What is the best way to travel from Indianapolis to Knoxville, TN?
Looking for a trip? Compare all the available Buses and Flights for the journey to Knoxville, TN from Indianapolis. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Knoxville, TN from Indianapolis?
You can get to Knoxville, TN with just $75 by taking a Bus from Greyhound US, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Greyhound US9h 45m09:10 AMIndianapolisCentral Bus Station6:55 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/5/2025 9:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/5/2025 6:55:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 9h 45m
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/5/2025 11:25:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/5/2025 10:40:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 11h 15m
Cheapest Buses Friday
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Spirit Airlines7h 2m05:30 AMIndianapolis AirportIndianapolis Airport12:32 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 5:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/7/2025 12:32:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 7h 2m
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Allegiant Air14h 42m08:00 AMIndianapolis AirportIndianapolis Airport10:42 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 8:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/7/2025 10:42:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 14h 42m
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Frontier Airlines10h 56m010:48 AMIndianapolis AirportIndianapolis Airport9:44 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 10:48:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/7/2025 9:44:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 10h 56m
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Skyscanner5h 3m05:45 AMIndianapolis AirportIndianapolis Airport10:48 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 5:45:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/7/2025 10:48:00 AM. 50 Economy ticket for $275 per person are available. Travel duration is 5h 3m
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United Airlines6h 2m07:15 AMIndianapolis AirportIndianapolis Airport1:17 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 7:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/7/2025 1:17:00 PM. 50 Economy ticket for $298 per person are available. Travel duration is 6h 2m
Cheapest Flights Sunday
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/8/2025 11:25:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/8/2025 10:40:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 11h 15m
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Greyhound US9h 45m09:10 AMIndianapolisCentral Bus Station6:55 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/8/2025 9:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/8/2025 6:55:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 9h 45m
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Spirit Airlines16h 19m05:30 AMIndianapolis AirportIndianapolis Airport9:49 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 5:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/8/2025 9:49:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 16h 19m
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Allegiant Air14h 43m07:30 AMIndianapolis AirportIndianapolis Airport10:13 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 7:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/8/2025 10:13:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 14h 43m
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Frontier Airlines10h 30m011:19 AMIndianapolis AirportIndianapolis Airport9:49 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 11:19:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/8/2025 9:49:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 10h 30m
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Skyscanner5h 3m05:45 AMIndianapolis AirportIndianapolis Airport10:48 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 5:45:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/8/2025 10:48:00 AM. 50 Economy ticket for $275 per person are available. Travel duration is 5h 3m
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United Airlines6h 2m07:15 AMIndianapolis AirportIndianapolis Airport1:17 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 7:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/8/2025 1:17:00 PM. 50 Economy ticket for $275 per person are available. Travel duration is 6h 2m
Cheapest Buses Monday
Cheapest Flights Monday
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/9/2025 11:25:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/9/2025 10:40:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 11h 15m
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Greyhound US9h 45m09:10 AMIndianapolisCentral Bus Station6:55 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/9/2025 9:10:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/9/2025 6:55:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 9h 45m
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/9/2025 11:25:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/9/2025 10:40:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 11h 15m
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Greyhound US9h 45m09:10 AMIndianapolisCentral Bus Station6:55 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/9/2025 9:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/9/2025 6:55:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 9h 45m
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Spirit Airlines24h 0m012:03 PMIndianapolis AirportIndianapolis Airport12:03 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/9/2025 12:03:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/10/2025 12:03:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 24h 0m
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Spirit Airlines28h 9m08:48 AMIndianapolis AirportIndianapolis Airport12:57 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/9/2025 8:48:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/10/2025 12:57:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 28h 9m
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Skyscanner5h 3m05:45 AMIndianapolis AirportIndianapolis Airport10:48 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/9/2025 5:45:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/9/2025 10:48:00 AM. 50 Economy ticket for $273 per person are available. Travel duration is 5h 3m
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Skyscanner4h 13m06:00 AMIndianapolis AirportIndianapolis Airport10:13 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/9/2025 6:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/9/2025 10:13:00 AM. 50 Economy ticket for $273 per person are available. Travel duration is 4h 13m
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United Airlines6h 2m07:15 AMIndianapolis AirportIndianapolis Airport1:17 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/9/2025 7:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/9/2025 1:17:00 PM. 50 Economy ticket for $273 per person are available. Travel duration is 6h 2m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
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Skyscanner5h 3m05:45 AMIndianapolis AirportIndianapolis Airport10:48 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 5:45:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/10/2025 10:48:00 AM. 50 Economy ticket for $275 per person are available. Travel duration is 5h 3m
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Skyscanner4h 13m06:00 AMIndianapolis AirportIndianapolis Airport10:13 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 6:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/10/2025 10:13:00 AM. 50 Economy ticket for $275 per person are available. Travel duration is 4h 13m
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Skyscanner3h 42m09:35 AMIndianapolis AirportIndianapolis Airport1:17 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 9:35:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/10/2025 1:17:00 PM. 50 Economy ticket for $275 per person are available. Travel duration is 3h 42m
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United Airlines6h 2m07:15 AMIndianapolis AirportIndianapolis Airport1:17 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 7:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/10/2025 1:17:00 PM. 50 Economy ticket for $275 per person are available. Travel duration is 6h 2m
Cheapest Flights Wednesday
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Greyhound US9h 45m09:10 AMIndianapolisCentral Bus Station6:55 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/11/2025 9:10:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/11/2025 6:55:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 9h 45m
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/11/2025 11:25:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/11/2025 10:40:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 11h 15m
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Greyhound US9h 45m09:10 AMIndianapolisCentral Bus Station6:55 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/11/2025 9:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/11/2025 6:55:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 9h 45m
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/11/2025 11:25:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/11/2025 10:40:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 11h 15m
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Allegiant Air14h 42m08:00 AMIndianapolis AirportIndianapolis Airport10:42 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/11/2025 8:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/11/2025 10:42:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 14h 42m
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Allegiant Air29h 44m011:00 AMIndianapolis AirportIndianapolis Airport4:44 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/11/2025 11:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/12/2025 4:44:00 PM. 50 Economy ticket for $153 per person are available. Travel duration is 29h 44m
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Spirit Airlines27h 7m08:48 AMIndianapolis AirportIndianapolis Airport11:55 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/11/2025 8:48:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/12/2025 11:55:00 AM. 50 Economy ticket for $167 per person are available. Travel duration is 27h 7m
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Spirit Airlines11h 3m05:30 AMIndianapolis AirportIndianapolis Airport4:33 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/11/2025 5:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/11/2025 4:33:00 PM. 50 Economy ticket for $172 per person are available. Travel duration is 11h 3m
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United Airlines6h 2m07:15 AMIndianapolis AirportIndianapolis Airport1:17 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/11/2025 7:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/11/2025 1:17:00 PM. 50 Economy ticket for $297 per person are available. Travel duration is 6h 2m
Cheapest Buses Thursday
Cheapest Flights Thursday
What are the fastest trips from Indianapolis to Knoxville, TN?
You can get to Knoxville, TN from Indianapolis in just 3h 42m with a Flight from Skyscanner. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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Greyhound US9h 45m09:10 AMIndianapolisCentral Bus Station6:55 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/5/2025 9:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/5/2025 6:55:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 9h 45m
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/5/2025 11:25:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/5/2025 10:40:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 11h 15m
Fastest Buses Friday
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Skyscanner5h 3m05:45 AMIndianapolis AirportIndianapolis Airport10:48 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 5:45:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/7/2025 10:48:00 AM. 50 Economy ticket for $275 per person are available. Travel duration is 5h 3m
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United Airlines6h 2m07:15 AMIndianapolis AirportIndianapolis Airport1:17 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 7:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/7/2025 1:17:00 PM. 50 Economy ticket for $298 per person are available. Travel duration is 6h 2m
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Spirit Airlines7h 2m05:30 AMIndianapolis AirportIndianapolis Airport12:32 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 5:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/7/2025 12:32:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 7h 2m
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Frontier Airlines10h 56m010:48 AMIndianapolis AirportIndianapolis Airport9:44 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 10:48:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/7/2025 9:44:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 10h 56m
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Allegiant Air14h 42m08:00 AMIndianapolis AirportIndianapolis Airport10:42 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/7/2025 8:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/7/2025 10:42:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 14h 42m
Fastest Flights Sunday
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Skyscanner5h 3m05:45 AMIndianapolis AirportIndianapolis Airport10:48 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 5:45:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/8/2025 10:48:00 AM. 50 Economy ticket for $275 per person are available. Travel duration is 5h 3m
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United Airlines6h 2m07:15 AMIndianapolis AirportIndianapolis Airport1:17 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 7:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/8/2025 1:17:00 PM. 50 Economy ticket for $275 per person are available. Travel duration is 6h 2m
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Frontier Airlines10h 30m011:19 AMIndianapolis AirportIndianapolis Airport9:49 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 11:19:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/8/2025 9:49:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 10h 30m
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Allegiant Air14h 43m07:30 AMIndianapolis AirportIndianapolis Airport10:13 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 7:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/8/2025 10:13:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 14h 43m
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Spirit Airlines16h 19m05:30 AMIndianapolis AirportIndianapolis Airport9:49 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/8/2025 5:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/8/2025 9:49:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 16h 19m
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Greyhound US9h 45m09:10 AMIndianapolisCentral Bus Station6:55 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/8/2025 9:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/8/2025 6:55:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 9h 45m
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/8/2025 11:25:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/8/2025 10:40:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 11h 15m
Fastest Flights Monday
Fastest Buses Monday
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Skyscanner4h 13m06:00 AMIndianapolis AirportIndianapolis Airport10:13 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/9/2025 6:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/9/2025 10:13:00 AM. 50 Economy ticket for $273 per person are available. Travel duration is 4h 13m
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Skyscanner5h 3m05:45 AMIndianapolis AirportIndianapolis Airport10:48 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/9/2025 5:45:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/9/2025 10:48:00 AM. 50 Economy ticket for $273 per person are available. Travel duration is 5h 3m
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United Airlines6h 2m07:15 AMIndianapolis AirportIndianapolis Airport1:17 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/9/2025 7:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/9/2025 1:17:00 PM. 50 Economy ticket for $273 per person are available. Travel duration is 6h 2m
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Spirit Airlines24h 0m012:03 PMIndianapolis AirportIndianapolis Airport12:03 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/9/2025 12:03:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/10/2025 12:03:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 24h 0m
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Spirit Airlines28h 9m08:48 AMIndianapolis AirportIndianapolis Airport12:57 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/9/2025 8:48:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/10/2025 12:57:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 28h 9m
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Greyhound US9h 45m09:10 AMIndianapolisCentral Bus Station6:55 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/9/2025 9:10:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/9/2025 6:55:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 9h 45m
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Greyhound US9h 45m09:10 AMIndianapolisCentral Bus Station6:55 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/9/2025 9:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/9/2025 6:55:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 9h 45m
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/9/2025 11:25:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/9/2025 10:40:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 11h 15m
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/9/2025 11:25:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/9/2025 10:40:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 11h 15m
Fastest Flights Tuesday
Fastest Buses Tuesday
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Skyscanner3h 42m09:35 AMIndianapolis AirportIndianapolis Airport1:17 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 9:35:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/10/2025 1:17:00 PM. 50 Economy ticket for $275 per person are available. Travel duration is 3h 42m
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Skyscanner4h 13m06:00 AMIndianapolis AirportIndianapolis Airport10:13 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 6:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/10/2025 10:13:00 AM. 50 Economy ticket for $275 per person are available. Travel duration is 4h 13m
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Skyscanner5h 3m05:45 AMIndianapolis AirportIndianapolis Airport10:48 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 5:45:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/10/2025 10:48:00 AM. 50 Economy ticket for $275 per person are available. Travel duration is 5h 3m
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United Airlines6h 2m07:15 AMIndianapolis AirportIndianapolis Airport1:17 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/10/2025 7:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/10/2025 1:17:00 PM. 50 Economy ticket for $275 per person are available. Travel duration is 6h 2m
Fastest Flights Wednesday
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United Airlines6h 2m07:15 AMIndianapolis AirportIndianapolis Airport1:17 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/11/2025 7:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/11/2025 1:17:00 PM. 50 Economy ticket for $297 per person are available. Travel duration is 6h 2m
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Spirit Airlines11h 3m05:30 AMIndianapolis AirportIndianapolis Airport4:33 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/11/2025 5:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/11/2025 4:33:00 PM. 50 Economy ticket for $172 per person are available. Travel duration is 11h 3m
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Allegiant Air14h 42m08:00 AMIndianapolis AirportIndianapolis Airport10:42 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/11/2025 8:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/11/2025 10:42:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 14h 42m
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Spirit Airlines27h 7m08:48 AMIndianapolis AirportIndianapolis Airport11:55 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/11/2025 8:48:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/12/2025 11:55:00 AM. 50 Economy ticket for $167 per person are available. Travel duration is 27h 7m
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Allegiant Air29h 44m011:00 AMIndianapolis AirportIndianapolis Airport4:44 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/11/2025 11:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/12/2025 4:44:00 PM. 50 Economy ticket for $153 per person are available. Travel duration is 29h 44m
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Greyhound US9h 45m09:10 AMIndianapolisCentral Bus Station6:55 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/11/2025 9:10:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/11/2025 6:55:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 9h 45m
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Greyhound US9h 45m09:10 AMIndianapolisCentral Bus Station6:55 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/11/2025 9:10:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/11/2025 6:55:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 9h 45m
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/11/2025 11:25:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/11/2025 10:40:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 11h 15m
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Greyhound US11h 15m011:25 AMIndianapolisCentral Bus Station10:40 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/11/2025 11:25:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/11/2025 10:40:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 11h 15m
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Here you will find all operators and timetables for a
Bus from Indianapolis to Knoxville, TN
What are the most popular stations in Indianapolis and Knoxville, TN?
In Indianapolis, you will usually depart from Central Bus Station, Greyhound Bus Station or Downtown Transit Center, while in Knoxville, TN you will be arriving at Knoxville Area Transit Bus Stop, Greyhound Bus Station or Transit Center, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Knoxville, TN from Indianapolis? With 6 connections between 1 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Indianapolis and Knoxville, TN, you can pay as low as $75 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Skyscanner: you will get to Knoxville, TN in just 3h 42m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Indianapolis and Knoxville, TN are Greyhound US, Skyscanner and Spirit Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Indianapolis and Knoxville, TN is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Beech Grove, IN or to Wildwood, TN, and look at flights from Indianapolis Airport, and landing at Knoxville Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Indianapolis to Knoxville, TN?
The most popular companies between Indianapolis and Knoxville, TN, are Greyhound US, Skyscanner and Spirit Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US
Airlines: Skyscanner, Spirit Airlines, United Airlines and 2 more.
All you need to know when you travel from Indianapolis to Knoxville, TN
Check all information on comfort and services on all modes of transports from Indianapolis to Knoxville, TN. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Indianapolis to Knoxville, TN
How can I reach Knoxville, TN from Indianapolis?
Every day, there are on average 6 connections between Bus and Flight, with which you can get to Knoxville, TN from Indianapolis.
How far is Knoxville, TN from Indianapolis?
The distance between Indianapolis and Knoxville, TN is 289.8 miles.
What is the most ecofriendly mode of transport between Indianapolis and Knoxville, TN?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 13 kgs of CO2, a train 16 kgs, a car 79 kgs, and a flight 115 kgs.
What is the cheapest mode of transport from Indianapolis to Knoxville, TN?
You can get to Knoxville, TN with just $75 by taking a Bus from Greyhound US.
What is the fastest way to get from Indianapolis to Knoxville, TN?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Knoxville, TN in just 3h 42m with a Flight from Skyscanner.
More routes to Indianapolis and to Knoxville, TN
Looking for more options? Here you can see the most popular routes to Indianapolis and to Knoxville, TN. Simply click on a connection, and you’ll find all the details about the route!

