What is the best way to travel from Indianapolis to Knoxville, TN?
Looking for a trip? Compare all the available Flights and Buses for the journey to Knoxville, TN from Indianapolis. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Knoxville, TN from Indianapolis?
You can get to Knoxville, TN with just $57 by taking a Bus from Greyhound US, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Allegiant Air13h 6m07:30 AMIndianapolis AirportIndianapolis Airport8:36 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/2/2026 7:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/2/2026 8:36:00 PM. 50 Economy ticket for $202 per person are available. Travel duration is 13h 6m
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Frontier Airlines16h 37m07:33 PMIndianapolis AirportIndianapolis Airport12:10 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/2/2026 7:33:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/3/2026 12:10:00 PM. 50 Economy ticket for $271 per person are available. Travel duration is 16h 37m
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United Airlines6h 9m07:15 AMIndianapolis AirportIndianapolis Airport1:24 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/2/2026 7:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/2/2026 1:24:00 PM. 50 Economy ticket for $274 per person are available. Travel duration is 6h 9m
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Skyscanner4h 19m09:05 AMIndianapolis AirportIndianapolis Airport1:24 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/2/2026 9:05:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/2/2026 1:24:00 PM. 50 Economy ticket for $274 per person are available. Travel duration is 4h 19m
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Spirit Airlines6h 50m010:38 AMIndianapolis AirportIndianapolis Airport5:28 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/2/2026 10:38:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/2/2026 5:28:00 PM. 50 Economy ticket for $406 per person are available. Travel duration is 6h 50m
Cheapest Flights Monday
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Spirit Airlines10h 47m05:10 AMIndianapolis AirportIndianapolis Airport3:57 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/4/2026 5:10:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/4/2026 3:57:00 PM. 50 Economy ticket for $223 per person are available. Travel duration is 10h 47m
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United Airlines4h 39m08:45 AMIndianapolis AirportIndianapolis Airport1:24 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/4/2026 8:45:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/4/2026 1:24:00 PM. 50 Economy ticket for $274 per person are available. Travel duration is 4h 39m
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United Airlines6h 52m02:00 PMIndianapolis AirportIndianapolis Airport8:52 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/4/2026 2:00:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/4/2026 8:52:00 PM. 50 Economy ticket for $274 per person are available. Travel duration is 6h 52m
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Skyscanner3h 59m09:25 AMIndianapolis AirportIndianapolis Airport1:24 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/4/2026 9:25:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/4/2026 1:24:00 PM. 50 Economy ticket for $274 per person are available. Travel duration is 3h 59m
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Skyscanner4h 49m010:00 AMIndianapolis AirportIndianapolis Airport2:49 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/4/2026 10:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/4/2026 2:49:00 PM. 50 Economy ticket for $274 per person are available. Travel duration is 4h 49m
Cheapest Flights Wednesday
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Greyhound US10h 20m09:10 AMIndianapolisCentral Bus Station7:30 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 2/5/2026 9:10:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 2/5/2026 7:30:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 10h 20m
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 2/5/2026 11:25:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 2/5/2026 10:40:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 11h 15m
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Greyhound US10h 20m09:10 AMIndianapolisCentral Bus Station7:30 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 2/5/2026 9:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 2/5/2026 7:30:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 10h 20m
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 2/5/2026 11:25:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 2/5/2026 10:40:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 11h 15m
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Allegiant Air14h 10m09:00 AMIndianapolis AirportIndianapolis Airport11:10 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/5/2026 9:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/5/2026 11:10:00 PM. 50 Economy ticket for $201 per person are available. Travel duration is 14h 10m
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Spirit Airlines29h 10m06:55 AMIndianapolis AirportIndianapolis Airport12:05 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/5/2026 6:55:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/6/2026 12:05:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 29h 10m
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Frontier Airlines13h 39m08:31 PMIndianapolis AirportIndianapolis Airport10:10 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/5/2026 8:31:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/6/2026 10:10:00 AM. 50 Economy ticket for $275 per person are available. Travel duration is 13h 39m
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United Airlines6h 9m07:15 AMIndianapolis AirportIndianapolis Airport1:24 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/5/2026 7:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/5/2026 1:24:00 PM. 50 Economy ticket for $303 per person are available. Travel duration is 6h 9m
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Skyscanner4h 32m06:00 AMIndianapolis AirportIndianapolis Airport10:32 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/5/2026 6:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/5/2026 10:32:00 AM. 50 Economy ticket for $303 per person are available. Travel duration is 4h 32m
Cheapest Buses Thursday
Cheapest Flights Thursday
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 2/7/2026 11:25:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 2/7/2026 10:40:00 PM. 50 Economy ticket for $145 per person are available. Travel duration is 11h 15m
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Greyhound US10h 20m09:10 AMIndianapolisCentral Bus Station7:30 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 2/7/2026 9:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 2/7/2026 7:30:00 PM. 50 Economy ticket for $146 per person are available. Travel duration is 10h 20m
Cheapest Buses Saturday
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 2/8/2026 11:25:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 2/8/2026 10:40:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 11h 15m
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Greyhound US10h 20m09:10 AMIndianapolisCentral Bus Station7:30 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 2/8/2026 9:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 2/8/2026 7:30:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 10h 20m
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Allegiant Air14h 10m09:00 AMIndianapolis AirportIndianapolis Airport11:10 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/8/2026 9:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/8/2026 11:10:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 14h 10m
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Spirit Airlines12h 15m010:38 AMIndianapolis AirportIndianapolis Airport10:53 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/8/2026 10:38:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/8/2026 10:53:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 12h 15m
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Frontier Airlines12h 36m09:34 PMIndianapolis AirportIndianapolis Airport10:10 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/8/2026 9:34:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/9/2026 10:10:00 AM. 50 Economy ticket for $149 per person are available. Travel duration is 12h 36m
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Skyscanner4h 59m09:50 AMIndianapolis AirportIndianapolis Airport2:49 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/8/2026 9:50:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/8/2026 2:49:00 PM. 50 Economy ticket for $272 per person are available. Travel duration is 4h 59m
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United Airlines6h 52m02:00 PMIndianapolis AirportIndianapolis Airport8:52 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/8/2026 2:00:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/8/2026 8:52:00 PM. 50 Economy ticket for $272 per person are available. Travel duration is 6h 52m
Cheapest Buses Sunday
Cheapest Flights Sunday
What are the fastest trips from Indianapolis to Knoxville, TN?
You can get to Knoxville, TN from Indianapolis in just 3h 59m with a Flight from Skyscanner. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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Skyscanner4h 19m09:05 AMIndianapolis AirportIndianapolis Airport1:24 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/2/2026 9:05:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/2/2026 1:24:00 PM. 50 Economy ticket for $274 per person are available. Travel duration is 4h 19m
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United Airlines6h 9m07:15 AMIndianapolis AirportIndianapolis Airport1:24 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/2/2026 7:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/2/2026 1:24:00 PM. 50 Economy ticket for $274 per person are available. Travel duration is 6h 9m
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Spirit Airlines6h 50m010:38 AMIndianapolis AirportIndianapolis Airport5:28 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/2/2026 10:38:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/2/2026 5:28:00 PM. 50 Economy ticket for $406 per person are available. Travel duration is 6h 50m
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Allegiant Air13h 6m07:30 AMIndianapolis AirportIndianapolis Airport8:36 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/2/2026 7:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/2/2026 8:36:00 PM. 50 Economy ticket for $202 per person are available. Travel duration is 13h 6m
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Frontier Airlines16h 37m07:33 PMIndianapolis AirportIndianapolis Airport12:10 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/2/2026 7:33:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/3/2026 12:10:00 PM. 50 Economy ticket for $271 per person are available. Travel duration is 16h 37m
Fastest Flights Monday
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Skyscanner3h 59m09:25 AMIndianapolis AirportIndianapolis Airport1:24 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/4/2026 9:25:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/4/2026 1:24:00 PM. 50 Economy ticket for $274 per person are available. Travel duration is 3h 59m
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United Airlines4h 39m08:45 AMIndianapolis AirportIndianapolis Airport1:24 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/4/2026 8:45:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/4/2026 1:24:00 PM. 50 Economy ticket for $274 per person are available. Travel duration is 4h 39m
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Skyscanner4h 49m010:00 AMIndianapolis AirportIndianapolis Airport2:49 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/4/2026 10:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/4/2026 2:49:00 PM. 50 Economy ticket for $274 per person are available. Travel duration is 4h 49m
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United Airlines6h 52m02:00 PMIndianapolis AirportIndianapolis Airport8:52 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/4/2026 2:00:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/4/2026 8:52:00 PM. 50 Economy ticket for $274 per person are available. Travel duration is 6h 52m
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Spirit Airlines10h 47m05:10 AMIndianapolis AirportIndianapolis Airport3:57 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/4/2026 5:10:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/4/2026 3:57:00 PM. 50 Economy ticket for $223 per person are available. Travel duration is 10h 47m
Fastest Flights Wednesday
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Skyscanner4h 32m06:00 AMIndianapolis AirportIndianapolis Airport10:32 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/5/2026 6:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/5/2026 10:32:00 AM. 50 Economy ticket for $303 per person are available. Travel duration is 4h 32m
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United Airlines6h 9m07:15 AMIndianapolis AirportIndianapolis Airport1:24 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/5/2026 7:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/5/2026 1:24:00 PM. 50 Economy ticket for $303 per person are available. Travel duration is 6h 9m
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Frontier Airlines13h 39m08:31 PMIndianapolis AirportIndianapolis Airport10:10 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/5/2026 8:31:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/6/2026 10:10:00 AM. 50 Economy ticket for $275 per person are available. Travel duration is 13h 39m
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Allegiant Air14h 10m09:00 AMIndianapolis AirportIndianapolis Airport11:10 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/5/2026 9:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/5/2026 11:10:00 PM. 50 Economy ticket for $201 per person are available. Travel duration is 14h 10m
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Spirit Airlines29h 10m06:55 AMIndianapolis AirportIndianapolis Airport12:05 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/5/2026 6:55:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/6/2026 12:05:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 29h 10m
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Greyhound US10h 20m09:10 AMIndianapolisCentral Bus Station7:30 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 2/5/2026 9:10:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 2/5/2026 7:30:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 10h 20m
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Greyhound US10h 20m09:10 AMIndianapolisCentral Bus Station7:30 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 2/5/2026 9:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 2/5/2026 7:30:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 10h 20m
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 2/5/2026 11:25:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 2/5/2026 10:40:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 11h 15m
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 2/5/2026 11:25:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 2/5/2026 10:40:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 11h 15m
Fastest Flights Thursday
Fastest Buses Thursday
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Greyhound US10h 20m09:10 AMIndianapolisCentral Bus Station7:30 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 2/7/2026 9:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 2/7/2026 7:30:00 PM. 50 Economy ticket for $146 per person are available. Travel duration is 10h 20m
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 2/7/2026 11:25:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 2/7/2026 10:40:00 PM. 50 Economy ticket for $145 per person are available. Travel duration is 11h 15m
Fastest Buses Saturday
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Skyscanner4h 59m09:50 AMIndianapolis AirportIndianapolis Airport2:49 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/8/2026 9:50:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/8/2026 2:49:00 PM. 50 Economy ticket for $272 per person are available. Travel duration is 4h 59m
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United Airlines6h 52m02:00 PMIndianapolis AirportIndianapolis Airport8:52 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/8/2026 2:00:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/8/2026 8:52:00 PM. 50 Economy ticket for $272 per person are available. Travel duration is 6h 52m
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Spirit Airlines12h 15m010:38 AMIndianapolis AirportIndianapolis Airport10:53 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/8/2026 10:38:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/8/2026 10:53:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 12h 15m
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Frontier Airlines12h 36m09:34 PMIndianapolis AirportIndianapolis Airport10:10 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/8/2026 9:34:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/9/2026 10:10:00 AM. 50 Economy ticket for $149 per person are available. Travel duration is 12h 36m
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Allegiant Air14h 10m09:00 AMIndianapolis AirportIndianapolis Airport11:10 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 2/8/2026 9:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 2/8/2026 11:10:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 14h 10m
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Greyhound US10h 20m09:10 AMIndianapolisCentral Bus Station7:30 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 2/8/2026 9:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 2/8/2026 7:30:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 10h 20m
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 2/8/2026 11:25:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 2/8/2026 10:40:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 11h 15m
Fastest Flights Sunday
Fastest Buses Sunday
Here you will find all operators and timetables for a
Bus from Indianapolis to Knoxville, TN
What are the most popular stations in Indianapolis and Knoxville, TN?
In Indianapolis, you will usually depart from Central Bus Station, Greyhound Bus Station or Downtown Transit Center, while in Knoxville, TN you will be arriving at Knoxville Area Transit Bus Stop, Greyhound Bus Station or Transit Center, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Knoxville, TN from Indianapolis? With 5 connections between 1 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Indianapolis and Knoxville, TN, you can pay as low as $57 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Skyscanner: you will get to Knoxville, TN in just 3h 59m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Indianapolis and Knoxville, TN are Greyhound US, United Airlines and Skyscanner, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Indianapolis and Knoxville, TN is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Beech Grove, IN or to Wildwood, TN, and look at flights from Indianapolis Airport, and landing at Knoxville Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Indianapolis to Knoxville, TN?
The most popular companies between Indianapolis and Knoxville, TN, are Greyhound US, United Airlines and Skyscanner. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US
Airlines: United Airlines, Skyscanner, Spirit Airlines and 2 more.
All you need to know when you travel from Indianapolis to Knoxville, TN
Check all information on comfort and services on all modes of transports from Indianapolis to Knoxville, TN. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Indianapolis to Knoxville, TN
How can I reach Knoxville, TN from Indianapolis?
Every day, there are on average 5 connections between Flight and Bus, with which you can get to Knoxville, TN from Indianapolis.
How far is Knoxville, TN from Indianapolis?
The distance between Indianapolis and Knoxville, TN is 289.8 miles.
What is the most ecofriendly mode of transport between Indianapolis and Knoxville, TN?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 13 kgs of CO2, a train 16 kgs, a car 79 kgs, and a flight 115 kgs.
What is the cheapest mode of transport from Indianapolis to Knoxville, TN?
You can get to Knoxville, TN with just $57 by taking a Bus from Greyhound US.
What is the fastest way to get from Indianapolis to Knoxville, TN?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Knoxville, TN in just 3h 59m with a Flight from Skyscanner.
More routes to Indianapolis and to Knoxville, TN
Looking for more options? Here you can see the most popular routes to Indianapolis and to Knoxville, TN. Simply click on a connection, and you’ll find all the details about the route!
