What is the best way to travel from Greenville, SC to Fort Myers, FL?
Looking for a trip? Compare all the available Flights and Buses for the journey to Fort Myers, FL from Greenville, SC. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Fort Myers, FL from Greenville, SC?
You can get to Fort Myers, FL with just $99 by taking a Bus from Greyhound US, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Greyhound US23h 5m011:15 AMGreenville, SCWoodruff Rd10:20 AMFort Myers, FLRosa Parks Transit Center0EconomyA Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/3/2026 11:15:00 AM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/4/2026 10:20:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 23h 5m
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Greyhound US21h 55m02:45 PMGreenville, SCWoodruff Rd12:40 PMFort Myers, FLRosa Parks Transit Center0EconomyA Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/3/2026 2:45:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/4/2026 12:40:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 21h 55m
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FlixBus36h 20m010:00 PMGreenville, SCWoodruff Rd10:20 AMFort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 6/3/2026 10:00:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/5/2026 10:20:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 36h 20m
Cheapest Buses Wednesday
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Greyhound US21h 55m02:45 PMGreenville, SCWoodruff Rd12:40 PMFort Myers, FLRosa Parks Transit Center0EconomyA Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/4/2026 2:45:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/5/2026 12:40:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 21h 55m
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FlixBus36h 20m010:00 PMGreenville, SCWoodruff Rd10:20 AMFort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 6/4/2026 10:00:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/6/2026 10:20:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 36h 20m
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FlixBus21h 0m01:20 PMGreenville, SCWoodruff Rd10:20 AMFort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 6/4/2026 1:20:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/5/2026 10:20:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 21h 0m
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Breeze Airways1h 47m07:51 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport9:38 PMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Breeze Airways goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/4/2026 7:51:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/4/2026 9:38:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 1h 47m
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Allegiant Air22h 21m03:48 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport2:09 PMPunta Gorda AirportPunta Gorda Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/4/2026 3:48:00 PM to Punta Gorda Airport, Punta Gorda Airport (USA) arriving at 6/5/2026 2:09:00 PM. 50 Economy ticket for $182 per person are available. Travel duration is 22h 21m
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Allegiant Air23h 36m03:17 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport2:53 PMPunta Gorda AirportPunta Gorda Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/4/2026 3:17:00 PM to Punta Gorda Airport, Punta Gorda Airport (USA) arriving at 6/5/2026 2:53:00 PM. 50 Economy ticket for $201 per person are available. Travel duration is 23h 36m
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Breeze Airways13h 4m08:19 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport9:23 AMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Breeze Airways goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/4/2026 8:19:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/5/2026 9:23:00 AM. 50 Economy ticket for $220 per person are available. Travel duration is 13h 4m
Cheapest Buses Thursday
Cheapest Flights Thursday
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Breeze Airways13h 10m09:20 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport10:30 AMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Breeze Airways goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/5/2026 9:20:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/6/2026 10:30:00 AM. 50 Economy ticket for $183 per person are available. Travel duration is 13h 10m
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Allegiant Air32h 18m03:21 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport11:39 PMPunta Gorda AirportPunta Gorda Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/5/2026 3:21:00 PM to Punta Gorda Airport, Punta Gorda Airport (USA) arriving at 6/6/2026 11:39:00 PM. 50 Economy ticket for $214 per person are available. Travel duration is 32h 18m
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Allegiant Air12h 22m08:29 AMGreenville–Spartanburg AirportGreenville–Spartanburg Airport8:51 PMPunta Gorda AirportPunta Gorda Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/5/2026 8:29:00 AM to Punta Gorda Airport, Punta Gorda Airport (USA) arriving at 6/5/2026 8:51:00 PM. 50 Economy ticket for $216 per person are available. Travel duration is 12h 22m
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Allegiant Air29h 48m03:21 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport9:09 PMPunta Gorda AirportPunta Gorda Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/5/2026 3:21:00 PM to Punta Gorda Airport, Punta Gorda Airport (USA) arriving at 6/6/2026 9:09:00 PM. 50 Economy ticket for $222 per person are available. Travel duration is 29h 48m
Cheapest Flights Friday
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Breeze Airways1h 47m07:51 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport9:38 PMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Breeze Airways goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/7/2026 7:51:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/7/2026 9:38:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 1h 47m
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Allegiant Air23h 6m08:44 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport7:50 PMPunta Gorda AirportPunta Gorda Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/7/2026 8:44:00 PM to Punta Gorda Airport, Punta Gorda Airport (USA) arriving at 6/8/2026 7:50:00 PM. 50 Economy ticket for $209 per person are available. Travel duration is 23h 6m
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Breeze Airways13h 4m08:19 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport9:23 AMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Breeze Airways goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/7/2026 8:19:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/8/2026 9:23:00 AM. 50 Economy ticket for $279 per person are available. Travel duration is 13h 4m
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Allegiant Air17h 56m08:44 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport2:40 PMPunta Gorda AirportPunta Gorda Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/7/2026 8:44:00 PM to Punta Gorda Airport, Punta Gorda Airport (USA) arriving at 6/8/2026 2:40:00 PM. 50 Economy ticket for $298 per person are available. Travel duration is 17h 56m
Cheapest Flights Sunday
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Allegiant Air47h 10m08:29 AMGreenville–Spartanburg AirportGreenville–Spartanburg Airport7:39 AMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/8/2026 8:29:00 AM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/10/2026 7:39:00 AM. 50 Economy ticket for $155 per person are available. Travel duration is 47h 10m
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Allegiant Air32h 36m01:22 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport9:58 PMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/8/2026 1:22:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/9/2026 9:58:00 PM. 50 Economy ticket for $158 per person are available. Travel duration is 32h 36m
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Breeze Airways35h 11m08:28 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport7:39 AMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Breeze Airways goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/8/2026 8:28:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/10/2026 7:39:00 AM. 50 Economy ticket for $174 per person are available. Travel duration is 35h 11m
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Breeze Airways14h 0m09:20 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport11:20 AMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Breeze Airways goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/8/2026 9:20:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/9/2026 11:20:00 AM. 50 Economy ticket for $177 per person are available. Travel duration is 14h 0m
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Breeze Airways15h 50m09:20 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport1:10 PMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Breeze Airways goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/8/2026 9:20:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/9/2026 1:10:00 PM. 50 Economy ticket for $224 per person are available. Travel duration is 15h 50m
Cheapest Flights Monday
What are the fastest trips from Greenville, SC to Fort Myers, FL?
You can get to Fort Myers, FL from Greenville, SC in just 1h 47m with a Flight from Breeze Airways. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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Greyhound US21h 55m02:45 PMGreenville, SCWoodruff Rd12:40 PMFort Myers, FLRosa Parks Transit Center0EconomyA Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/3/2026 2:45:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/4/2026 12:40:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 21h 55m
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Greyhound US23h 5m011:15 AMGreenville, SCWoodruff Rd10:20 AMFort Myers, FLRosa Parks Transit Center0EconomyA Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/3/2026 11:15:00 AM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/4/2026 10:20:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 23h 5m
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FlixBus36h 20m010:00 PMGreenville, SCWoodruff Rd10:20 AMFort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 6/3/2026 10:00:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/5/2026 10:20:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 36h 20m
Fastest Buses Wednesday
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Breeze Airways1h 47m07:51 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport9:38 PMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Breeze Airways goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/4/2026 7:51:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/4/2026 9:38:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 1h 47m
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Breeze Airways13h 4m08:19 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport9:23 AMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Breeze Airways goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/4/2026 8:19:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/5/2026 9:23:00 AM. 50 Economy ticket for $220 per person are available. Travel duration is 13h 4m
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Allegiant Air22h 21m03:48 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport2:09 PMPunta Gorda AirportPunta Gorda Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/4/2026 3:48:00 PM to Punta Gorda Airport, Punta Gorda Airport (USA) arriving at 6/5/2026 2:09:00 PM. 50 Economy ticket for $182 per person are available. Travel duration is 22h 21m
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Allegiant Air23h 36m03:17 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport2:53 PMPunta Gorda AirportPunta Gorda Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/4/2026 3:17:00 PM to Punta Gorda Airport, Punta Gorda Airport (USA) arriving at 6/5/2026 2:53:00 PM. 50 Economy ticket for $201 per person are available. Travel duration is 23h 36m
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FlixBus21h 0m01:20 PMGreenville, SCWoodruff Rd10:20 AMFort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 6/4/2026 1:20:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/5/2026 10:20:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 21h 0m
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Greyhound US21h 55m02:45 PMGreenville, SCWoodruff Rd12:40 PMFort Myers, FLRosa Parks Transit Center0EconomyA Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/4/2026 2:45:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/5/2026 12:40:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 21h 55m
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FlixBus36h 20m010:00 PMGreenville, SCWoodruff Rd10:20 AMFort Myers, FLRosa Parks Transit Center0EconomyA Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 6/4/2026 10:00:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/6/2026 10:20:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 36h 20m
Fastest Flights Thursday
Fastest Buses Thursday
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Allegiant Air12h 22m08:29 AMGreenville–Spartanburg AirportGreenville–Spartanburg Airport8:51 PMPunta Gorda AirportPunta Gorda Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/5/2026 8:29:00 AM to Punta Gorda Airport, Punta Gorda Airport (USA) arriving at 6/5/2026 8:51:00 PM. 50 Economy ticket for $216 per person are available. Travel duration is 12h 22m
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Breeze Airways13h 10m09:20 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport10:30 AMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Breeze Airways goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/5/2026 9:20:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/6/2026 10:30:00 AM. 50 Economy ticket for $183 per person are available. Travel duration is 13h 10m
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Allegiant Air29h 48m03:21 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport9:09 PMPunta Gorda AirportPunta Gorda Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/5/2026 3:21:00 PM to Punta Gorda Airport, Punta Gorda Airport (USA) arriving at 6/6/2026 9:09:00 PM. 50 Economy ticket for $222 per person are available. Travel duration is 29h 48m
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Allegiant Air32h 18m03:21 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport11:39 PMPunta Gorda AirportPunta Gorda Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/5/2026 3:21:00 PM to Punta Gorda Airport, Punta Gorda Airport (USA) arriving at 6/6/2026 11:39:00 PM. 50 Economy ticket for $214 per person are available. Travel duration is 32h 18m
Fastest Flights Friday
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Breeze Airways1h 47m07:51 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport9:38 PMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Breeze Airways goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/7/2026 7:51:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/7/2026 9:38:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 1h 47m
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Breeze Airways13h 4m08:19 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport9:23 AMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Breeze Airways goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/7/2026 8:19:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/8/2026 9:23:00 AM. 50 Economy ticket for $279 per person are available. Travel duration is 13h 4m
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Allegiant Air17h 56m08:44 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport2:40 PMPunta Gorda AirportPunta Gorda Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/7/2026 8:44:00 PM to Punta Gorda Airport, Punta Gorda Airport (USA) arriving at 6/8/2026 2:40:00 PM. 50 Economy ticket for $298 per person are available. Travel duration is 17h 56m
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Allegiant Air23h 6m08:44 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport7:50 PMPunta Gorda AirportPunta Gorda Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/7/2026 8:44:00 PM to Punta Gorda Airport, Punta Gorda Airport (USA) arriving at 6/8/2026 7:50:00 PM. 50 Economy ticket for $209 per person are available. Travel duration is 23h 6m
Fastest Flights Sunday
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Breeze Airways14h 0m09:20 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport11:20 AMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Breeze Airways goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/8/2026 9:20:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/9/2026 11:20:00 AM. 50 Economy ticket for $177 per person are available. Travel duration is 14h 0m
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Breeze Airways15h 50m09:20 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport1:10 PMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Breeze Airways goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/8/2026 9:20:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/9/2026 1:10:00 PM. 50 Economy ticket for $224 per person are available. Travel duration is 15h 50m
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Allegiant Air32h 36m01:22 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport9:58 PMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/8/2026 1:22:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/9/2026 9:58:00 PM. 50 Economy ticket for $158 per person are available. Travel duration is 32h 36m
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Breeze Airways35h 11m08:28 PMGreenville–Spartanburg AirportGreenville–Spartanburg Airport7:39 AMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Breeze Airways goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/8/2026 8:28:00 PM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/10/2026 7:39:00 AM. 50 Economy ticket for $174 per person are available. Travel duration is 35h 11m
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Allegiant Air47h 10m08:29 AMGreenville–Spartanburg AirportGreenville–Spartanburg Airport7:39 AMSouthwest Florida - Fort Myers AirportSouthwest Florida - Fort Myers Airport0EconomyA Flight from Allegiant Air goes from Greenville–Spartanburg Airport, Greenville–Spartanburg Airport (USA) at 6/8/2026 8:29:00 AM to Southwest Florida - Fort Myers Airport, Southwest Florida - Fort Myers Airport (USA) arriving at 6/10/2026 7:39:00 AM. 50 Economy ticket for $155 per person are available. Travel duration is 47h 10m
Fastest Flights Monday
Here you will find all operators and timetables for a
Bus from Greenville, SC to Fort Myers, FL
What are the most popular stations in Greenville, SC and Fort Myers, FL?
In Greenville, SC, you will usually depart from Woodruff Rd, McDonald's or Greyhound Bus Station, while in Fort Myers, FL you will be arriving at Daniels Pkwy, Rosa Parks Transit Center or Cleveland Ave, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Fort Myers, FL from Greenville, SC? With 5 connections between 2 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Greenville, SC and Fort Myers, FL, you can pay as low as $99 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Breeze Airways: you will get to Fort Myers, FL in just 1h 47m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Greenville, SC and Fort Myers, FL are Allegiant Air, Breeze Airways and Greyhound US, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Greenville, SC and Fort Myers, FL is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Welcome, SC or to Palmona Park, FL, and look at flights from Greenville–Spartanburg Airport, and landing at Punta Gorda Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Greenville, SC to Fort Myers, FL?
The most popular companies between Greenville, SC and Fort Myers, FL, are Allegiant Air, Breeze Airways and Greyhound US. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US and FlixBus
Airlines: Allegiant Air and Breeze Airways
All you need to know when you travel from Greenville, SC to Fort Myers, FL
Check all information on comfort and services on all modes of transports from Greenville, SC to Fort Myers, FL. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Greenville, SC to Fort Myers, FL
How can I reach Fort Myers, FL from Greenville, SC?
Every day, there are on average 5 connections between Flight and Bus, with which you can get to Fort Myers, FL from Greenville, SC.
How far is Fort Myers, FL from Greenville, SC?
The distance between Greenville, SC and Fort Myers, FL is 568.4 miles.
What is the most ecofriendly mode of transport between Greenville, SC and Fort Myers, FL?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 25 kgs of CO2, a train 32 kgs, a car 156 kgs, and a flight 225 kgs.
What is the cheapest mode of transport from Greenville, SC to Fort Myers, FL?
You can get to Fort Myers, FL with just $99 by taking a Bus from Greyhound US.
What is the fastest way to get from Greenville, SC to Fort Myers, FL?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Fort Myers, FL in just 1h 47m with a Flight from Breeze Airways.
More routes to Greenville, SC and to Fort Myers, FL
Looking for more options? Here you can see the most popular routes to Greenville, SC and to Fort Myers, FL. Simply click on a connection, and you’ll find all the details about the route!
