Bus from Chicago to Greenville, SC from $81

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Compare all timetables for the bus from Chicago to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Chicago to Greenville, SC from various bus operators like Greyhound US or FlixBus for the next days.
today
from $87
tomorrow
Friday
Saturday
from $81
Sunday
Monday
Tuesday

Cheapest bus trips today

Prices are for one way and one person
  • FlixBus
    22h 15m
    0
    6:00 PM
    Chicago
    Downtown Bus Station
    4:15 PM
    Greenville, SC
    Woodruff Rd
    0
    FlixBus
    Economy
    $87
  • FlixBus
    22h 15m
    0
    6:00 PM
    Chicago
    Downtown Bus Station
    4:15 PM
    Greenville, SC
    Woodruff Rd
    0
    FlixBus
    Economy
    $88
  • Greyhound US
    21h 15m
    0
    2:45 PM
    Chicago
    Downtown Bus Station
    12:00 PM
    Greenville, SC
    Woodruff Rd
    0
    Greyhound US
    Economy
    $91
  • Greyhound US
    21h 15m
    0
    2:45 PM
    Chicago
    Downtown Bus Station
    12:00 PM
    Greenville, SC
    Woodruff Rd
    0
    Greyhound US
    Economy
    $91
  • FlixBus
    21h 40m
    0
    1:00 PM
    Chicago
    Downtown Bus Station
    10:40 AM
    Greenville, SC
    Woodruff Rd
    0
    FlixBus
    Economy
    $93

Cheapest bus trips Saturday

Prices are for one way and one person
  • FlixBus
    21h 40m
    0
    1:00 PM
    Chicago
    Downtown Bus Station
    10:40 AM
    Greenville, SC
    Woodruff Rd
    0
    FlixBus
    Economy
    $81
  • Greyhound US
    21h 50m
    0
    2:10 PM
    Chicago
    95th Red Line Station
    12:00 PM
    Greenville, SC
    Woodruff Rd
    0
    Greyhound US
    Economy
    $81
  • Greyhound US
    21h 15m
    0
    2:45 PM
    Chicago
    Downtown Bus Station
    12:00 PM
    Greenville, SC
    Woodruff Rd
    0
    Greyhound US
    Economy
    $81
  • FlixBus
    21h 10m
    0
    1:30 PM
    Chicago
    95th Red Line Station
    10:40 AM
    Greenville, SC
    Woodruff Rd
    0
    FlixBus
    Economy
    $82
  • FlixBus
    22h 15m
    0
    6:00 PM
    Chicago
    Downtown Bus Station
    4:15 PM
    Greenville, SC
    Woodruff Rd
    0
    FlixBus
    Economy
    $82

Frequency of bus connections between Chicago and Greenville, SC

See here how frequent the connections between Chicago and Greenville, SC are, during different times and days of the week.
Wednesday is the busiest day, with more than 22 daily buses from Chicago to Greenville, SC. Wednesday has instead the fewest connections, with only 22 daily coaches between Chicago and Greenville, SC.
The busiest time of the day is the Evening, with 22 buses from Chicago to Greenville, SC, while Night sees the fewest connections between Chicago and Greenville, SC, with 2 offers.

Facts about the bus from Chicago to Greenville, SC

Compare all providers like Greyhound US and FlixBus that travel 22 times every day by bus from Chicago to Greenville, SC in one click! Book your bus ticket from Chicago to Greenville, SC starting from $81!

Cheapest Bus $81
Fastest Bus 21h 10m
Earliest Bus 5:45 AM
Latest Bus 11:50 PM
Daily Bus Routes 22 Ø
Distance 562.3 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from Chicago to Greenville, SC

Every day, 22 buses from 2 bus companies leave Chicago for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/21/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 05/18
Monday 05/19
Tuesday 05/20
Wednesday 05/21
$87
Thursday 05/22
Friday 05/23
Saturday 05/24
$81
Sunday 05/25
Monday 05/26
Tuesday 05/27
Wednesday 05/28
Thursday 05/29
$96
Friday 05/30
Saturday 05/31
$88
Sunday 06/01
$121
Monday 06/02
$101
Tuesday 06/03
Wednesday 06/04
$95
Thursday 06/05
Friday 06/06
$105
Saturday 06/07
$104
Sunday 06/08
Monday 06/09
$72
Tuesday 06/10
Wednesday 06/11
Thursday 06/12
Friday 06/13
Saturday 06/14

The cheapest time to travel from Chicago to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to Greenville, SC, for the next 30 days.
With a price starting from $81, Saturday is the cheapest day for a bus from Chicago to Greenville, SC. Wednesday instead is the most expensive day with prices starting from $87.
Afternoon is the cheapest day time for bus tickets from Chicago to Greenville, SC, with $81. Night is the most expensive time of the day with prices starting from $96.

How to save money travelling from Chicago to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to Greenville, SC are also emptier.

All bus stations and stops in Chicago and Greenville, SC

In the map below, you can see where to find all bus stations in Chicago and Greenville, SC.

Service and Comfort on the bus from Chicago to Greenville, SC

Want to know which seat classes are available on the buses from Chicago to Greenville, SC? Or which bus companies serve the route Chicago to Greenville, SC? Below you will find answers to your questions.

FAQs about the Chicago to Greenville, SC bus

How much does a Chicago Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $81 and takes 21h 40m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Chicago to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $81 and $172. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Chicago to Greenville, SC each day?

Every day, the Chicago to Greenville, SC bus route is served by approximately 22 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to Greenville, SC take?

The fastest bus from Chicago to Greenville, SC is offered by FlixBus and takes 21h 10m. Bus tickets for this connection cost $137. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to Greenville, SC?

The earliest bus arriving in Greenville, SC from Chicago starts at 5:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to Greenville, SC?

The latest bus trip departing from Chicago for Greenville, SC starts at 11:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago Greenville, SC route?

When traveling by bus from Chicago to Greenville, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and Greenville, SC?

You can check all the direct connections between Chicago and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Chicago to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to Greenville, SC on your planned travel date.

Available seat classes which are offered on the bus route Chicago to Greenville, SC

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to Greenville, SC

Here’s an overview of the most popular bus routes to Chicago and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
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