Bus Greenville, SC to Fort Myers, FL: Compare prices and save money

Compare all timetables for the bus from Greenville, SC to Fort Myers, FL

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to Fort Myers, FL from various bus operators like Greyhound US or FlixBus for the next days.

today

$86

tomorrow

$85

Wednesday

$104

Thursday

Friday

$88

Saturday

$89

Sunday

$82

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	18h 30m	5:45 PM	Greenville, SC	Woodruff Rd	12:15 PM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$86	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/22/2026 5:45:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/23/2026 12:15:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 18h 30m
FlixBus	21h 0m	1:20 PM	Greenville, SC	Woodruff Rd	10:20 AM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$88	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 6/22/2026 1:20:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/23/2026 10:20:00 AM. 50 Economy ticket for $88 per person are available. Travel duration is 21h 0m
Greyhound US	20h 15m	8:20 PM	Greenville, SC	Woodruff Rd	4:35 PM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$104	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/22/2026 8:20:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/23/2026 4:35:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 20h 15m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 15m	8:20 PM	Greenville, SC	Woodruff Rd	4:35 PM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$85	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/23/2026 8:20:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/24/2026 4:35:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 20h 15m
Greyhound US	21h 30m	2:45 PM	Greenville, SC	Woodruff Rd	12:15 PM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$87	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/23/2026 2:45:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/24/2026 12:15:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 21h 30m
FlixBus	21h 0m	1:20 PM	Greenville, SC	Woodruff Rd	10:20 AM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$88	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 6/23/2026 1:20:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/24/2026 10:20:00 AM. 50 Economy ticket for $88 per person are available. Travel duration is 21h 0m
FlixBus	36h 45m	9:35 PM	Greenville, SC	Woodruff Rd	10:20 AM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$88	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 6/23/2026 9:35:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/25/2026 10:20:00 AM. 50 Economy ticket for $88 per person are available. Travel duration is 36h 45m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 5m	11:15 AM	Greenville, SC	Woodruff Rd	10:20 AM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$104	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/24/2026 11:15:00 AM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/25/2026 10:20:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 23h 5m
Greyhound US	21h 30m	2:45 PM	Greenville, SC	Woodruff Rd	12:15 PM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$104	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/24/2026 2:45:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/25/2026 12:15:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 21h 30m
FlixBus	36h 45m	9:35 PM	Greenville, SC	Woodruff Rd	10:20 AM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$105	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 6/24/2026 9:35:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/26/2026 10:20:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 36h 45m
Greyhound US	20h 15m	8:20 PM	Greenville, SC	Woodruff Rd	4:35 PM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$114	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/24/2026 8:20:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/25/2026 4:35:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 20h 15m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 0m	1:20 PM	Greenville, SC	Woodruff Rd	10:20 AM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$88	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 6/26/2026 1:20:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/27/2026 10:20:00 AM. 50 Economy ticket for $88 per person are available. Travel duration is 21h 0m
Greyhound US	21h 30m	2:45 PM	Greenville, SC	Woodruff Rd	12:15 PM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$90	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/26/2026 2:45:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/27/2026 12:15:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 21h 30m
FlixBus	36h 45m	9:35 PM	Greenville, SC	Woodruff Rd	10:20 AM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$91	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 6/26/2026 9:35:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/28/2026 10:20:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 36h 45m
Greyhound US	20h 15m	8:20 PM	Greenville, SC	Woodruff Rd	4:35 PM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$101	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/26/2026 8:20:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/27/2026 4:35:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 20h 15m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 30m	2:45 PM	Greenville, SC	Woodruff Rd	12:15 PM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$89	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/27/2026 2:45:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/28/2026 12:15:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 21h 30m
FlixBus	21h 0m	1:20 PM	Greenville, SC	Woodruff Rd	10:20 AM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$90	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 6/27/2026 1:20:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/28/2026 10:20:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 21h 0m
FlixBus	36h 45m	9:35 PM	Greenville, SC	Woodruff Rd	10:20 AM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$92	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 6/27/2026 9:35:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/29/2026 10:20:00 AM. 50 Economy ticket for $92 per person are available. Travel duration is 36h 45m
Greyhound US	20h 15m	8:20 PM	Greenville, SC	Woodruff Rd	4:35 PM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$123	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/27/2026 8:20:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/28/2026 4:35:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 20h 15m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 30m	2:45 PM	Greenville, SC	Woodruff Rd	12:15 PM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$82	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/28/2026 2:45:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/29/2026 12:15:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 21h 30m
FlixBus	21h 0m	1:20 PM	Greenville, SC	Woodruff Rd	10:20 AM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$83	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 6/28/2026 1:20:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/29/2026 10:20:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 21h 0m
FlixBus	36h 45m	9:35 PM	Greenville, SC	Woodruff Rd	10:20 AM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$86	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 6/28/2026 9:35:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/30/2026 10:20:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 36h 45m
Greyhound US	20h 15m	8:20 PM	Greenville, SC	Woodruff Rd	4:35 PM	Fort Myers, FL	Rosa Parks Transit Center	Economy	$136	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 6/28/2026 8:20:00 PM to Rosa Parks Transit Center, Fort Myers, FL (USA) arriving at 6/29/2026 4:35:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 20h 15m

Best Price Offer: The price for the cheapest bus from Greenville, SC to Fort Myers, FL is $82 on 6/28/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Greenville, SC and Fort Myers, FL

See here how frequent the connections between Greenville, SC and Fort Myers, FL are, during different times and days of the week.

Tuesday is the busiest day, with more than 8 daily buses from Greenville, SC to Fort Myers, FL. Monday has instead the fewest connections, with only 3 daily coaches between Greenville, SC and Fort Myers, FL.

The busiest time of the day is the Evening, with 17 buses from Greenville, SC to Fort Myers, FL, while Morning sees the fewest connections between Greenville, SC and Fort Myers, FL, with 2 offers.

Facts about the bus from Greenville, SC to Fort Myers, FL

Compare all providers like Greyhound US and FlixBus that travel 5 times every day by bus from Greenville, SC to Fort Myers, FL in one click! Book your bus ticket from Greenville, SC to Fort Myers, FL starting from $82!

Cheapest Bus	$82
Fastest Bus	18h 30m
Earliest Bus	1:20 PM
Latest Bus	9:35 PM
Daily Bus Routes	5 Ø
Distance	568.4 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Greenville, SC to Fort Myers, FL

Every day, 5 buses from 2 bus companies leave Greenville, SC for Fort Myers, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/22/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 06/21

Monday 06/22

$86

Tuesday 06/23

$89

Wednesday 06/24

$104

Thursday 06/25

Friday 06/26

$88

Saturday 06/27

$93

Sunday 06/28

$82

Monday 06/29

Tuesday 06/30

Wednesday 07/01

Thursday 07/02

Friday 07/03

Saturday 07/04

Sunday 07/05

Monday 07/06

Tuesday 07/07

Wednesday 07/08

Thursday 07/09

$96

Friday 07/10

$93

Saturday 07/11

Sunday 07/12

$89

Monday 07/13

$86

Tuesday 07/14

$99

Wednesday 07/15

Thursday 07/16

$95

Friday 07/17

$95

Saturday 07/18

The cheapest time to travel from Greenville, SC to Fort Myers, FL

See here on which day and which time of the day you can find the cheapest bus ticket from Greenville, SC to Fort Myers, FL, for the next 30 days.

With a price starting from $82, Sunday is the cheapest day for a bus from Greenville, SC to Fort Myers, FL. Wednesday instead is the most expensive day with prices starting from $104.

Afternoon is the cheapest day time for bus tickets from Greenville, SC to Fort Myers, FL, with $82. Morning is the most expensive time of the day with prices starting from $104.

How to save money travelling from Greenville, SC to Fort Myers, FL

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to Fort Myers, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to Fort Myers, FL, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to Fort Myers, FL are also emptier.

All bus stations and stops in Greenville, SC and Fort Myers, FL

In the map below, you can see where to find all bus stations in Greenville, SC and Fort Myers, FL.

Woodruff Rd

Woodruff Rd 1116

N Church St

Greyhound Bus Station

Hendrix Dr 9

Guadalajara Supermarket

White Horse Rd 2803

McDonald's

Woodruff Rd 1111

Bus Station

Plaza Drive 6050

Rosa Parks Transit Center

Widman Way 2250

Florida Gulf Coast University

Parking Lot Five

Daniels Pkwy

Cleveland Ave

Service and Comfort on the bus from Greenville, SC to Fort Myers, FL

Want to know which seat classes are available on the buses from Greenville, SC to Fort Myers, FL? Or which bus companies serve the route Greenville, SC to Fort Myers, FL? Below you will find answers to your questions.

FAQs about the Greenville, SC to Fort Myers, FL bus

How much does a Greenville, SC Fort Myers, FL bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $82 and takes 21h 30m to reach Fort Myers, FL. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to Fort Myers, FL?

This route is offered by 2 companies with a range of ticket prices between $82 and $136. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Fort Myers, FL.

On average, how many connections are available from Greenville, SC to Fort Myers, FL each day?

Every day, the Greenville, SC to Fort Myers, FL bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to Fort Myers, FL take?

The fastest bus from Greenville, SC to Fort Myers, FL is offered by Greyhound US and takes 18h 30m. Bus tickets for this connection cost $86. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to Fort Myers, FL?

The earliest bus arriving in Fort Myers, FL from Greenville, SC starts at 1:20 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to Fort Myers, FL?

The latest bus trip departing from Greenville, SC for Fort Myers, FL starts at 9:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC Fort Myers, FL route?

When traveling by bus from Greenville, SC to Fort Myers, FL, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and Fort Myers, FL?

You can check all the direct connections between Greenville, SC and Fort Myers, FL by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Greenville, SC to Fort Myers, FL bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC Fort Myers, FL bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC Fort Myers, FL bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to Fort Myers, FL on your planned travel date.

How does CheckMyBus find the best bus deals from Greenville, SC to Fort Myers, FL?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between Greenville, SC and Fort Myers, FL. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Greenville, SC to Fort Myers, FL?

Prices and availability for 5 trips between Greenville, SC and Fort Myers, FL change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Greenville, SC to Fort Myers, FL

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to Fort Myers, FL

Here’s an overview of the most popular bus routes to Greenville, SC and to Fort Myers, FL. Simply click on the connection of your choice, and you will find all the details about your bus route!