville, TN
    Greyhound Bus Station
    12:15 PM
    Gainesville, FL
    Rosa Parks Transfer station
    0
    Greyhound US
    Economy
    $170
  • Did you know that if you travel from Knoxville, TN to Gainesville, FL via Atlanta, GA, you can save more than $81? You can find the corresponding connections below.
    • FlixBus
      11h 0m
      0
      7:25 PM
      Knoxville, TN
      Greyhound Bus Station
      11:20 PM
      Atlanta, GA
      Garnett Transit Station
      0
      FlixBus
      Economy
      $46
      • Waiting Time 1h 30m
    • FlixBus
      5h 35m
      0
      12:50 AM
      Atlanta, GA
      Garnett Transit Station
      6:25 AM
      Gainesville, FL
      Greyhound Bus Station
      0
      FlixBus
      Economy
      $43
    Travel time is the same as the direct connection, but you will save $81

Cheapest bus trips Wednesday

Prices are for one way and one person
  • Greyhound US
    11h 0m
    0
    7:25 PM
    Knoxville, TN
    Greyhound Bus Station
    6:25 AM
    Gainesville, FL
    Greyhound Bus Station
    0
    Greyhound US
    Economy
    $127
  • Greyhound US
    16h 50m
    0
    7:25 PM
    Knoxville, TN
    Greyhound Bus Station
    12:15 PM
    Gainesville, FL
    Rosa Parks Transfer station
    0
    Greyhound US
    Economy
    $165
  • Did you know that if you travel from Knoxville, TN to Gainesville, FL via Atlanta, GA, you can save more than $51? You can find the corresponding connections below.
    • FlixBus
      11h 0m
      0
      7:25 PM
      Knoxville, TN
      Greyhound Bus Station
      11:20 PM
      Atlanta, GA
      Garnett Transit Station
      0
      FlixBus
      Economy
      $33
      • Waiting Time 1h 30m
    • FlixBus
      5h 35m
      0
      12:50 AM
      Atlanta, GA
      Garnett Transit Station
      6:25 AM
      Gainesville, FL
      Greyhound Bus Station
      0
      FlixBus
      Economy
      $43
    Travel time is the same as the direct connection, but you will save $51

Cheapest bus trips Friday

Prices are for one way and one person
  • Greyhound US
    11h 0m
    0
    7:25 PM
    Knoxville, TN
    Greyhound Bus Station
    6:25 AM
    Gainesville, FL
    Greyhound Bus Station
    0
    Greyhound US
    Economy
    $141
  • Greyhound US
    16h 50m
    0
    7:25 PM
    Knoxville, TN
    Greyhound Bus Station
    12:15 PM
    Gainesville, FL
    Rosa Parks Transfer station
    0
    Greyhound US
    Economy
    $142
  • Did you know that if you travel from Knoxville, TN to Gainesville, FL via Atlanta, GA, you can save more than $65? You can find the corresponding connections below.
    • FlixBus
      11h 0m
      0
      7:25 PM
      Knoxville, TN
      Greyhound Bus Station
      11:20 PM
      Atlanta, GA
      Garnett Transit Station
      0
      FlixBus
      Economy
      $33
      • Waiting Time 1h 30m
    • FlixBus
      5h 35m
      0
      12:50 AM
      Atlanta, GA
      Garnett Transit Station
      6:25 AM
      Gainesville, FL
      Greyhound Bus Station
      0
      FlixBus
      Economy
      $43
    Travel time is the same as the direct connection, but you will save $65

Facts about the bus from Knoxville, TN to Gainesville, FL

Compare all providers like Greyhound US that travel 2 times every day by bus from Knoxville, TN to Gainesville, FL in one click! Book your bus ticket from Knoxville, TN to Gainesville, FL starting from $125!

Cheapest Bus $125
Fastest Bus 11h 0m
Earliest Bus 7:25 PM
Latest Bus 7:25 PM
Daily Bus Routes 2 Ø
Distance 446.4 miles
Bus Companies Greyhound US

Cheapest bus connections from Knoxville, TN to Gainesville, FL

Every day, 2 buses from 1 bus companies leave Knoxville, TN for Gainesville, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/15/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 06/15
$125
Monday 06/16
Tuesday 06/17
$170
Wednesday 06/18
$127
Thursday 06/19
Friday 06/20
$141
Saturday 06/21
Sunday 06/22
Monday 06/23
Tuesday 06/24
Wednesday 06/25
Thursday 06/26
Friday 06/27
Saturday 06/28
Sunday 06/29
Monday 06/30
Tuesday 07/01
Wednesday 07/02
Thursday 07/03
Friday 07/04
Saturday 07/05
Sunday 07/06
Monday 07/07
Tuesday 07/08
Wednesday 07/09
Thursday 07/10
Friday 07/11
Saturday 07/12

How to save money travelling from Knoxville, TN to Gainesville, FL

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Knoxville, TN to Gainesville, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Knoxville, TN to Gainesville, FL, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Knoxville, TN to Gainesville, FL are also emptier.

Beloved bus companies from Knoxville, TN to Gainesville, FL

These are the most booked bus companies between Knoxville, TN to Gainesville, FL from our users.

Greyhound US from Knoxville, TN to Gainesville, FL

Greyhound US

Here you will find the key facts about the Greyhound US bus route Knoxville, TN to Gainesville, FL:

Cheapest Price $125
Fastest Bus 11h 0m
Earliest Bus 7:25 PM
Last Bus 7:25 PM
Daily Connections 2 Ø
Found on 6/12/2025

All bus stations and stops in Knoxville, TN and Gainesville, FL

In the map below, you can see where to find all bus stations in Knoxville, TN and Gainesville, FL.

Service and Comfort on the bus from Knoxville, TN to Gainesville, FL

Want to know which seat classes are available on the buses from Knoxville, TN to Gainesville, FL? Or which bus companies serve the route Knoxville, TN to Gainesville, FL? Below you will find answers to your questions.

FAQs about the Knoxville, TN to Gainesville, FL bus

How much does a Knoxville, TN Gainesville, FL bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $125 and takes 11h 0m to reach Gainesville, FL. Compare offers to save money!

How much could I save by comparing buses from Knoxville, TN to Gainesville, FL?

This route is offered by 1 companies with a range of ticket prices between $125 and $170. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Gainesville, FL.

On average, how many connections are available from Knoxville, TN to Gainesville, FL each day?

Every day, the Knoxville, TN to Gainesville, FL bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Knoxville, TN to Gainesville, FL take?

The fastest bus from Knoxville, TN to Gainesville, FL is offered by Greyhound US and takes 11h 0m. Bus tickets for this connection cost $125. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Knoxville, TN to Gainesville, FL?

The earliest bus arriving in Gainesville, FL from Knoxville, TN starts at 7:25 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Knoxville, TN to Gainesville, FL?

The latest bus trip departing from Knoxville, TN for Gainesville, FL starts at 7:25 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Knoxville, TN Gainesville, FL route?

When traveling by bus from Knoxville, TN to Gainesville, FL, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Knoxville, TN and Gainesville, FL?

You can check all the direct connections between Knoxville, TN and Gainesville, FL by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Knoxville, TN to Gainesville, FL bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Knoxville, TN Gainesville, FL bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Knoxville, TN Gainesville, FL bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Knoxville, TN to Gainesville, FL on your planned travel date.

Available seat classes which are offered on the bus route Knoxville, TN to Gainesville, FL

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Knoxville, TN and to Gainesville, FL

Here’s an overview of the most popular bus routes to Knoxville, TN and to Gainesville, FL. Simply click on the connection of your choice, and you will find all the details about your bus route!
From New York to Knoxville, TN bus From New York to Knoxville, TN bus
Bus to Knoxville, TN from Washington, DC Bus to Knoxville, TN from Washington, DC
Bus Louisville, KY to Knoxville, TN Bus Louisville, KY to Knoxville, TN
Indianapolis to Knoxville, TN bus Indianapolis to Knoxville, TN bus
Bus Sarasota, FL to Gainesville, FL Bus Sarasota, FL to Gainesville, FL
From Boca Raton, FL to Gainesville, FL bus From Boca Raton, FL to Gainesville, FL bus
Buses Port Saint Lucie, FL to Gainesville, FL Buses Port Saint Lucie, FL to Gainesville, FL
Bus Saint Petersburg, FL to Gainesville, FL Bus Saint Petersburg, FL to Gainesville, FL
Popular Airport Shuttles to Knoxville, TN and to Gainesville, FL
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